Characterization of Schizosaccharomyces pombeHus1: a PCNA-Related Protein That Associates with Rad1 and Rad9

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Molecular and Cellular Biology

• Publication date

  2000-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.20.4.1254-1262.2000PMID 10648611PMCID PMC85258
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell cycle control and cancer.

  2000cited by this paper
• A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins

  1999cited by this paper
• Conserved domains in DNA repair proteins and evolution of repair systems.

  1999influential reference
• Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

  1999cited by this paper
• A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins.

  1999influential reference
• The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.

  1999influential reference
• Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex*

  1999influential reference
• Role of a Complex Containing Rad17, Mec3, and Ddc1 in the Yeast DNA Damage Checkpoint Pathway

  1999influential reference
• DNA structure checkpoint pathways in Schizosaccharomyces pombe.

  1999cited by this paper
• Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

  1998cited by this paper
• Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses

  1998cited by this paper
• Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage

  1998influential reference
• Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen

  1998cited by this paper
• Replication checkpoint enforced by kinases Cds1 and Chk1.

  1998cited by this paper
• Functional and Physical Interaction between Rad24 and Rfc5 in the Yeast Checkpoint Pathways

  1998influential reference
• S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.

  1998cited by this paper
• A Human Homologue of the Schizosaccharomyces pombe rad1 + Checkpoint Gene Encodes an Exonuclease*

  1998cited by this paper
• Functional sites of human PCNA which interact with p21 (Cip1/Waf1), DNA polymerase δ and replication factor C

  1998cited by this paper
• Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.

  1998cited by this paper
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  1998cited by this paper
• Fission Yeast rad12+Regulates Cell Cycle Checkpoint Control and Is Homologous to the Bloom’s Syndrome Disease Gene

  1998cited by this paper
• Heterologous modules for efficient and versatile PCR‐based gene targeting in Schizosaccharomyces pombe

  1998cited by this paper
• Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.

  1997cited by this paper
• Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation

  1997cited by this paper
• Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance

  1997cited by this paper
• Molecular analysis of hus1+, a fission yeast gene required for S-M and DNA damage checkpoints

  1997cited by this paper
• CRM1 is responsible for intracellular transport mediated by the nuclear export signal

  1997cited by this paper
• The fission yeast UVDR DNA repair pathway is inducible.

  1997cited by this paper
• Analysis of radiation-sensitive mutants of fission yeast.

  1997cited by this paper
• Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.

  1997influential reference
• Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.

  1997cited by this paper
• Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.

  1997cited by this paper
• Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint.

  1997influential reference
• rad-Dependent Response of the chk1-Encoded Protein Kinase at the DNA Damage Checkpoint

  1996cited by this paper
• The REC1 gene of Ustilago maydis, which encodes a 3'-->5' exonuclease, couples DNA repair and completion of DNA synthesis to a mitotic checkpoint.

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• A Flexible Motif Search Technique Based on Generalized Profiles

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• A kinase from fission yeast responsible for blocking mitosis in S phase

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• Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins.

  1995influential reference
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  1995cited by this paper
• DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.

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• The REC1 gene of Ustilago maydis involved in the cellular response to DNA damage encodes an exonuclease.

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• Cell cycle control and cancer.

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• Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

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• Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins.

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• Checkpoint controls in Schizosaccharomyces pombe: rad1.

  1992cited by this paper
• Fission yeast genes involved in coupling mitosis to completion of DNA replication.

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• Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.

  1991cited by this paper
• Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis.

  1988cited by this paper
• The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae.

  1988cited by this paper

• Energetically equivalent structural transitions in the Rad17–Rad9–Hus1–Rad1–Rhino complex underlie the sequential progression from activation through maintenance to inactivation of the ATR-dependent DNA damage response

  2026cites this paper
• Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin

  2023cites this paper
• The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamploader interface.

  2023cites this paper
• From Processivity to Genome Maintenance: The Many Roles of Sliding Clamps

  2022cites this paper
• Rad17 Translocates to Nucleolus upon UV Irradiation through Nucleolar Localization Signal in the Central Basic Domain

  2022cites this paper
• An AMPKα2-specific phospho-switch controls lysosomal targeting for activation.

  2022cites this paper
• Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3

  2022cites this paper
• Environmental control of Pub1 (NEDD4 family E3 ligase) in S. pombe is regulated by TORC2 and Gsk3

  2021cites this paper
• A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans

  2021cites this paper
• Preservation of lagging strand integrity at sites of stalled replication by Pol α-primase and 9-1-1 complex

  2021cites this paper
• Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation.

  2020cites this paper
• mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

  2020cites this paper
• Optimised bacterial expression of three DNA quality

  2020influential citation
• SUMO modification of Rad 22 , the Schizosaccharomyces pombe homologue of the recombination protein Rad 52

  2019cites this paper
• mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

  2019cites this paper
• Schizosaccharomyces pombe Checkpoint Response to DNA

  2019cites this paper
• The conserved Fanconi anemia nuclease Fan 1 and the SUMO E 3 ligase Pli 1 act in two novel Pso 2 independent pathways of DNA interstrand crosslink repair in yeast

  2019cites this paper
• Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling

  2019cites this paper
• The tumour suppressor protein flap endonuclease 1 interacts physically with the heterotrimeric checkpoint protein complex Rad9, Rad1 and Hus1

  2019cites this paper
• The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of rapamycin activity

  2018cites this paper
• A novel role for ATR/Rad3 in G1 phase

  2018cites this paper
• Nutrient Limitation Inactivates Mrc1-to-Cds1 Checkpoint Signalling in Schizosaccharomyces pombe

  2018cites this paper
• tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway

  2018cites this paper
• The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks

  2017cites this paper
• Functions of Multiple Clamp and Clamp-Loader Complexes in Eukaryotic DNA Replication.

  2017cites this paper
• A checkpoint-independent mechanism delays entry into mitosis after UV irradiation

  2017cites this paper
• Activation of Gcn2 in response to different stresses

  2017cites this paper
• Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control

  2017cites this paper
• The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress

  2017cites this paper
• S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion

  2017cites this paper
• Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast

  2017cites this paper
• Explorer The essential functions of NEDD 8 are mediated via distinct surface regions , and not by polyneddylation in Schizosaccharomyces pombe

  2017influential citation
• Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9‐1‐1 complex components during the DNA damage response in Leishmania

  2016cites this paper
• Novel Cellular Activities of The Cell Cycle Checkpoint Protein Rad1 Revealed by a New High-quality anti-Rad1 Antibody

  2016cites this paper
• Consequences of abnormal CDK activity in S phase

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• Sample Preparation Techniques for Soil, Plant, and Animal Samples

  2016cites this paper
• Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2

  2016cites this paper
• TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis

  2016cites this paper
• Nucleic Acid and Protein Sample Preparation from Yeasts

  2016cites this paper
• Multiple crosstalk between TOR and the cell integrity MAPK signaling pathway in fission yeast

  2016cites this paper
• Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking

  2016cites this paper
• Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe

  2015cites this paper
• Stress-induced inhibition of translation independently of eIF2α phosphorylation

  2015cites this paper
• New roles of S.pombe Casein kinase 1 epsilon (Hhp1) in DNA replicatation stress

  2015influential citation
• Nitrogen Regulates AMPK to Control TORC1 Signaling

  2015cites this paper
• Novel Variants of the DNA Damage Checkpoint Protein Hus1 in Fission Yeast and Human Cells

  2014cites this paper
• Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells

  2014cites this paper
• An investigation into the function of the SUMOylation of Nse2 and PCNA in S. pombe

  2014cites this paper
• Hyperactive Cdc 2 kinase interferes with the response to broken replication forks by trapping S . pombe Crb 2 in its mitotic T 215 phosphorylated state

  2014cites this paper
• Characterisation of the roles of Poz1 and Stn1 at Schizosaccharomyces pombe telomeres

  2014cites this paper
• Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state

  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
• The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast

  2013cites this paper
• xopAC-triggered Immunity against Xanthomonas Depends on Arabidopsis Receptor-Like Cytoplasmic Kinase Genes PBL2 and RIPK

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• Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition

  2013cites this paper
• Comparing the mechanism of the E. coli and S. cerevisiae clamp loaders

  2013cites this paper
• The interaction between Rad9 and Tousled-like kinase 1 in the cell cycle and the DNA damage response

  2013cites this paper
• Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition

  2013cites this paper
• LmHus1 is required for the DNA damage response in Leishmania major and forms a complex with an unusual Rad9 homologue

  2013cites this paper
• Analysis of telomere maintenance mechanisms in the roundworm Caenorhabditis elegans

  2013cites this paper
• Quantitative proteomic analysis of chromatin-bound proteins in the fission yeast Schizosaccharomyces pombe

  2012cites this paper
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  2012cites this paper
• The DNA damage and the DNA synthesis checkpoints converge at the MBF transcription factor

  2012cites this paper
• TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeast

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  2012influential citation
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• The Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner

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• Potential use of the Oncorhynchus mykiss checkpoint proteins Rad1 and Hus1 as genotoxicity biomarkers

  2011cites this paper
• REGULATION OF THE CDC25 MITOTIC INDUCER FOLLOWING REPLICATION ARREST AND DNA DAMAGE

  2011cites this paper
• The Hus1 homologue of Leishmania major encodes a nuclear protein that participates in DNA damage response.

  2011cites this paper
• Novel insights into the DNA interstrand cross-link repair in Schizosaccharomyces pombe: characterisation of Fan1 through standard and high-throughput genetic analysis

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• The Phosphorylation Network for Efficient Activation of the DNA Replication Checkpoint in Fission Yeast*

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• The Essential Functions of NEDD8 Are Mediated via Distinct Surface Regions, and Not by Polyneddylation in Schizosaccharomyces pombe

  2011influential citation
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• The DNA Damage Checkpoint Regulates a Transition between Yeast and Hyphal Growth in Schizosaccharomyces japonicus

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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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