Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths

The epithelial-mesenchymal transition is involved in several physiological processes. However, it is also believed to contribute to cancer progression. Conversely, cellular senescence constitutes a failsafe program against cancer progression. Interestingly, EMT and senescence seem to cross paths, with several factors playing dominant roles in both settings. Here, we describe recent observations that link these important cellular processes.

• Publication year

  2010

• Venue

  Aging

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.18632/AGING.100209PMID 20975209PMCID 2993803
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Oncogene].

  2019cited by this paper
• TWISTing an embryonic transcription factor into an oncoprotein

  2010cited by this paper
• Senescence in tumours: evidence from mice and humans

  2010cited by this paper
• The essence of senescence.

  2010cited by this paper
• The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?

  2010cited by this paper
• Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence.

  2010cited by this paper
• PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage

  2010cited by this paper
• TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma

  2010cited by this paper
• Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors.

  2010cited by this paper
• Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells

  2010cited by this paper
• Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence.

  2009cited by this paper
• Oncogenic Braf induces melanocyte senescence and melanoma in mice.

  2009cited by this paper
• Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

  2009cited by this paper
• p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

  2009cited by this paper
• Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

  2009cited by this paper
• Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells

  2009cited by this paper
• Senescence-messaging secretome: SMS-ing cellular stress

  2009cited by this paper
• A Twist-Snail Axis Critical for TrkB-Induced Epithelial-Mesenchymal Transition-Like Transformation, Anoikis Resistance, and Metastasis

  2009cited by this paper
• Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function.

  2009cited by this paper
• Epithelial-mesenchymal transitions in development and disease.

  2009cited by this paper
• BRafV600E cooperates with Pten silencing to elicit metastatic melanoma

  2009cited by this paper
• Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

  2009cited by this paper
• Metastasis-induction and apoptosis-protection by TWIST in gastric cancer cells

  2009cited by this paper
• Metastasis mechanisms.

  2009cited by this paper
• p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

  2009cited by this paper
• Constitutively active MEK1 is sufficient to induce epithelial‐to‐mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis

  2009cited by this paper
• Twisted epithelial–mesenchymal transition blocks senescence

  2008cited by this paper
• Deregulating EMT and senescence: double impact by a single twist.

  2008cited by this paper
• Cellular senescence in vivo: a barrier to tumorigenesis.

  2008cited by this paper
• Chemokine signaling via the CXCR2 receptor reinforces senescence.

  2008cited by this paper
• Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front

  2008cited by this paper
• Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.

  2008cited by this paper
• The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer.

  2008cited by this paper
• Zeb1 links epithelial-mesenchymal transition and cellular senescence

  2008influential reference
• Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

  2008influential reference
• Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas

  2008cited by this paper
• Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence.

  2008cited by this paper
• Twist and p53 reciprocally regulate target genes via direct interaction

  2008cited by this paper
• Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

  2008cited by this paper
• The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2.

  2008cited by this paper
• BRAFE600 in benign and malignant human tumours

  2008cited by this paper
• Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition.

  2007cited by this paper
• Role of p 14 ARF in TWIST-mediated senescence in prostate epithelial cells

  2007cited by this paper
• Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

  2007cited by this paper
• Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells.

  2007cited by this paper
• Expression of snail in pancreatic cancer promotes metastasis and chemoresistance.

  2007cited by this paper
• A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.

  2006cited by this paper
• Oncogene-induced cell senescence--halting on the road to cancer.

  2006cited by this paper
• ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.

  2006cited by this paper
• New signals from the invasive front

  2006cited by this paper
• Invasion and Metastasis in Colorectal Cancer: Epithelial-Mesenchymal Transition, Mesenchymal-Epithelial Transition, Stem Cells and β-Catenin

  2005cited by this paper
• Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

  2005cited by this paper
• Tumour biology: Senescence in premalignant tumours

  2005cited by this paper
• BRAFE600-associated senescence-like cell cycle arrest of human naevi

  2005cited by this paper
• Molecular requirements for epithelial-mesenchymal transition during tumor progression.

  2005cited by this paper
• DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells

  2005cited by this paper
• c-erbB2-induced epithelial-mesenchymal transition in mammary epithelial cells is suppressed by cell-cell contact and initiated prior to E-cadherin downregulation.

  2005cited by this paper
• The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis.

  2004cited by this paper
• Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist.

  2004cited by this paper
• Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells.

  2004cited by this paper
• Regulation of Cellular Senescence and p16INK4a Expression by Id1 and E47 Proteins in Human Diploid Fibroblast*

  2004cited by this paper
• Snail blocks the cell cycle and confers resistance to cell death.

  2004cited by this paper
• Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.

  2004cited by this paper
• Epithelial-mesenchymal transition and its implications for fibrosis.

  2003cited by this paper
• The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

  2003cited by this paper
• Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

  2003cited by this paper
• Expression profiling of epithelial plasticity in tumor progression

  2003cited by this paper
• Epithelial–mesenchymal transitions in tumour progression

  2002cited by this paper
• The SLUG zinc-finger protein represses E-cadherin in breast cancer.

  2002cited by this paper
• Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.

  2002influential reference
• Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

  2002cited by this paper
• A New Role for E12/E47 in the Repression ofE-cadherin Expression and Epithelial-Mesenchymal Transitions*

  2001cited by this paper
• The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.

  2001cited by this paper
• The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

  2000cited by this paper
• The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

  2000cited by this paper
• Twist is a potential oncogene that inhibits apoptosis.

  1999cited by this paper
• E-cadherin Mediates Aggregation-dependent Survival of Prostate and Mammary Epithelial Cells through the Retinoblastoma Cell Cycle Control Pathway*

  1999cited by this paper
• RB and c-Myc Activate Expression of the E-Cadherin Gene in Epithelial Cells through Interaction with Transcription Factor AP-2

  1998cited by this paper
• Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame

  1997cited by this paper
• Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

  1997cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997cited by this paper
• Inactivation of retinoblastoma family proteins by SV40 T antigen results in creation of a hepatocyte growth factor/scatter factor autocrine loop associated with an epithelial-fibroblastoid conversion and invasiveness.

  1997cited by this paper
• The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila.

  1991cited by this paper
• Cells with persistent twist expression are the embryonic precursors of adult muscles in Drosophila.

  1991cited by this paper
• Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

  year unknowncited by this paper

• Noncoding RNAs, Vital Players in Breast Cancer Metastasis

  2025cites this paper
• Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer

  2025cites this paper
• Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice

  2025cites this paper
• ARv7 promotes the escape of prostate cancer cells from androgen deprivation therapy-induced senescence by mediating the SKP2/p27 axis

  2025cites this paper
• A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma

  2025cites this paper
• Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging

  2025cites this paper
• Circulating tumor cells: indicators of cancer progression, plasticity and utility for therapies

  2025cites this paper
• Intricate relationship between cancer stemness, metastasis, and drug resistance

  2024cites this paper
• A Boolean network model of hypoxia, mechanosensing and TGF-β signaling captures the role of phenotypic plasticity and mutations in tumor metastasis

  2024cites this paper
• Radiation-induced senescence in glioblastoma: An overview of the mechanisms and eradication strategies.

  2024cites this paper
• HHIP’s Dynamic Role in Epithelial Wound Healing Reveals a Potential Mechanism of COPD Susceptibility

  2024cites this paper
• Empagliflozin attenuates epithelial to mesenchymal transition through senescence in peritoneal dialysis.

  2024cites this paper
• Epithelial-Mesenchymal Transition: A Fundamental Cellular and Microenvironmental Process in Benign and Malignant Prostate Pathologies

  2024cites this paper
• Cancer prevention with rapamycin

  2023cites this paper
• MAPKs in the early steps of senescence implemEMTation

  2023cites this paper
• Boolean modeling of mechanosensitive epithelial to mesenchymal transition and its reversal

  2023cites this paper
• p38 Mitogen-Activated Protein Kinase Inhibition of Mesenchymal Transdifferentiated Tumor Cells in Head and Neck Squamous Cell Carcinoma

  2023cites this paper
• Cellular senescence triggers intracellular acidification and lysosomal pH alkalinized via ATP6AP2 attenuation in breast cancer cells

  2023cites this paper
• Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis

  2023influential citation
• Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging

  2023cites this paper
• PTEN overexpression and nuclear β-catenin stabilization promote morular differentiation through induction of epithelial–mesenchymal transition and cancer stem cell-like properties in endometrial carcinoma

  2022cites this paper
• The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance

  2022cites this paper
• Role of Notch Signalling in Oxidative Stress and Stem Cell Self-Renewal During Colitis and Colon Cancer

  2022cites this paper
• DOC2B is a Negative Regulator of Wnt/β-catenin Signaling Pathway in Cervical Cancer.

  2022cites this paper
• The functional multipotency of transforming growth factor β signaling at the intersection of senescence and cancer

  2022influential citation
• Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity

  2021cites this paper
• Low Dose Chronic Angiotensin II Induces Selective Senescence of Kidney Endothelial Cells

  2021influential citation
• B7 family member H4 induces epithelial-mesenchymal transition and promotes the proliferation, migration and invasion of colorectal cancer cells

  2021cites this paper
• Age-related epithelial defects limit thymic function and regeneration

  2021cites this paper
• Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?

  2021cites this paper
• Gene signatures associated with barrier dysfunction and infection in oral lichen planus identified by analysis of transcriptomic data

  2021cites this paper
• Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence

  2021cites this paper
• Epithelial‐to‐mesenchymal‐like transition events in melanoma

  2021cites this paper
• Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence

  2021cites this paper
• Cell Signaling in Hepatocellular Carcinoma

  2020cites this paper
• Cell Biology International

  2020cites this paper
• The secretome of aged fibroblasts promotes EMT-like phenotype in primary keratinocytes from elderly donors through BDNF-TrkB axis.

  2020cites this paper
• Microsecond Pulsed Electric Fields: An Effective Way to Selectively Target and Radiosensitize Medulloblastoma Cancer Stem Cells.

  2020cites this paper
• Epithelial-to-Mesenchymal Transition and Migration of Human Peritoneal Mesothelial Cells Undergoing Senescence

  2019cites this paper
• Resveratrol induced premature senescence and inhibited epithelial-mesenchymal transition of cancer cells via induction of tumor suppressor Rad9

  2019cites this paper
• EMT and Cancer: More Than Meets the Eye.

  2019cites this paper
• Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells

  2019cites this paper
• Endothelial/Epithelial Mesenchymal Transition in Ascending Aortas of Patients With Bicuspid Aortic Valve

  2019cites this paper
• Epithelial Mesenchymal Transition (EMT) -associated S100 proteins are modulators for the progression of bladder cancer

  2019cites this paper
• Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression

  2019cites this paper
• Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transition

  2018cites this paper
• Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features

  2018cites this paper
• MicroRNA regulatory networks reflective of polyhexamethylene guanidine phosphate-induced fibrosis in A549 human alveolar adenocarcinoma cells.

  2018cites this paper
• Different Biological Pathways Are Up-regulated in the Elderly With Asthma: Sputum Transcriptomic Analysis

  2018cites this paper
• Carbon nanotubes physicochemical properties influence the overall cellular behavior and fate.

  2018influential citation
• Transcriptional response to organic compounds from diverse gasoline and biogasoline fuel emissions in human lung cells.

  2018cites this paper
• Prospective Epigenetic Paradigms and Models for Cellular Senescence and Epithelial–Mesenchymal Transition in Organismal Development and Aging

  2017cites this paper
• Snail1 transcription factor controls telomere transcription and integrity

  2017cites this paper
• EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression

  2017cites this paper
• Gene regulatory network underlying the immortalization of epithelial cells

  2017influential citation
• p16INK4A induces senescence and inhibits EMT through microRNA‐141/microRNA‐146b‐5p‐dependent repression of AUF1

  2017cites this paper
• Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5

  2017cites this paper
• Metformin reverses bFGF-induced epithelial-mesenchymal transition in HCC cells

  2017cites this paper
• MicroRNA profiling analysis revealed different cellular senescence mechanisms in human mesenchymal stem cells derived from different origin.

  2017cites this paper
• The Role of Cytoplasmic Polyadenylation Element Binding Protein -2 (CPEB-2) in Human Breast Cancer

  2017cites this paper
• Regulation and function of S100 proteins in pancreatic carcinoma

  2017cites this paper
• The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1

  2016cites this paper
• MicroRNA-138 modulates metastasis and EMT in breast cancer cells by targeting vimentin.

  2016cites this paper
• Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis

  2016cites this paper
• The influence of ageing and culture conditions on limbal epithelial cells

  2015cites this paper
• OVOL guides the epithelial-hybrid-mesenchymal transition

  2015cites this paper
• A prospective epigenetic paradigm between cellular senescence and epithelial-mesenchymal transition in organismal development and aging.

  2015cites this paper
• Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer

  2014cites this paper
• Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell

  2014cites this paper
• Aging and IPF: What Is the Link?

  2014cites this paper
• Twist2, the key Twist isoform related to prognosis, promotes invasion of cervical cancer by inducing epithelial-mesenchymal transition and blocking senescence.

  2014cites this paper
• Inflammation and cancer stem cells.

  2014cites this paper
• hRAD9 functions as a tumor suppressor by inducing p21-dependent senescence and suppressing epithelial-mesenchymal transition through inhibition of Slug transcription.

  2014cites this paper
• Adhesion and proliferation of HeLa and fibroblast cells on chemically-modified gold surfaces.

  2014cites this paper
• Novel merosesquiterpene exerts a potent antitumor activity against breast cancer cells in vitro and in vivo.

  2014cites this paper
• Overexpression of S100A4 as a biomarker of metastasis and recurrence in oral squamous cell carcinoma

  2014cites this paper
• Exploiting tumor cell senescence in anticancer therapy

  2014cites this paper
• MiR‐506 suppresses proliferation and induces senescence by directly targeting the CDK4/6–FOXM1 axis in ovarian cancer

  2014cites this paper
• Tumor suppressor NDRG2 tips the balance of oncogenic TGF-β via EMT inhibition in colorectal cancer

  2014cites this paper
• Research progress of ZEB1 in epithelial-to-mesenchymal transition of lung cancer

  2013cites this paper
• Snail expression is associated with a poor prognosis in malignant pleural mesotheliomas.

  2013cites this paper
• Mesenchymal traits are selected along with stem features in breast cancer cells grown as mammospheres

  2012cites this paper
• Regulation of stem cell plasticity: mechanisms and relevance to tissue biology and cancer.

  2012cites this paper
• Rapalogs in cancer prevention

  2012cites this paper
• Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response

  2012cites this paper
• Assessing Cell and Organ Senescence Biomarkers

  2012cites this paper
• The “Sharp” blade against HIF-mediated metastasis

  2012cites this paper
• Tissue-specific expression of p73 C-terminal isoforms in mice

  2012cites this paper
• Correlation of TWIST2 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma.

  2012cites this paper
• Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor

  2011cites this paper
• miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

  2011cites this paper
• Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells

  2011cites this paper
• Twisted Epithelial-to-Mesenchymal Transition Promotes Progression of Surviving Bladder Cancer T24 Cells with hTERT-Dysfunction

  2011cites this paper
• Forkhead factors regulate epithelial plasticity: Impact on cancer progression

  2011cites this paper
• Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer

  2011cites this paper
• Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions.

  2011cites this paper
• epositioning chloroquine and metformin to eliminate cancer stem cell traits in re-malignant lesions

  2011cites this paper
• Autophagy positively regulates the CD44+CD24-/low breast cancer stem-like phenotype

  2011cites this paper
• Overexpression of TWIST2 correlates with poor prognosis in Head and Neck Squamous Cell Carcinomas

  2011cites this paper
• Review Assessing Cell and Organ Senescence Biomarkers Telomere-dependent Senescence and Aging

  year unknowncites this paper