FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Trends in Neurosciences

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.tins.2015.11.003PMID 26687454
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The triplet puzzle theory indicates extensive formation of heteromers between opioid and chemokine receptor subtypes

  2015cited by this paper
• A Role for Galanin N-Terminal Fragment (1–15) in Anxiety- and Depression-Related Behaviors in Rats

  2015cited by this paper
• Why study moonlighting proteins?

  2015cited by this paper
• The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural–glial networks

  2015cited by this paper
• Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration

  2015cited by this paper
• Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system.

  2015cited by this paper
• On the Role of the Balance of GPCR Homo/ Heteroreceptor Complexes in the Brain

  2015cited by this paper
• Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression.

  2015cited by this paper
• Developments in the field of antidepressants, where do we go now?

  2015cited by this paper
• Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems.

  2015cited by this paper
• A randomized double-blind crossover trial of deep brain stimulation of the subcallosal cingulate gyrus in patients with treatment-resistant depression: a pilot study of relapse prevention.

  2015cited by this paper
• Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5

  2015cited by this paper
• Somatodendritic dopamine release: recent mechanistic insights

  2015cited by this paper
• The role of D2-autoreceptors in regulating dopamine neuron activity and transmission.

  2014cited by this paper
• A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei.

  2014cited by this paper
• Moonlighting Proteins and Protein–Protein Interactions as Neurotherapeutic Targets in the G Protein-Coupled Receptor Field

  2014cited by this paper
• Antidepressant-like effects of cortical deep brain stimulation coincide with pro-neuroplastic adaptations of serotonin systems.

  2014cited by this paper
• Pharmacology and clinical potential of vortioxetine in the treatment of major depressive disorder

  2014cited by this paper
• The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

  2014cited by this paper
• Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization

  2014cited by this paper
• Guanidine-based α2-adrenoceptor ligands: Towards selective antagonist activity.

  2014cited by this paper
• Deep brain stimulation in major depression: plastic changes of 5-hydroxytryptamine neurons.

  2014cited by this paper
• The impact of receptor–receptor interactions in heteroreceptor complexes on brain plasticity

  2014cited by this paper
• Dopamine receptor heteromeric complexes and their emerging functions.

  2014cited by this paper
• Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression

  2014cited by this paper
• Neurotrophins and psychiatric disorders.

  2014cited by this paper
• Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2.

  2013cited by this paper
• Sustained impairment of α2A-adrenergic autoreceptor signaling mediates neurochemical and behavioral sensitization to amphetamine.

  2013cited by this paper
• Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond.

  2013cited by this paper
• Serotonin and beyond: therapeutics for major depression

  2013cited by this paper
• Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research

  2013cited by this paper
• G protein-coupled receptor heterodimerization in the brain.

  2013cited by this paper
• Serotonin receptors involved in antidepressant effects.

  2013cited by this paper
• Bioluminescence resonance energy transfer methods to study G protein-coupled receptor-receptor tyrosine kinase heteroreceptor complexes.

  2013cited by this paper
• Neurotransmitter targeting in the treatment of depression.

  2013cited by this paper
• Monoamine neurocircuitry in depression and strategies for new treatments.

  2013cited by this paper
• Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity.

  2012cited by this paper
• On the existence and function of galanin receptor heteromers in the central nervous system

  2012cited by this paper
• Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects

  2012cited by this paper
• Noradrenergic antidepressants increase cortical dopamine: potential use in augmentation strategies.

  2012cited by this paper
• Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking

  2012cited by this paper
• Modeling depression in animal models.

  2012cited by this paper
• Moonlighting characteristics of G protein‐coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration

  2011cited by this paper
• Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum.

  2011cited by this paper
• The discovery of central monoamine neurons gave volume transmission to the wired brain.

  2010cited by this paper
• Triplet Puzzle: Homologies of Receptor Heteromers

  2010cited by this paper
• Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization.

  2010cited by this paper
• α2-Adrenoceptor Blockade Accelerates the Neurogenic, Neurotrophic, and Behavioral Effects of Chronic Antidepressant Treatment

  2010cited by this paper
• FGF acts as a co-transmitter through adenosine A2A receptor to regulate synaptic plasticity

  2008cited by this paper
• Presynaptic autoreceptors regulating transmitter release.

  2008cited by this paper
• Antidepressant-like effects of intracerebroventricular FGF2 in rats.

  2008cited by this paper
• The fibroblast growth factor family and mood disorders.

  2008cited by this paper
• The fibroblast growth factor system is downregulated following social defeat.

  2008cited by this paper
• Sustained administration of bupropion alters the neuronal activity of serotonin, norepinephrine but not dopamine neurons in the rat brain.

  2008cited by this paper
• From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: wiring and volume transmission.

  2007cited by this paper
• Role of neurotrophic factors in depression.

  2007cited by this paper
• The fibroblast growth factor system and mood disorders.

  2006cited by this paper
• Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder.

  2006cited by this paper
• Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells.

  2006cited by this paper
• A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

  2006cited by this paper
• Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine.

  2005cited by this paper
• Protective actions of human recombinant basic fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion

  2004cited by this paper
• Region‐specific targeting of dopamine D2‐receptors and somatodendritic vesicular monoamine transporter 2 (VMAT2) within ventral tegmental area subdivisions

  2002cited by this paper
• Increased density of galanin binding sites in the dorsal raphe in a genetic rat model of depression.

  2002cited by this paper
• Differential addressing of 5-HT1A and 5-HT1B receptors in epithelial cells and neurons.

  1999cited by this paper
• Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel- and diencephalon of the rat.

  1998cited by this paper
• Comparative localization of fibroblast growth factor receptor‐1, ‐2, and ‐3 mRNAs in the rat brain: In situ hybridization analysis

  1997cited by this paper
• The chronic mild stress depression model: future developments from a drug discovery perspective

  1997cited by this paper
• Computer-assisted mapping of basic fibroblast growth factor immunoreactive nerve cell populations in the rat brain.

  1996cited by this paper
• Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists.

  1996cited by this paper
• On the regional distribution of heparan sulfate proteoglycan immunoreactivity in the rat brain.

  1994cited by this paper
• Basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity exists in the noradrenaline, adrenaline and 5-HT nerve cells of the rat brain.

  1993cited by this paper
• Basic FGF is present in dopaminergic neurons of the ventral midbrain of the rat.

  1991cited by this paper
• Galanin/5-HT interactions in the rat central nervous system. Relevance for depression

  1991cited by this paper
• Acetylcholine receptor: an allosteric protein.

  1984cited by this paper
• The effect of imipramine of central 5‐hydroxytryptamine neurons

  1968cited by this paper
• The Biochemistry of Affective Disorders

  1967cited by this paper
• Localization of 5‐hydroxytryptamine uptake in rat brain after intraventricular injection

  1967cited by this paper
• EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.

  1964cited by this paper

• Minimizing Artifacts in BRET and FRET Assays: Novel Controls for Enhanced RET Accuracy in Mammalian Systems

  2025cites this paper
• Dysregulation of FGFR1 signaling in the hippocampus facilitates depressive disorder

  2025cites this paper
• Single-molecule localization microscopy as a tool to quantify di/oligomerization of receptor tyrosine kinases and G protein-coupled receptors

  2025cites this paper
• ADGRG1, an adhesion G protein‐coupled receptor, forms oligomers

  2024cites this paper
• Understanding electrical and chemical transmission in the brain

  2024cites this paper
• Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor–Receptor Interactions

  2024cites this paper
• Neuritin Controls Axonal Branching in Serotonin Neurons: A Possible Mediator Involved in the Regulation of Depressive and Anxiety Behaviors via FGF Signaling

  2024cites this paper
• 5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression

  2023cites this paper
• D1R-5-HT2AR Uncoupling Reduces Depressive Behaviours via HDAC Signalling

  2023cites this paper
• The integrative role of G protein-coupled receptor heterocomplexes in Parkinson’s disease

  2022cites this paper
• New developments in the biology of fibroblast growth factors.

  2022cites this paper
• Study of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay

  2021cites this paper
• Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia—Relevance for Mental Diseases

  2021cites this paper
• The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects

  2021cites this paper
• New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism

  2021cites this paper
• FGF/FGFR signaling in health and disease

  2020cites this paper
• Tandospirone enhances the anti-myocardial fibrosis effect of valsartan in spontaneously hypertensive rats.

  2020cites this paper
• The Role of Serotonin in Singultus: A Review

  2020cites this paper
• G-protein signaling is required for increasing germline stem cell division frequency in response to mating in Drosophila males

  2020cites this paper
• Abnormalities in FGF family members and their roles in modulating depression‐related molecules

  2019cites this paper
• Crosstalk between receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCR) in the brain: Focus on heteroreceptor complexes and related functional neurotrophic effects.

  2019cites this paper
• Fibroblast Growth Factors in Depression

  2019cites this paper
• Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

  2019cites this paper
• Luminescence- and Fluorescence-Based Complementation Assays to Screen for GPCR Oligomerization: Current State of the Art

  2019cites this paper
• Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS

  2019cites this paper
• Heterómeros de receptores CB1, CB2, GPR55 y GPR18: Señalización celular, farmacología y análisis de su potencial como dianas terapéuticas de enfermedades neurodegenerativas

  2018cites this paper
• G-Protein signaling increases germline stem cell activity in Drosophila males in response to multiple rounds of mating

  2018cites this paper
• G-Protein signaling accelerates stem cell divisions in Drosophila males

  2018cites this paper
• In vivo relationship between serotonin 1A receptor binding and gray matter volume in the healthy brain and in major depressive disorder

  2018cites this paper
• Electrophysiological Approach to GPCR–RTK Interaction Study in Hippocampus of Adult Rats

  2018cites this paper
• Differential activation of arginine-vasopressin receptor subtypes in the amygdaloid modulation of anxiety in the rat by arginine-vasopressin

  2018cites this paper
• Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims

  2018cites this paper
• Glutamate heteroreceptor complexes in the brain

  2018cites this paper
• Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors

  2018cites this paper
• Receptor–Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

  2018cites this paper
• Regulation of G-protein coupled receptor signalling underpinning neurobiology of mood disorders and depression.

  2017cites this paper
• Critical period for murine olfactory map formation

  2017cites this paper
• Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition

  2017cites this paper
• Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures.

  2017cites this paper
• Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression

  2017cites this paper
• Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease

  2017influential citation
• The role of 5-HT receptors in depression

  2017cites this paper
• Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes

  2016cites this paper
• Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication

  2016cites this paper
• Serotonin system in Alzheimer's disease : from a molecular and biomarkers perspective

  2016cites this paper