The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Nature

• Publication date

  2009-12-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature08593PMID 20016594
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of genetics in breast and reproductive cancers

  2010cited by this paper
• RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

  2009cited by this paper
• The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

  2009cited by this paper
• E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

  2008cited by this paper
• New players in the BRCA1-mediated DNA damage responsive pathway.

  2008cited by this paper
• Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

  2008cited by this paper
• The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.

  2007cited by this paper
• Regulation of protein tyrosine phosphatase 1B by sumoylation

  2007cited by this paper
• E2–BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

  2007cited by this paper
• Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

  2007cited by this paper
• Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

  2007cited by this paper
• Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.

  2007cited by this paper
• RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

  2007cited by this paper
• CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response

  2007cited by this paper
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  2007cited by this paper
• Ubc13/Rnf8ユビキチンリガーゼはDNS損傷に反応してRap80/Abraxas/Brca1/Brca1/Brcc36複合体のフォーカス形成を制御する

  2007cited by this paper
• A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.

  2007cited by this paper
• Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

  2007cited by this paper
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

  2007cited by this paper
• CCDC98 targets BRCA1 to DNA damage sites

  2007cited by this paper
• Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

  2007cited by this paper
• SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy

  2007cited by this paper
• A dark yellow fluorescent protein (YFP)-based Resonance Energy-Accepting Chromoprotein (REACh) for Förster resonance energy transfer with GFP.

  2006cited by this paper
• Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.

  2006cited by this paper
• PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress

  2006cited by this paper
• Detection of modification by ubiquitin-like proteins.

  2006cited by this paper
• A conserved pathway to activate BRCA1‐dependent ubiquitylation at DNA damage sites

  2006cited by this paper
• Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.

  2006cited by this paper
• A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.

  2005cited by this paper
• SUMO: a history of modification.

  2005cited by this paper
• Human MMS21/NSE2 Is a SUMO Ligase Required for DNA Repair

  2005cited by this paper
• Imaging protein molecules using FRET and FLIM microscopy.

  2005influential reference
• Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions.

  2005cited by this paper
• Global and pixel kinetic data analysis for FRET detection by multi-photon time-domain FLIM

  2005cited by this paper
• BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.

  2004cited by this paper
• Imaging molecular interactions by multiphoton FLIM

  2004cited by this paper
• Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase*

  2004cited by this paper
• PIAS-1 Is a Checkpoint Regulator Which Affects Exit from G1 and G2 by Sumoylation of p73

  2004cited by this paper
• DNA Cross-Link Repair Protein SNM1A Interacts with PIAS1 in Nuclear Focus Formation

  2004cited by this paper
• BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.

  2004cited by this paper
• Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs.

  2004cited by this paper
• Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

  2003cited by this paper
• PIAS/SUMO: new partners in transcriptional regulation

  2003cited by this paper
• PML Residue Lysine 160 Is Required for the Degradation of PML Induced by Herpes Simplex Virus Type 1 Regulatory Protein ICP0

  2003cited by this paper
• The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin*

  2003cited by this paper
• BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

  2003cited by this paper
• Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 and Its Isolated RING Finger Domain Act as Ubiquitin E3 Ligases In Vitro

  2002cited by this paper
• Extracellular ubiquitination and proteasome-mediated degradation of the ascidian sperm receptor

  2002influential reference
• Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

  2002cited by this paper
• The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation*

  2001cited by this paper
• Imaging protein kinase Calpha activation in cells.

  1999cited by this paper
• Imaging Protein Kinase Cα Activation in Cells

  1999cited by this paper
• RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

  1999cited by this paper
• THE TOXICITY OF POISONS APPLIED JOINTLY1

  1939cited by this paper

• SUMOylation is destined for regulatory T cell-related immune dysregulation

  2026cites this paper
• SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair.

  2025cites this paper
• DNA double strand break repair: a model of specificity and complexity in SUMO signalling

  2025cites this paper
• Diagnostic Potential of a Recombinant Candida albicans Hyr1 Protein

  2025cites this paper
• UFMylation orchestrates chromatin engagement of core NHEJ components to promote DNA double-strand break repair

  2025cites this paper
• ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity

  2025cites this paper
• PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma

  2025cites this paper
• Ulp1 association with nuclear pore complexes is required for the maintenance of global SUMOylation.

  2025cites this paper
• Role of Ionizing Radiation in Shaping the Complex Multi-Layered Epigenome

  2025cites this paper
• GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination

  2025cites this paper
• To Ub or not to Ub: The epic dilemma of histones that regulate gene expression and epigenetic cross-talk.

  2024cites this paper
• NFATC2IP is a mediator of SUMO-dependent genome integrity

  2024cites this paper
• The role of SUMOylation in biomolecular condensate dynamics and protein localization

  2024cites this paper
• Sequential post-translational modifications regulate damaged DNA-binding protein DDB2 function

  2024cites this paper
• PARticular MARks: Histone ADP-ribosylation and the DNA damage response.

  2024cites this paper
• SUMO4 promotes SUMO deconjugation required for DNA double-strand break repair

  2024cites this paper
• DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability

  2024cites this paper
• Cellular Resiliency and Survival of a Neuro-2a Cell Line Under Extreme Stress.

  2024cites this paper
• SUMO and the DNA damage response

  2024cites this paper
• The complex biology of aryl hydrocarbon receptor activation in cancer and beyond

  2023cites this paper
• SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer.

  2023cites this paper
• The SUMOylation and ubiquitination crosstalk in cancer

  2023cites this paper
• UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer

  2023cites this paper
• Paradoxes of Cellular SUMOylation Regulation: A Role of Biomolecular Condensates?

  2023cites this paper
• Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges

  2023cites this paper
• SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

  2023cites this paper
• Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair

  2023cites this paper
• The Next Frontier: Translational Development of Ubiquitination, SUMOylation, and NEDDylation in Cancer

  2022cites this paper
• Pathological implication of protein post-translational modifications in cancer.

  2022cites this paper
• ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination

  2022cites this paper
• Sumoylation in Physiology, Pathology and Therapy

  2022cites this paper
• TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair

  2022cites this paper
• Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification

  2022cites this paper
• cGAS in nucleus: The link between immune response and DNA damage repair

  2022cites this paper
• Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin

  2022cites this paper
• Role of Post-translational Modification of Silent Mating Type Information Regulator 2 Homolog 1 in Cancer and Other Disorders

  2022cites this paper
• PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining

  2022cites this paper
• Small-molecule enhancers of CRISPR-induced homology-directed repair in gene therapy: a medicinal chemist's perspective.

  2022cites this paper
• A novel risk model of SUMOylation-related genes associated with prognosis in endometrial cancer.

  2022cites this paper
• RAD51 wrestles with SUMO

  2022cites this paper
• Protein sumoylation in normal and cancer stem cells

  2022cites this paper
• Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment.

  2022cites this paper
• Histone H2A variants: Diversifying chromatin to ensure genome integrity.

  2022cites this paper
• Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair

  2022cites this paper
• DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR.

  2022cites this paper
• Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors.

  2021cites this paper
• Gene mutation can be treated in breast cancer by gene therapy

  2021cites this paper
• Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.

  2021cites this paper
• Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies

  2021cites this paper
• The BRCA1/BARD1 ubiquitin ligase and its substrates.

  2021cites this paper
• RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

  2021cites this paper
• Ubiquitylation in DNA double-strand break repair.

  2021cites this paper
• Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

  2021cites this paper
• SUMOylation mediates CtIP’s functions in DNA end resection and replication fork protection

  2021cites this paper
• Advances in SUMO-based regulation of homologous recombination.

  2021cites this paper
• Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex.

  2021cites this paper
• The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review

  2020cites this paper
• A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation

  2020cites this paper
• Optimization of High Field Asymmetric Waveform Ion Mobility Spectrometry to enhance the comprehensiveness of mass spectrometry-based proteomic analyses

  2020cites this paper
• Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins.

  2020cites this paper
• The HSV-1 ubiquitin ligase ICP0: Modifying the cellular proteome to promote infection

  2020cites this paper
• The implication of the SUMOylation pathway in breast cancer pathogenesis and treatment

  2020cites this paper
• Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas

  2020cites this paper
• Protein Sumoylation with SUMO1 Promoted by Pin1 in Glioma Stem Cells Augments Glioblastoma Malignancy.

  2020cites this paper
• The Role of Posttranslational Modifications in DNA Repair

  2020cites this paper
• PIAS4, upregulated in hepatocellular carcinoma, promotes tumorigenicity and metastasis

  2020cites this paper
• SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1

  2020cites this paper
• Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

  2020cites this paper
• Methods to study SUMO dynamics in yeast.

  2019cites this paper
• Roles of Ubiquitination and SUMOylation in DNA Damage Response.

  2019cites this paper
• Sodium Iodate-Induced Mouse Model of Age-Related Macular Degeneration Displayed Altered Expression Patterns of Sumoylation Enzymes E1, E2 and E3.

  2019cites this paper
• Methodologies for Improving HDR Efficiency

  2019cites this paper
• hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy

  2019cites this paper
• A conserved SUMO-Ubiquitin pathway directed by RNF4/SLX5-SLX8 and PIAS4/SIZ1 drives proteasomal degradation of topoisomerase DNA-protein crosslinks

  2019cites this paper
• Roles of Ubiquitination and SUMOylation in the Regulation of Angiogenesis.

  2019cites this paper
• RNF4—A Paradigm for SUMOylation‐Mediated Ubiquitination

  2019cites this paper
• DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

  2019cites this paper
• Post-translational Modifications (PTMs), from a Cancer Perspective: An Overview

  2019cites this paper
• Integrated Analysis of the Altered lncRNAs and mRNAs Expression in 293T Cells after Ionizing Radiation Exposure

  2019cites this paper
• Identifying regulatory targets in parkinson’s disease pathology and screening potential therapeutics

  2019influential citation
• SUMOylation in Glioblastoma: A Novel Therapeutic Target

  2019cites this paper
• Chapter 1 Ubiquitylation and SUMOylation : An Orchestrated Regulation During DNA Damage Repair

  2019cites this paper
• Characterisation of three zinc finger proteins ZC3H8, ZC3H11A and ZC3H14, identified as new partners of ATM, the central regulator of biological response to DNA double strand breaks

  2019cites this paper
• Different SUMO paralogues determine the fate of wild-type and mutant CFTRs: biogenesis versus degradation

  2019influential citation
• Preserving genome integrity and function: the DNA damage response and histone modifications

  2019cites this paper
• Beyond reversal: ubiquitin and ubiquitin-like proteases and the orchestration of the DNA double strand break repair response

  2019cites this paper
• Complex interactomes and post-translational modifications of the regulatory proteins HABP4 and SERBP1 suggest pleiotropic cellular functions

  2019cites this paper
• Nucleases and histone acetyltransferases in DNA repair and immune diversity

  2019cites this paper
• Chordate PIAS proteins act as conserved repressors of the TRAF6 self-polyubiquitination.

  2019cites this paper
• Involvement of the AAA ATPase

  2019cites this paper
• SUMOylation homeostasis in tumorigenesis.

  2019cites this paper
• Intricate SUMO-based control of the homologous recombination machinery

  2019cites this paper
• Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation

  2019influential citation
• The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms

  2018influential citation
• SUMOylation of XRCC1 activated by poly (ADP-ribosyl)ation regulates DNA repair

  2018cites this paper
• Site-specific characterization of endogenous SUMOylation across species and organs

  2018cites this paper
• Gas-Phase Enrichment of Multiply Charged Peptide Ions by Differential Ion Mobility Extend the Comprehensiveness of SUMO Proteome Analyses

  2018cites this paper
• SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes.

  2018cites this paper
• Ubiquitin, SUMO and PAR : deciphering recruitment signals at DNA damage sites

  2018influential citation
• The post-translational modification, SUMOylation, and cancer (Review)

  2018cites this paper