Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Nature

• Publication date

  2011-08-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature10346PMID 21866153PMCID PMC3812235
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Wound healing and blastema formation in regenerating digit tips of adult mice.

  2011cited by this paper
• Fate restriction in the growing and regenerating zebrafish fin.

  2011cited by this paper
• Regeneration and reprogramming compared

  2010cited by this paper
• Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases

  2009cited by this paper
• Cells keep a memory of their tissue origin during axolotl limb regeneration

  2009cited by this paper
• Limb blastema cell: A stem cell for morphological regeneration

  2009cited by this paper
• Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth

  2008cited by this paper
• Hair follicle stem cells are specified and function in early skin morphogenesis.

  2008cited by this paper
• Development and regeneration of the neonatal digit tip in mice.

  2008cited by this paper
• Stem cells and blastema cells.

  2008cited by this paper
• Stem Cells and ßλατημa Cells

  2008cited by this paper
• Endochondral ossification is required for hematopoietic stem cell niche formation

  2008cited by this paper
• Biological Restoration. (Book Reviews: A History of Regeneration Research. Milestones in the Evolution of a Science.)

  2007cited by this paper
• A global double‐fluorescent Cre reporter mouse

  2007cited by this paper
• Systemic Bud Induction and Retinoic Acid Signaling Underlie Whole Body Regeneration in the Urochordate Botrylloides leachi

  2007cited by this paper
• Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

  2007cited by this paper
• Stem Cell Therapy in Bone Repair and Regeneration

  2007cited by this paper
• CD45‐Positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice

  2007cited by this paper
• Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene

  2007cited by this paper
• Striving for normality: whole body regeneration through a series of abnormal generations

  2007cited by this paper
• Comment on Papers by Chong et al., Nishio et al., and Suri et al. on Diabetes Reversal in NOD Mice

  2006cited by this paper
• Hematopoietic stem cells

  2006cited by this paper
• VE‐cadherin‐CreERT2 transgenic mouse: A model for inducible recombination in the endothelium

  2006cited by this paper
• Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.

  2005cited by this paper
• Appendage Regeneration in Adult Vertebrates and Implications for Regenerative Medicine

  2005cited by this paper
• Cell lineage tracing during Xenopus tail regeneration

  2004cited by this paper
• Vascular supplies differ in regenerating and nonregenerating amputated rodent digits.

  2004cited by this paper
• [Plasticity of adult stem cells].

  2003cited by this paper
• Temporal Cre‐mediated recombination exclusively in endothelial cells using Tie2 regulatory elements

  2002cited by this paper
• Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells

  2002cited by this paper
• Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer

  2002cited by this paper
• Development and evolution of the mammalian limb: adaptive diversification of nails, hooves, and claws

  2001cited by this paper
• Physiological Migration of Hematopoietic Stem and Progenitor Cells

  2001cited by this paper
• Stem Cells Units of Development, Units of Regeneration, and Units in Evolution

  2000cited by this paper
• Regeneration in the metazoans: why does it happen?

  2000cited by this paper
• Regeneration in the metazoans: why does it happen?

  2000cited by this paper
• Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation.

  2000cited by this paper
• The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin.

  1999cited by this paper
• Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases.

  1999cited by this paper
• Whole-body protochordate regeneration from totipotent blood cells.

  1995cited by this paper
• Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice.

  1995cited by this paper
• Regeneration of the Distal Phalanx

  1993cited by this paper
• Phalangeal regrowth in rodents: postamputational bone regrowth depends upon the level of amputation.

  1993cited by this paper
• Mice regrow the tips of their foretoes.

  1982cited by this paper
• Nonoperative management of distal fingertip amputations in children.

  1979cited by this paper
• Trapped fingers and amputated fingertips in children

  1975cited by this paper
• Trapped fingers and amputated finger tips in children.

  1974cited by this paper
• WOUND HEALING PROCESSES IN AMPUTATED MOUSE DIGITS

  1959cited by this paper

• Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation

  2026cites this paper
• Approaching Scarless Wound Healing: From Passive Anti-Fibrotic to Proactive and Programmable Pro-Regenerative Strategies.

  2026cites this paper
• Breaking down to rebuild: lymphatic ablation enhances osteoclast-driven regeneration

  2026influential citation
• Mouse digit AAV gene delivery into fibroblasts regulates regenerative outcome

  2026cites this paper
• From fragment to form: whole-body regeneration in a model urochordate

  2025cites this paper
• Osteoprogenitor cells from non-regenerative bone show greater resistance to cellular stress than those from regenerative bone

  2025cites this paper
• Advances in CRISPR‐Cas9 in lineage tracing of model animals

  2025cites this paper
• Cellular Dedifferentiation. Revisiting Betty Hay's Legacy.

  2025cites this paper
• Resolving the design principles that control post-natal vascular growth and scaling

  2025cites this paper
• Ear pinna growth and differentiation is conserved in murids and requires BMP signaling for chondrocyte proliferation

  2025cites this paper
• Schwann cells in regeneration and cancer: an epithelial–mesenchymal transition perspective

  2025cites this paper
• Specific cell states underlie complex tissue regeneration in spiny mice

  2025cites this paper
• Regulation of tissue regeneration and repair by the peripheral nervous system.

  2025cites this paper
• A Single Cell Atlas of the Newt Iris During Lens Regeneration

  2025cites this paper
• UFObow: A single-wavelength excitable Brainbow for simultaneous multicolor ex-vivo and in-vivo imaging of mammalian cells

  2024cites this paper
• Modulating DNA Polα Enhances Cell Reprogramming Across Species

  2024cites this paper
• Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies.

  2024cites this paper
• Marvels of spiny mouse regeneration: cellular players and their interactions in restoring tissue architecture in mammals.

  2024cites this paper
• Hallmarks of regeneration.

  2024cites this paper
• Mechanisms and Translational Applications of Regeneration in Limbs: From Renewable Animals to Humans.

  2024cites this paper
• Mechanisms of regeneration: to what extent do they recapitulate development?

  2024cites this paper
• Role of vascular smooth muscle cell clonality in atherosclerosis

  2023cites this paper
• Old bones control smooth muscle clones

  2023cites this paper
• Hallmarks of peripheral nerve function in bone regeneration

  2023cites this paper
• Skin immunity in wound healing and cancer

  2023cites this paper
• Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth

  2023cites this paper
• Neural crest cells give rise to non-myogenic mesenchymal tissue in the adult murid ear pinna

  2023cites this paper
• Cloning by SCNT: Integrating Technical and Biology-Driven Advances.

  2023cites this paper
• Deer antler renewal gives insights into mammalian epimorphic regeneration

  2023cites this paper
• Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart.

  2023cites this paper
• Toeing the line between regeneration and fibrosis

  2023influential citation
• Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue.

  2023cites this paper
• The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques

  2023cites this paper
• Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax

  2023cites this paper
• Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis

  2023cites this paper
• Clonal Expansion in Cardiovascular Pathology

  2023cites this paper
• Age of the bone marrow dictates clonality of smooth muscle-derived cells in the atherosclerotic plaque

  2022cites this paper
• Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration

  2022influential citation
• Microscopical observations on the regenerating tail of tsinling dwarf skink (Scincella tsinlingensis).

  2022cites this paper
• Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine

  2022cites this paper
• Hippo-Yap/Taz signalling in zebrafish regeneration

  2022cites this paper
• Microcomputed tomography staging of bone histolysis in the regenerating mouse digit

  2022cites this paper
• The use of single-cell sequencing to reveal stem/progenitor cells in animal organ regeneration

  2022cites this paper
• The Contribution of Innervation to Tissue Repair and Regeneration.

  2022cites this paper
• Macrophage Fate Mapping

  2022cites this paper
• Nail-associated mesenchymal cells contribute to and are essential for dorsal digit tip regeneration.

  2022cites this paper
• Multicolor strategies for investigating clonal expansion and tissue plasticity

  2022cites this paper
• Wound healing and regeneration in spiny mice (Acomys cahirinus).

  2022cites this paper
• In vivo partial cellular reprogramming enhances liver plasticity and regeneration

  2022cites this paper
• Mammalian organ regeneration in spiny mice

  2022cites this paper
• To regenerate or not to regenerate: Vertebrate model organisms of regeneration‐competency and ‐incompetency

  2022cites this paper
• Sox9 is required for nail bed differentiation and digit tip regeneration.

  2022cites this paper
• Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state

  2022cites this paper
• Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration

  2022cites this paper
• Tissue origin of cytotoxic natural killer cells dictates their differential roles in mouse digit tip regeneration and progenitor cell survival

  2022cites this paper
• Limb blastema formation: How much do we know at a genetic and epigenetic level?

  2022cites this paper
• Epimorphic regeneration of the mouse digit tip is finite

  2022cites this paper
• Cell autonomous TGFβ signaling is essential for stem/progenitor cell recruitment into degenerative tendons

  2021cites this paper
• Regenerative Medicine and Angiogenesis; Focused on Cardiovascular Disease

  2021cites this paper
• Alveoli form directly by budding led by a single epithelial cell

  2021influential citation
• Current Status and Challenges of Stem Cell Treatment for Alzheimer’s Disease

  2021cites this paper
• Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation during Digit Tip Regeneration

  2021influential citation
• Cellular Basis for Tissue Regeneration: Cellular Dedifferentiation

  2021cites this paper
• Determining lineage relationships in kidney development and disease

  2021cites this paper
• A pan‐metazoan concept for adult stem cells: the wobbling Penrose landscape

  2021cites this paper
• Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells

  2021cites this paper
• A finger on the pulse of regeneration: insights into the cellular mechanisms of adult digit tip regeneration.

  2021cites this paper
• Opposing effects of Wnt/β-catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea

  2021cites this paper
• The Potential of Nail Mini-Organ Stem Cells in Skin, Nail and Digit Tips Regeneration

  2021cites this paper
• Anal skin-like epithelium mediates colonic wound healing

  2021cites this paper
• Intravital microscopy imaging of kidney injury and regeneration

  2021cites this paper
• Apoptosis in the foetal testis eliminates developmentally defectivegerm cell clones

  2021cites this paper
• Animal regeneration in the era of transcriptomics

  2021cites this paper
• Mammalian Digit Tip Regeneration: Moving from Phenomenon to Molecular Mechanism.

  2021cites this paper
• Parabiosis modeling: protocol, application and perspectives

  2021cites this paper
• Appendage regeneration is context dependent at the cellular level

  2021cites this paper
• Finding Solutions for Fibrosis: Understanding the Innate Mechanisms Used by Super‐Regenerator Vertebrates to Combat Scarring

  2021cites this paper
• Specialized Smooth Muscle Cell Progenitors in Pulmonary Hypertension

  2020cites this paper
• Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

  2020cites this paper
• Model systems for regeneration: Xenopus

  2020cites this paper
• Tools and Concepts for Interrogating and Defining Cellular Identity.

  2020cites this paper
• Basics of Self-Regeneration

  2020cites this paper
• Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility

  2020cites this paper
• Evolution of epimorphosis in mammals.

  2020cites this paper
• Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration

  2020cites this paper
• Discovering New Progenitor Cell Populations through Lineage Tracing and In Vivo Imaging.

  2020cites this paper
• Chronic Kidney Disease and the Vascular Endothelium

  2020cites this paper
• Pulmonary neuroendocrine cells: physiology, tissue homeostasis and disease

  2020cites this paper
• Creation of bladder assembloids mimicking tissue regeneration and cancer

  2020cites this paper
• Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review

  2020cites this paper
• Cell autonomous TGF-beta signaling is essential for cell recruitment into degenerating tendons

  2020cites this paper
• Cellular and molecular mechanisms that regulate mammalian digit tip regeneration

  2020influential citation
• Maturating Articular Cartilage Can Induce Ectopic Joint-Like Structures in Neonatal Mice

  2020cites this paper
• Apoptosis in the fetal testis eliminates developmentally defective germ cell clones

  2020cites this paper
• Cardiac Regeneration: New Hope for an Old Dream.

  2020cites this paper
• Proximal digit tip amputation initiates simultaneous blastema and transient fibrosis formation and results in partial regeneration

  2020cites this paper
• Articular cartilage regeneration by activated skeletal stem cells

  2020cites this paper
• Anatomical and Immunohistochemical Variations Regarding the Epidermal Stem Cell among Different Traumatic Fingers of Hands in Iraqi Male Workers

  2020cites this paper
• Methods in lineage tracing

  2020cites this paper
• A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions

  2020cites this paper