Enantioselective Iridium-Catalyzed Allylation of Acetylenic Ketones via 2-Propanol-Mediated Reductive Coupling of Allyl Acetate: C14-C23 of Pladienolide D.

Alkyne-Directed Chemo- and Enantioselectivity. Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14-C23 of pladienolide D in half the steps previously required.

• Publication year

  2019

• Venue

  Angewandte Chemie

• Publication date

  2019-11-07

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/anie.201908939PMID 31490591PMCID PMC6917958
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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