Ligand-induced internalization and phosphorylation-dependent degradation of growth hormone receptor in human IM-9 cells.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  1994-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0303-7207(94)90187-2PMID 7895916
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Treatment of IM-9 cells with human growth hormone (GH) promotes rapid disulfide linkage of the GH receptor.

  1994cited by this paper
• Preparation of monoclonal antibodies for immunoblotting human growth hormone receptor and growth hormone-binding protein.

  1994cited by this paper
• Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes.

  1994cited by this paper
• Targeting of membrane proteins to endosomes and lysosomes.

  1994cited by this paper
• Signal-dependent membrane protein trafficking in the endocytic pathway.

  1993cited by this paper
• Stimulation of tyrosine phosphorylation in human cells by activation of the growth hormone receptor.

  1993cited by this paper
• Annexin I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor

  1993cited by this paper
• Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.

  1993cited by this paper
• Human growth hormone (GH) receptor is characterized as the 134-kilodalton tyrosine-phosphorylated protein activated by GH treatment in IM-9 cells.

  1993cited by this paper
• Evidence for involvement of the growth hormone receptor-associated tyrosine kinase in actions of growth hormone.

  1993cited by this paper
• Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.

  1992cited by this paper
• Rational design of potent antagonists to the human growth hormone receptor.

  1992cited by this paper
• A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.

  1992cited by this paper
• Comparison of the effects of hypertonic sucrose and intracellular potassium depletion on growth hormone receptor binding kinetics and down-regulation in IM-9 cells: evidence for a sequential block of receptor--mediated endocytosis.

  1991cited by this paper
• Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule.

  1991cited by this paper
• Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

  1991cited by this paper
• Staurosporine: An Effective Inhibitor for Ca2+/Calmodulin‐Dependent Protein Kinase II

  1991cited by this paper
• The mechanism of receptor-mediated endocytosis.

  1991cited by this paper
• Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization

  1990cited by this paper
• Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells

  1990cited by this paper
• Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body.

  1990cited by this paper
• Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis.

  1990cited by this paper
• Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated with the receptor in the down-regulation.

  1990cited by this paper
• Membrane traffic in endocytosis: insights from cell-free assays.

  1989cited by this paper
• Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation.

  1989cited by this paper
• Characterization of the growth hormone-binding protein of human serum using a panel of monoclonal antibodies.

  1989cited by this paper
• Cellular mechanisms in the processing of growth hormone and its receptor.

  1989cited by this paper
• Receptor-mediated endocytosis and degradation of bovine growth hormone in rat liver.

  1988cited by this paper
• Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

  1988cited by this paper
• Biological activities of EGF‐receptor mutants with individually altered autophosphorylation sites.

  1988cited by this paper
• Intracellular processing of growth hormone receptors by adipocytes in primary culture.

  1988cited by this paper
• Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potent inhibitor of insulin receptor than IGF-I receptor.

  1988cited by this paper
• Receptor-mediated endocytosis and degradative processing of growth hormone by rat adipocytes in primary culture.

  1987cited by this paper
• Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing.

  1987cited by this paper
• Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.

  1987cited by this paper
• Growth hormone receptor and serum binding protein: purification, cloning and expression

  1987cited by this paper
• A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

  1987cited by this paper
• Intracellular potassium depletion in IM-9 lymphocytes suppresses the slowly dissociating component of human growth hormone binding and the down-regulation of its receptors but does not affect insulin receptors.

  1986cited by this paper
• Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.

  1986cited by this paper
• Binding and degradation of [125I]human growth hormone in rat adipocytes.

  1984cited by this paper
• Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

  1984cited by this paper
• Processing of human growth hormone by rat hepatocytes in monolayer culture.

  1984cited by this paper
• Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics

  1984cited by this paper
• Inhibitors of lysosomal function.

  1983cited by this paper
• Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line.

  1982cited by this paper
• Polypeptide hormone degradation and receptor regulation are coupled to ligand internalization. A direct biochemical and morphologic demonstration.

  1981cited by this paper
• Binding, internalization, and lysosomal association of 125I-human growth hormone in cultured human lymphocytes: a quantitative morphological and biochemical study

  1980cited by this paper
• Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes.

  1976cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expression

  2025cites this paper
• Eliminative Signaling by Janus Kinases: Role in the Downregulation of Associated Receptors

  2014cites this paper
• Signal Transduction Mechanisms Underlying Growth Hormone ReceptorAction

  2012cites this paper
• Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system.

  2008cites this paper
• Determinants of growth hormone receptor down-regulation.

  2007cites this paper
• Ubiquitin system-dependent regulation of growth hormone receptor signal transduction.

  2004cites this paper
• Jak2 and proteasome activities control the availability of cell surface growth hormone receptors during ligand exposure.

  2003cites this paper
• Nuclear translocation and retention of growth hormone.

  2003cites this paper
• Pharmacokinetics and acute lipolytic actions of growth hormone. Impact of age, body composition, binding proteins, and other hormones.

  2002cites this paper
• Proteasomes are involved in the constitutive degradation of growth hormone receptors.

  2001cites this paper
• Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation.

  2000cites this paper
• Tumor Necrosis Factor- a Converting Enzyme (TACE) Is a Growth Hormone Binding Protein (GHBP) Sheddase: The Metalloprotease TACE/ADAM-17 Is Critical for (PMA-Induced) GH Receptor Proteolysis and GHBP Generation*

  2000cites this paper
• Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation.

  2000cites this paper
• Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity.

  1999cites this paper
• Role of ecto-kinase in phorbol ester-enhanced growth hormone-binding protein release from human IM-9 cells.

  1999cites this paper
• Characterization of an antagonist monoclonal antibody, GHBP116, specific for human growth hormone receptors.

  1999cites this paper
• Antibody to Epitope Tag Induces Internalization of Human Muscarinic Subtype 1 Receptor

  1998cites this paper
• Dexamethasone Impairs Growth Hormone (GH)-Stimulated Growth by Suppression of Local Insulin-Like Growth Factor (IGF)-I Production and Expression of GH- and IGF-I-Receptor in Cultured Rat Chondrocytes.

  1998cites this paper
• The Growth Hormone Receptor

  1998cites this paper
• Growth hormone induces detergent insolubility of GH receptors in IM-9 cells.

  1997cites this paper
• Growth hormone induces detergent insolubility of GH receptors in IM-9 cells.

  1997cites this paper
• Growth Hormone-induced Signal Transduction Depends on an Intact Ubiquitin System*

  1997cites this paper
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  1996cites this paper
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  1996cites this paper
• Release of a soluble form of growth hormone receptors (growth hormone-binding proteins) from human IM-9 cells by proteolytic cleavage.

  1995cites this paper