p16INK4A induces senescence and inhibits EMT through microRNA‐141/microRNA‐146b‐5p‐dependent repression of AUF1

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular Carcinogenesis

• Publication date

  2017-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/mc.22564PMID 27596953
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Forging a signature of in vivo senescence

  2015cited by this paper
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• Aging, cellular senescence, and cancer.

  2013cited by this paper
• p16INK4A Positively Regulates p21WAF1 Expression by suppressing AUF1-dependent mRNA decay

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• A p21-ZEB1 Complex Inhibits Epithelial-Mesenchymal Transition through the MicroRNA 183-96-182 Cluster

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• MicroRNAs linking inflamm-aging, cellular senescence and cancer.

  2013cited by this paper
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• PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition

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  2013cited by this paper
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• The Cyclin-dependent Kinase Inhibitor p16INK4a Physically Interacts with Transcription Factor Sp1 and Cyclin-dependent Kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p Spontaneously and in Response to Ultraviolet Light-induced DNA Damage*

  2013cited by this paper
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• mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription.

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• Lamin B1 loss is a senescence-associated biomarker

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• Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer*

  2012cited by this paper
• From cellular senescence to age-associated diseases: the miRNA connection

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• Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype*

  2011cited by this paper
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• p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

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• p16INK4A Positively Regulates Cyclin D1 and E2F1 through Negative Control of AUF1

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• Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines

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• Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging

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• MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

  2009cited by this paper
• The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2*

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• Zeb1 links epithelial-mesenchymal transition and cellular senescence

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• The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

  2008cited by this paper
• AUF1 Isoform-Specific Regulation of Anti-inflammatory IL10 Expression in Monocytes

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• AUF1 and HuR Proteins Stabilize Interleukin-8 mRNA in Human Saliva

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  2008cited by this paper
• The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.

  2008cited by this paper
• Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.

  2008cited by this paper
• A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

  2008cited by this paper
• Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation

  2007cited by this paper
• The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light

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• Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.

  2005influential reference
• p21 (WAF1/CIP1) Mediates the Growth Response to TGF-b in Human Epithelial Cells

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• Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

  2004cited by this paper
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