Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Science

• Publication date

  2011-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/science.1201043PMID 21719680
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Amygdala circuitry mediating reversible and bidirectional control of anxiety

  2011cited by this paper
• Encoding of conditioned fear in central amygdala inhibitory circuits

  2010cited by this paper
• Genetic dissection of an amygdala microcircuit that gates conditioned fear

  2010cited by this paper
• A neural switch for active and passive fear.

  2010cited by this paper
• The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.

  2009cited by this paper
• Panic disorder subtypes: deceptive somatic impersonators.

  2009cited by this paper
• Rapid strengthening of thalamo-amygdala synapses mediates cue–reward learning

  2008cited by this paper
• Centrally released oxytocin mediates mating-induced anxiolysis in male rats

  2007cited by this paper
• Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model.

  2006cited by this paper
• Gastric myoelectrical activity as an index of emotional arousal.

  2006cited by this paper
• The primate amygdala represents the positive and negative value of visual stimuli during learning

  2006cited by this paper
• Characterization of neurons in the rat central nucleus of the amygdala: Cellular physiology, morphology, and opioid sensitivity

  2006cited by this paper
• Basic emotions are associated with distinct patterns of cardiorespiratory activity.

  2006cited by this paper
• Excitatory action of hypocretin/orexin on neurons of the central medial amygdala.

  2006cited by this paper
• Brain Oxytocin Correlates with Maternal Aggression: Link to Anxiety

  2005cited by this paper
• Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala

  2005cited by this paper
• Interactions between NPY and CRF in the amygdala to regulate emotionality.

  2004cited by this paper
• The Emotional Brain, Fear, and the Amygdala

  2003cited by this paper
• Social Engagement and Attachment

  2003cited by this paper
• Physiological properties of central amygdala neurons: species differences

  2002cited by this paper
• Distinct neurochemical populations in the rat central nucleus of the amygdala and bed nucleus of the stria terminalis: Evidence for their selective activation by interleukin‐1β

  1999cited by this paper
• An anxiolytic action of oxytocin is enhanced by estrogen in the mouse.

  1996cited by this paper
• An electrophysiological characterization of the projection from the central nucleus of the amygdala to the periaqueductal gray of the rat: the role of opioid receptors.

  1995cited by this paper
• Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear

  1988cited by this paper
• Fluorescent latex microspheres as a retrograde neuronal marker for in vivo and in vitro studies of visual cortex

  1984cited by this paper
• Amygdaloid and basal forebrain direct connections with the nucleus of the solitary tract and the dorsal motor nucleus

  1982cited by this paper

• Modulation of the association between blood glucose homeostasis and social hierarchy among co-housed mice by diet and amygdala activities

  2026cites this paper
• Oxytocin's Impact on the Social Brain: Individual Differences and Context Shape a Core Amygdala-Mediated Mechanism.

  2026cites this paper
• Early life adversity impairs visually evoked innate defensive behaviors via oxytocin signaling.

  2026cites this paper
• The Neuroendocrine Role of Oxytocinergic Pathways in Obesity.

  2026cites this paper
• The Central Amygdala as a Pathological Hub: A Multi-Level Review of Pain-Emotion Comorbidity.

  2026cites this paper
• Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

  2025cites this paper
• Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

  2025cites this paper
• Stress induces oxytocin-Gαi-dependent remodeling of astrocytes to shape neuronal response in the amygdala

  2025cites this paper
• Neurons of the Central Nucleus of the Amygdala That Express Angiotensin Type 2 Receptors Couple Lowered Blood Pressure with Anxiolysis in Male Mice

  2025cites this paper
• Negative allosteric modulation of mGlu7 disrupts fear memory reconsolidation and glutamatergic signaling in rat and human brain tissue

  2025cites this paper
• Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal

  2025cites this paper
• Prenatal maternal life adversity impacts on learning and memory in offspring: implication to transgenerational epigenetic inheritance

  2025cites this paper
• Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice

  2025cites this paper
• Biologically Inspired Deep Neural Network Models for Visual Emotion Processing

  2025cites this paper
• Central amygdala NPBWR1 neurons facilitate social novelty seeking and new social interactions

  2025cites this paper
• Neural circuit plasticity transforms infant neglect into maternal care

  2025cites this paper
• Social buffering in rats reduces fear by oxytocin triggering sustained changes in central amygdala neuronal activity

  2024influential citation
• The translocator protein 18 kDa (TSPO) ligand etifoxine in an animal model of anxiety: line- and sex-dependent effects on emotionality, stress reactivity, spine density, oxytocin receptors, steroids, and microbiome composition.

  2024cites this paper
• Effects of intranasal oxytocin on fear extinction learning

  2024cites this paper
• Effects of ayahuasca on fear and anxiety: cross-talk between 5HT1A and 5HT2A receptors

  2024cites this paper
• Acupressure bladder meridian alleviates anxiety disorder in rats by regulating MAPK and BDNF signal pathway.

  2024cites this paper
• Sex differences in fear expression and persistence in an animal model of Post-Traumatic Stress Disorder.

  2024cites this paper
• Input-specific properties of excitatory synapses on oxytocin receptor-expressing neurons in the lateral septum.

  2024cites this paper
• Oxytocin Gαi signaling-induced amygdala astrocytes processes retraction shapes behavioral stress response

  2024cites this paper
• Neuropeptides affecting social behavior in mammals: oxytocin.

  2024cites this paper
• Impaired oxytocin signalling in the central amygdala in rats with chronic heart failure

  2024cites this paper
• Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice

  2024cites this paper
• Like sisters but not twins – vasopressin and oxytocin excite BNST neurons via cell type-specific expression of oxytocin receptor to reduce anxious arousal

  2024cites this paper
• The Multifaceted Role of Oxytocinergic System and OXTR Gene

  2024cites this paper
• µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice

  2024cites this paper
• Understanding the heterogeneity of anxiety using a translational neuroscience approach

  2024cites this paper
• Top-down control of flight by a non-canonical cortico-amygdala pathway

  2024cites this paper
• The role of intraamygdaloid oxytocin in spatial learning and avoidance learning.

  2024cites this paper
• Central amygdala‐to‐pre‐Bötzinger complex neurotransmission is direct and inhibitory

  2024cites this paper
• Developmental Shifts in Amygdala Function.

  2024cites this paper
• The mother-child interface: A neurobiological metamorphosis.

  2024cites this paper
• Water deprivation induces hypoactivity in rats independently of oxytocin receptor signaling at the central amygdala

  2023cites this paper
• Neuromedin B excites central lateral amygdala neurons and reduces cardiovascular output and fear‐potentiated startle

  2023influential citation
• Selective oxytocin receptor activation prevents prefrontal circuit dysfunction and social behavioral alterations in response to chronic prefrontal cortex activation in male rats

  2023cites this paper
• Stimulating oxytocin receptors in the basolateral amygdala enhances stimulus processing: Differential and consistent effects for stimuli paired with fear versus sucrose in extinction and reversal learning.

  2023cites this paper
• El abrazo, de las bases a su expresión en la vida y el arte

  2023cites this paper
• The Nature and Neurobiology of Fear and Anxiety: State of the Science and Opportunities for Accelerating Discovery.

  2023cites this paper
• Impaired oxytocin signaling in the central amygdala in rats with chronic heart failure

  2023cites this paper
• PACAP-mediated gating of anxiety-controlling circuits

  2023cites this paper
• From aversive associations to defensive programs: experience-dependent synaptic modifications in the central amygdala.

  2023cites this paper
• Oxytocin Reduces Sensitized Stress-Induced Alcohol Relapse in a Model of Posttraumatic Stress Disorder and Alcohol Use Disorder Comorbidity.

  2022cites this paper
• The Role of Oxytocin in Abnormal Brain Development: Effect on Glial Cells and Neuroinflammation

  2022cites this paper
• Selective oxytocin receptor activation prevents prefrontal circuit dysfunction and social behavioral alterations in response to chronic prefrontal cortex activation in rats

  2022cites this paper
• The modulation of emotional and social behaviors by oxytocin signaling in limbic network

  2022cites this paper
• Synaptic plasticity in two cell types of central amygdala for regulation of emotion and pain

  2022cites this paper
• Mitigating the impact of adolescence isolation on the development of social anxiety: A potential role for oxytocin

  2022cites this paper
• The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum

  2022cites this paper
• Autism Spectrum Disorder Model Mice Induced by Prenatal Exposure to Valproic Acid Exhibit Enhanced Empathy-Like Behavior via Oxytocinergic Signaling.

  2022cites this paper
• Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation.

  2022cites this paper
• Dysfunctional Heteroreceptor Complexes as Novel Targets for the Treatment of Major Depressive and Anxiety Disorders

  2022cites this paper
• A central alarm system that gates multi-sensory innate threat cues to the amygdala

  2022cites this paper
• Genomic analysis of Tibetan ground tits identifies molecular adaptations associated with cooperative breeding

  2022cites this paper
• Oxytocin Facilitates Allomaternal Behavior under Stress in Laboratory Mice

  2022cites this paper
• Exogenous estradiol and oxytocin modulate sex differences in hippocampal reactivity during the encoding of episodic memories

  2022cites this paper
• Impacts of vitamin A deficiency on biological rhythms: Insights from the literature

  2022cites this paper
• Cognitive neural mechanisms underlying the impact of oxytocin on fear acquisition and extinction

  2022influential citation
• Evaluating sickness-induced anxiety versus lethargy at the behavioral and neuronal activity level

  2022cites this paper
• Oxytocin receptor activation does not mediate associative fear deficits in a Williams Syndrome model

  2021cites this paper
• Oxytocin and vasopressin: the social networking buttons of the body

  2021cites this paper
• Intranasal oxytocin compensates for estrus cycle-specific reduction of conditioned safety memory in rats: Implications for psychiatric disorders

  2021cites this paper
• Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care.

  2021cites this paper
• Prediction errors and valence: from single units to multidimensional encoding in the amygdala.

  2021cites this paper
• Limbic Neuropeptidergic Modulators of Emotion and Their Therapeutic Potential for Anxiety and Post-Traumatic Stress Disorder

  2021cites this paper
• Activation of hypothalamic oxytocin neurons reduces binge-like alcohol drinking through signaling at central oxytocin receptors

  2021cites this paper
• Combination therapy with neuropeptides for the treatment of anxiety disorder.

  2021cites this paper
• Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

  2021cites this paper
• in in Humans.

  2021influential citation
• Roles of Oxytocin in Stress Responses, Allostasis and Resilience

  2021cites this paper
• A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

  2021cites this paper
• Sex-Related Predisposition to Post-Traumatic Stress Disorder Development—The Role of Neuropeptides

  2021cites this paper
• Revisit the Effectiveness of Educational Kinesiology on Stress and Anxiety Amelioration in Kindergarteners With Special Needs Using Biological Measures

  2021cites this paper
• Oxytocin Attenuates the Stress-Induced Reinstatement of Alcohol-Seeking in Male Rats: Role of the Central Amygdala

  2021influential citation
• The Toolbox

  2021cites this paper
• Exogenous Estradiol and Oxytocin Modulate Sex Differences in Hippocampal Reactivity and Episodic Memory

  2021cites this paper
• Emotionality vs. Other Biobehavioural Traits: A Look at Neurochemical Biomarkers for Their Differentiation

  2021cites this paper
• A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae.

  2021cites this paper
• Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala.

  2021cites this paper
• Convergent neuroendocrine mechanisms of social buffering and stress contagion.

  2021cites this paper
• Behavioural and cardiovascular effects of orexin-A infused into the central amygdala under basal and fear conditions in rats.

  2021cites this paper
• Activation of septal OXTr neurons induces anxiety- but not depressive-like behaviors

  2021cites this paper
• Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?

  2021cites this paper
• De novo protein synthesis in distinct centrolateral amygdala interneurons is required for associative emotional memories

  2020cites this paper
• Oxytocin selectively excites interneurons and inhibits output neurons of the bed nucleus of the stria terminalis (BNST)

  2020cites this paper
• Oxytocin and the role of “regulator of emotions”: Definition, neurobiochemical and clinical contexts, practical applications and contraindications

  2020cites this paper
• Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis.

  2020influential citation
• Anxiolytic and Anxiogenic? How the Transcription Factor MEF2 Might Explain the Manifold Behavioral Effects of Oxytocin

  2020cites this paper
• The Role of the Central Amygdala in Alcohol Dependence.

  2020cites this paper
• Oxytocin receptor antagonist reverses the blunting effect of pair bonding on fear learning in monogamous prairie voles.

  2020cites this paper
• On the Nature of the Mother-Infant Tie and Its Interaction With Freudian Drives

  2020cites this paper
• Modulation of expression of fear by oxytocin signaling in the central amygdala: From reduction of fear to regulation of defensive behavior style.

  2020cites this paper
• Oxytocin Acts on Astrocytes in the Central Amygdala to Promote a Positive Emotional State

  2020cites this paper
• Mentoring Millennial Women in Academia

  2020cites this paper
• Care for the Self, Care for the World from Neurophysiology to the Biosphere : Notes on the Coronavirus, Fear, and the Environment

  2020cites this paper
• Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms.

  2020cites this paper
• The Insula Cortex Contacts Distinct Output Streams of the Central Amygdala

  2020cites this paper