The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nucleic Acids Research

• Publication date

  2002-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/NAR/GKF611PMID 12433984PMCID PMC137159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: Identification of a new mutation (recQ1) that blocks the RecF recombination pathway

  2004cited by this paper
• Generation of Double-stranded Breaks in Hypernegatively Supercoiled DNA by Drosophila Topoisomerase IIIβ, a Type IA Enzyme*

  2002cited by this paper
• RecQ helicases and topoisomerases: components of a conserved complex for the regulation of genetic recombination

  2001cited by this paper
• Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: Studies of fusion proteins

  2001influential reference
• BLM, the Bloom’s syndrome protein, varies during the cell cycle in its amount, distribution, and co-localization with other nuclear proteins

  2001cited by this paper
• The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

  2001cited by this paper
• Regulation and Localization of the Bloom Syndrome Protein in Response to DNA Damage

  2001cited by this paper
• Topoisomerase III Acts Upstream of Rad53p in the S-Phase DNA Damage Checkpoint

  2001cited by this paper
• DNA topoisomerases: structure, function, and mechanism.

  2001cited by this paper
• Mapping the DNA Topoisomerase III Binding Domain of the Sgs1 DNA Helicase*

  2001cited by this paper
• DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.

  2001cited by this paper
• Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.

  2001cited by this paper
• Evidence for BLM and Topoisomerase IIIα interaction in genomic stability

  2001cited by this paper
• The Bloom's syndrome gene product promotes branch migration of holliday junctions.

  2000cited by this paper
• Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest

  2000cited by this paper
• RecQ family helicases: roles in cancer and aging.

  2000cited by this paper
• Cloning and characterization of Drosophila topoisomerase IIIbeta. Relaxation of hypernegatively supercoiled DNA.

  2000cited by this paper
• The Bloom's Syndrome Gene Product Interacts with Topoisomerase III*

  2000cited by this paper
• Binding and melting of D-loops by the Bloom syndrome helicase.

  2000cited by this paper
• Roles of RecQ family helicases in the maintenance of genome stability.

  2000cited by this paper
• Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.

  2000influential reference
• RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination.

  1999cited by this paper
• Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1

  1999cited by this paper
• Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe.

  1999cited by this paper
• Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.

  1999cited by this paper
• A role for PML and the nuclear body in genomic stability

  1999cited by this paper
• The essential role of yeast topoisomerase III in meiosis depends on recombination

  1999influential reference
• The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity.

  1999influential reference
• Purification and characterization of human DNA topoisomerase IIIalpha.

  1999cited by this paper
• Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

  1999cited by this paper
• Cloning of cDNA Encoding a Novel Mouse DNA Topoisomerase III (Topo IIIβ) Possessing Negatively Supercoiled DNA Relaxing Activity, Whose Message Is Highly Expressed in the Testis*

  1998cited by this paper
• Mammalian DNA topoisomerase IIIα is essential in early embryogenesis

  1998cited by this paper
• The Bloom’s Syndrome Helicase Unwinds G4 DNA*

  1998cited by this paper
• RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination.

  1998cited by this paper
• Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis.

  1998cited by this paper
• RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli.

  1997cited by this paper
• rqh1+, a fission yeast gene related to the Bloom‘s and Werner's syndrome genes, is required for reversible S phase arrest

  1997cited by this paper
• The Bloom’s Syndrome Gene Product Is a 3′-5′ DNA Helicase*

  1997cited by this paper
• Human TOP3: a single-copy gene encoding DNA topoisomerase III.

  1996cited by this paper
• Positional Cloning of the Werner's Syndrome Gene

  1996cited by this paper
• SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae.

  1996cited by this paper
• DNA topoisomerases.

  1996cited by this paper
• The Bloom's syndrome gene product is homologous to RecQ helicases.

  1995cited by this paper
• The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase

  1994cited by this paper
• Bloom Syndrome: A Mendelian Prototype of Somatic Mutational Disease

  1993cited by this paper
• Mutator phenotype of Werner syndrome is characterized by extensive deletions.

  1989cited by this paper
• A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase.

  1989influential reference
• A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.

  1974cited by this paper

• Mechanistic basis for relaxation of DNA supercoils by human topoisomerase IIIα–RMI1–RMI2

  2026cites this paper
• MRN and Topoisomerase IIIα-RMI1/2 synchronize DNA resection motor proteins

  2022cites this paper
• The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins

  2022cites this paper
• Bloom syndrome and the underlying causes of genetic instability.

  2021cites this paper
• Unravelling the mechanisms of Type 1A topoisomerases using single-molecule approaches

  2021cites this paper
• The many lives of type IA topoisomerases

  2020cites this paper
• The Unresolved Problem of DNA Bridging

  2018cites this paper
• The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates

  2018cites this paper
• Osteosarcoma: Molecular Pathogenesis and iPSC Modeling.

  2017cites this paper
• Potential Strategies to Target Protein-Protein Interactions in the DNA Damage Response and Repair Pathways.

  2017cites this paper
• Bloom's Syndrome: Clinical Spectrum, Molecular Pathogenesis, and Cancer Predisposition

  2016cites this paper
• Diverse Roles of Plant and Viral Helicases: Current Status and Future Perspective

  2016cites this paper
• DNA topoisomerases and nucleosome dynamics in fission yeast

  2015cites this paper
• The dissolution of double Holliday junctions.

  2014cites this paper
• Potent in vitro interference of fleroxacin in DNA-binding, unwinding and ATPase activities of Bloom helicase.

  2013cites this paper
• DNA Topoisomerase III Localizes to Centromeres and Affects Centromeric CENP-A Levels in Fission Yeast

  2013cites this paper
• New mechanistic and functional insights into DNA topoisomerases.

  2013cites this paper
• Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases

  2013cites this paper
• Topoisomerases and Carcinogenesis: Topoisomerase IIIα and BLM

  2012cites this paper
• Essential Functions of Topoisomerase IIIα in the Nucleus and Mitochondria

  2012cites this paper
• The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres

  2012cites this paper
• Topoisomerase III-alpha in Double Holliday Junction Dissolution

  2012cites this paper
• Essential Functions of C Terminus of Drosophila Topoisomerase IIIα in Double Holliday Junction Dissolution♦

  2012cites this paper
• The role of DNA helicases and their interaction partners in genome stability and meiotic recombination in plants.

  2011cites this paper
• Meiotic Recombination Intermediates Are Resolved with Minimal Crossover Formation during Return-to-Growth, an Analogue of the Mitotic Cell Cycle

  2011cites this paper
• Processing of homologous recombination repair intermediates by the Sgs1-Top3-Rmi1 and Mus81-Mms4 complexes

  2011cites this paper
• RecQ helicases; at the crossroad of genome replication, repair, and recombination

  2011cites this paper
• Research on prokaryocyte expression and biological activity of the core region of Bloom's Syndrome protein

  2010cites this paper
• Human Topoisomerase IIIα Is a Single-stranded DNA Decatenase That Is Stimulated by BLM and RMI1*

  2010cites this paper
• Genomic instability and cancer: lessons from analysis of Bloom's syndrome.

  2009cites this paper
• The role of metnase in DNA replication fork stress response and DNA damage

  2009cites this paper
• Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.

  2008cites this paper
• mus309 mutation, defective in DNA double-strand break repair, affects intergenic but not intragenic meiotic recombination in Drosophila melanogaster.

  2008cites this paper
• Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3β

  2008cites this paper
• The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1.

  2008cites this paper
• Topoisomerase IIIα is required for normal proliferation and telomere stability in alternative lengthening of telomeres

  2008cites this paper
• Association of human DNA helicase RecQ5beta with RNA polymerase II and its possible role in transcription.

  2008cites this paper
• Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

  2008cites this paper
• Amino acids 39-456 of the large subunit and 210-262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania.

  2008cites this paper
• Protein Kinase A Subunit Expression is Altered in Bloom Syndrome Fibroblasts and the BLM Protein is Increased in Adrenocortical Hyperplasias: Inverse Findings for BLM and PRKAR1A

  2008cites this paper
• Molecular genetics of RecQ helicase disorders

  2007cites this paper
• Dedicated to the core: understanding the Fanconi anemia complex.

  2006cites this paper
• DNA helicases required for homologous recombination and repair of damaged replication forks.

  2006cites this paper
• Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.

  2006cites this paper
• Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability.

  2006cites this paper
• The Absence of Top3 Reveals an Interaction Between the Sgs1 and Pif1 DNA Helicases in Saccharomyces cerevisiae

  2006cites this paper
• Mechanisms by Which Bloom Protein Can Disrupt Recombination Intermediates of Okazaki Fragment Maturation*

  2006cites this paper
• Structure and function of the human RecQ DNA helicases

  2005influential citation
• A role for topoisomerase III in a recombination pathway alternative to RuvABC

  2005influential citation
• The Fanconi Anemia/BRCA pathway: new faces in the crowd.

  2005cites this paper
• The HRDC domain of BLM is required for the dissolution of double Holliday junctions

  2005cites this paper
• Phosphorylation of BLM, Dissociation from Topoisomerase IIIα, and Colocalization with γ-H2AX after Topoisomerase I-Induced Replication Damage

  2005cites this paper
• Drosophila melanogaster Topoisomerase IIIα Preferentially Relaxes a Positively or Negatively Supercoiled Bubble Substrate and Is Essential during Development*

  2005cites this paper
• Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.

  2005cites this paper
• Phosphorylation of BLM, Dissociation from Topoisomerase III (cid:2) , and Colocalization with (cid:3) -H2AX after Topoisomerase I-Induced Replication Damage

  2005cites this paper
• Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases

  2004cites this paper
• Crosslinks and crosstalk: human cancer syndromes and DNA repair defects.

  2004cites this paper
• Understanding the roles of RecQ helicases in the maintenance of genome integrity and suppression of tumorigenesis.

  2004cites this paper
• Stimulation of Flap Endonuclease-1 by the Bloom's Syndrome Protein*

  2004cites this paper
• THE BLM HELICASE FUNCTIONS IN ALTERNATIVE LENGTHENING OF TELOMERES

  2004cites this paper
• The DNA Binding Properties of the Escherichia coli RecQ Helicase*

  2004cites this paper
• Junction of RecQ Helicase Biochemistry and Human Disease*

  2004cites this paper
• Human diseases deficient in RecQ helicases.

  2003cites this paper
• RecQ Helicase Stimulates Both DNA Catenation and Changes in DNA Topology by Topoisomerase III*

  2003cites this paper
• Functional Interaction between the Bloom's Syndrome Helicase and the RAD51 Paralog, RAD51L3 (RAD51D)*

  2003cites this paper
• RecQ helicases: caretakers of the genome

  2003cites this paper
• RecQ helicases: suppressors of tumorigenesis and premature aging.

  2003cites this paper
• Werner protein stimulates topoisomerase I DNA relaxation activity.

  2003cites this paper
• The Bloom's syndrome helicase suppresses crossing over during homologous recombination

  2003cites this paper
• Recognition of small interfering RNA by a viral suppressor of RNA silencing

  2003cites this paper
• Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.

  2003cites this paper
• Roles of the Bloom's syndrome helicase in the maintenance of genome stability.

  2001cites this paper
• Cellular and Molecular Life Sciences the Blm Dissolvasome in Dna Replication and Repair

  year unknowncites this paper