Calcium-dependent phospholipid scrambling by TMEM16F

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nature

• Publication date

  2010-12-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nature09583PMID 21107324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The distribution and function of phosphatidylserine in cellular membranes.

  2010cited by this paper
• Expression and Function of Epithelial Anoctamins*

  2010cited by this paper
• Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing*

  2009cited by this paper
• Absence of platelet-dependent fibrin formation in a patient with Scott syndrome

  2009cited by this paper
• Molecular mediators of macrophage fusion.

  2009cited by this paper
• The TMEM16 protein family: a new class of chloride channels?

  2009cited by this paper
• Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.

  2008cited by this paper
• A Matter of Life and Death

  2008cited by this paper
• TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

  2008cited by this paper
• Messenger RNA regulation: to translate or to degrade

  2008cited by this paper
• TMEM16A confers receptor-activated calcium-dependent chloride conductance

  2008cited by this paper
• Phospholipid Flippases*

  2007cited by this paper
• Transbilayer Phospholipid Movements in ABCA1-Deficient Cells

  2007cited by this paper
• MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

  2007cited by this paper
• Trophoblast fusion: fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion.

  2006cited by this paper
• Dynasore, a cell-permeable inhibitor of dynamin.

  2006cited by this paper
• Expression of Developmental Endothelial Locus-1 in a Subset of Macrophages for Engulfment of Apoptotic Cells1

  2004cited by this paper
• Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids.

  2004cited by this paper
• Calcium signalling: dynamics, homeostasis and remodelling

  2003cited by this paper
• Exposure of platelet membrane phosphatidylserine regulates blood coagulation.

  2003cited by this paper
• Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites.

  2003cited by this paper
• Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics.

  2003cited by this paper
• Aminophospholipid asymmetry: A matter of life and death.

  2003cited by this paper
• Identification of a factor that links apoptotic cells to phagocytes

  2002cited by this paper
• Phospholipid scramblase activation pathways in lymphocytes.

  2001cited by this paper
• Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation.

  2001cited by this paper
• Plat-E: an efficient and stable system for transient packaging of retroviruses

  2000cited by this paper
• Lipid-protein interactions in blood coagulation.

  1998cited by this paper
• Exposure of phosphatidylethanolamine on the surface of apoptotic cells.

  1997cited by this paper
• Family studies in Scott syndrome.

  1997cited by this paper
• Scott syndrome, characterized by impaired transmembrane migration of procoagulant phosphatidylserine and hemorrhagic complications, is an inherited disorder.

  1996cited by this paper
• A novel peptide probe for studying the transbilayer movement of phosphatidylethanolamine.

  1994cited by this paper
• Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome.

  1994cited by this paper
• Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family.

  1993cited by this paper
• Purification and characterization of the receptor for murine granulocyte colony-stimulating factor.

  1990cited by this paper
• Amplification of a gene coding for human T-cell differentiation antigen

  1983cited by this paper

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  2026cites this paper
• ADAM17-induced shedding of glypican-1 as a mechanism of impaired endothelial shear stress mechanotransduction.

  2026cites this paper
• Procoagulant platelets: linking coagulation and thromboinflammation in cardiovascular disease.

  2026cites this paper
• ATP8B1–TMEM30B Flippase Activity Maintains Stereocilia Lipid Asymmetry Required for Hearing

  2026cites this paper
• Phosphatidylserine Externalization in Cancer: Biology, Immune Suppression, and Emerging Theragnostic Strategies

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  2026cites this paper
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  2026cites this paper
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  2025cites this paper
• Phosphatidylserine affinity for and flip-flop dependence on Ca2+ and Mg2+ ions.

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• Phagocytic clearance of targeted cells with a synthetic ligand.

  2025cites this paper
• Physical and Mechanobiological Basis of Biological Functions of Platelets

  2025cites this paper
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  2025cites this paper
• A single vesicle fluorescence microscopy platform to quantify phospholipid scrambling

  2025cites this paper
• Transmembrane thiol isomerase TMX1 inhibits fibrin formation by down-regulation of platelet phosphatidylserine exposure

  2025cites this paper
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  2025cites this paper
• Lipid Scrambling Pathways in the Sec61 Translocon Complex

  2025cites this paper
• Phospholipid Scramblases TMEM16F and Xkr8 mediate distinct features of Phosphatidylserine (PS) externalization and immune suppression to promote tumor growth

  2025cites this paper
• Analysis and Validation of Mitophagy-Related Genes in Diabetic Foot Ulcers

  2025cites this paper
• Ion Channel Function of Human TMEM16F Is Associated with Phospholipid Transport through Its Subunit Cavity.

  2025cites this paper
• S100A9 protein activates microglia and stimulates phagocytosis, resulting in synaptic and neuronal loss.

  2025cites this paper
• Loss of lipid asymmetry facilitates plasma membrane blebbing by decreasing membrane lipid packing

  2025cites this paper
• Deciphering Platelets: Are They Cells or an Evolved Form of Extracellular Vesicles?

  2025cites this paper
• Special Issue “Ion Conductance and Ion Regulation in Human Health and Disease”

  2025cites this paper
• TMEM16F phospholipid scramblase regulates tumorigenesis by modulating the tumor immune microenvironment.

  2025cites this paper
• LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis

  2025cites this paper
• A Contemporary View of Mechanosensory Transduction in Auditory Hair Cells.

  2025cites this paper
• Phospholipid scramblases TMEM16F and Xkr8 mediate distinct features of phosphatidylserine (PS) externalization and immune suppression to promote tumor growth

  2025cites this paper
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  2025cites this paper
• TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience

  2025cites this paper
• A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane

  2025cites this paper
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  2025cites this paper
• Newcastle disease virus acquires phosphatidylserine through the budding process to enhance infectivity

  2025cites this paper
• [The role of phospholipids in regulating the resilience of cellular functions].

  2025cites this paper
• Cryo-EM structure of the ATP11C Q79E mutant reveals the structural basis for altered Phospholipid recognition

  2025cites this paper
• MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony

  2025cites this paper
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  2025cites this paper
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  2025influential citation
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• [Transmembrane protein 16A--a new target for the treatment of airway inflammatory diseases].

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• “Find Me” and “Eat Me” signals: tools to drive phagocytic processes for modulating antitumor immunity

  2024cites this paper
• Interaction between TRP channels and anoctamins.

  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper