Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  European Journal of Pharmacology

• Publication date

  2007-04-10

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/J.EJPHAR.2006.12.023PMID 17300777
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selenium: biochemical role as a component of glutathione peroxidase.

  2009cited by this paper
• Evaluation of hybrid liposomes-encapsulated silymarin regarding physical stability and in vivo performance.

  2006cited by this paper
• Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication.

  2006cited by this paper
• Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats.

  2006cited by this paper
• The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties

  2006cited by this paper
• Protective effect of black tea extract on the levels of lipid peroxidation and antioxidant enzymes in liver of mice with pesticide‐induced liver injury

  2006cited by this paper
• Herbal Medicines for Liver Diseases

  2005cited by this paper
• Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver.

  2005cited by this paper
• Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis.

  2005cited by this paper
• Silybin and silymarin--new effects and applications.

  2005cited by this paper
• Dietary Antioxidant Compounds and Liver Health

  2004cited by this paper
• Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats.

  2003cited by this paper
• Harper's Illustrated Biochemistry

  2003cited by this paper
• Chemopreventive effect of garlic powder diet in diethylnitrosamine-induced rat hepatocarcinogenesis.

  2003cited by this paper
• Inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats.

  2003cited by this paper
• Pharmacology of Silymarin

  2002influential reference
• Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats.

  2001cited by this paper
• Diethylnitrosamine causes pituitary damage, disturbs hormone levels, and reduces sexual dimorphism of certain liver functions in the rat.

  2001cited by this paper
• Therapeutic potential of glutathione.

  2000cited by this paper
• Hepatic and renal oxidative stress in acute toxicity of N-nitrosodiethylamine in rats.

  2000cited by this paper
• Milk Thistle (Silybum marianum) for the Therapy of Liver Disease

  1998cited by this paper
• Effect of Emblica officinalis extract on hepatocarcinogenesis and carcinogen metabolism

  1998cited by this paper
• Oxidative stress: oxidants and antioxidants

  1997cited by this paper
• Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine.

  1997cited by this paper
• Suppressive effect of molybdenum on hepatotoxicity of N-nitrosodiethylamine in rats.

  1995cited by this paper
• Suppressive effect of molybdenum on hepatotoxicity of N-nitrosodiethylamine in rats.

  1995cited by this paper
• Vitamin E in the genesis and prevention of cancer. A review.

  1994cited by this paper
• Free radical damage and its control

  1994cited by this paper
• Silymarin protects against paracetamol‐induced lipid peroxidation and liver damage

  1992cited by this paper
• Drugs and the liver part 1: Testing liver function

  1991cited by this paper
• Prevention by silymarin of membrane alterations in acute CCI4 liver damage

  1990cited by this paper
• Mechanisms of action of N-nitroso compounds.

  1989influential reference
• [Liver-protective action of silymarin therapy in chronic alcoholic liver diseases].

  1989cited by this paper
• Carcinogenic nitrosamines: free radical aspects of their action.

  1989cited by this paper
• Selectivity of Silymarin on the Increase of the Glutathione Content in Different Tissues of the Rat

  1989cited by this paper
• Superoxide dismutases.

  1986cited by this paper
• Models of hepatocarcinogenesis in the rat--contrasts and comparisons.

  1986cited by this paper
• The derivation of nitrosamines from some therapeutic amines in the human environment.

  1985cited by this paper
• Drugs and the liver.

  1984cited by this paper
• Microanalysis in Medical Biochemistry

  1983cited by this paper
• Purification and characterization of two forms of a low-affinity Ca2+-ATPase from erythrocyte membranes.

  1983cited by this paper
• A comparative study of plasma membrane Mg2+ -ATPase activities in normal, regenerating and malignant cells.

  1982cited by this paper
• Calcium potentiates the peroxidation of erythrocyte membrane lipids.

  1981cited by this paper
• IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans

  1980cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids.

  1979cited by this paper
• Hormones, vitamins, drugs and poisons

  1976cited by this paper
• Superoxide dismutases.

  1975cited by this paper
• Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.

  1974cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974cited by this paper
• Colorimetric assay of catalase.

  1972cited by this paper
• Drugs and the liver

  1968cited by this paper
• Practical Clinical Biochemistry

  1967cited by this paper
• Microanalysis in Medical Biochemistry

  1964cited by this paper
• Improved method for the determination of blood glutathione.

  1963cited by this paper
• Hepatic glutathione reductase. I. Purification and general kinetic properties.

  1962cited by this paper
• The clinical significance of transaminase activities of serum.

  1959cited by this paper
• Tissue sulfhydryl groups.

  1959cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper
• THE COLORIMETRIC DETERMINATION OF PHOSPHORUS

  1925cited by this paper
• THE COLORIMETRIC DETERMINATION OF PHOSPHOROUS

  year unknowncited by this paper

• Post-treatment of rat aflatoxicosis by camel milk and silymarin

  2025cites this paper
• Amelioration of diethylnitrosamine-induced acute brain injury by α-eudesmol and β-eudesmol.

  2025cites this paper
• Susceptibility to Secondary Bacterial Infections in Growing Rabbits Exposed to Ochratoxin A and Protected or Not by Herbal Supplements

  2025cites this paper
• The Novel Effect and Potential Mechanism of Lactoferrin on Organ Fibrosis Prevention

  2025cites this paper
• Mitigating cardiotoxicity and nephrotoxicity: the role of naringin-dextrin nanoparticles in male Wistar rats

  2025influential citation
• Revolutionizing Veterinary Medicine: The Role of Nanoparticles in Advancing Animal Health, Nutrition and Disease Management

  2025cites this paper
• Biocontrol Agents and Natural Feed Supplements as a Safe and Cost-Effective Way for Preventing Health Ailments Provoked by Mycotoxins

  2025cites this paper
• Study the Potential Role of Tribulus terrestris Extract on Cancer Treatment

  2024cites this paper
• Exploring the potential of silymarin-loaded nanovesicles as an effective drug delivery system for cancer therapy: in vivo, in vitro, and in silico experiments

  2024cites this paper
• Hypolipidemic and Hypoglycemic Effects of Silybum marianum (L.) Gaertn. (Milk Thistle) Ethanol Seed Extract in Streptozotocin-induced Diabetes in Rats

  2024cites this paper
• Natural feed additives and bioactive supplements versus chemical additives as a safe and practical approach to combat foodborne mycotoxicoses

  2024cites this paper
• Synthesis, characterization, and toxicity assessments of Silymarin-loaded Ni-Fe Metal-organic frameworks: Evidence from in vitro and in vivo evaluations

  2024cites this paper
• Effect of Silymarin on Carbon-Tetra Chloride Induced Parotid and Submandibular Salivary Glands Damage in rats.

  2023influential citation
• Protective Effect of Silymarin on Liver in Experimental in the Sepsis Model of Rats

  2023cites this paper
• The Biological, Biochemical, and Immunological Impact of Broccoli and Green Pea Sprouts on Acrylamide Intoxicated Rats

  2023cites this paper
• Folic Acid Conjugated Graphene Oxide Graviola Nanoparticle for Sono-Photodynamic Leukemia Treatment: Up-To-Date Cancer Treatment Modality

  2022cites this paper
• The immune status of the organism of bulls under cadmium load and the effects of correcting factors

  2022cites this paper
• Ultrasound Allied Laser Sono-Photobiomodulation Activated Nano-Curcumin: Up-and-Coming Selective Cancer Cell Killing Modality

  2022cites this paper
• Eumelanin protects the liver against diethylnitrosamine-induced liver injury.

  2022cites this paper
• Hepato-defensive effect of Cysteine, Ursodeoxycholic acid and Silymarin on histopathological and some biochemical parameters of Wister albino rat intoxicated by CCl4

  2022cites this paper
• Microencapsulation of Plant Phenolic Extracts Using Complex Coacervation Incorporated in Ultrafiltered Cheese Against AlCl3-Induced Neuroinflammation in Rats

  2022cites this paper
• Mechanisms underlying the hepatoprotective effect of silymarin on fluoxetine-induced liver injury in rats: the implication of peroxisome proliferator–activated receptor-gamma (PPAR-γ)

  2022cites this paper
• Effect of dried Persimmon fruit (Diospyros kaki) on acute carbon tetrachloride induced hepatotoxicity in laboratory rats

  2022cites this paper
• Beetroot Improves the Therapeutic Efficacy of Bone Marrow-Derived Mesenchymal Stem Cells in Preventing Cisplatin Induced Nephrotoxicity in Male Rats

  2022cites this paper
• 'Silymarin' a Potential Treatment Targeting Hepatic Fibrosis of Schistosomiasis

  2021cites this paper
• Hepatoprotective Effects of Calotropis procera (Ait.) R. Br Root Bark Extracts against Diethylnitrosamine Induced Liver Injury in Rats

  2021cites this paper
• The evaluation of the therapeutic potential of hesperetin on diethylnitrosamine and phenobarbital induced liver injury in rats

  2021cites this paper
• Acupuncture and Phytotherapy Applications in Non-Alcoholic Fatty Liver

  2021cites this paper
• A review on the mechanisms of the effect of silymarin in milk thistle (Silybum marianum) on some laboratory animals

  2021influential citation
• The Protective Effect of Silymarin against Ochratoxin A Induced Histopathological and Biochemical Changes in Chicks

  2021cites this paper
• CABBAGE PLANT (BRASSICA OLERACEA L.) AS NUTRACEUTICAL TO COPE WITH HEPATITIS AND DIABETES MELLITUS IN SPRAGUE DAWLEY ALBINO RATS

  2021cites this paper
• Cisplatin‐conjugated gold nanoparticles‐based drug delivery system for targeting hepatic tumors

  2021cites this paper
• Dietary Silymarin (silybum marianum) to Improve The Health Status of Layer Chickens

  2021cites this paper
• Effect of different levels of organic biotronic and nano-crystall silymarin supplement with and without LPS on liver chemical function, histology, cellular immunity and blood parameters in 21-24day-old broilers

  2021cites this paper
• Potential protective effects of Spirulina platensis on liver, kidney, and brain acrylamide toxicity in rats

  2021cites this paper
• Metformin Improves Biochemical and Pathophysiological Changes in Hepatocellular Carcinoma with Pre-Existed Diabetes Mellitus Rats

  2021cites this paper
• Inhibition of Lysozyme Amyloid Fibrillation by Silybin Diastereoisomers: The Effects of Stereochemistry

  2021cites this paper
• Efficacy of silymarin-nanohydrogle complex in attenuation of aflatoxins toxicity in Japanese quails

  2020cites this paper
• Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators

  2020cites this paper
• Fumaria parviflora improves liver damage and lipid profile changes in STZ-induced diabetic rats

  2020cites this paper
• Exopolysaccharide-peptide complex from oyster mushroom (Pleurotus ostreatus) protects against hepatotoxicity in rats

  2020cites this paper
• Concurrent metformin and silibinin therapy in diabetes: assessments in zebrafish (Danio rerio) animal model

  2020cites this paper
• Role of Panax Ginseng as an Antioxidant and Hepatoprotective after Liver Toxicity caused by Flutamide in Adult Male Rats

  2020cites this paper
• Diosmin protects against acrylamide-induced toxicity in rats: Roles of oxidative stress and inflammation

  2020cites this paper
• In Vitro Protective Effect of Paste and Sauce Extract Made with Protaetia brevitarsis Larvae on HepG2 Cells Damaged by Ethanol

  2020cites this paper
• Metformin and silymarin afford protection in cyclosporine A induced hepatorenal toxicity in rat by modulating redox status and inflammation

  2020cites this paper
• Cinnamon Extract Ameliorates Liver Damage And Oxidative Stress Induced By Paracetamol In Male Rats

  2020cites this paper
• Investigation of the Protective and / or Therapeutic Effects of Lycopene on Diethylnitrosamine-Induced Chronic Hepatotoxicity Using Biochemical, Molecular and Histopathological Data

  2020cites this paper
• Protective effects of thymoquinone against acrylamide-induced liver, kidney and brain oxidative damage in rats

  2020cites this paper
• Protective Effects of Silymarin on Gentamicin-Induced Nephrotoxicity in Infectious Patients: A Randomized Double Blinded Placebo-Controlled Clinical Trial

  2020cites this paper
• Effect of pretreatment with paste and sauce extract made using Tenebrio molitor larvae on ethanol‐damaged HepG2 cells

  2019cites this paper
• Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats

  2019cites this paper
• Phosphodiestrase‐1 and 4 inhibitors ameliorate liver fibrosis in rats: Modulation of cAMP/CREB/TLR4 inflammatory and fibrogenic pathways

  2019cites this paper
• Effects of silymarin on growth performance, antioxidant capacity and immune response in turbot ( Scophthalmus maximus L.)

  2019cites this paper
• Clinical Role of Silymarin in Oxidative Stress and Infertility: A Short Review for Pharmacy Practitioners

  2019cites this paper
• The ameliorative effects of Spirulina platensis against Diethylnitrosamine induced hepatotoxicity in rats

  2019cites this paper
• Selected herbal feed additives showing protective effects against ochratoxin A toxicosis in broiler chicks

  2019cites this paper
• Evaluation of ameliorating effect of lycopene against testicular toxicity due to diethylnitrosamine using biochemical, spermatological and histopathological data

  2019cites this paper
• Application of nanoencapsulated silymarin to improve its antioxidant and hepatoprotective activities against carbon tetrachloride-induced oxidative stress in broiler chickens

  2019cites this paper
• Sono and photo stimulated Chlorine E6 nanocomposite in tumor-bearing mice: upcoming cancer treatment

  2019cites this paper
• Biochemical and biophysical study of chemopreventive and chemotherapeutic anti-tumor potential of some Egyptian plant extracts

  2019cites this paper
• Biochemical and pathological evaluation of the effectiveness of nano-targeted sono-photodynamic therapy in breast cancer

  2019influential citation
• Sono and Photo Sensitized Gallium-Porphyrin Nanocomposite in Tumor-Bearing Mice: new Concept of Cancer Treatment

  2019cites this paper
• Antioxidants and hepatoprotective effects of chitosan nanoparticles against hepatotoxicity induced in rats

  2019cites this paper
• Hepatoprotective role of Legalon 70 against hydrogen peroxide in chickens

  2019cites this paper
• Effects of silymarin on productive performance, liver function and serum biochemical profile in broiler Japanese quail challenged with dietary aflatoxins

  2019cites this paper
• Phytotherapy for the Liver

  2019cites this paper
• Hepatoprotective effects of silymarin on CCl4-induced hepatic damage in broiler chickens model

  2019cites this paper
• Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective.

  2018cites this paper
• Heat shock protein 47 as indispensible participant in liver fibrosis: Possible protective effect of lactoferrin

  2018cites this paper
• Effect of Senna mimosoides leaf aqueous extract on the lactase activity, total protein and the electrolyte- inducing potentials of carbon tetrachloride induced hepatoxicity in Wistar albino rats NWORAH Florence Nkechi, NKWOCHA Chinelo Chinenye and NWACHUKWU

  2018cites this paper
• Phytofabrication of Silver nanoparticles: Novel Drug to overcome hepatocellular ailments

  2018cites this paper
• Hepatoprotective effect of royal jelly, grape seed extract, and Lycium barbarum against diethylnitrosamine-induced liver toxicity in rats

  2018cites this paper
• HINOKITIOL-AMELIORATED DIETHYLNITROSAMINE-INDUCED HEPATOCARCINOGENESIS THROUGH ANTIOXIDANT MECHANISM IN RATS: IN VITRO AND IN VIVO STUDY

  2018cites this paper
• Effect of Juglansregia and Nasturtum officinalis on biochemical parameters following toxicity of kidney by CCl4 in Wistar rats

  2018cites this paper
• Sono-photodynamic modality for cancer treatment using bio-degradable bio-conjugated sonnelux nanocomposite in tumor-bearing mice: Activated cancer therapy using light and ultrasound.

  2018cites this paper
• AMELIORATIVE ROLE OF BEE HONEY AND ROYAL JELLY AGAINST CISPLATIN INDUCED ALTERATION IN HEMATOLOGICAL PARAMETERS IN MALE WISTER ALBINO RAT

  2018cites this paper
• Dietary Supplementing with Resveratrol Improves Antioxidant Status in Hypercholestrolemic Rats

  2018cites this paper
• Silymarin-laden PVP-PEG polymeric composite for enhanced aqueous solubility and dissolution rate: Preparation and in vitro characterization

  2018cites this paper
• Amelioration of diethylnitrosamine (DEN)-induced hepatocellular carcinogenesis in animal models via knockdown oxidative stress and proinflammatory markers by Madhuca longifolia embedded silver nanoparticles

  2018cites this paper
• Silymarin prevents acetaminophen-induced hepatotoxicity via up-regulation of the glutathione conjugation capacity in mice

  2018cites this paper
• BIOLOGICALLY PRODUCED NANO-SELINUM REDUCES INITIATION STAGE OF DIETHYL NITROSAMINE HEPATOCARCINOGENESIS IN RATS

  2018cites this paper
• Antihyperuricemic and xanthine oxidase inhibitory activities of Silymarin in a rat gout model

  2018cites this paper
• Triterpenoids principle of Wedelia calendulacea attenuated diethynitrosamine-induced hepatocellular carcinoma via down-regulating oxidative stress, inflammation and pathology via NF-kB pathway

  2018influential citation
• Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways.

  2018cites this paper
• Performance and serum biochemical profile of Japanese quail supplemented with silymarin and contaminated with aflatoxin B1

  2018cites this paper
• β-Carotene supplementation ameliorates experimental liver fibrogenesis via restoring antioxidant status and hepatic stellate cells activity

  2018cites this paper
• Inulin nanoparticles and silymarin counteract chlorpromazine-induced injury in the liver and kidney of rats

  2017cites this paper
• In vitro assessment of hepatoprotective agents against damage induced by acetaminophen and CCl4

  2017cites this paper
• Sequential analysis and staging of a diethylnitrosamine-induced hepatocellular carcinoma in male Wistar albino rat model.

  2017cites this paper
• Phyllanthus Niruri Standardized Extract Alleviates the Progression of Non-Alcoholic Fatty Liver Disease and Decreases Atherosclerotic Risk in Sprague–Dawley Rats

  2017cites this paper
• Abrogation of carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats by Ajwa date fruit extract through ameliorating oxidative stress and apoptosis.

  2017cites this paper
• 5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction

  2017cites this paper
• Novel glycoside from Wedelia calendulacea inhibits diethyl nitrosamine-induced renal cancer via downregulating the COX-2 and PEG2 through nuclear factor-κB pathway

  2017cites this paper
• In vivo antitumour potential of camel’s milk against hepatocellular carcinoma in rats and its improvement of cisplatin renal side effects

  2017cites this paper
• Anti-tumor activity of phloretin in treatment of induced hepatocellular carcinoma in rats.

  2017cites this paper
• Hesperidin protects against diethylnitrosamine/carbon tetrachloride-induced renal repercussions via up-regulation of Nrf2/HO-1 signaling and attenuation of oxidative stress -

  2017cites this paper
• Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product

  2017cites this paper
• Protective role of dietary corn silk supplements against A. hydrophila infection

  2017cites this paper
• Exacerbation of N-nitrosodiethylamine Induced Hepatotoxicity and DNA Damage in Mice Exposed to Chronic Unpredictable Stress

  2017cites this paper