The circadian clock and pathology of the ageing brain

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Nature Reviews Neuroscience

• Publication date

  2012-03-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrn3208PMID 22395806PMCID PMC3718301
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

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  2009cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper

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