20 S proteasomes are imported as precursor complexes into the nucleus of yeast.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Molecular Biology

• Publication date

  2002-03-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/JMBI.2002.5443PMID 11922673
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 20S proteasome biogenesis.

  2001cited by this paper
• RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit

  2001cited by this paper
• Evidence for Separable Functions of Srp1p, the Yeast Homolog of Importin α (Karyopherin α): Role for Srp1p and Sts1p in Protein Degradation

  2000cited by this paper
• Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes.

  2000cited by this paper
• Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.

  2000cited by this paper
• The ubiquitin system

  2000cited by this paper
• Getting across the nuclear pore complex.

  1999cited by this paper
• Subcellular Localization, Stoichiometry, and Protein Levels of 26 S Proteasome Subunits in Yeast*

  1999cited by this paper
• The Import Pathway of Human and Thermoplasma 20S Proteasomes into HeLa Cell Nuclei Is Different from That of Classical NLS-Bearing Proteins

  1999cited by this paper
• Transport between the cell nucleus and the cytoplasm.

  1999cited by this paper
• In or out? Regulating nuclear transport.

  1999cited by this paper
• Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function.

  1999cited by this paper
• Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope–ER network in yeast

  1998cited by this paper
• Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.

  1998cited by this paper
• The ubiquitin system.

  1998cited by this paper
• Late events in the assembly of 20S proteasomes.

  1998cited by this paper
• Intracellular distribution of proteasomes.

  1998cited by this paper
• Localization of the 26S proteasome during mitosis and meiosis in fission yeast

  1998cited by this paper
• Dynamics of proteasome distribution in living cells

  1997cited by this paper
• Structure of 20S proteasome from yeast at 2.4Å resolution

  1997cited by this paper
• A distinct nuclear import pathway used by ribosomal proteins.

  1997cited by this paper
• A Proteasome Cap Subunit Required for Spindle Pole Body Duplication in Yeast

  1997cited by this paper
• Import of human and Thermoplasma 20S proteasomes into nuclei of HeLa cells requires functional NLS sequences.

  1997cited by this paper
• The Active Sites of the Eukaryotic 20 S Proteasome and Their Involvement in Subunit Precursor Processing*

  1997cited by this paper
• Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor β subunits

  1997cited by this paper
• Maturation of mammalian 20 S proteasome: purification and characterization of 13 S and 16 S proteasome precursor complexes.

  1997cited by this paper
• Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits.

  1997cited by this paper
• Ubiquitin-dependent protein degradation.

  1996cited by this paper
• Analysis of mammalian 20S proteasome biogenesis: the maturation of beta‐subunits is an ordered two‐step mechanism involving autocatalysis.

  1996cited by this paper
• Functional analysis of eukaryotic 20S proteasome nuclear localization signal.

  1996cited by this paper
• Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly.

  1996cited by this paper
• Nuclear localization signals of human and Thermoplasma proteasomal alpha subunits are functional in vitro.

  1995cited by this paper
• The yeast nuclear import receptor is required for mitosis.

  1995cited by this paper
• Identification of a Yeast Karyopherin Heterodimer That Targets Import Substrate to Mammalian Nuclear Pore Complexes (*)

  1995cited by this paper
• Yeast Srp1p has homology to armadillo/plakoglobin/beta-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure.

  1994cited by this paper
• 20 S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13-16 S preproteasome complexes.

  1994cited by this paper
• Changes in intracellular localization of proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role in cell cycle control.

  1993cited by this paper
• Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae.

  1993cited by this paper
• S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase

  1993cited by this paper
• Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase.

  1992cited by this paper
• Nuclear targeting sequences--a consensus?

  1991cited by this paper
• Possible mechanism of nuclear translocation of proteasomes

  1990cited by this paper

• Proteasome dynamics in response to metabolic changes

  2025cites this paper
• Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity

  2024cites this paper
• Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1

  2024cites this paper
• Reversible protein assemblies in the proteostasis network in health and disease

  2023cites this paper
• AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans

  2023cites this paper
• AKIR-1 Regulates Proteasome Localization and Function in Caenorhabditis elegans

  2022cites this paper
• Intracellular localization of the proteasome in response to stress conditions

  2022cites this paper
• Interaction with the Assembly Chaperone Ump1 Promotes Incorporation of the β7 Subunit into Half-Proteasome Precursor Complexes Driving Their Dimerization

  2022cites this paper
• Proteasomal subunit depletions differentially affect germline integrity in C. elegans

  2022cites this paper
• Structure, Dynamics and Function of the 26S Proteasome.

  2021cites this paper
• Macromolecular Protein Complexes III: Structure and Function

  2021cites this paper
• Knowledge Box Knowledge Box

  2020cites this paper
• Ubiquitin–proteasome-mediated cyclin C degradation promotes cell survival following nitrogen starvation

  2020cites this paper
• The Sts1 nuclear import adapter uses a non-canonical bipartite nuclear localization signal and is directly degraded by the proteasome

  2020cites this paper
• Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases

  2019cites this paper
• Nuclear Transport of Yeast Proteasomes

  2019influential citation
• Dynamic Regulation of the 26S Proteasome: From Synthesis to Degradation

  2019influential citation
• Importin α: functions as a nuclear transport factor and beyond

  2018cites this paper
• The paradox of proteasome granules

  2018cites this paper
• Heat stress reveals high molecular mass proteasomes in Arabidopsis thaliana suspension cells cultures

  2018cites this paper
• Compromising the 20S Proteasome Activates a Quality Control Pathway to Mitigate Proteotoxic Stress

  2017cites this paper
• Putting it all together: intrinsic and extrinsic mechanisms governing proteasome biogenesis

  2017influential citation
• Proteasome-mediated degradation of tyrosine hydroxylase triggered by its phosphorylation: a new question as to the intracellular location at which the degradation occurs

  2016cites this paper
• Catalytically Active Proteasomes Function Predominantly in the Cytosol*

  2016cites this paper
• N-Myristoylation of the Rpt2 subunit of the yeast 26S proteasome is implicated in the subcellular compartment-specific protein quality control system.

  2016cites this paper
• Proteasome dynamics between proliferation and quiescence stages of Saccharomyces cerevisiae

  2016cites this paper
• Protein Quality Control at the Inner Nuclear Membrane – The Asi complex in Saccharomyces cerevisiae

  2016cites this paper
• Open Peer Review

  2016cites this paper
• Intracellular Dynamics of the Ubiquitin-Proteasome-System.

  2015cites this paper
• Intracellular Dynamics of the Ubiquitin-Proteasome-System

  2015influential citation
• The amazing ubiquitin-proteasome system: structural components and implication in aging.

  2015cites this paper
• N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging

  2015cites this paper
• Nuclear Import of Yeast Proteasomes

  2015influential citation
• Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association

  2015cites this paper
• Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles*

  2015cites this paper
• Proteasome dynamics.

  2014cites this paper
• The Biogenesis of the Eukaryotic Proteasome

  2014cites this paper
• Proteasome assembly

  2014cites this paper
• Yeast Importin-α (Srp1) Performs Distinct Roles in the Import of Nuclear Proteins and in Targeting Proteasomes to the Nucleus*

  2014cites this paper
• Assembly of the 20S proteasome.

  2014cites this paper
• Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome

  2014cites this paper
• The proteasome activator Blm10 facilitates nuclear import of mature proteasome core particles in yeast

  2014influential citation
• Nuclear Transport of Yeast Proteasomes

  2014influential citation
• Snapshots of proteasomal precursor complexes reveal chaperone involvement in 20S proteasome biogenesis

  2014cites this paper
• Blm10 facilitates nuclear import of proteasome core particles

  2013influential citation
• Nuclear Import Factor Srp1 and Its Associated Protein Sts1 Couple Ribosome-bound Nascent Polypeptides to Proteasomes for Cotranslational Degradation*

  2013cites this paper
• The Role of Ubiquitin on Yeast Proteasome Dynamics in Quiescence

  2013cites this paper
• Biochemical and Biophysical Characterization of Recombinant Yeast Proteasome Maturation Factor Ump1

  2013cites this paper
• Cdc48 Chaperone and Adaptor Ubx4 Distribute the Proteasome in the Nucleus for Anaphase Proteolysis*

  2013cites this paper
• Nuclear Import of Chromatin Remodeler Isw1 Is Mediated by Atypical Bipartite cNLS and Classical Import Pathway

  2013cites this paper
• Étude des rôles et des partenaires du domaine C terminal de Rpn11, une sous-unité du protéasome 26S, dans la dynamique mitochondriale chez Saccharomyces cerevisiae

  2012cites this paper
• Heterochromatin effects in Friedreich's ataxia and sexual dimorphism

  2012cites this paper
• A Cdc48p cofactor affects ubiquitinated protein levels, endoplasmic reticulum associated degradation and proteasome subtypes

  2012cites this paper
• Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome

  2012cites this paper
• Investigations on the Usefulness of CEACAMs as Potential Imaging Targets for Molecular Imaging Purposes

  2011cites this paper
• Nuclear import of an intact preassembled proteasome particle

  2011cites this paper
• Proteasomes crossing the nuclear border

  2011cites this paper
• Txl1 and Txc1 Are Co-Factors of the 26S Proteasome in Fission Yeast

  2011cites this paper
• Adding 3D-structural context to protein-protein interaction data from high-throughput experiments

  2011cites this paper
• Ubiquitin-proteasome dependent catabolite degradation of fructose-1,6-bisphosphatase : localization and involvement of novel components

  2010cites this paper
• Sts1 Plays a Key Role in Targeting Proteasomes to the Nucleus*

  2010cites this paper
• Extracellular alveolar proteasome: possible role in lung injury and repair.

  2010cites this paper
• Ecm29 fulfils quality control functions in proteasome assembly.

  2010cites this paper
• Reduced Immunoproteasome Formation and Accumulation of Immunoproteasomal Precursors in the Brains of Lymphocytic Choriomeningitis Virus-Infected Mice

  2010cites this paper
• Choriomeningitis Virus-Infected Mice Precursors in the Brains of Lymphocytic Accumulation of Immunoproteasomal Reduced Immunoproteasome Formation and

  2010cites this paper
• Catalytic mechanism and assembly of the proteasome.

  2009cites this paper
• Exploring the dynamics of the yeast proteome by means of 2‐DE

  2009cites this paper
• Immunoproteasome assembly in the brain of LCMV-infected mice

  2009cites this paper
• Blm10 binds to pre‐activated proteasome core particles with open gate conformation

  2008cites this paper
• Differential gene expression in the honeybee head after a bacterial challenge.

  2008cites this paper
• Forging a proteasome α-ring with dedicated proteasome chaperones

  2008cites this paper
• Chaperone-driven proteasome assembly.

  2008cites this paper
• PACemakers of proteasome core particle assembly.

  2008cites this paper
• Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis

  2008cites this paper
• Mass spectrometry analysis of proteome-wide proteolytic post-translational degradation of proteins.

  2008cites this paper
• Integrated 'omic' study on the molecular events in the honey bee head after bacterial challenge

  2008cites this paper
• Reversible cytoplasmic localization of the proteasome in quiescent yeast cells

  2008cites this paper
• Classical NLS proteins from Saccharomyces cerevisiae.

  2008cites this paper
• Identification of a Gastrin Response Element in the Vesicular Monoamine Transporter Type 2 Promoter and Requirement of 20 S Proteasome Subunits for Transcriptional Activity*

  2007cites this paper
• TFIIH trafficking and its nuclear assembly during early Drosophila embryo development.

  2007cites this paper
• Sts1 Can Overcome the Loss of Rad23 and Rpn10 and Represents a Novel Regulator of the Ubiquitin/Proteasome Pathway*

  2007cites this paper
• Ubiquitin-dependent proteolysis of the microtubule end-binding protein 1, EB1, is controlled by the COP9 signalosome: possible consequences for microtubule filament stability.

  2007cites this paper
• The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum

  2007cites this paper
• Crossing the Nuclear Envelope: Hierarchical Regulation of Nucleocytoplasmic Transport

  2007cites this paper
• The C-terminal Extension of the β7 Subunit and Activator Complexes Stabilize Nascent 20 S Proteasomes and Promote Their Maturation*

  2007cites this paper
• Oxidized proteins: intracellular distribution and recognition by the proteasome.

  2007cites this paper
• 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals.

  2007cites this paper
• Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation.

  2006cites this paper
• The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome.

  2006cites this paper
• The nuclear proteasome and the degradation of oxidatively damaged proteins

  2006cites this paper
• Intracellular distribution of oxidized proteins and proteasome in HT22 cells during oxidative stress.

  2006cites this paper
• Proteasomes from structure to function: perspectives from Archaea.

  2006cites this paper
• Yeast Proteasome Structure and Biogenesis

  2006cites this paper
• Lokalisation, Isolierung und in vitro Generierung von Assemblierungsintermediaten des humanen 20S Proteasoms

  2006influential citation
• TFIIH trafficking and its nuclear assembly during early Drosophila embryo development

  2006cites this paper
• The nuclear ubiquitin-proteasome system

  2006cites this paper
• Functional analysis of the cytoplasmic domain of complement receptor type II (CR2/CD21)

  2006cites this paper
• STUDIES OF METAZOAN PROTEASOME REGULATION AND FUNCTION

  2005cites this paper
• Nuclear import of TFIIB is mediated by Kap114p, a karyopherin with multiple cargo-binding domains.

  2005cites this paper
• Integrated transcriptome and proteome data: the challenges ahead.

  2004cites this paper