Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Cell Science

• Publication date

  2012-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.101337PMID 22357950
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The Central 5‐HT1A Receptors: Pharmacological, Biochemical, Functional, and Regulatory Properties a

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