The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Peptides

• Publication date

  2007-03-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/J.PEPTIDES.2006.11.002PMID 17161886
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• G-protein-coupled OX1 Orexin/hcrtr-1 Hypocretin Receptors Induce Caspase-dependent and -independent Cell Death through p38 Mitogen-/Stress-activated Protein Kinase*

  2006cited by this paper
• Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task.

  2006cited by this paper
• The effect of intrahippocampal insulin microinjection on spatial learning and memory.

  2006cited by this paper
• Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867.

  2005cited by this paper
• Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats.

  2004cited by this paper
• Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo.

  2004cited by this paper
• Encoding versus retrieval of spatial memory: Double dissociation between the dentate gyrus and the perforant path inputs into CA3 in the dorsal hippocampus

  2004cited by this paper
• Effect of reversible inactivation of the supramammillary nucleus on spatial learning and memory in rats.

  2004cited by this paper
• The study of spatial memory in adult male rats with injection of testosterone enanthate and flutamide into the basolateral nucleus of the amygdala in Morris water maze.

  2003cited by this paper
• Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats.

  2003cited by this paper
• Effects of orexin-A on memory processing.

  2002cited by this paper
• SB-334867-A antagonises orexin mediated excitation in the locus coeruleus.

  2002cited by this paper
• Orexins and appetite regulation.

  2002cited by this paper
• Molecular psychology: roles for the ERK MAP kinase cascade in memory.

  2002cited by this paper
• The action of orexin A on passive avoidance learning. Involvement of transmitters.

  2002cited by this paper
• Orexin‐A, an hypothalamic peptide with analgesic properties

  2001cited by this paper
• Reinforcement of Early Long-Term Potentiation (Early-LTP) in Dentate Gyrus by Stimulation of the Basolateral Amygdala: Heterosynaptic Induction Mechanisms of Late-LTP

  2001cited by this paper
• SB‐334867‐A: the first selective orexin‐1 receptor antagonist

  2001cited by this paper
• Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats.

  2001cited by this paper
• Differential expression of orexin receptors 1 and 2 in the rat brain

  2001cited by this paper
• Orexins, feeding and the big picture

  2000cited by this paper
• The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.

  2000cited by this paper
• The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats

  2000cited by this paper
• Centrally administered orexin/hypocretin activates HPA axis in rats

  2000cited by this paper
• Lidocaine reversible inactivation of the median raphe nucleus has no effect on reference memory but enhances working memory versions of the Morris water maze task.

  2000cited by this paper
• The hypocretins are weak agonists at recombinant human orexin‐1 and orexin‐2 receptors

  2000cited by this paper
• Possible involvement of orexin in the stress reaction in rats.

  2000cited by this paper
• Structure and Function of Human Prepro-orexin Gene*

  1999cited by this paper
• Long-term potentiation--a decade of progress?

  1999cited by this paper
• Distribution of orexin neurons in the adult rat brain.

  1999cited by this paper
• Orexins and orexin receptors: implication in feeding behavior.

  1999cited by this paper
• Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell‐line using FLIPR

  1999cited by this paper
• Orexins/hypocretins regulate drinking behaviour.

  1999cited by this paper
• Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.

  1999cited by this paper
• Orexins, orexigenic hypothalamic neuropeptides, suppress the pulsatile secretion of luteinizing hormone in ovariectomized female rats.

  1999cited by this paper
• Distribution of orexin neurons in the adult rat brain.

  1999cited by this paper
• The MAPK cascade is required for mammalian associative learning

  1998cited by this paper
• Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

  1998cited by this paper
• Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

  1998cited by this paper
• Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

  1998cited by this paper
• Distribution of orexin receptor mRNA in the rat brain

  1998cited by this paper
• The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

  1998cited by this paper
• Stress and glucocorticoids impair retrieval of long-term spatial memory

  1998cited by this paper
• Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner.

  1998cited by this paper
• A post-tetanic time window for the reinforcement of long-term potentiation by appetitive and aversive stimuli.

  1997cited by this paper
• Lateral hypothalamic stimulation inhibits dentate granule cell LTP: direct connections.

  1997cited by this paper
• A theory of hippocampal function in memory

  1996cited by this paper
• Effects of intrastriatal injections of platelet-activating factor and the PAF antagonist BN 52021 on memory.

  1996cited by this paper
• Computational analysis of the role of the hippocampus in memory

  1994cited by this paper
• A synaptic model of memory: long-term potentiation in the hippocampus

  1993cited by this paper
• The neuropharmacological and neurochemical basis of place learning in the Morris water maze.

  1993cited by this paper
• Computational constraints suggest the need for two distinct input systems to the hippocampal CA3 network

  1992cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper

• Role of OX/OXR cascade in insomnia and sleep deprivation link Alzheimer's disease and Parkinson's disease: Therapeutic avenue of Dual OXR Antagonist (DORA).

  2025cites this paper
• Spatial mRNA expression patterns of orexin receptors in the dorsal hippocampus

  2024cites this paper
• International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology

  2024cites this paper
• Regulation of neuronal plasticity associated with neuropsychiatric disorders by the orexinergic system

  2024cites this paper
• Orexin and cannabinoid systems modulate long-term potentiation of the hippocampus CA1 area in anesthetized rats

  2024cites this paper
• A novel, non-opioid, selective orexin-1 receptor antagonist for the treatment of substance use disorders

  2024cites this paper
• Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice

  2023cites this paper
• Nasal administration of orexin A partially rescues dizocilpine-induced cognitive impairments in female C57BL/6J mice.

  2023cites this paper
• Spatial memory requires hypocretins to elevate medial entorhinal gamma oscillations.

  2023cites this paper
• The ability of orexin-A to modify pain-induced cyclooxygenase-2 and brain-derived neurotrophic factor expression is associated with its ability to inhibit capsaicin-induced pulpal nociception in rats

  2022cites this paper
• Hippocampal orexin receptors: Localization and function.

  2022cites this paper
• Genetic Mapping of Behavioral Traits Using the Collaborative Cross Resource

  2022cites this paper
• The Modulatory Role of Orexin 1 Receptor in Nucleus Accumbens (NAc) on Spatial Memory in Rats.

  2022cites this paper
• Selective Orexin 1 Receptor Antagonist SB-334867 Aggravated Cognitive Dysfunction in 3xTg-AD Mice.

  2022cites this paper
• Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

  2021cites this paper
• Orexin (hypocretin) mediates light‐dependent fluctuation of hippocampal function in a diurnal rodent

  2021cites this paper
• Intranasal insulin and orexins to treat age-related cognitive decline.

  2021cites this paper
• Changes in the Orexin System in Rats Exhibiting Learned Helplessness Behaviors

  2021cites this paper
• Mechanisms of memory impairment induced by orexin-A via orexin 1 and orexin 2 receptors in post-traumatic stress disorder rats.

  2020cites this paper
• Orexin and Alzheimer’s Disease: A New Perspective

  2020cites this paper
• Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation.

  2020cites this paper
• Phospholipase Cβ3 in the hippocampus may mediate impairment of memory by long-term blockade of orexin 1 receptors assessed by the Morris water maze.

  2020cites this paper
• The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation

  2020cites this paper
• Hypocretin (Orexin) Replacement Therapies

  2020cites this paper
• OREXIN AS A STRESS REGULATOR AND ITS RELATIONSHIP WITH COGNITION

  2020cites this paper
• Irreversible hippocampal changes induced by high fructose diet in rats

  2020cites this paper
• Orexin in Respiratory and Autonomic Regulation, Health and Diseases.

  2020cites this paper
• Light as a modulator of emotion and cognition: Lessons learned from studying a diurnal rodent.

  2019cites this paper
• Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats

  2019cites this paper
• Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits

  2019cites this paper
• High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss

  2019cites this paper
• Decreased serum orexin A levels in drug-naive children with attention deficit and hyperactivity disorder

  2019cites this paper
• Kisspeptin-13 Improves Spatial Memory Consolidation and Retrieval against Amyloid-β Pathology

  2019cites this paper
• Visual Attention and Distraction: Contribution of Orexins

  2019cites this paper
• Orexin 1 receptors in the anterior cingulate and orbitofrontal cortex regulate cost and benefit decision‐making

  2019cites this paper
• The basolateral amygdala orexin 1 and 2 receptors' involvement in modulating spatial reference memory.

  2019cites this paper
• Orexin‐1 receptors in the rostral ventromedial medulla are involved in the modulation of capsaicin evoked pulpal nociception and impairment of learning and memory

  2018cites this paper
• SB-334867 (an Orexin-1 Receptor Antagonist) Effects on Morphine-Induced Sensitization in Mice—a View on Receptor Mechanisms

  2018cites this paper
• Increased training compensates for OX1R blockage‐impairment of spatial memory and c‐Fos expression in different cortical and subcortical areas

  2018influential citation
• Orexin A Differentially Influences the Extinction Retention of Recent and Remote Fear Memory

  2018cites this paper
• The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders

  2018cites this paper
• Neuroprotective Effects of Physical Activity: Evidence from Human and Animal Studies

  2017cites this paper
• Exercise Influence on Hippocampal Function: Possible Involvement of Orexin-A

  2017cites this paper
• The Effects of Intranasal Orexin-A on Mk-801-Induced Attentional Deficits: Addressing Cognitive Impairment in An Nmda Receptor Hypofunction Model of Schizophrenia

  2017cites this paper
• Orexin/hypocretin treatment restores hippocampal‐dependent memory in orexin‐deficient mice

  2017influential citation
• Orexin A induces bidirectional modulation of synaptic plasticity: Inhibiting long-term potentiation and preventing depotentiation.

  2016cites this paper
• Orexin/hypocretin receptor 1 signaling mediates Pavlovian cue-food conditioning and extinction.

  2016cites this paper
• Involvement of orexin-1 and orexin-2 receptors within the dentate gyrus of the hippocampus in the acquisition, expression and extinction of lateral hypothalamic-induced conditioned place preference in the rats.

  2016cites this paper
• Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis

  2016cites this paper
• Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism.

  2016cites this paper
• SB 334867, a selective orexin receptor type 1 antagonist, elevates seizure threshold in mice.

  2016cites this paper
• The Identification Of The Direct And Indirect Pathways Through Which Leptin Facilitates Synaptic Plasticity In The Hippocampus

  2016cites this paper
• The role of trigeminal nucleus caudalis orexin 1 receptors in orofacial pain transmission and in orofacial pain-induced learning and memory impairment in rats.

  2016cites this paper
• Age-Related Sleep Changes and its Implication in Neurodegenerative Diseases.

  2016cites this paper
• Changes in hippocampal orexin 1 receptor expression involved in tooth pain-induced learning and memory impairment in rats.

  2015cites this paper
• Orexin A-induced enhancement of attentional processing in rats: role of basal forebrain neurons

  2015cites this paper
• Nucleus incertus inactivation impairs spatial learning and memory in rats.

  2015cites this paper
• The role of orexin in post-stroke inflammation, cognitive decline, and depression

  2015cites this paper
• Sleep disorders, obesity, and aging: the role of orexin.

  2015cites this paper
• The Hypocretin/Orexin System: An Increasingly Important Role in Neuropsychiatry

  2015cites this paper
• Possible Mechanisms for Impairments to Learning, Memory, and Attention due to Sleep Deprivation

  2014cites this paper
• K‐Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation

  2014cites this paper
• Temporary inactivation of the rodent hippocampus: an evaluation of the current methodology.

  2014cites this paper
• The hypocretins/orexins: integrators of multiple physiological functions

  2014cites this paper
• Phospholipase Cascades in OX1 Orexin Receptor Signaling

  2014cites this paper
• The Hypocretin/Orexin System Mediates the Extinction of Fear Memories

  2014cites this paper
• Orexin-A-induced ERK1/2 activation reverses impaired spatial learning and memory in pentylenetetrazol-kindled rats via OX1R-mediated hippocampal neurogenesis.

  2014cites this paper
• Orexin-1 receptor antagonist in central nucleus of the amygdala attenuates the acquisition of flavor-taste preference in rats.

  2014cites this paper
• Inflammation-sleep interface in brain disease: TNF, insulin, orexin

  2014cites this paper
• The action of orexin B on passive avoidance learning. Involvement of neurotransmitters.

  2014cites this paper
• Diurnal inhibition of NMDA‐EPSCs at rat hippocampal mossy fibre synapses through orexin‐2 receptors

  2014cites this paper
• Promoting Sleep at Doses That Do Not Disrupt Cognition Orexin Receptor Antagonists Differ from Standard Sleep Drugs by

  2013cites this paper
• Catalytic staudinger/aza-wittig sequence by in situ phosphane oxide reduction

  2013cites this paper
• Inteligencia para la alimentación, alimentación para la inteligencia

  2013cites this paper
• L-type calcium channel blockade alleviates molecular and reversal spatial learning and memory alterations induced by entorhinal amyloid pathology in rats.

  2013cites this paper
• Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition

  2013cites this paper
• Role of Orexin in the Pathophysiology of Depression: Potential for Pharmacological Intervention

  2013cites this paper
• Functional inactivation of orexin 1 receptors in the cerebellum disrupts trace eyeblink conditioning and local theta oscillations in guinea pigs.

  2013cites this paper
• Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory.

  2013cites this paper
• Possible Mechanisms for the Effects of Orexin on Hippocampal Functioning and Spatial Learning (analytical review)

  2013cites this paper
• Intelligence for food: food for intelligence

  2013cites this paper
• Chronic intracerebroventricular administration of dimethyl sulfoxide attenuates streptozotocin-iduced memory loss in rats

  2013cites this paper
• Hypocretin/Orexin Neurons Contribute to Hippocampus-Dependent Social Memory and Synaptic Plasticity in Mice

  2013cites this paper
• [Possible mechanisms for orexin effects on the functioning of the hippocampus and spatial learning (analytical review)].

  2012cites this paper
• Orexins increase penicillin-induced epileptic activity.

  2012cites this paper
• Orexins cause epileptic activity.

  2012cites this paper
• Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking.

  2011cites this paper
• The role of the hippocampus and post-learning hippocampal activity in long-term consolidation of context memory

  2011influential citation
• Aging-related alterations in orexin/hypocretin modulation of septo-hippocampal amino acid neurotransmission.

  2011cites this paper
• Inflammatory regulation of hypothalamic neurons in sickness behavior

  2011cites this paper
• Depression in Narcolepsy

  2011cites this paper
• Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal.

  2011cites this paper
• Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats.

  2011cites this paper
• SB-334867-A, a selective orexin-1 receptor antagonist, enhances taste aversion learning and blocks taste preference learning in rats.

  2011cites this paper
• Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant

  2010cites this paper
• Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats

  2010cites this paper
• Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement.

  2010cites this paper
• Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats

  2009cites this paper
• Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

  2009cites this paper
• Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear.

  2008cites this paper