Role of complement and complement regulators in the removal of apoptotic cells.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Molecular Immunology

• Publication date

  2008-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.MOLIMM.2007.09.008PMID 17961651
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• C4b-binding Protein and Factor H Compensate for the Loss of Membrane-bound Complement Inhibitors to Protect Apoptotic Cells against Excessive Complement Attack*

  2007cited by this paper
• The simple design of complement factor H: Looks can be deceiving.

  2007cited by this paper
• Generation of Inhibitory NFκB Complexes and Phosphorylated cAMP Response Element-binding Protein Correlates with the Anti-inflammatory Activity of Complement Protein C1q in Human Monocytes*

  2007cited by this paper
• Ficolin-2 recognizes DNA and participates in the clearance of dying host cells.

  2007cited by this paper
• The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.

  2006cited by this paper
• ADAM10-mediated Release of Complement Membrane Cofactor Protein during Apoptosis of Epithelial Cells*

  2006cited by this paper
• Apoptotic cell removal in development and tissue homeostasis.

  2006cited by this paper
• Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus

  2006cited by this paper
• Recognition ligands on apoptotic cells: a perspective

  2006cited by this paper
• Autoimmunity to protective molecules: is it the perpetuum mobile (vicious cycle) of autoimmune rheumatic diseases?

  2006cited by this paper
• Complement regulator loss on apoptotic neuronal cells causes increased complement activation and promotes both phagocytosis and cell lysis.

  2006cited by this paper
• Clearance of apoptotic and necrotic cells and its immunological consequences

  2006cited by this paper
• Anti-phospholipid antibodies associated with alcoholic liver disease target oxidized phosphatidylserine on apoptotic cell plasma membranes.

  2006cited by this paper
• Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus1

  2006cited by this paper
• The role of defective complement control in hemolytic uremic syndrome.

  2006cited by this paper
• The apoptotic cell receptor CR3, but not αvβ5, is a regulator of human dendritic cell immunostimulatory function

  2006cited by this paper
• Nuclear Autoantigen Translocation and Autoantibody Opsonization Lead to Increased Dendritic Cell Phagocytosis and Presentation of Nuclear Antigens: A Novel Pathogenic Pathway for Autoimmunity? 1

  2005cited by this paper
• C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation

  2005cited by this paper
• Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte.

  2005cited by this paper
• Viable, apoptotic and necrotic monocytes expose phosphatidylserine: cooperative binding of the ligand Annexin V to dying but not viable cells and implications for PS-dependent clearance

  2005cited by this paper
• Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus

  2005cited by this paper
• Protective Molecules–C-Reactive Protein (CRP), Serum Amyloid P (SAP), Pentraxin3 (PTX3), Mannose-Binding Lectin (MBL), and Apolipoprotein A1 (Apo A1), and Their Autoantibodies: Prevalence and Clinical Significance in Autoimmunity

  2005cited by this paper
• Predominant role of IgM‐dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow‐derived macrophages in vitro

  2005cited by this paper
• The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis.

  2005cited by this paper
• Mannose-Binding Lectin-Deficient Mice Display Defective Apoptotic Cell Clearance but No Autoimmune Phenotype1

  2005cited by this paper
• Mannose binding lectin: genetics and autoimmune disease.

  2005cited by this paper
• Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation.

  2005cited by this paper
• CD46 Plays a Key Role in Tailoring Innate Immune Recognition of Apoptotic and Necrotic Cells*

  2005cited by this paper
• Nucleic Acid Is a Novel Ligand for Innate, Immune Pattern Recognition Collectins Surfactant Proteins A and D and Mannose-binding Lectin*

  2004cited by this paper
• Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form

  2004cited by this paper
• Nucleosomes Are Exposed at the Cell Surface in Apoptosis1

  2004cited by this paper
• Anti‐C1q autoantibodies in murine lupus nephritis

  2004cited by this paper
• Complement: a unique innate immune sensor for danger signals.

  2004cited by this paper
• Complement Activation by Apoptotic Cells Occurs Predominantly via IgM and is Limited to Late Apoptotic (Secondary Necrotic) Cells

  2004cited by this paper
• The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophages.

  2004cited by this paper
• The C4b-binding Protein-Protein S Complex Inhibits the Phagocytosis of Apoptotic Cells*

  2004cited by this paper
• Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes.

  2004cited by this paper
• Increased sensitivity of early apoptotic cells to complement‐mediated lysis

  2004cited by this paper
• Complement activation by necrotic cells in normal plasma environment compares to that by late apoptotic cells and involves predominantly IgM

  2004cited by this paper
• The human complement factor H: functional roles, genetic variations and disease associations.

  2004cited by this paper
• CD46: expanding beyond complement regulation.

  2004cited by this paper
• Complement inhibitor C4b-binding protein-friend or foe in the innate immune system?

  2004cited by this paper
• Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice

  2004cited by this paper
• Maturation of dendritic cells abrogates C1q production in vivo and in vitro.

  2004cited by this paper
• Cooperation between C1q and DNase I in the clearance of necrotic cell-derived chromatin.

  2004cited by this paper
• Mannose‐binding lectin engagement with late apoptotic and necrotic cells

  2003cited by this paper
• CCP1-4 of the C4b-binding protein alpha-chain are required for factor I mediated cleavage of complement factor C3b.

  2003cited by this paper
• Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells

  2003cited by this paper
• "Eat me" and "don't eat me" signals govern the innate immune response and tissue repair in the CNS: emphasis on the critical role of the complement system.

  2003cited by this paper
• The binding of protein S and the protein S–C4BP complex to neutrophils is apoptosis dependent

  2003cited by this paper
• Autoantibodies against mannose‐binding lectin in systemic lupus erythematosus

  2003cited by this paper
• Beyond lysis: how complement influences cell fate.

  2003cited by this paper
• Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells

  2003cited by this paper
• Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome

  2003cited by this paper
• Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

  2002cited by this paper
• Opsonization of Apoptotic Cells by Autologous iC3b Facilitates Clearance by Immature Dendritic Cells, Down-regulates DR and CD86, and Up-regulates CC Chemokine Receptor 7

  2002cited by this paper
• Antiprothrombin Antibodies in Patients With Systemic Lupus Erythematosus or With Primary Antiphospholipid Syndrome

  2002cited by this paper
• I-PLA2 Activation during Apoptosis Promotes the Exposure of Membrane Lysophosphatidylcholine Leading to Binding by Natural Immunoglobulin M Antibodies and Complement Activation

  2002cited by this paper
• Vitamin K-Dependent Protein S Localizing Complement Regulator C4b-Binding Protein to the Surface of Apoptotic Cells1

  2002cited by this paper
• Complement binding is an early feature of necrotic and a rather late event during apoptotic cell death

  2001cited by this paper
• Autoantibodies to complement components.

  2001cited by this paper
• Factor H family proteins: on complement, microbes and human diseases.

  2001cited by this paper
• The Globular Heads of C1q Specifically Recognize Surface Blebs of Apoptotic Vascular Endothelial Cells1

  2001cited by this paper
• Complement and apoptosis.

  2001cited by this paper
• C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

  2001cited by this paper
• Annexin V Binds to Positively Selected B Cells1

  2001cited by this paper
• Ultraviolet-radiation-induced keratinocyte apoptosis in C1q-deficient mice.

  2001cited by this paper
• Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells

  2001cited by this paper
• Down-regulation of the macrophage lineage through interaction with OX2 (CD200).

  2000cited by this paper
• Role of CD47 as a marker of self on red blood cells.

  2000cited by this paper
• A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo

  2000cited by this paper
• Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.

  2000cited by this paper
• C1q Deficiency and Autoimmunity: The Effects of Genetic Background on Disease Expression1

  2000cited by this paper
• A critical role for murine complement regulator crry in fetomaternal tolerance.

  2000cited by this paper
• Cutting edge: C1q protects against the development of glomerulonephritis independently of C3 activation.

  1999cited by this paper
• A Cluster of Positively Charged Amino Acids in the C4BP α-Chain Is Crucial for C4b Binding and Factor I Cofactor Function*

  1999cited by this paper
• Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

  1998cited by this paper
• Complement-dependent Clearance of Apoptotic Cells by Human Macrophages

  1998cited by this paper
• The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

  1998cited by this paper
• C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited.

  1997cited by this paper
• Expression of complement in the brain: role in health and disease.

  1996cited by this paper
• Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

  1996cited by this paper
• Autoantibodies to the collagenous region of C1q occur in three strains of lupus‐prone mice

  1996cited by this paper
• Complement regulatory molecules: application to therapy and transplantation.

  1995cited by this paper
• Isoforms of human C4b-binding protein. I. Molecular basis for the C4BP isoform pattern and its variations in human plasma.

  1995cited by this paper
• Apoptosis is associated with reduced expression of complement regulatory molecules, adhesion molecules and other receptors on polymorphonuclear leucocytes: functional relevance and role in inflammation.

  1995cited by this paper
• Differential regulation of alpha and beta chains of C4b-binding protein during acute-phase response resulting in stable plasma levels of free anticoagulant protein S

  1994cited by this paper
• Differential regulation of alpha and beta chains of C4b-binding protein during acute-phase response resulting in stable plasma levels of free anticoagulant protein S.

  1994cited by this paper
• Structure and function of decay accelerating factor CD55.

  1994cited by this paper
• Activation of the alternative pathway of human complement by apoptotic human umbilical vein endothelial cells.

  1994cited by this paper
• The Fc-recognizing, collagen-like C1q molecule is a putative type II membrane protein of macrophages.

  1993cited by this paper
• DNA binds and activates complement via residues 14-26 of the human C1q A chain.

  1992cited by this paper
• C4b-binding protein, a regulatory component of the classical pathway of complement, is an acute-phase protein and is elevated in systemic lupus erythematosus.

  1990cited by this paper
• Protein S binding in relation to the subunit composition of human C4b‐binding protein

  1989cited by this paper
• Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b.

  1983cited by this paper
• Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator.

  1979cited by this paper
• Human C4-binding protein. I. Isolation and characterization

  1978cited by this paper

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