Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of antibiotics (Tokyo. 1968)

• Publication date

  2004-03-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.7164/ANTIBIOTICS.57.173PMID 15152802
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities.

  2004cited by this paper
• Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics

  2003cited by this paper
• HIF-1 as a target for drug development

  2003cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• Regulation of angiogenesis by hypoxia: role of the HIF system

  2003cited by this paper
• Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.

  2002cited by this paper
• NK30424A and B, novel inhibitors of lipopolysaccharide-induced tumour necrosis factor alpha production, produced by Streptomyces sp. NA30424.

  2001cited by this paper
• Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel.

  1999cited by this paper
• The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target

  1998cited by this paper
• Inhibitory effect of E3330, a novel quinone derivative able to suppress tumor necrosis factor-alpha generation, on activation of nuclear factor-kappa B.

  1996cited by this paper
• Isolation and characterization of a new 12-membered macrolide FD-895.

  1994cited by this paper
• Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.

  1992cited by this paper
• The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.

  1991cited by this paper
• Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.

  1991cited by this paper
• Fluorometric Deoxyribonucleic Acid-Deoxyribonucleic Acid Hybridization in Microdilution Wells as an Alternative to Membrane Filter Hybridization in which Radioisotopes Are Used To Determine Genetic Relatedness among Bacterial Strains

  1989cited by this paper
• Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

  1989cited by this paper
• Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

  1988cited by this paper
• [Carbon 13 NMR spectroscopy].

  1976cited by this paper
• Simplified approach to identification of aerobic actinomycetes by thin-layer chromatography.

  1974cited by this paper
• Cooperative description of type cultures of Streptomyces. IV. Species descriptions from the second, third and fourth studies**

  1969cited by this paper
• Cooperative description of type cultures of Streptomyces.: II. Species descriptions from first study

  1968cited by this paper
• Cooperative Description of Type Cultures of STREPTOMYCES III. Additional Species Descriptions from First and Second Studies

  1968cited by this paper
• Methods for characterization of Streptomyces species

  1966cited by this paper
• Classification, identification and descriptions of genera and species

  1961cited by this paper
• The Utilization of Carbon Compounds by Some Actinomycetales as an Aid for Species Determination

  1948cited by this paper

• U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations

  2025cites this paper
• Decoding spliceosome inhibition: Isobaric tag-based proteomic profiling of pladienolide B treated human cell lines.

  2025cites this paper
• Copper(I)-Catalyzed Asymmetric Nucleophilic Addition to Aldehydes with Skipped Enynes.

  2024cites this paper
• The splicing factor SF3B1 confers ferroptosis resistance and promotes lung adenocarcinoma progression via upregulation of SLC7A11

  2024cites this paper
• Yamaguchi esterification: a key step toward the synthesis of natural products and their analogs—a review

  2024cites this paper
• Copper-Catalyzed Enantioselective and Regiodivergent Allylation of Ketones with Allenylsilanes.

  2023cites this paper
• Stereochemical Control of Splice Modulation in FD-895 Analogues.

  2023cites this paper
• Synthesis and Conformational Analysis of FR901464-Based RNA Splicing Modulators and Their Synergism in Drug-Resistant Cancers

  2023cites this paper
• An intricate rewiring of cancer metabolism via alternative splicing.

  2023cites this paper
• Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review

  2023cites this paper
• Somatic Mutations in Core Spliceosome Components Promote Tumorigenesis and Generate an Exploitable Vulnerability in Human Cancer

  2022cites this paper
• Expedient Total Syntheses of Pladienolide-Derived Spliceosome Modulators.

  2021cites this paper
• The role of alternative splicing in human cancer progression.

  2021cites this paper
• Total Syntheses of Pladienolide-Derived Spliceosome Modulators

  2021cites this paper
• Perspectives on Precision Medicine in Chronic Lymphocytic Leukemia: Targeting Recurrent Mutations—NOTCH1, SF3B1, MYD88, BIRC3

  2021cites this paper
• Splicing modulators: on the way from nature to clinic

  2021influential citation
• Spliceosome-regulated RSRP1-dependent NF-κB activation promotes the glioblastoma mesenchymal phenotype.

  2021cites this paper
• Total Synthesis of the Spliceosome Modulator Pladienolide B via Asymmetric Alcohol-Mediated syn- and anti-Diastereoselective Carbonyl Crotylation.

  2021cites this paper
• Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation.

  2021cites this paper
• Splicing factor SF3B1 promotes endometrial cancer progression via regulating KSR2 RNA maturation

  2020cites this paper
• Bacteria and bacterial anticancer agents as a promising alternative for cancer therapeutics.

  2020cites this paper
• Reclassification of Streptomyces hygroscopicus subsp. glebosus and Streptomyces libani subsp. rufus as later heterotypic synonyms of Streptomyces platensis.

  2020cites this paper
• Design and Synthesis of 1,2-Deoxy-pyranose Derivatives of Spliceostatin A toward Prostate Cancer Treatment.

  2020cites this paper
• Splice Modulation Synergizes Cell Cycle Inhibition.

  2020cites this paper
• A Comprehensive Overview of Structure‐Activity Relationships of Small‐Molecule Splicing Modulators Targeting SF3B1 as Anticancer Agents

  2020cites this paper
• Identification and Antibacterial Activity of Actinomycetes Isolated From Medicinal Plant Andrographis paniculata Rhizosphere Soil

  2020cites this paper
• Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

  2020cites this paper
• An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

  2019cites this paper
• Streptomyces as a Source of Antimicrobials: Novel Approaches to Activate Cryptic Secondary Metabolite Pathways

  2019cites this paper
• Splicing and cancer: Challenges and opportunities

  2019cites this paper
• Enantioselective Iridium-Catalyzed Allylation of Acetylenic Ketones via 2-Propanol-Mediated Reductive Coupling of Allyl Acetate: C14-C23 of Pladienolide D.

  2019cites this paper
• Total Syntheses of Thailanstatins A-C, Spliceostatin D, and Analogues Thereof. Stereodivergent Synthesis of Tetrasubstituted Dihydro- and Tetrahydropyrans and Design, Synthesis, Biological Evaluation, and Discovery of Potent Antitumor Agents.

  2018cites this paper
• Therapy-induced stress response is associated with downregulation of pre-mRNA splicing in cancer cells

  2018cites this paper
• Alternative splicing in prostate cancer

  2018cites this paper
• Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity.

  2018cites this paper
• Recent applications of Stille reaction in total synthesis of natural products: An update

  2018cites this paper
• Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester.

  2018cites this paper
• The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues

  2017cites this paper
• Modulating splicing with small molecular inhibitors of the spliceosome

  2017cites this paper
• Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

  2017cites this paper
• Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches.

  2017cites this paper
• Pursuing the unlimited potential of microorganisms—progress and prospect of a fermentation company†

  2017cites this paper
• A Challenging Pie to Splice: Drugging the Spliceosome.

  2017cites this paper
• Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A

  2017cites this paper
• Twelve‐membered macrolactones: privileged scaffolds for the development of new therapeutics

  2017cites this paper
• Increasing evidence for the presence of alternative proteins in human tissues and cell lines

  2017cites this paper
• Das Spliceosom als Angriffspunkt für Pharmaka

  2017cites this paper
• Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry.

  2017cites this paper
• Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy.

  2016cites this paper
• Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.

  2016cites this paper
• Therapeutic targeting of splicing in cancer

  2016cites this paper
• Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

  2016cites this paper
• "Pruning of biomolecules and natural products (PBNP)": an innovative paradigm in drug discovery.

  2015cites this paper
• Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy

  2015influential citation
• Design and synthesis of analogues of natural products.

  2015cites this paper
• Identification of Small Molecule Inhibitors of Pre-mRNA Splicing

  2014cites this paper
• Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives

  2014cites this paper
• Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors.

  2014cites this paper
• Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate–dependent dioxygenase

  2014cites this paper
• Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives.

  2014cites this paper
• Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line.

  2014cites this paper
• Splicing Inhibitors: From Small Molecule to RNA Metabolism

  2014cites this paper
• Alternative splicing in cancer: implications for biology and therapy

  2014cites this paper
• Synthesis of Pladienolide B and Its 7‐Epimer with Insights into the Role of the Allylic Acetate

  2014cites this paper
• Recent advances of desymmetrization protocol applied in natural product total synthesis

  2014cites this paper
• NAD(P)H quinone oxidoreductase 1 (NQO1)-bioactivated pronqodine A regulates prostaglandin release from human synovial sarcoma cells.

  2013cites this paper
• Modulation of LPS induced inflammatory response by Lawsonyl monocyclic terpene from the marine derived Streptomyces sp.

  2013cites this paper
• Enantioselective synthesis of pladienolide B and truncated analogues as new anticancer agents.

  2013cites this paper
• The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

  2013cites this paper
• Remediating cancer via splicing modulation.

  2013cites this paper
• Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.

  2013cites this paper
• Coherence between Cellular Responses and in Vitro Splicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs*

  2013cites this paper
• Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors

  2013cites this paper
• High antitumor activity of pladienolide B and its derivative in gastric cancer

  2013cites this paper
• A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors

  2013cites this paper
• Natural Products as Tools for Discovering New Cancer Targets

  2013cites this paper
• A High-Throughput Splicing Assay Identifies New Classes of Inhibitors of Human and Yeast Spliceosomes

  2013cites this paper
• Targeting the deregulated spliceosome core machinery in cancer cells triggers mTOR blockade and autophagy.

  2013cites this paper
• Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma.

  2013cites this paper
• Target identification of bioactive compounds.

  2012cites this paper
• The spliceosome as a target of novel antitumour drugs

  2012cites this paper
• Ruthenium-Catalyzed Olefin Metathesis after Tetra-n-butylammonium Fluoride-Mediated Desilylation.

  2012cites this paper
• Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitor.

  2012cites this paper
• Splicing in oncogenesis and tumor suppression

  2012cites this paper
• Langkolide, a 32-membered macrolactone antibiotic produced by Streptomyces sp. Acta 3062.

  2012cites this paper
• Pre-mRNA splicing in disease and therapeutics.

  2012cites this paper
• Natural products: an evolving role in future drug discovery.

  2011cites this paper
• Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.

  2011cites this paper
• Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.

  2011cites this paper
• Protein-protein interactions and cancer: targeting the central dogma.

  2011cites this paper
• Biological validation that SF3b is a target of the antitumor macrolide pladienolide

  2011cites this paper
• Synthesis of a pladienolide B analogue with the fully functionalized core structure.

  2011cites this paper
• Evaluation of FR901464 analogues in vitro and in vivo

  2011cites this paper
• Natural Products in Drug Discovery: Impacts and Opportunities — An Assessment

  2011cites this paper
• Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer

  2011cites this paper
• Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor

  2011cites this paper
• Geographic Distribution of Secondary Metabolite Genes in the Marine Actinomycete Salinispora arenicola

  2011cites this paper
• Phenelfamycins G and H, new elfamycin-type antibiotics produced by Streptomyces albospinus Acta 3619

  2011cites this paper
• Phase I studies

  2010cites this paper
• Natural Product Biosynthesis: Friend or Foe? From Anti-tumor Agent to Disease Causation

  2010cites this paper