Benzannulated spiroketal natural products: isolation, biological activity, biosynthesis, and total synthesis.

The spiroketal moiety is an important privileged scaffold that occurs extensively in natural products, drugs, and bioactive molecules. Naturally occurring spiroketals are numerous, however aryl-fused spiroketals are relatively rare. The only comprehensive review disclosing the isolation, biological activity, and synthesis of benzannulated spiroketal natural products was published nearly a decade ago. This review will serve as an update of the 2009 review and include all known families of benzannulated spiroketals, detailing their isolation and biological activity where relevant. Although not exhaustive, endeavours towards their total synthesis will be discussed.

• Publication year

  2019

• Venue

  Organic and biomolecular chemistry

• Publication date

  2019-09-18

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/c9ob01598aPMID 31478048
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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