Membrane Lipid Remodeling Takes Center Stage in Growth Factor Receptor-Driven Cancer Development.

Enhanced growth factor signaling is a hallmark of cancer, allowing cancer cells to thrive in a challenging environment. In this issue of Cell Metabolism, Bi et al. (2019) identify LPCAT1, a key membrane lipid remodeling enzyme, as a central link between genetically driven growth factor receptor expression, signaling, and tumor growth, highlighting lipid remodeling as a therapeutic target in cancer.

• Publication year

  2019

• Venue

  Cell Metabolism

• Publication date

  2019-09-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cmet.2019.08.016PMID 31484051
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

  2019cited by this paper
• Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

  2018cited by this paper
• Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer

  2018cited by this paper
• Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma

  2017cited by this paper
• The multifaceted roles of fatty acid synthesis in cancer

  2016cited by this paper
• Lysophosphatidylcholine Acyltransferase1 Overexpression Promotes Oral Squamous Cell Carcinoma Progression via Enhanced Biosynthesis of Platelet-Activating Factor

  2015cited by this paper
• Architecture and membrane interactions of the EGF receptor.

  2013cited by this paper
• Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.

  2013cited by this paper
• De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.

  2010cited by this paper
• EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

  2009cited by this paper
• Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer

  2008cited by this paper
• Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway

  2000cited by this paper

• Targeting glycerophospholipid biosynthesis overcomes chemoresistance driven by SLFN11 loss in Ewing sarcoma

  2026cites this paper
• High-throughput phenotyping of microglial membrane Capacitance: Linking label-free dielectric signatures to polarization continuum and phospholipid remodeling.

  2026cites this paper
• SLFN11 Loss-Induced Chemoresistance is Associated with Overexpression of Glycerophospholipid Biosynthesis in Ewing Sarcoma

  2025cites this paper
• Plasma Membrane Epichaperome–Lipid Interface: Regulating Dynamics and Trafficking

  2025cites this paper
• LPCAT1 enhances the invasion and migration in gastric cancer: Based on computational biology methods and in vitro experiments

  2023cites this paper
• Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression

  2023cites this paper
• Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential

  2023cites this paper
• Recent advancements in nanomedicine based lipid metabolism for tumour immunotherapy

  2023cites this paper
• STAT proteins in cancer: orchestration of metabolism

  2023cites this paper
• A review on the role of fatty acids in colorectal cancer progression

  2022cites this paper
• LPCAT1 promotes gefitinib resistance via upregulation of the EGFR/PI3K/AKT signaling pathway in lung adenocarcinoma

  2022cites this paper
• Metabolic-Dysregulation-Based iEESI-MS Reveals Potential Biomarkers Associated with Early-Stage and Progressive Colorectal Cancer.

  2022cites this paper
• Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective

  2022cites this paper
• Identification and validation of a five apoptosis-related genes signature for prediction of disease-free survival for testicular germ cell tumors

  2021cites this paper
• Comprehensive Analysis of LPCATs Highlights the Prognostic and Immunological Values of LPCAT1/4 in Hepatocellular Carcinoma

  2021cites this paper
• Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression

  2021influential citation
• Classification and Functional Analysis between Cancer and Normal Tissues Using Explainable Pathway Deep Learning through RNA-Sequencing Gene Expression

  2021cites this paper
• Lipid Metabolism and Lipidomics Applications in Cancer Research.

  2021cites this paper
• Elevated expression of LPCAT1 predicts a poor prognosis and is correlated with the tumour microenvironment in endometrial cancer

  2021cites this paper
• LPCAT1 is a Prognostic Biomarker and Correlated with Tumor Microenvironment in Endometrial Cancer

  2021cites this paper
• A miR-205-LPCAT1 axis contributes to proliferation and progression in multiple cancers.

  2020cites this paper
• Identi fi cation and characterization of CLEC11A and its derived immune signature in gastric cancer

  year unknowncites this paper