Werner protein stimulates topoisomerase I DNA relaxation activity.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Cancer Research

• Publication date

  2003-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 14612507
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• RecQ helicases: caretakers of the genome

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• Colocalization, Physical, and Functional Interaction between Werner and Bloom Syndrome Proteins*

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• Homologous Recombination Resolution Defect in Werner Syndrome

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• Sumoylation of Topoisomerase I Is Involved in Its Partitioning between Nucleoli and Nucleoplasm and Its Clearing from Nucleoli in Response to Camptothecin*

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• The N-terminal Domain Anchors Human Topoisomerase I at Fibrillar Centers of Nucleoli and Nucleolar Organizer Regions of Mitotic Chromosomes*

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• Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome Protein*

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• The Werner syndrome protein: an update

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• Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

  1999cited by this paper
• Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

  1999cited by this paper
• The Werner Syndrome Gene Product Co-purifies with the DNA Replication Complex and Interacts with PCNA and Topoisomerase I*

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• The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

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• Impaired nuclear localization of defective DNA helicases in Werner's syndrome

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• An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

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• Kinetic Analysis of DNA and RNA Strand Transfer Reactions Catalyzed by Vaccinia Topoisomerase*

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• The nucleolus: Coordinating stress response and genomic stability.

  2024cites this paper
• RNA interacts with topoisomerase I to adjust DNA topology.

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• G-quadruplex-containing oligodeoxynucleotides as DNA topoisomerase I inhibitors.

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