Abnormalities in FGF family members and their roles in modulating depression‐related molecules

The role of the fibroblast growth factor (FGF) system in depression has received considerable attention in recent years. To understand the role of this system, it is important to identify the specific members of the FGF family that have been implicated and the various mechanisms that they modulated. Here, we review the role of FGFs in depression and integrate evidence from clinical and basic research. These data suggest that changes in the FGF family are involved in depression and possibly in a wider range of psychiatric disorders. We analyse the abnormalities of FGF family members in depression and their roles in modulating depression‐related molecules. The role of the FGF family in depression and related disorders needs to be studied in more detail.

• Publication year

  2019

• Venue

  European Journal of Neuroscience

• Publication date

  2019-09-23

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1111/ejn.14570PMID 31491043
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tricyclic Antidepressant

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  2018cited by this paper
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  2018cited by this paper
• Inflammatory theory of depression.

  2018influential reference
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  2018cited by this paper
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  2018cited by this paper
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  2018influential reference
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  2016cited by this paper
• FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression.

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  2015cited by this paper
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  2015influential reference
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  2015influential reference
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  2015influential reference
• 5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.

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• Decreased serum fibroblast growth factor - 2 levels in pre- and post-treatment patients with major depressive disorder.

  2014influential reference
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Serotonin and beyond: therapeutics for major depression

  2013cited by this paper
• Monoamine neurocircuitry in depression and strategies for new treatments.

  2013cited by this paper
• Treatment of Comorbid Anxiety and Depression with Escitalopram: Results of a Post-Marketing Surveillance Study

  2012cited by this paper
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  2012influential reference
• Vascular endothelial growth factor (VEGF) and its role in the central nervous system: A new element in the neurotrophic hypothesis of antidepressant drug action

  2012cited by this paper
• The fibroblast growth factor family: neuromodulation of affective behavior.

  2012cited by this paper
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  2011influential reference
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
• Dysregulation of the fibroblast growth factor system in major depression.

  2004influential reference
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  2003cited by this paper
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  2001influential reference
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  2001cited by this paper
• Self-secretion of fibroblast growth factor-9 supports basal forebrain cholinergic neurons in an autocrine/paracrine manner.

  2000cited by this paper
• Brain corticosteroid receptor balance in health and disease.

  1998cited by this paper
• HPA axis dysfunction in depression: correlation with monoamine system abnormalities.

  1997cited by this paper
• GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells.

  1996cited by this paper
• Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists.

  1996cited by this paper
• Regulation of neurogenesis in the embryonic and adult brain by fibroblast growth factors.

  1994cited by this paper
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  1993cited by this paper
• Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.

  1984cited by this paper
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  1968cited by this paper

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