WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  DNA Repair

• Publication date

  2008-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.dnarep.2008.08.008PMID 18805512PMCID PMC2606036
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Delayed kinetics of DNA double‐strand break processing in normal and pathological aging

  2008cited by this paper
• DNA double-strand break repair: from mechanistic understanding to cancer treatment.

  2007cited by this paper
• Werner syndrome protein prevents DNA breaks upon chromatin structure alteration

  2007cited by this paper
• WRN counteracts the NHEJ pathway upon camptothecin exposure.

  2007influential reference
• Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links

  2006cited by this paper
• Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.

  2006cited by this paper
• Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest

  2006cited by this paper
• Topoisomerase I inhibitors: camptothecins and beyond

  2006cited by this paper
• DNA damage-induced cell death by apoptosis.

  2006cited by this paper
• The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase β

  2006cited by this paper
• Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.

  2005cited by this paper
• Deficient DNA repair in the human progeroid disorder, Werner syndrome.

  2005cited by this paper
• SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity

  2005cited by this paper
• Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival.

  2005influential reference
• p53 modulates RPA-dependent and RPA-independent WRN helicase activity.

  2005cited by this paper
• TDP1 Overexpression in Human Cells Counteracts DNA Damage Mediated by Topoisomerases I and II*

  2004cited by this paper
• Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.

  2004cited by this paper
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  2003cited by this paper
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• Werner protein stimulates topoisomerase I DNA relaxation activity.

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• Mechanisms of human DNA repair: an update.

  2003cited by this paper
• Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes*

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  2003cited by this paper
• Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions.

  2003cited by this paper
• p53 stimulates human topoisomerase I activity by modulating its DNA binding.

  2003cited by this paper
• Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3.

  2003cited by this paper
• Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1

  2002cited by this paper
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• Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir.

  2002cited by this paper
• X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance.

  2002cited by this paper
• The mechanism of topoisomerase I poisoning by a camptothecin analog

  2002cited by this paper
• Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSalpha mismatch-binding activity.

  2002cited by this paper
• p53 Modulates the Exonuclease Activity of Werner Syndrome Protein*

  2001cited by this paper
• Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.

  2001cited by this paper
• Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells.

  2001cited by this paper
• Werner helicase relocates into nuclear foci in response to DNA damaging agents and co‐localizes with RPA and Rad51

  2001cited by this paper
• DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells.

  2001cited by this paper
• Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage.

  2000cited by this paper
• Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

  1999cited by this paper
• Replication‐mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA‐dependent protein kinase and dissociates RPA:DNA‐PK complexes

  1999cited by this paper
• A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.

  1998cited by this paper
• Ubiquitin-dependent Destruction of Topoisomerase I Is Stimulated by the Antitumor Drug Camptothecin*

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• Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.

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• Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.

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• Heterogeneity in Radiation-Induced DNA Damage and Repair in Tumor and Normal Cells Measured Using the “Comet” Assay

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• Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay.

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• Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.

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• New Natural Products in Cancer Chemotherapy

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  1989influential reference
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  1989cited by this paper
• Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

  1985influential reference

• KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells.

  2024cites this paper
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  2022cites this paper
• Transcription-associated DNA breaks and cancer: A matter of DNA topology.

  2021cites this paper
• Glioblastoma chemotherapeutic agents used in the clinical setting and in clinical trials: nanomedicine approaches to improve their efficacy.

  2020cites this paper
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  2015cites this paper
• DNA double-strand break formation and signalling in response to transcription-blocking topoisomerase I complexes

  2015cites this paper
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  2014cites this paper
• Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks

  2014cites this paper
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  2014influential citation
• The Drosophila Werner Exonuclease Participates in an Exonuclease-Independent Response to Replication Stress

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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
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• Roles of Werner syndrome protein in protection of genome integrity.

  2010cites this paper
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  2009cites this paper
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• CORRELATION BETWEEN AGING AND TUMORIGENESIS: THE ROLE OF GENETIC FACTORS IN WERNER SYNDROME AND RELATED SYNDROMES

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