Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota – current analytical methodologies

ABSTRACT Introduction: Selenium plays many key roles in health especially in connection with cancer and neurodegenerative diseases. However, it needs to be appreciated that the essentiality/toxicity of selenium depends on both, a narrow range of concentration and the chemical specie involved. In this context, selenoproteins are essential biomolecules against these disorders, mainly due to its antioxidant action. To this end, analytical methodologies may allow identifying and quantifying individual selenospecies in human biofluids and tissues. Areas covered: This review focus on the role of selenoproteins in medicine, with special emphasis in cancer and neurodegenerative diseases, considering the possible link with gut microbiota. In particular, this article reviews the analytical techniques and procedures recently developed for the absolute quantification of selenoproteins and selenometabolites in human biofluids and tissues. Expert commentary: The beneficial role of selenium in human health has been extensively studied and reviewed. However, several challenges remain unsolved as discussed in this article: (i) speciation of selenium (especially selenoproteins) in cancer and neurodegenerative disease patients; (ii) supplementation of selenium in humans using functional foods and nutraceuticals; (iii) the link between selenium and selenoproteins expression and the gut microbiota and (iv) analytical methods and pitfalls for the absolute quantification of selenoproteins and selenometabolites.

• Publication year

  2019

• Venue

  Espert Review of Proteomics

• Publication date

  2019-09-18

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1080/14789450.2019.1664292PMID 31482748
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Selenium and selenium species in the etiology of Alzheimer's dementia: The potential for bias of the case-control study design.

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• Influence of the selenium level on overall survival in lung cancer.

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• Selenoprotein SELENOK Enhances the Migration and Phagocytosis of Microglial Cells by Increasing the Cytosolic Free Ca2+ Level Resulted from the Up-Regulation of IP3R.

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• Selenoproteins in colon cancer

  2018cited by this paper
• Microbiota effects on cancer: from risks to therapies

  2018cited by this paper
• Environmental Metallomics.

  2018cited by this paper
• Selenium positively affects the proteome of 3 × Tg‐AD mice cortex by altering the expression of various key proteins: unveiling the mechanistic role of selenium in AD prevention

  2018cited by this paper
• Selenium, selenoprotein P, and Alzheimer's disease: is there a link?

  2018cited by this paper
• Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer

  2018cited by this paper
• The Selenium Transport Protein, Selenoprotein P, Requires Coding Sequence Determinants to Promote Efficient Selenocysteine Incorporation.

  2018cited by this paper
• Selenium and Selenoproteins in Gut Inflammation—A Review

  2018cited by this paper
• Effects of Dietary Selenium Supplementation on Intestinal Barrier and Immune Responses Associated with Its Modulation of Gut Microbiota

  2018cited by this paper
• Altered Gut Microbiota in Type 2 Diabetes: Just a Coincidence?

  2018cited by this paper
• Moving beyond microbiome-wide associations to causal microbe identification

  2017cited by this paper
• Akkermansia muciniphila and its role in regulating host functions.

  2017cited by this paper
• Chapter Two: Selenoproteins in Tumorigenesis and Cancer Progression

  2017cited by this paper
• TXNRD1 Is an Unfavorable Prognostic Factor for Patients with Hepatocellular Carcinoma

  2017cited by this paper
• Panel on Dietetic Products , Nutrition and Allergies ( NDA ) ; Scientific Opinion Part II on the substantiation of health claims related to various food

  2017cited by this paper
• Common SEP15 polymorphisms and susceptibility to cancer: a systematic review and meta-analysis

  2017cited by this paper
• Intestinal barrier and gut microbiota: Shaping our immune responses throughout life

  2017cited by this paper
• Direct interaction between selenoprotein R and Aβ42.

  2017cited by this paper
• Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention

  2017cited by this paper
• A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

  2016cited by this paper
• Selenium bioaccessibility in stomach, small intestine and colon: Comparison between pure Se compounds, Se-enriched food crops and food supplements.

  2016cited by this paper
• Accurate Quantification of Selenoprotein P (SEPP1) in Plasma Using Isotopically Enriched Seleno-peptides and Species-Specific Isotope Dilution with HPLC Coupled to ICP-MS/MS.

  2016cited by this paper
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  2016cited by this paper
• Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

  2016cited by this paper
• Transcriptomic Determinants of Scrapie Prion Propagation in Cultured Ovine Microglia

  2016cited by this paper
• Interplay of Selenoproteins and Different Antioxidant Systems in Various Cancers

  2016cited by this paper
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  2015cited by this paper
• Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers

  2015cited by this paper
• Mechanisms in endocrinology: Gut microbiota in patients with type 2 diabetes mellitus.

  2015cited by this paper
• Conditional Effect of Selenium on the Mammalian Hind Gut Microbiota

  2015cited by this paper
• Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort

  2015cited by this paper
• Gut microbiota: a source of novel tools to reduce the risk of human disease?

  2015cited by this paper
• Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.

  2015cited by this paper
• Homeostasis of metals in the progression of Alzheimer’s disease

  2014cited by this paper
• Childhood Brain Tumor Epidemiology: A Brain Tumor Epidemiology Consortium Review

  2014cited by this paper
• Characterization of metal profiles in serum during the progression of Alzheimer's disease.

  2014cited by this paper
• Cadmium toxicity in Mus musculus mice based on a metallomic study. Antagonistic interaction between Se and Cd in the bloodstream.

  2014cited by this paper
• Association of Prostate Cancer Risk Variants with Gene Expression in Normal and Tumor Tissue

  2014cited by this paper
• A Prospective Study of Plasma Selenoprotein P and Lung Cancer Risk among Low-Income Adults

  2014influential reference
• Heavy Metals and Neurodegenerative Diseases: An Observational Study

  2014cited by this paper
• STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells

  2014cited by this paper
• Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function.

  2014cited by this paper
• Application of metallomic and metabolomic approaches in exposure experiments on laboratory mice for environmental metal toxicity assessment.

  2014cited by this paper
• Selenium and Selenoproteins in Inflammatory Bowel Diseases and Experimental Colitis

  2014cited by this paper
• Selenoprotein P and apolipoprotein E receptor‐2 interact at the blood‐brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration

  2014cited by this paper
• Development of a new column switching method for simultaneous speciation of selenometabolites and selenoproteins in human serum.

  2013cited by this paper
• A Low Selenium Level Is Associated with Lung and Laryngeal Cancers

  2013cited by this paper
• Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β.

  2013cited by this paper
• Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

  2012cited by this paper
• Isolation of Selenoprotein-P and Determination of Se Concentration Incorporated in Proteins in Human and Mouse Plasma by Tandem Heparin Affinity and Size-exclusion Column HPLC-ICPMS

  2012cited by this paper
• Production of Selenoprotein P (Sepp1) by Hepatocytes Is Central to Selenium Homeostasis*

  2012cited by this paper
• Selenium and human health.

  2012cited by this paper
• Metallomic study of selenium biomolecules metabolized by the microalgae Chlorella sorkiniana in the biotechnological production of functional foods enriched in selenium

  2012cited by this paper
• Current knowledge in species-related bioavailability of selenium in food

  2012cited by this paper
• Selenium and Alzheimer's Disease: A Systematic Review

  2011influential reference
• Dietary selenium affects host selenoproteome expression by influencing the gut microbiota

  2011cited by this paper
• People's Republic of China

  2011cited by this paper
• Selenoprotein K Knockout Mice Exhibit Deficient Calcium Flux in Immune Cells and Impaired Immune Responses

  2011cited by this paper
• Extracorporeal shock wave lithotripsy (ESWL) versus ureteroscopic management for ureteric calculi.

  2011cited by this paper
• An Emerging Picture of the Biological Roles of Selenoprotein K

  2011cited by this paper
• Biotransformation of l-Selenomethionine and Selenite in Rat Gut Contents

  2011cited by this paper
• A systematic approach to the accurate quantification of selenium in serum selenoalbumin by HPLC-ICP-MS.

  2010cited by this paper
• Loss of glutathione peroxidase 3 expression is correlated with epigenetic mechanisms in endometrial adenocarcinoma

  2010cited by this paper
• Effects of Selenium Status and Polymorphisms in Selenoprotein Genes on Prostate Cancer Risk in a Prospective Study of European Men

  2010cited by this paper
• Selenium in the prevention of human cancers

  2010cited by this paper
• Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer's disease.

  2010cited by this paper
• Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice.

  2009cited by this paper
• Protection against reactive oxygen species by selenoproteins.

  2009cited by this paper
• The gastrointestinal microbiota affects the selenium status and selenoprotein expression in mice.

  2009cited by this paper
• Novel approaches for selenium speciation in foodstuffs and biological specimens: a review.

  2009cited by this paper
• Reduced Serum Selenoprotein P Concentrations in German Prostate Cancer Patients

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• Nutritional status of selenium in Alzheimer's disease patients

  2009cited by this paper
• Tissue Microarray Assessment of Selenoprotein P Expression in Gastric Adenocarcinoma

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• Bacteria Associated with Immunoregulatory Cells in Mice

  2009cited by this paper
• Variation in the Selenoenzyme Genes and Risk of Advanced Distal Colorectal Adenoma

  2008cited by this paper
• Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma.

  2008cited by this paper
• Aberrant expression of selenoproteins in the progression of colorectal cancer.

  2008cited by this paper
• Determination of trace elements in human brain tissues using neutron activation analysis

  2008cited by this paper
• Quantification of selenium-tagged proteins in human plasma using species-unspecific isotope dilution ICP-DRC-qMS coupled on-line with anion exchange chromatography

  2008cited by this paper
• Plasma Selenium Over Time and Cognitive Decline in the Elderly

  2007cited by this paper
• A comparative study in Alzheimer’s and normal brains of trace element distribution using PIXE and INA analyses and glucose metabolism by positron emission tomography

  2007cited by this paper
• Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis.

  2007cited by this paper
• Investigation of the stability of selenoproteins during storage of human serum by size-exclusion LC-ICP-MS.

  2007cited by this paper
• All regions of mouse brain are dependent on selenoprotein P for maintenance of selenium.

  2007cited by this paper
• Involvement of selenoprotein P in protection of human astrocytes from oxidative damage.

  2006cited by this paper
• Fractionation of selenium-containing proteins in serum by multiaffinity liquid chromatography before size-exclusion chromatography–ICPMS

  2006cited by this paper
• Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy.

  2006cited by this paper
• Serum selenium measurements in women with early-stage breast cancer with and without chemotherapy-induced ovarian failure

  2006cited by this paper
• Isotope dilution analysis for elemental speciation: a tutorial review

  2005cited by this paper
• Metabolomics of Selenium: Se Metabolites Based on Speciation Studies

  2005cited by this paper
• The use of high-selenium yeast to raise selenium status: how does it measure up?

  2004cited by this paper
• Expression Profiling and Genetic Alterations of the Selenoproteins GI-GPx and SePP in Colorectal Carcinogenesis

  2004cited by this paper
• The neurobiology of selenium: lessons from transgenic mice.

  2004cited by this paper
• Selenium and brain function: a poorly recognized liaison.

  2004cited by this paper

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