Transforming growth factor-β and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Cell and Tissue Research

• Publication date

  1999-04-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s004410051283PMID 10382266
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Analysis of the expression pattern of the latent transforming growth factor β binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase‐sensitive hinge region

  1998cited by this paper
• Decorin gene transfer-mediated suppression of TGF-β synthesis abrogates experimental malignant glioma growth in vivo

  1998influential reference
• Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.

  1998cited by this paper
• Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat.

  1998cited by this paper
• Human ex vivo carcinoma cells produce transforming growth factor β and thereby can inhibit lymphocyte functions in vitro

  1997cited by this paper
• Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases.

  1997influential reference
• Tyrosine kinase dependent expression of TGF-beta induced by stretch in mesangial cells.

  1997cited by this paper
• Reversal of in vivo drug resistance by the transforming growth factor‐β inhibitor decorin

  1997cited by this paper
• Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis.

  1997cited by this paper
• Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice.

  1997cited by this paper
• Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis.

  1997cited by this paper
• In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor beta.

  1997cited by this paper
• Biosynthesis of the proteoglycan decorin -- identification of intermediates in galactosaminoglycan assembly.

  1997cited by this paper
• Identification of a Bimodal Regulatory Element Encompassing a Canonical AP-1 Binding Site in the Proximal Promoter Region of the Human Decorin Gene*

  1996cited by this paper
• Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney

  1996cited by this paper
• Distinct Isoforms of Chicken Decorin Contain Either One or Two Dermatan Sulfate Chains*

  1996cited by this paper
• Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function

  1996influential reference
• Decorin-induced Growth Suppression Is Associated with Up-regulation of p21, an Inhibitor of Cyclin-dependent Kinases*

  1996influential reference
• A mutation in the transforming growth factor beta type II receptor gene promoter associated with loss of gene expression.

  1996cited by this paper
• Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

  1996cited by this paper
• Stimulation of sulphated glycosaminoglycan and decorin production in adult dermal fibroblasts by recombinant human interleukin-4.

  1995cited by this paper
• The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-beta, T-cell apoptosis, and the immune privilege of the brain.

  1995influential reference
• De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells.

  1995cited by this paper
• Transcriptional regulation of decorin gene expression. Induction by quiescence and repression by tumor necrosis factor-alpha

  1995influential reference
• The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation.

  1994cited by this paper
• Structural and functional characterization of the human decorin gene promoter. A homopurine-homopyrimidine S1 nuclease-sensitive region is involved in transcriptional control.

  1994cited by this paper
• Altered proteoglycan gene expression and the tumor stroma.

  1994influential reference
• Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.

  1994cited by this paper
• Particular types of tumor cells have the capacity to convert transforming growth factor-β from a latent to an active form

  1993cited by this paper
• Altered proteoglycan gene expression and the tumor stroma

  1993cited by this paper
• Excessive production of transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production.

  1993cited by this paper
• Preferential gene expression in quiescent human lung fibroblasts.

  1993cited by this paper
• Excessive production of transforming growth-factor beta 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth.

  1992cited by this paper
• Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

  1992cited by this paper
• Endocytosis of different members of the small chondroitin/dermatan sulfate proteoglycan family.

  1992cited by this paper
• Particular types of tumor cells have the capacity to convert transforming growth factor beta from a latent to an active form.

  1992cited by this paper
• Transforming growth factor-beta complexes with thrombospondin.

  1992cited by this paper
• Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes.

  1992cited by this paper
• Excessive production of transforming growth-factor β1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth

  1992cited by this paper
• Molecular characterization of vascular smooth muscle decorin: deduced core protein structure and regulation of gene expression.

  1992cited by this paper
• Proteoglycans as modulators of growth factor activities.

  1991cited by this paper
• Hypomethylation of the decorin proteoglycan gene in human colon cancer.

  1991cited by this paper
• Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues.

  1990cited by this paper
• Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels.

  1990influential reference
• Negative regulation of transforming growth factor-beta by the proteoglycan decorin.

  1990cited by this paper
• Negative regulation of transforming growth factor-β by the proteoglycan decorin

  1990influential reference
• Transforming growth factor-beta regulates production of proteoglycans by mesangial cells.

  1990influential reference
• Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation

  1988cited by this paper
• Immunocytochemical investigation on the distribution of small chondroitin sulfate-dermatan sulfate proteoglycan in the human.

  1986cited by this paper
• Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA.

  1986cited by this paper
• Solubility of Collagen Fibrils formed in vitro in the Presence of Sulphated Acid Mucopolysaccharide-protein

  1969cited by this paper
• Dermatan sulfate-protein: isolation from and interaction with collagen.

  1968cited by this paper

• Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes

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• TGF-β signaling: critical nexus of fibrogenesis and cancer

  2024cites this paper
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• Comparative Analysis of Differential Cellular Transcriptome and Proteome Regulation by HIV-1 and HIV-2 Pseudovirions in the Early Phase of Infection

  2023cites this paper
• Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.

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• Role of Decorin in the Lens and Ocular Diseases

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• Effect of decorin and selected glycosylation inhibitors on the adhesion of caruncular epithelial cells of pregnant cows-part I.

  2021cites this paper
• Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling.

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• Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis

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• Distribution and Function of Glycosaminoglycans and Proteoglycans in the Development, Homeostasis and Pathology of the Ocular Surface

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  2020cites this paper
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  2020cites this paper
• Expression and localization of the small proteoglycans decorin and biglycan in articular cartilage of Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency

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• The role of decorin in cardiovascular diseases: more than just a decoration

  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Recombinant fibromodulin and decorin effects on NF-κB and TGFβ1 in the 4T1 breast cancer cell line.

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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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• Identification of novel biomarker candidates for immunohistochemical diagnosis to distinguish low‐grade chondrosarcoma from enchondroma

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• Intratumoral Decorin Gene Delivery by AAV Vector Inhibits Brain Glioblastomas and Prolongs Survival of Animals by Inducing Cell Differentiation

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Human decorin regulates proliferation and migration of human lung cancer A549 cells

  2013cites this paper
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  2012cites this paper
• Differential expression of class I small leucine-rich proteoglycans in an animal model of partial bladder outlet obstruction.

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• Decorin is a novel VEGFR-2-binding antagonist for the human extravillous trophoblast.

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• Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ

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• The novel use of decorin in prevention of the development of proliferative vitreoretinopathy (PVR)

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• Through PDCD 4 and MicroRNA-21 Signaling by the Matrix Proteoglycan Decorin Controls Inflammation

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• Antimicrobial Peptide Expression Psoriasis and Promotes Keratinocyte Family Signaling System That Is Active in IL-1F5, -F6, -F8, and -F9: A Novel IL-1

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  2011cites this paper
• Decreased Expression of Decorin and p57(KIP2) Correlates with Poor Survival and Lymphatic Metastasis in Lung Cancer Patients

  2011cites this paper
• Expression of extracellular matrix proteins in adenomatoid odontogenic tumor.

  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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