In order to assess the prognostic value of renal transplant biopsies for identifying patients at risk for chronic vascular rejection (CVR), 99 biopsies performed at 6 months after renal transplantation were evaluated as part of a prospective study. A chronic graft damage (CGD) score was calculated from the scores of vascular intimal hyperplasia, glomerular mesangial changes, focal lymphocytic infiltration, focal and diffuse interstitial fibrosis, and tubular atrophy, features compatible with CVR. The mean score for the whole patient population was 4.7±2.9 (range 0‐11). There was a strong association between the CGD score at 6 months and the risk of graft loss up to 2 and 3 years following transplantation. Patients with a CGD‐score of ≥6 had a higher graft loss rate at 2 years than those with a score of <6 (6/35 vs 2/54; p=0.037). In patients with a functioning graft at 2 years, the CGD‐score at 6 months correlated with graft function at 2 years. In addition to higher serum creatinine (p= 0.003) and lower GFR (p=0.01), patients with a CGD‐score of ≥6 at 6 months also had a higher degree of albuminuria (p=0.008) at 2 years as compared with patients with a CGD‐score of <6. At 3 years 10/35 patients with a CGD score of ≥6 and 2/54 patients with a CGD‐score of <6 had lost their grafts (p=0.002). The relative risk for graft loss associated with a CGD‐score of ≥6 was 7.65. In patients with a functioning graft there was still a significant positive correlation between graft function at 3 years and the CGD‐score at 6 months (p=0.003). In conclusion, the histopathological picture at 6 months is a prognostic indicator of graft function and graft loss at 2 and 3 years after transplantation. Patients with a high CGD‐score, as indicated here ≥6, may benefit from pharmacological or other interventional measures directed towards the progression of CVR.
Can histopathological findings in early renal allograft biopsies identify patients at risk for chronic vascular rejection?
E. Dimény,J. Wahlberg,E. Larsson,B. Fellström
Published 1995 in Clinical Transplantation
ABSTRACT
PUBLICATION RECORD
- Publication year
1995
- Venue
Clinical Transplantation
- Publication date
1995-04-01
- Fields of study
Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- albuminuria
Urinary albumin excretion used here as a marker of kidney damage or dysfunction at follow-up.
- chronic graft damage (cgd) score
A composite histopathology score calculated from vascular intimal hyperplasia, glomerular mesangial changes, focal lymphocytic infiltration, interstitial fibrosis, and tubular atrophy in the 6-month biopsy.
Aliases: CGD score, CGD-score
- chronic vascular rejection (cvr)
The chronic rejection process in renal allografts whose compatible histological features are represented by the CGD scoring components.
Aliases: CVR
- glomerular filtration rate (gfr)
An estimated measure of kidney filtration function assessed in patients with functioning grafts at follow-up.
Aliases: GFR
- graft loss
Failure of the transplanted kidney graft as an outcome assessed at 2 and 3 years after transplantation.
Aliases: loss of graft, lost their grafts
- renal transplant biopsy
A kidney allograft tissue biopsy performed 6 months after transplantation and evaluated histologically in the study.
Aliases: early renal allograft biopsy, renal allograft biopsy
- serum creatinine
A blood marker of kidney function measured in patients with functioning grafts at follow-up.
Aliases: creatinine
REFERENCES
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