Mining iron: Iron uptake and transport in plants

Iron uptake in plants is highly regulated in order to supply amounts sufficient for optimal growth while preventing excess accumulation. In response to iron deficiency, plants induce either reduction‐based or chelation‐based mechanisms to enhance iron uptake from the soil. Genes involved in each mechanism have been identified from various model plants including Arabidopsis and rice. Iron transport within plants is also tightly controlled. New information has emerged on transporters that play a role in xylem loading and phloem loading/unloading of iron, and on the iron chelators involved in iron homeostasis. Some of the components regulating iron deficiency responses also have been elucidated, demonstrating that iron dependent gene regulation occurs at both the transcriptional and post‐transcriptional levels.

• Publication year

  2007

• Venue

  FEBS Letters

• Publication date

  2007-05-25

• Fields of study

  Biology, Medicine, Materials Science, Environmental Science

• Identifiers
  DOI 10.1016/j.febslet.2007.04.043PMID 17485078
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PIC1, an Ancient Permease in Arabidopsis Chloroplasts, Mediates Iron Transport[W]

  2007cited by this paper
• The FRD3-Mediated Efflux of Citrate into the Root Vasculature Is Necessary for Efficient Iron Translocation1[OA]

  2007cited by this paper
• Localization of Iron in Arabidopsis Seed Requires the Vacuolar Membrane Transporter VIT1

  2006cited by this paper
• AtIREG2 Encodes a Tonoplast Transport Protein Involved in Iron-dependent Nickel Detoxification in Arabidopsis thaliana Roots*

  2006cited by this paper
• Mutations in Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 Reveal Their Roles in Metal Ion Homeostasis and Loading of Metal Ions in Seeds1

  2006cited by this paper
• Light-Regulated, Tissue-Specific, and Cell Differentiation-Specific Expression of the Arabidopsis Fe(III)-Chelate Reductase Gene AtFRO61

  2006cited by this paper
• Cloning and Characterization of Deoxymugineic Acid Synthase Genes from Graminaceous Plants*

  2006cited by this paper
• A specific transporter for iron(III)-phytosiderophore in barley roots.

  2006cited by this paper
• Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+.

  2006cited by this paper
• TcYSL3, a member of the YSL gene family from the hyper-accumulator Thlaspi caerulescens, encodes a nicotianamine-Ni/Fe transporter.

  2006cited by this paper
• Ethylene could influence ferric reductase, iron transporter, and H+-ATPase gene expression by affecting FER (or FER-like) gene activity.

  2006influential reference
• Expression profiling of the Arabidopsis ferric chelate reductase (FRO) gene family reveals differential regulation by iron and copper

  2006cited by this paper
• A putative function for the arabidopsis Fe-Phytosiderophore transporter homolog AtYSL2 in Fe and Zn homeostasis.

  2005cited by this paper
• Two plasma membrane H(+)-ATPase genes are differentially expressed in iron-deficient cucumber plants.

  2005cited by this paper
• A loss-of-function mutation in AtYSL1 reveals its role in iron and nicotianamine seed loading.

  2005cited by this paper
• Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron

  2005cited by this paper
• Molecular and biochemical characterization of the Fe(III) chelate reductase gene family in Arabidopsis thaliana.

  2005cited by this paper
• Mineral nutrition of plants

  2005cited by this paper
• AtbHLH29 of Arabidopsis thaliana is a functional ortholog of tomato FER involved in controlling iron acquisition in strategy I plants

  2005cited by this paper
• FRD3 Controls Iron Localization in Arabidopsis1

  2004cited by this paper
• Kinetic properties of a micronutrient transporter from Pisum sativum indicate a primary function in Fe uptake from the soil

  2004cited by this paper
• Arabidopsis Yellow Stripe-Like2 (YSL2): a metal-regulated gene encoding a plasma membrane transporter of nicotianamine-metal complexes.

  2004cited by this paper
• The Essential Basic Helix-Loop-Helix Protein FIT1 Is Required for the Iron Deficiency Response

  2004cited by this paper
• FRU (BHLH029) is required for induction of iron mobilization genes in Arabidopsis thaliana

  2004cited by this paper
• ZmYS1 Functions as a Proton-coupled Symporter for Phytosiderophore- and Nicotianamine-chelated Metals*

  2004cited by this paper
• OsYSL2 is a rice metal-nicotianamine transporter that is regulated by iron and expressed in the phloem.

  2004cited by this paper
• Isolation and characterization of Fe(III)-chelate reductase gene LeFRO1 in tomato

  2004cited by this paper
• AtNRAMP3, a multispecific vacuolar metal transporter involved in plant responses to iron deficiency.

  2003cited by this paper
• Role of nicotianamine in the intracellular delivery of metals and plant reproductive development.

  2003cited by this paper
• Iron uptake, trafficking and homeostasis in plants

  2003cited by this paper
• Differential Regulation of nramp and irt Metal Transporter Genes in Wild Type and Iron Uptake Mutants of Tomato*

  2003cited by this paper
• Dual Regulation of the Arabidopsis High-Affinity Root Iron Uptake System by Local and Long-Distance Signals1

  2003cited by this paper
• Overexpression of the FRO2 Ferric Chelate Reductase Confers Tolerance to Growth on Low Iron and Uncovers Posttranscriptional Control1

  2003cited by this paper
• IRT1, an Arabidopsis Transporter Essential for Iron Uptake from the Soil and for Plant Growth Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001388.

  2002cited by this paper
• The tomato fer gene encoding a bHLH protein controls iron-uptake responses in roots

  2002cited by this paper
• Convergence and divergence of stress-induced mitogen-activated protein kinase signaling pathways at the level of two distinct mitogen-activated protein kinase kinases.

  2002cited by this paper
• A Metal-binding Member of the Late Embryogenesis Abundant Protein Family Transports Iron in the Phloem ofRicinus communis L.*

  2002cited by this paper
• Expression of the IRT1 Metal Transporter Is Controlled by Metals at the Levels of Transcript and Protein Accumulation Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001263.

  2002cited by this paper
• The metal ion transporter IRT1 is necessary for iron homeostasis and efficient photosynthesis in Arabidopsis thaliana.

  2002cited by this paper
• Characterization of FRO1, a Pea Ferric-Chelate Reductase Involved in Root Iron Acquisition1

  2002cited by this paper
• Knock-out of Arabidopsis metal transporter gene IRT1 results in iron deficiency accompanied by cell differentiation defects

  2002cited by this paper
• Local and long-range signaling pathways regulating plant responses to nitrate.

  2002cited by this paper
• FRD3, a Member of the Multidrug and Toxin Efflux Family, Controls Iron Deficiency Responses in Arabidopsis Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001495.

  2002cited by this paper
• CCC1 Is a Transporter That Mediates Vacuolar Iron Storage in Yeast*

  2001cited by this paper
• Phylogenetic relationships within cation transporter families of Arabidopsis.

  2001cited by this paper
• Structure and differential expression of the four members of the Arabidopsis thaliana ferritin gene family.

  2001cited by this paper
• Arabidopsis IRT2 gene encodes a root-periphery iron transporter.

  2001cited by this paper
• Maize yellow stripe1 encodes a membrane protein directly involved in Fe(III) uptake

  2001cited by this paper
• Two iron-regulated cation transporters from tomato complement metal uptake-deficient yeast mutants

  2001cited by this paper
• Fe homeostasis in plant cells: Does nicotianamine play multiple roles in the regulation of cytoplasmic Fe concentration?

  2001cited by this paper
• Iron stress-induced changes in root epidermal cell fate are regulated independently from physiological responses to low iron availability.

  2001cited by this paper
• Enhanced tolerance of rice to low iron availability in alkaline soils using barley nicotianamine aminotransferase genes

  2001cited by this paper
• A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.

  2000cited by this paper
• Cloning and Characterization of IAR1, a Gene Required for Auxin Conjugate Sensitivity in Arabidopsis

  2000cited by this paper
• Two dioxygenase genes, Ids3 and Ids2, from Hordeum vulgare are involved in the biosynthesis of mugineic acid family phytosiderophores

  2000cited by this paper
• Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes.

  2000cited by this paper
• Involvement of NRAMP1 from Arabidopsis thaliana in iron transport.

  2000cited by this paper
• Nicotianamine chelates both FeIII and FeII. Implications for metal transport in plants

  1999cited by this paper
• A ferric-chelate reductase for iron uptake from soils

  1999cited by this paper
• Iron acquisition by plants.

  1999cited by this paper
• Light-Dependent Iron Transport into Isolated Barley Chloroplasts

  1997cited by this paper
• A novel iron-regulated metal transporter from plants identified by functional expression in yeast.

  1996cited by this paper
• Shoot-to-Root Signal Transmission Regulates Root Fe(III) Reductase Activity in the dgl Mutant of Pea

  1996cited by this paper
• Genetic evidence that induction of root Fe(III) chelate reductase activity is necessary for iron uptake under iron deficiency.

  1996cited by this paper
• Subcellular Localization and Characterization of Excessive Iron in the Nicotianamine-less Tomato Mutant chloronerva

  1995cited by this paper
• Iron: Nutritious, Noxious, and Not Readily Available

  1994cited by this paper
• Nicotianamine aminotransferase activities are correlated to the phytosiderophore secretions under Fe-deficient conditions in Gramineae

  1994influential reference
• Biologically relevant metal ion‐dependent hydroxyl radical generation An update

  1992cited by this paper
• Pleiotropic Effects of brz: A Mutation in Pisum sativum (L.) cv ;Sparkle' Conditioning Decreased Nodulation and Increased Iron Uptake and Leaf Necrosis.

  1990cited by this paper
• Function of iron in chloroplasts

  1986cited by this paper
• The Enhancement of Soil Fertility by Plant Roots

  1981cited by this paper
• Mineral nutrition of plants.

  1948cited by this paper

• Dissecting the genetic basis of seed-iron content in Chickpea using a combinatorial approach of QTL-Seq and molecular haplotyping

  2026cites this paper
• Low pKa values of acid hydrogen donor groups in mimosine enable efficient iron chelation at alkaline pH

  2026cites this paper
• Iron-oxide nanoparticle release from jellyfish-based hydrogels for agricultural fertilization

  2026cites this paper
• Seasonality in Apple Leaf Molybdenum Contents During the Growing Season and Stages of Greatest Need in This Nutrient

  2025cites this paper
• Investigation of Iron- and Organic-Rich Waterworks Sludge for Fertilizer Application

  2025cites this paper
• Bacillus subtilis reprograms host transcriptome and rhizosphere microbiome via systemic signaling to confer alkaline stress tolerance in garden pea

  2025cites this paper
• Iron oxide nanoparticles (FeO-NPs) mitigate salt stress in peanut seedlings by enhancing photosynthesis, osmoregulation, and antioxidant activity.

  2025cites this paper
• Whole-Genome Duplication Reshapes Adaptation: Autotetraploid Arabidopsis arenosa Leverages its High Genetic Variation to Compensate for Selection Constraints

  2025influential citation
• Biofortification strategies for wheat: Enhancing zinc and iron nutritional quality to combat micronutrient deficiencies and ensure food security

  2025cites this paper
• Single-cell transcriptional decoding of iron deficiency responses in maize root tips

  2025cites this paper
• A comparative study on the efficacy of synthetic organic ligands on functional iron status in wheat plants

  2025cites this paper
• Fortifying crops with micronutrients for sustainable global nutritional security

  2025cites this paper
• Manganese mitigates the effects of excess iron on Zeyheria tuberculosa (Vell.) Bureau ex Verl. plants

  2025cites this paper
• Efficacy of Peroxidase Activity and Isozyme as Molecular Markers for Assessing Iron Deficiency and Toxicity Via in Vitro Culture as a Rapid Technique in Banana

  2025cites this paper
• Molecular Basis for Vacuolar Iron Transport by OsVIT2, a Target for Iron Biofortification in Rice

  2025cites this paper
• Effects of Particle Size on Ilmenite and TiO2 Toxicity to the Growth of Common Radish, Raphanus sativus

  2025cites this paper
• Protective Role of GABA in Aromatic Rice Under Lead and Cadmium Toxicity: Physiological and Biochemical Insights

  2025cites this paper
• Regulation of mineral elements in Hordeum brevisubulatum by Epichloë bromicola under Cd stress

  2024cites this paper
• Fostering nutritional wealth: unveiling iron and zinc enhancement in pulse crops—mechanisms, achievements and future frontiers

  2024cites this paper
• Barriers and carriers for transition metal homeostasis in plants

  2024cites this paper
• Global change impacts on mineral nutritional quality of cereal grains: Coordinated datasets and analyses to advance a systems-based understanding

  2024cites this paper
• Mobility, bioavailability and distribution of Fe and Cu in mangroves (Avicennia schaueriana and Rhizophora mangle) from a semiarid coast in NE Brazil.

  2024cites this paper
• Nano-Fe3O4: Enhancing the tolerance of Elymus nutans to Cd stress through regulating programmed cell death.

  2024cites this paper
• PcWRKY1 Represses Transcription of Yellow Stripe‐Like 3 (PcYSL3) to Negatively Regulate Radial Cadmium Transport in Poplar Stems

  2024cites this paper
• Impacts of Rhizobium inoculation and Fe3O4 nanoparticles on common beans plants: a magnetic study of absorption, translocation, and accumulation processes

  2024cites this paper
• Extent of As(III) versus As(V) adsorption on iron (oxyhydr) oxides depends on the presence of vacancy cluster-like micropore sites: Insights into a seesaw effect.

  2024cites this paper
• Identification and pyramiding of iron and zinc homeostasis genes introgressed from non-progenitor Aegilops species to bread wheat

  2024cites this paper
• Changes in precipitation patterns alter aggregate stability-related cations and micronutrients in a desert grassland

  2024cites this paper
• Functional Identification of MhPYL4 Involved in Iron-Deficiency Stress in Malus Halliana Koehne

  2024cites this paper
• Evaluation of Synthesized Nanoscale Fe Carriers for Enhanced Wheat Crop Nutrition in a Typic Ustifluvents

  2024cites this paper
• Micronutrients biofortification of millets: A sustainable approach

  2024cites this paper
• Transcription factor MYB8 regulates iron deficiency stress response in Arabidopsis.

  2024cites this paper
• Chemical Determination of Base Status Metals in Soil Sediments and Particulate Matter in Wellington Industrial Estate Location

  2024cites this paper
• Over-expression of the BnVIT-L2 gene improves the lateral root development and biofortification under iron stress.

  2024cites this paper
• Synthesis, Characterization and Controlled Release Pattern of Novel Fe-Containing Nanoclay Polymer Composites (Fe-NCPC) in Non-calcareous and Calcareous Soil

  2023cites this paper
• Cellular clarity: a logistic regression approach to identify root epidermal regulators of iron deficiency response

  2023cites this paper
• Iron Accumulation of Halophytes in the Littoral Zone of the White Sea

  2023cites this paper
• Physiological response of new citrus rootstocks under the effect of lime induced iron chlorosis stress conditions

  2023influential citation
• Salinity stress and nanoparticles: Insights into antioxidative enzymatic resistance, signaling, and defense mechanisms.

  2023cites this paper
• Effects of Heat Stress on Plant-Nutrient Relations: An Update on Nutrient Uptake, Transport, and Assimilation

  2023cites this paper
• Genetic structure and first genome‐wide insights into the adaptation of a wild relative of grapevine, Vitis berlandieri

  2023cites this paper
• Aquaporins-mediated water availability in substrates for cannabis cultivation in relation to CBD yield

  2023cites this paper
• Uptake of micronutrients in severely HLB-affected grapefruit trees grown on Florida Indian River flatwood soils

  2023cites this paper
• Multi-copper oxidases SKU5 and SKS1 coordinate cell wall formation using apoplastic redox-based reactions in roots

  2023cites this paper
• Iron accumulation and partitioning in hydroponically grown wild and cultivated chickpea (Cicer arietinum L)

  2023cites this paper
• Contrasting patterns and drivers of soil micronutrient availability in paddy and maize fields of eastern China

  2023cites this paper
• Assay of Fe(III) Chelate Reductase Activity in Arabidopsis thaliana Root.

  2023cites this paper
• Phytotoxicity effect study on Vigna radiata as affected by variation of palm oil mill effluent (POME) concentrations

  2023cites this paper
• Iron transport and homeostasis in plants: current updates and applications for improving human nutrition values and sustainable agriculture

  2023cites this paper
• Understanding the Mechanisms of Fe Deficiency in the Rhizosphere to Promote Plant Resilience

  2023cites this paper
• Biofortification to avoid malnutrition in humans in a changing climate: Enhancing micronutrient bioavailability in seed, tuber, and storage roots

  2023cites this paper
• A Plant Biostimulant from Ascophyllum nodosum Potentiates Plant Growth Promotion and Stress Protection Activity of Pseudomonas protegens CHA0

  2023cites this paper
• Iron Accumulation of Halophytes on the White Sea Littoral Zone

  2023cites this paper
• Biofortification of Crops to Fight Anemia: Role of Vacuolar Iron Transporters.

  2023cites this paper
• Hydropriming and Nutripriming of Bread Wheat Seeds Improved the Flour’s Nutritional Value of the First Unprimed Offspring

  2023cites this paper
• Improving the growth, yield and iron concentration of strawberry using sodium hydrosulfide (NaHS) under soilless culture

  2023cites this paper
• Genetic sequencing provides insights into molecular and genetic mechanisms of Lysobacter enzymogenes HYP18 involved in soil organic nitrogen and phosphorus mobilization and plant growth promotion

  2023cites this paper
• Nano Zinc-Enabled Strategies in Crops for Combatting Zinc Malnutrition in Human Health.

  2023cites this paper
• Combined effect of elevated CO2 and Fe deficiency on common bean metabolism and mineral profile

  2023cites this paper
• Effect of Fluorescent-Producing Rhizobacteria on Cereal Growth Through Siderophore Exertion

  2023cites this paper
• Melatonin Promotes Iron Reactivation and Reutilization in Peach Plants under Iron Deficiency

  2023cites this paper
• Iron and zinc biofortification of rice by synergistic expression of OsNAS2 gene with monocot (Pennisetum glaucum) and dicot (Phaseolus vulgaris) ferritins.

  2023cites this paper
• Decrease in hemicellulose content and its retention of iron contributes to phosphorus deficiency alleviated iron deficiency in Arabidopsis thaliana.

  2023cites this paper
• Dissection of Crop Metabolome Responses to Nitrogen, Phosphorus, Potassium, and Other Nutrient Deficiencies

  2022cites this paper
• Iron hazard in an impacted estuary: Contrasting controls of plants and implications to phytoremediation.

  2022cites this paper
• FE UPTAKE INDUCING PEPTIDE1 maintains Fe translocation by controlling Fe deficiency response genes in the vascular tissue of Arabidopsis.

  2022cites this paper
• The Relative Sensitivity of Marigold vs. Tomato to Iron (Fe) Toxicity Is Associated with Root Traits: Root-to-Shoot Mass Ratio, Failure to Sequester Fe in Roots, and Levels of the Major Fe-Uptake Protein, IRT

  2022cites this paper
• OsZIP11 is a trans-Golgi-residing transporter required for rice iron accumulation and development.

  2022cites this paper
• Seed Priming and Foliar Application of Nutrients Influence the Productivity of Relay Grass Pea (Lathyrus sativus L.) through Accelerating the Photosynthetically Active Radiation (PAR) Use Efficiency

  2022cites this paper
• Iron chlorosis in fruit stone trees with emphasis on chlorosis correction mechanisms in orchards: a review

  2022cites this paper
• Iron biofortification of the edible cactus Nopalea cochenillifera grown under hydroponic conditions

  2022cites this paper
• Genetic and morphological analysis tolerance to ferrous and ferric forms of iron in rice

  2022cites this paper
• Functional Activity Analysis of Plasma Membrane H+-Atpase Gene Promoter and Physiological Functional Identification of Interactive Transcription Factor in Blueberry

  2022cites this paper
• Foliar Spray of Micronutrients Alleviates Heat and Moisture Stress in Lentil (Lens culinaris Medik) Grown Under Rainfed Field Conditions

  2022cites this paper
• Soil and foliar applications of zinc sulfate and iron sulfate alleviate the destructive impacts of drought stress in wheat

  2022cites this paper
• Physiological and Molecular Changes in Cherry Red Tobacco in Response to Iron Deficiency Stress

  2022cites this paper
• Endophytic Fungus Phomopsis liquidambaris Enhances Fe Absorption in Peanuts by Reducing Hydrogen Peroxide

  2022cites this paper
• Effects of Fe and Mn Deficiencies on the Root Protein Profiles of Tomato (Solanum lycopersicum) Using Two-Dimensional Electrophoresis and Label-Free Shotgun Analyses

  2022cites this paper
• Transcriptome analysis provides new insight into the distribution and transport of selenium and its associated metals in selenium-rich rice.

  2022cites this paper
• The Role of Membrane Transporters in the Biofortification of Zinc and Iron in Plants

  2022cites this paper
• Heme oxygenase-nitric oxide crosstalk-mediated iron homeostasis in plants under oxidative stress.

  2022cites this paper
• Loss-of-function mutations in the ERF96 gene enhance iron-deficient tolerance in Arabidopsis.

  2022cites this paper
• The neglected role of micronutrients in predicting soil microbial structure

  2022cites this paper
• Mycorrhizal Fungi Inoculation Improves Capparis spinosa’s Yield, Nutrient Uptake and Photosynthetic Efficiency under Water Deficit

  2022cites this paper
• Impact of nanoparticles and their ionic counterparts derived from heavy metals on the physiology of food crops.

  2022cites this paper
• Physiological and biochemical characterization of Kalongi (Nigella sativa) against arsenic stress: Implications for human health risk assessment.

  2022cites this paper
• Long‐distance mobile mRNA CAX3 modulates iron uptake and zinc compartmentalization

  2022cites this paper
• Plant-growth promotion by proteobacterial strains depends on the availability of phosphorus and iron in Arabidopsis thaliana plants

  2022cites this paper
• Insights on plant–microbe interactions in soil in relation to iron dynamics

  2022cites this paper
• Plant ionomics: toward high-throughput nutrient profiling

  2022cites this paper
• Mimosine facilitates Fe uptake by Leucaena leucocephala subsp. glabrata in alkaline soils by solubilizing Fe-oxides

  2022cites this paper
• Biotechnological approaches for generating iron-rich crops

  2022cites this paper
• Phenotypic Acclimation of Maize Plants Grown under S Deprivation and Implications to Sulfur and Iron Allocation Dynamics

  2022cites this paper
• The Influence of Iron and Ligand Type on Plutonium Uptake in Two Strains of Hydroponically Grown Corn (Zea Mays)

  2022cites this paper
• Combined morpho-physiological, ionomic and transcriptomic analyses reveal adaptive responses of allohexaploid wheat (Triticum aestivum L.) to iron deficiency

  2022influential citation
• Alkaline soil pH affects bulk soil, rhizosphere and root endosphere microbiomes of plants growing in a Sandhills ecosystem.

  2021cites this paper
• Evaluation of Requirements and Efficiency Parameters in the Use, Absorption, and Translocation of Nutrients in the Production of Hymenaea courbaril L. Seedlings, a Fruit Tree of Neotropical Importance

  2021cites this paper
• Delineation of mechanistic approaches employed by plant growth promoting microorganisms for improving drought stress tolerance in plants.

  2021cites this paper
• Plant mineral transport systems and the potential for crop improvement

  2021cites this paper
• Uranium(VI) toxicity in tobacco BY-2 cell suspension culture - A physiological study.

  2021cites this paper