CD4+ T Cells and the Proinflammatory Cytokines Gamma Interferon and Interleukin-6 Contribute to Alveolar Bone Loss in Mice

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Infection and Immunity

• Publication date

  1999-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.67.6.2804-2809.1999PMID 10338484PMCID PMC96585
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic Control of Susceptibility toPorphyromonas gingivalis-Induced Alveolar Bone Loss in Mice

  2000cited by this paper
• Serum antibody response to oral infection precedes but does not prevent Porphyromonas gingivalis-induced alveolar bone loss in mice.

  1999cited by this paper
• Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism.

  1997cited by this paper
• Porphyromonas gingivalis lipopolysaccharide-stimulated bone resorption via CD14 is inhibited by broad-spectrum antibiotics

  1997cited by this paper
• Relevance of local Th2‐type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases

  1997cited by this paper
• Cell-mediated immune system regulation in periodontal diseases.

  1997cited by this paper
• Effects of T cell adoptive transfer into nude mice on alveolar bone resorption induced by endotoxin.

  1996cited by this paper
• Abnormally short serum half‐lives of IgG in β2‐microglobulin‐deficient mice

  1996cited by this paper
• Expression of Haemophilus influenzae type b idiotype 1 on naturally acquired antibodies

  1996cited by this paper
• Selected Th1 and Th2 cytokine mRNA expression by CD4+ T cells isolated from inflamed human gingival tissues

  1996influential reference
• Role of Th1 and Th2 cells in bacterial infections.

  1996cited by this paper
• T lymphocytes play a critical role in the development of cyclosporin A-induced osteopenia.

  1996cited by this paper
• The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor.

  1996cited by this paper
• Inflammatory cytokine gene expression in human periodontal ligament fibroblasts stimulated with bacterial lipopolysaccharides

  1995cited by this paper
• Mouse NK1+ T cells.

  1995cited by this paper
• A peptide, ALTTE, within the fimbrial subunit protein from Porphyromonas gingivalis, induces production of interleukin 6, gene expression and protein phosphorylation in human peripheral blood mononuclear cells.

  1995cited by this paper
• Periodontal diseases in HIV-infected patients.

  1994cited by this paper
• Impaired immune and acute-phase responses in interleukin-6-deficient mice

  1994cited by this paper
• The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo.

  1994cited by this paper
• IL-4- and IL-6-producing cells in human periodontal disease tissue.

  1994cited by this paper
• Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.

  1994cited by this paper
• Assessment of interleukin-6 in the pathogenesis of periodontal disease.

  1994cited by this paper
• Adoptive transfer of cloned T helper cells ameliorates periodontal disease in nude rats.

  1994cited by this paper
• Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice.

  1994cited by this paper
• Oral manifestations of HIV infection: a Panamerican perspective.

  1993cited by this paper
• Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.

  1993cited by this paper
• Immunopathogenesis of chronic inflammatory periodontal disease: cellular and molecular mechanisms.

  1993cited by this paper
• Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues.

  1993cited by this paper
• Host responses in periodontal diseases: current concepts.

  1992cited by this paper
• Increased osteoclast development after estrogen loss: mediation by interleukin-6.

  1992cited by this paper
• Immunologic mechanisms of pathogenesis in periodontal diseases: an assessment.

  1991cited by this paper
• Mice lacking MHC class II molecules.

  1991cited by this paper
• Bone and the Immune System

  1991cited by this paper
• Porphyromonas gingivalis‐specific serum IgG and IgA antibodies originate from immunoglobulin‐secreting cells in inflamed gingiva

  1991cited by this paper
• Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

  1990cited by this paper
• Interleukin-6: an overview.

  1990cited by this paper
• Two complementary methods of assessing periodontal bone level in rats.

  1989cited by this paper
• Limit dilution analysis of peripheral blood T lymphocytes specific to periodontopathic bacteria.

  1989cited by this paper
• Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in human periodontal diseases.

  1988cited by this paper
• Human serum antibody responses to oral microorganisms. IV. Correlation with homologous infection.

  1987cited by this paper
• Immunologic dysfunction in the pathogenesis of periodontal diseases.

  1987cited by this paper
• Phenotypic studies of cells from periodontal disease tissues.

  1984cited by this paper
• Bone and Mineral Research, Annual 1: A Yearly Survey of Developments in the Field of Bone and Mineral Metabolism

  1983cited by this paper
• The effects of immunosuppressive drugs on periodontal inflammation in human renal allograft patients.

  1982cited by this paper
• Periodontitis in Man and Other Animals: A Comparative Review

  1982cited by this paper
• Alveolar bone destruction in the immunosuppressed rat.

  1982cited by this paper
• A study of the bacteria associated with advancing periodontitis in man.

  1979cited by this paper

• Distinct spatial organization governs oral mucosal immunity

  2026cites this paper
• Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections

  2025cites this paper
• IRF3 Promotes Production of IL-6 and Nitric Oxide but Represses CCL22 in RAW264.7 Macrophage Cells Exposed to Lipopolysaccharides in Culture

  2025cites this paper
• Cytokine responses of CD4+ T cells and NKT cells to periodontitis‐associated bacteria in individuals with or without periodontitis

  2024cites this paper
• The role of acquired host immunity in periodontal diseases.

  2024cites this paper
• Serum TNF-α level and probing depth as a combined indicator for peri-implant disease

  2024cites this paper
• Graphene quantum dots enhance the osteogenic differentiation of PDLSCs in the inflammatory microenvironment

  2023cites this paper
• Granzyme B promotes matrix metalloproteinase-1 (MMP-1) release from gingival fibroblasts in a PAR1- and Erk1/2-dependent manner: A novel role in periodontal inflammation.

  2023cites this paper
• The role of microbiome-host interactions in the development of Alzheimer´s disease

  2023cites this paper
• Protein expression after gingival injection of messenger RNA encoding platelet-derived growth factor-bb in ligature-induced rat periodontitis

  2023cites this paper
• Immunosenescence and inflammaging: Conspiracies against alveolar bone turnover.

  2023cites this paper
• ICAM‐1‐mediated osteoblast‐T lymphocyte direct interaction increases mineralization through TGF‐β1 suppression

  2023cites this paper
• Chronological analysis of periodontal bone loss in experimental periodontitis in mice

  2023cites this paper
• IL-33 deficiency suppresses alveolar bone loss in a ligature-induced periodontitis model.

  2023cites this paper
• Illuminating the Oral Microbiome and its Host Interactions: Animal models of disease.

  2023cites this paper
• Association between Porphyromonas Gingivalis and systemic diseases: Focus on T cells-mediated adaptive immunity

  2022cites this paper
• Meta-Analysis of Two Human RNA-seq Datasets to Determine Periodontitis Diagnostic Biomarkers and Drug Target Candidates

  2022cites this paper
• A vitronectin-derived peptide prevents and restores alveolar bone loss by modulating bone remodeling and expression of RANKL and IL-17A.

  2022cites this paper
• Neutralization of Staphylococcus aureus Protein A Prevents Exacerbated Osteoclast Activity and Bone Loss during Osteomyelitis

  2022cites this paper
• Interleukin-17 is disease promoting in early stages and protective in late stages of experimental periodontitis

  2022cites this paper
• Resolvin D1 modulates periodontal ligament fibroblast function.

  2022cites this paper
• Maintaining homeostatic control of periodontal bone tissue.

  2021cites this paper
• Human gingiva-derived mesenchymal stem cells promote osteogenic differentiation through their immunosuppressive function.

  2021cites this paper
• Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response

  2021cites this paper
• Vitkovskyi O. METHOD OF TREATMENT WITH TITANIUM NICKELIDE DILATOR TO IMPROVE DRAINAGE OF SURGICAL WOUNDS IN CASES OF MANDIBULAR FRACTURES

  2021cites this paper
• Chronic-periodontitis: could it be a connived-culprit of COVID-19?

  2021cites this paper
• CTHRC1 Knockdown Promotes Inflammatory Responses Partially by p38 MAPK Activation in Human Periodontal Ligament Cells

  2021cites this paper
• Filifactor alocis: Recent Insights and Advances

  2021cites this paper
• Pyroptosis in Osteoblasts: A Novel Hypothesis Underlying the Pathogenesis of Osteoporosis

  2021cites this paper
• Estrogen deficiency and the pathogenesis of osteoporosis

  2021cites this paper
• Phenotypic and Functional Alterations of Immune Effectors in Periodontitis; A Multifactorial and Complex Oral Disease

  2021cites this paper
• Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure

  2020cites this paper
• Microbial Lipid A Remodeling Controls Cross-Presentation Efficiency and CD8 T Cell Priming by Modulating Dendritic Cell Function

  2020cites this paper
• A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis.

  2020cites this paper
• Osteoclasts in Cardiovascular Calcification

  2020cites this paper
• Intracellular Staphylococcus aureus in Bone and Joint Infections: A Mechanism of Disease Recurrence, Inflammation, and Bone and Cartilage Destruction.

  2020cites this paper
• The blockade of kappa opioid receptors exacerbates alveolar bone resorption in rats.

  2020cites this paper
• The IL-17/Th17 Axis as a Therapeutic Target in Periodontitis

  2020cites this paper
• Central regulatory role of cytokines in periodontitis and targeting options.

  2020cites this paper
• Roles of Porphyromonas gingivalis and its virulence factors in periodontitis.

  2020cites this paper
• The inflammatory response to bone infection – a review based on animal models and human patients

  2020cites this paper
• Frontline Science: Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection

  2020cites this paper
• Oral Microbes and Mucosal Dendritic Cells, “Spark and Flame” of Local and Distant Inflammatory Diseases

  2020cites this paper
• Inflammation in Bone Loss

  2020cites this paper
• Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis

  2020cites this paper
• The Role of the Immune Response in Chronic Marginal and Apical Periodontitis.

  2020cites this paper
• Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

  2020cites this paper
• Transient Expression of IL-17A in Foxp3 Fate-Tracked Cells in Porphyromonas gingivalis-Mediated Oral Dysbiosis

  2020cites this paper
• Plant-Derived Exosomal Nanoparticles Inhibit Pathogenicity of Porphyromonas gingivalis

  2019cites this paper
• Oral Mucosal Immunity and Microbiome

  2019cites this paper
• Exendin-4 regulates Wnt and NF-κB signaling in lipopolysaccharide-induced human periodontal ligament stem cells to promote osteogenic differentiation.

  2019cites this paper
• Immunological Pathways Triggered by Porphyromonas gingivalis and Fusobacterium nucleatum: Therapeutic Possibilities?

  2019cites this paper
• Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions

  2019cites this paper
• Immune responses in women with periodontitis and preterm low birth weight: Levels of CD4+ and CD8+ T cells in gingival granulation tissue.

  2019cites this paper
• Cyclic compression emerged dual effects on the osteogenic and osteoclastic status of LPS-induced inflammatory human periodontal ligament cells according to loading force

  2019cites this paper
• T Helper 17 Cells as Pathogenic Drivers of Periodontitis.

  2019cites this paper
• TNF-α is responsible for the contribution of stromal cells to osteoclast and odontoclast formation during orthodontic tooth movement

  2019cites this paper
• Osteoimmunology: evolving concepts in bone–immune interactions in health and disease

  2019cites this paper
• Osteoimmunology: Inflammatory osteolysis and regeneration of the alveolar bone.

  2019cites this paper
• Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms

  2019cites this paper
• Cyclic compression emerged dual effects on the bone homeostasis of LPS-induced inflammatory human periodontal ligament cells according to loading force

  2019cites this paper
• Immunomodulatory Properties of Dental-Derived Mesenchymal Stem Cells

  2018cites this paper
• Mechanistic links between periodontitis and diabetes

  2018cites this paper
• Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption

  2018cites this paper
• Association of liver enzyme levels and alveolar bone loss: A cross-sectional clinical study in Sado Island

  2018cites this paper
• The positive effects of secreting cytokines IL‐17 and IFN‐&ggr; on the early‐stage differentiation and negative effects on the calcification of primary osteoblasts in vitro

  2018cites this paper
• Porphyromonas gingivalis induces exacerbated periodontal disease during pregnancy.

  2018cites this paper
• Costimulation of Murine Osteoblasts with Interferon-γ and Tumor Necrosis Factor-α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria

  2018cites this paper
• IFN-g stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation

  2018cites this paper
• TBX21‐1993T/C polymorphism association with Th1 and Th17 response at periapex and with periapical lesions development risk

  2018cites this paper
• Bone mesenchymal stem cell secretion of sRANKL/OPG/M-CSF in response to macrophage-mediated inflammatory response influences osteogenesis on nanostructured Ti surfaces.

  2018cites this paper
• Interleukin‐2, ‐16, and ‐17 gene polymorphisms in Iranian patients with chronic periodontitis

  2018cites this paper
• Regulation of Osteoclast Differentiation by Cytokine Networks

  2018cites this paper
• Influence of static forces on the expression of selected parameters of inflammation in periodontal ligament cells and alveolar bone cells in a co-culture in vitro model

  2018cites this paper
• Resolvin D2 Restrains Th1 Immunity and Prevents Alveolar Bone Loss in Murine Periodontitis

  2018cites this paper
• Innate lymphoid cells are present in gingivitis and periodontitis

  2018cites this paper
• Preventive effects of the novel antimicrobial peptide Nal-P-113 in a rat Periodontitis model by limiting the growth of Porphyromonas gingivalis and modulating IL-1β and TNF-α production

  2017cites this paper
• Therapeutic effect of Lianbeijuqin (a Chinese herbal cocktail) on periodontitis in rat

  2017cites this paper
• Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later

  2017cites this paper
• Genes Critical for Developing Periodontitis: Lessons from Mouse Models

  2017cites this paper
• Bone and the Immune System

  2017cites this paper
• Discriminating between Interstitial and Circulating Leukocytes in Tissues of the Murine Oral Mucosa Avoiding Nasal-Associated Lymphoid Tissue Contamination

  2017cites this paper
• Fucoidan inhibits LPS‐induced inflammation in vitro and during the acute response in vivo

  2017cites this paper
• Human periodontal ligament stem cells suppress T‐cell proliferation via down‐regulation of non‐classical major histocompatibility complex‐like glycoprotein CD1b on dendritic cells

  2017cites this paper
• Inhibition and attenuation of pathogenicity of Porphyromonas gingivalis by leupeptin: A review

  2017cites this paper
• CD8+ T Cells in Chronic Periodontitis: Roles and Rules

  2017cites this paper
• Treg regulation in periodontal disease during pregnancy.

  2017influential citation
• Periodontal and periapical lesions etiology : Similarities and peculiarities

  2017cites this paper
• Parodontite et apnée du sommeil, deux pathologies liées ?

  2017cites this paper
• Tissue-Specific Immunity at the Oral Mucosal Barrier.

  2017cites this paper
• Phenotype and Function of Myeloid-Derived Suppressor Cells Induced by Porphyromonas gingivalis Infection

  2017cites this paper
• Diarylheptanoid Hirsutenone Attenuates Osteoclastogenesis by Suppressing IFNγ and NF-κB Signaling in Th1 and Preosteoclastic Cells.

  2017cites this paper
• Oral pathogenesis of Aggregatibacter actinomycetemcomitans.

  2017cites this paper
• A T cell-specific knockout reveals an important role for protease-activated receptor 2 in lymphocyte development.

  2017cites this paper
• NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis

  2017cites this paper
• Tumor Necrosis Factor- from macrophage in response to bacteria via Toll-like Receptor 2 is responsible for osteoclastogenesis

  2017cites this paper
• Manipulation of Neutrophils by Porphyromonas gingivalis in the Development of Periodontitis

  2017cites this paper
• Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis–Driven Alveolar Bone Destruction

  2016cites this paper
• Inhibitory effect of 1,25-dihydroxyvitamin D3 on Porphyromonas gingivalis-induced inflammation and bone resorption in vivo.

  2016cites this paper
• Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis

  2016cites this paper