Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Neuropsychopharmacology

• Publication date

  2003-05-21

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/sj.npp.1300191PMID 12784115
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events.

  2001cited by this paper
• Effects of sertraline on regional neuropeptide concentrations in olfactory bulbectomized rats.

  2001cited by this paper
• Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders.

  2001influential reference
• Corticotropin-releasing hormone in depression and post-traumatic stress disorder.

  2001cited by this paper
• Chronic cold exposure potentiates CRH-evoked increases in electrophysiologic activity of locus coeruleus neurons.

  2001cited by this paper
• Pharmacodynamic and receptor binding changes during chronic lorazepam administration.

  2001cited by this paper
• Decreased corticotropin-releasing hormone (CRH) concentrations in the cerebrospinal fluid of eucortisolemic suicide attempters.

  2001cited by this paper
• A follow up study of suicide attempters: increase of CSF-somatostatin but no change in CSF-CRH.

  2001cited by this paper
• Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated.

  2000cited by this paper
• Quantitative distribution of monoamine oxidase A in brainstem monoamine nuclei is normal in major depression.

  1999cited by this paper
• Molecular control of locus coeruleus neurotransmission.

  1999cited by this paper
• Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression.

  1999cited by this paper
• Discrete local application of corticotropin‐releasing factor increases locus coeruleus discharge and extracellular norepinephrine in rat hippocampus

  1999cited by this paper
• Long-term regulation of locus ceruleus sensitivity to corticotropin-releasing factor by swim stress.

  1999cited by this paper
• Corticotropin-releasing factor, norepinephrine, and stress.

  1999cited by this paper
• Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat.

  1999cited by this paper
• Cerebrospinal fluid concentrations of corticotropin‐releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment

  1998cited by this paper
• Amygdaloid Corticotropin‐Releasing Factor Targets Locus Coeruleus Dendrites: Substrate for the Co‐ordination of Emotional and Cognitive Limbs of the Stress Response

  1998cited by this paper
• Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression

  1997cited by this paper
• Pharmacology and Distribution of Norepinephrine Transporters in the Human Locus Coeruleus and Raphe Nuclei

  1997cited by this paper
• Low cerebrospinal fluid corticotropin-releasing hormone concentrations in eucortisolemic depression.

  1997cited by this paper
• Corticotropin-releasing factor binding sites in cortex of depressed suicides

  1997cited by this paper
• Locus coeruleus activation by colon distention: role of corticotropin-releasing factor and excitatory amino acids.

  1997cited by this paper
• Corticotropin-releasing factor receptor antagonist infused into the locus coeruleus attenuates immobilization stress-induced defensive withdrawal in rats.

  1996cited by this paper
• Corticotropin‐releasing factor‐containing axon terminals synapse onto catecholamine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain

  1996cited by this paper
• Evidence for divergent projections to the brain noradrenergic system and the spinal parasympathetic system from Barrington's nucleus.

  1996cited by this paper
• Reciprocal cross-desensitization of locus coeruleus electrophysiological responsivity to corticotropin-releasing factor and stress.

  1996cited by this paper
• Localization of corticotropin-releasing hormone in the human locus coeruleus and pedunculopontine tegmental nucleus: an immunocytochemical and in situ hybridization study.

  1995cited by this paper
• Previous stress alters corticotropin-releasing factor neurotransmission in the locus coeruleus.

  1995cited by this paper
• Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies.

  1995cited by this paper
• Corticotropin-releasing factor administered into the locus coeruleus, but not the parabrachial nucleus, stimulates norepinephrine release in the prefrontal cortex.

  1995cited by this paper
• Pharmacological comparison of two corticotropin-releasing factor antagonists: in vivo and in vitro studies.

  1994cited by this paper
• The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders.

  1994cited by this paper
• Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients.

  1994cited by this paper
• Effects of electroconvulsive therapy on the CRH-ACTH-cortisol system in melancholic depression: preliminary findings.

  1994cited by this paper
• Elevated Tyrosine Hydroxylase in the Locus Coeruleus of Suicide Victims

  1994cited by this paper
• Corticotropin‐Releasing Factor Stimulates Catecholamine Release in Hypothalamus and Prefrontal Cortex in Freely Moving Rats as Assessed by Microdialysis

  1993cited by this paper
• Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression.

  1993cited by this paper
• Hypothalamic norepinephrine depletion inhibits CRF-41 release following neural stimuli.

  1993cited by this paper
• Stress-induced norepinephrine release in the paraventricular nucleus of rats with brainstem hemisections: a microdialysis study.

  1993cited by this paper
• Branching projections of catecholaminergic brainstem neurons to the paraventricular hypothalamic nucleus and the central nucleus of the amygdala in the rat.

  1993cited by this paper
• Corticotropin-releasing factor innervation of the locus coeruleus region: distribution of fibers and sources of input.

  1992cited by this paper
• Hypothalamic-pituitary-adrenal axis function and suicidal behavior in depression.

  1992cited by this paper
• Coordinate Regulation of the Cyclic AMP System with Firing Rate and Expression of Tyrosine Hydroxylase in the Rat Locus Coeruleus: Effects of Chronic Stress and Drug Treatments

  1992cited by this paper
• HPA-related CSF neuropeptides in suicide attempters.

  1992cited by this paper
• Activation of noradrenergic locus coeruleus neurons by hemodynamic stress is due to local release of corticotropin-releasing factor.

  1991cited by this paper
• Involvement of corticotropin-releasing factor in chronic stress regulation of the brain noradrenergic system.

  1991cited by this paper
• Neuropeptide Concentrations in the Cerebrospinal Fluid of Depressed Patients Treated with Electroconvulsive Therapy

  1991cited by this paper
• Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus

  1990cited by this paper
• Behavioral effects of corticotropin-releasing factor

  1990cited by this paper
• Cortical concentrations of corticotropin-releasing hormone and its receptor in Alzheimer type dementia and major depression.

  1990cited by this paper
• Elevated CSF CRF in suicide victims.

  1989cited by this paper
• Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.

  1988cited by this paper
• Acetylcholine and norepinephrine stimulate the release of corticotropin-releasing factor-41 from the rat hypothalamus in vitro.

  1988cited by this paper
• CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia.

  1987cited by this paper
• Inhibitory effect of norepinephrine on immunoreactive corticotropin-releasing factor release from the rat hypothalamus in vitro.

  1987cited by this paper
• Immunocytochemical evidence for stimulatory control by the ventral noradrenergic bundle of parvocellular neurons of the paraventricular nucleus secreting corticotropin releasing hormone and vasopressin in rats.

  1986cited by this paper
• Alterations in corticotropin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress

  1986cited by this paper
• Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients.

  1984cited by this paper
• A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility.

  1981cited by this paper
• The family history method using diagnostic criteria

  1978cited by this paper
• A diagnostic interview: the schedule for affective disorders and schizophrenia.

  1978cited by this paper
• The family history method using diagnostic criteria. Reliability and validity.

  1977cited by this paper
• Disrupted 24-hour patterns of cortisol secretion in psychotic depression.

  1973cited by this paper

• Arousal increases locus coeruleus blood flow, salience-related brain responses, and modulates negative-valence attentional biases

  2025cites this paper
• The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC).

  2024cites this paper
• A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease

  2024cites this paper
• Role of the locus coeruleus-noradrenergic system in stress-related psychopathology and resilience: clinical and pre-clinical evidences.

  2024cites this paper
• Sex Differences in Stress Response: Classical Mechanisms and Beyond

  2023cites this paper
• Role of CRF and the hypothalamic‐pituitary‐adrenal axis in stroke: revisiting temporal considerations and targeting a new generation of therapeutics

  2022cites this paper
• Corticotropin releasing factor and drug seeking in substance use disorders: Preclinical evidence and translational limitations

  2022cites this paper
• Exploring the role of neuropeptides in depression and anxiety.

  2021cites this paper
• Anti‐stress effects of combined block of glucocorticoid and mineralocorticoid receptors in the paraventricular nucleus of the hypothalamus

  2021cites this paper
• Corticotropin releasing hormone receptor CRHR1 gene is associated with tianeptine antidepressant response in a large sample of outpatients from real-life settings

  2020cites this paper
• The role of the CRF-urocortin system in stress resilience

  2020cites this paper
• Chronic Environmental or Genetic Elevation of Galanin in Noradrenergic Neurons Confers Stress Resilience in Mice

  2020cites this paper
• Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease

  2019cites this paper
• Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease

  2019cites this paper
• Mom doesn't care: When increased brain CRF system activity leads to maternal neglect in rodents.

  2019cites this paper
• Sex differences in the hypothalamic–pituitary–adrenal axis: An obstacle to antidepressant drug development?

  2019cites this paper
• Increased protein and mRNA expression of corticotropin-releasing factor (CRF), decreased CRF receptors and CRF binding protein in specific postmortem brain areas of teenage suicide subjects.

  2019cites this paper
• Neurobiology of resilience in depression: immune and vascular insights from human and animal studies

  2019cites this paper
• Neurochemically distinct circuitry regulates locus coeruleus activity during female social stress depending on coping style

  2019cites this paper
• Melanin-Concentrating Hormone (MCH) and MCH-R1 in the Locus Coeruleus May Be Involved in the Regulation of Depressive-Like Behavior

  2018cites this paper
• The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.

  2018cites this paper
• The association between norepinephrine and metabolism in patients with major depression

  2018cites this paper
• The CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response

  2018cites this paper
• Psychosomatic Interrelations in Cardiovascular Diseases and Their Consequences on Patient’s Quality of Life

  2017cites this paper
• A comparison between antidepressant effects of transcranial near-infrared laser and citalopram in a rat model of depression

  2017cites this paper
• Resilience in refugee and Dutch adolescents: Genetic variability in the corticotropin releasing hormone receptor 1 ☆

  2017cites this paper
• Depression During Pregnancy.

  2017cites this paper
• Polycystic Ovary Syndrome and Sympathoexcitation: Management of Stress and Lifestyle

  2017cites this paper
• Corticotropin releasing factor dose‐dependently modulates excitatory synaptic transmission in the noradrenergic nucleus locus coeruleus

  2017cites this paper
• De l’importance des médiateurs du stress dans le contrôle de l’immunité

  2017cites this paper
• Alterations in the corticotropin-releasing hormone (CRH) neurocircuitry: Insights into post stroke functional impairments.

  2016cites this paper
• Stress Neurobiology and Developmental Psychopathology

  2016cites this paper
• Therapeutic effects of 10‐HzPulsed wave lasers in rat depression model: A comparison between near‐infrared and red wavelengths

  2016cites this paper
• T helper 17 cells may drive neuroprogression in major depressive disorder: Proposal of an integrative model

  2016cites this paper
• A role for CRH and HPA Activation in the Regulation of Plasticity Signaling, Neuroinflammation and Emotional/Mnesic Behavior Following Global Cerebral Ischemia in Rats

  2016cites this paper
• Sex-biased cellular signaling: molecular basis for sex differences in neuropsychiatric diseases

  2016cites this paper
• Neurobiología de la depresión mayor y de su tratamiento farmacológico

  2016cites this paper
• Human fear acquisition deficits in relation to genetic variants of the corticotropin‐releasing hormone receptor 1 and the serotonin transporter — revisited

  2016cites this paper
• Cognitive disruptions in stress-related psychiatric disorders: A role for corticotropin releasing factor (CRF).

  2015cites this paper
• Stress weakens prefrontal networks: molecular insults to higher cognition

  2015cites this paper
• Association analysis for corticotropin releasing hormone polymorphisms with the risk of major depressive disorder and the response to antidepressants.

  2015cites this paper
• Prenatal and Postpartum Evening Salivary Cortisol Levels in Association with Peripartum Depressive Symptoms

  2015cites this paper
• Neuronal correlates of depression

  2015cites this paper
• Evidence for the role of corticotropin-releasing factor in major depressive disorder.

  2015cites this paper
• Corticotropin releasing factor up‐regulates the expression and function of norepinephrine transporter in SK‐N‐BE (2) M17 cells

  2015cites this paper
• The Effects of Psychological Stress on Depression

  2015cites this paper
• The Corticotropin-Releasing Factor system in lactating rats: implications in the regulation of maternal behavior with special focus on the BNST

  2015cites this paper
• Neuropeptides : Active neuromodulators involved in the pathophysiology of suicidal behavior and major affective disorders

  2015cites this paper
• Genetic dissection of CRH-controlled neurocircuitries of stress

  2015cites this paper
• Diagnosis of male depression in the community and its correlation with cortisol and testosterone

  2015cites this paper
• Sex differences in stress-related psychiatric disorders: neurobiological perspectives.

  2014cites this paper
• Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers

  2014cites this paper
• Prenatal stress, anxiety and depression: a mechanism involving CRH peptide family.

  2014cites this paper
• Individual Differences in the Neurobiology of Social Stress: Implications for Depression-Cardiovascular Disease Comorbidity

  2014cites this paper
• Resilience to the effects of social stress: Evidence from clinical and preclinical studies on the role of coping strategies

  2014cites this paper
• Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function

  2014cites this paper
• Cellular adaptations of dorsal raphe serotonin neurons associated with the development of active coping in response to social stress.

  2013cites this paper
• The Role of Neuropeptides in Suicidal Behavior: A Systematic Review

  2013cites this paper
• GABAAR expression in brain noradrenergic and serotonergic centres and their plasticity in the context of stress induced behaviours

  2013cites this paper
• New insights into the role of perinatal HPA-axis dysregulation in postpartum depression.

  2013cites this paper
• Role of neuropeptides in anxiety, stress, and depression: from animals to humans.

  2013cites this paper
• CRF system and mood disorders.

  2013cites this paper
• Hypercortisolemia and glucocorticoid receptor-signaling insufficiency in Alzheimer's disease initiation and development.

  2013cites this paper
• Sex differences in stress-related receptors: ″micro″ differences with ″macro″ implications for mood and anxiety disorders

  2013cites this paper
• Black bile: are elevated monoamines an etiological factor in some cases of major depression?

  2013cites this paper
• Sex-Biased Stress Signaling: The Corticotropin-Releasing Factor Receptor as a Model

  2013cites this paper
• Neuropeptide Regulation of Stress-Induced Behavior

  2012cites this paper
• Heart rate variability in animal models of psychological-cardiovascular comorbidity

  2012cites this paper
• Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression

  2012cites this paper
• Sex Differences in Molecular and Cellular Substrates of Stress

  2012cites this paper
• Limonene attenuates anxiogenic- and depression-like effects of corticotropin-releasing factor in mice

  2012cites this paper
• The role of the central noradrenergic system in behavioral inhibition.

  2011cites this paper
• Corticotropin-Releasing Hormone, Glutamate, and γ-Aminobutyric Acid in Depression

  2011cites this paper
• Gene Regulation by Drugs Used to Treat Mood Disorders

  2011cites this paper
• Molecular signaling and translational significance of the corticotropin releasing factor system.

  2011cites this paper
• Participation of brainstem monoaminergic nuclei in behavioral depression.

  2011cites this paper
• Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants.

  2011cites this paper
• Childhood adversity and allostatic overload of the hypothalamic–pituitary–adrenal axis: A vulnerability model for depressive disorders

  2011cites this paper
• The hypothalamic-pituitary-adrenal axis and serotonin abnormalities: a selective overview for the implications of suicide prevention

  2010cites this paper
• Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: evidence from animal models.

  2010cites this paper
• Association of HPA axis genes with suicidal behaviour in schizophrenia

  2010cites this paper
• Comorbidity of insomnia and depression.

  2010cites this paper
• Gender variation of somatic symptoms of depression as possible indicators of its diagnosis and severity

  2010cites this paper
• Altered expression of glutamate signaling, growth factor and glia genes in the locus coeruleus of patients with major depression

  2010cites this paper
• The CRF system, stress, depression and anxiety—insights from human genetic studies

  2010cites this paper
• Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.

  2010cites this paper
• Chapter 21 – Multiple Sclerosis and Depression: A Neuroimmunological Perspective

  2010cites this paper
• Stress hormone regulation: biological role and translation into therapy.

  2010cites this paper
• Neonatal rearing conditions distinctly shape locus coeruleus neuronal activity, dendritic arborization, and sensitivity to corticotrophin-releasing factor.

  2010cites this paper
• Pathogenic involvement of neuropeptides in anxiety and depression.

  2010cites this paper
• 92 – The Neuroendocrinology of Mood Disorders

  2009cites this paper
• Through the looking glass: examining neuroanatomical evidence for cellular alterations in major depression.

  2009cites this paper
• Antidepressants Influence Somatostatin Levels and Receptor Pharmacology in Brain

  2009cites this paper
• Stress, depression and cardiovascular dysregulation: A review of neurobiological mechanisms and the integration of research from preclinical disease models

  2009cites this paper
• Glucocorticoid Receptor Polymorphisms in Major Depression

  2009cites this paper
• Modulation of stress by imidazoline binding sites: Implications for psychiatric disorders

  2009cites this paper
• Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders.

  2008cites this paper
• Sex Differences in the Effects of Acute and Chronic Stress and Recovery after Long-Term Stress on Stress-Related Brain Regions of Rats

  2008cites this paper
• The link between childhood trauma and depression: insights from HPA axis studies in humans.

  2008cites this paper
• The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma.

  2008cites this paper