Epigenetic Deregulation of DNA Repair and Its Potential for Therapy

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Clinical Cancer Research

• Publication date

  2009-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-08-1169PMID 19671858
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.

  2009cited by this paper
• Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

  2009cited by this paper
• Long-term survival of patients with glioblastoma treated with radiotherapy and lomustine plus temozolomide.

  2009cited by this paper
• Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.

  2009cited by this paper
• DNA mismatch binding and antiproliferative activity of rhodium metalloinsertors.

  2009cited by this paper
• Roles of the Werner syndrome RecQ helicase in DNA replication.

  2008cited by this paper
• Targeted therapy for cancer using PARP inhibitors.

  2008cited by this paper
• Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity.

  2008cited by this paper
• WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.

  2008cited by this paper
• Promoter Methylation and Polymorphisms of the MGMT Gene in Glioblastomas: A Population-Based Study

  2008cited by this paper
• p21WAF1/CIP1 induction by 5-azacytosine nucleosides requires DNA damage

  2008cited by this paper
• Comprehensive genomic characterization defines human glioblastoma genes and core pathways

  2008cited by this paper
• Hypermethylation of the FANCC and FANCL Promoter Regions in Sporadic Acute Leukaemia

  2008cited by this paper
• Triple-Negative Breast Cancer: Risk Factors to Potential Targets

  2008cited by this paper
• The epigenomics of cancer.

  2007cited by this paper
• DNA damage signalling guards against activated oncogenes and tumour progression

  2007cited by this paper
• MGMT prognostic impact on glioblastoma is dependent on therapeutic modalities

  2007cited by this paper
• Targeting Poly(ADP-Ribose) Polymerase: A Two-Armed Strategy for Cancer Therapy

  2007cited by this paper
• Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil–Based Chemotherapy

  2007cited by this paper
• Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.

  2006cited by this paper
• The multifaceted mismatch-repair system

  2006cited by this paper
• Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

  2005cited by this paper
• Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors

  2005cited by this paper
• MGMT gene silencing and benefit from temozolomide in glioblastoma.

  2005cited by this paper
• In vivo Therapeutic Responses Contingent on Fanconi Anemia/BRCA2 Status of the Tumor

  2005cited by this paper
• Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

  2005cited by this paper
• Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.

  2004cited by this paper
• Hallmarks of 'BRCAness' in sporadic cancers

  2004cited by this paper
• MGMT: its role in cancer aetiology and cancer therapeutics

  2004cited by this paper
• Clinical Trial Substantiates the Predictive Value of O-6-Methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastoma Patients Treated with Temozolomide

  2004cited by this paper
• Role of DNA mismatch repair defects in the pathogenesis of human cancer.

  2003cited by this paper
• Gene silencing in cancer in association with promoter hypermethylation.

  2003cited by this paper
• The Fanconi anaemia/BRCA pathway

  2003cited by this paper
• Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumors

  2003cited by this paper
• Inactivation of BRCA1 and BRCA2 in ovarian cancer.

  2002cited by this paper
• Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.

  2002cited by this paper
• Genome maintenance mechanisms for preventing cancer

  2001cited by this paper
• A gene hypermethylation profile of human cancer.

  2001cited by this paper
• Repair of O(6)-alkylguanine by alkyltransferases.

  2000cited by this paper
• Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

  2000cited by this paper
• Repair of O6-alkylguanine by alkyltransferases

  2000cited by this paper
• Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent.

  2000cited by this paper
• A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

  1999cited by this paper
• Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

  1999cited by this paper
• Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.

  1998cited by this paper
• Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers.

  1997cited by this paper

• Loss of CDKN2A/B is a Hallmark of RTK II Glioblastomas

  2026cites this paper
• Ultra-Fast Intraoperative IDH-Mutation Analysis Enables Rapid Stratification and Therapy Planning in Diffuse Gliomas

  2025cites this paper
• Efficacy of Adding Veliparib to Temozolomide for Patients With MGMT-Methylated Glioblastoma: A Randomized Clinical Trial.

  2024cites this paper
• The role of epigenetic methylations in thyroid Cancer

  2024cites this paper
• Dissecting the Methylomes of EGFR-Amplified Glioblastoma Reveals Altered DNA Replication and Packaging, and Chromatin and Gene Silencing Pathways

  2023cites this paper
• EGFR Amplification Is a Phenomenon of IDH Wildtype and TERT Mutated High-Grade Glioma: An Integrated Analysis Using Fluorescence In Situ Hybridization and DNA Methylome Profiling

  2022cites this paper
• Methylome Profiling of PD-L1-Expressing Glioblastomas Shows Enrichment of Post-Transcriptional and RNA-Associated Gene Regulation

  2022cites this paper
• A systematic review on fluoride-induced epigenetic toxicity in mammals

  2022cites this paper
• Integrated analysis of programmed cell death ligand 1 expression reveals increased levels in high-grade glioma

  2021cites this paper
• Epigenetic based synthetic lethal strategies in human cancers

  2020cites this paper
• Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression

  2020cites this paper
• Blood Dna Methylation As A Surrogate Epigenetic Biomarker In Study Of Night Shift Work And Breast Cancer

  2020cites this paper
• Epigenetic heterogeneity in cancer

  2019cites this paper
• Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.

  2019cites this paper
• Novel therapeutic targets in pediatric neural tumors

  2018cites this paper
• S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1

  2018cites this paper
• Changes of DNA repair gene methylation in blood of chronic fluorosis patients and rats.

  2018cites this paper
• Emergence of exosomal DNA in molecular neuropathology

  2018cites this paper
• Identification of Methylation-Driven, Differentially Expressed STXBP6 as a Novel Biomarker in Lung Adenocarcinoma

  2017cites this paper
• Epigenetic Basis of Human Cancer

  2017cites this paper
• Promoter hypermethylation of MGMT gene may contribute to the pathogenesis of gastric cancer

  2017cites this paper
• Chapter 18 DNA Repair and Resistance to Cancer Therapy

  2017cites this paper
• Alterations of the epigenome in brain cancer: loss of 5-hydroxymethylcytosine

  2017cites this paper
• Epigenetics and Its Role in Human Cancer

  2017cites this paper
• CHARLES UNIVERSITY FACULTY OF MEDICINE IN PILSEN

  2016cites this paper
• The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer

  2016influential citation
• Fanconi anemia genes in lung adenocarcinoma- a pathway-wide study on cancer susceptibility

  2016cites this paper
• The Fanconi Anemia Pathway and Interstrand Cross-Link Repair

  2016cites this paper
• Influence of PJ34 on the genotoxicity induced by melphalan in human multiple myeloma cells

  2015cites this paper
• PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R.

  2015cites this paper
• MGMT promoter methylation status in brain metastases from colorectal cancer and corresponding primary tumors.

  2015cites this paper
• The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells

  2014cites this paper
• Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial–mesenchymal transition

  2014cites this paper
• A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma

  2014cites this paper
• Management of Patients with High-Grade Glioma

  2014cites this paper
• Methylation of DNA repair genes and the efficacy of DNA targeted anticancer treatment

  2014cites this paper
• The continuing evolution: biology and treatment of brain tumors.

  2014cites this paper
• TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine.

  2014cites this paper
• DNA Repair and Resistance to Cancer Therapy

  2013cites this paper
• Patterns of histone acetylation as targets for novel therapeutic approaches in neurological diseases

  2013cites this paper
• Cancer Epigenetics: New Therapies and New Challenges

  2013cites this paper
• Protein expression and methylation of DNA repair genes hMLH1, hMSH2, MGMT and BRCA1 and their correlation with clinicopathological parameters and prognosis in basal‐like breast cancer

  2013cites this paper
• Biosemiotic Entropy of the Genome: Mutations and Epigenetic Imbalances Resulting in Cancer

  2013cites this paper
• Epigenetics and Brain Cancer

  2013cites this paper
• A review of the alterations in DNA methylation in esophageal squamous cell carcinoma

  2013cites this paper
• PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy

  2012cites this paper
• Gene Therapy Extended Survival of Glioblastoma Patients After Chemoprotective HSC

  2012cites this paper
• Extended Survival of Glioblastoma Patients After Chemoprotective HSC Gene Therapy

  2012cites this paper
• Individualized Targeted Therapy for Glioblastoma: Fact or Fiction?

  2012cites this paper
• Incongruous differential immunoexpression of the MGMT protein in a double adenoma of the pituitary with homogeneous nonmethylated MGMT promoter genotype.

  2012cites this paper
• Modulation of Epigenetic Targets for Anticancer Therapy: Clinicopathological Relevance, Structural Data and Drug Discovery Perspectives

  2012cites this paper
• O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems.

  2012cites this paper
• Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators.

  2012cites this paper
• Evaluation of high resolution melting methodology for biomarker studies in non-small cell lung cancer

  2011cites this paper
• Combined Modality Approaches in the Management of Adult Glioblastoma

  2011cites this paper
• MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers

  2011cites this paper
• The host genetic background of DNA repair mechanisms is an independent predictor of survival in diffuse large B-cell lymphoma.

  2011cites this paper
• Epigenetic disruption of cell signaling in nasopharyngeal carcinoma

  2011cites this paper
• Histone Acetylation Patterns of Typical and Atypical Pituitary Adenomas Indicate Epigenetic Shift of these Tumours

  2011cites this paper
• Pancreatic Adenocarcinoma Associated With Werner's Syndrome (Adult-Onset Progeria).

  2011cites this paper
• (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells.

  2011cites this paper
• Application of molecular findings to the diagnosis and management of breast disease: recent advances and challenges.

  2011cites this paper
• Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite pyrosequencing, is associated with poor prognosis.

  2010cites this paper
• Down-regulation of Mus81 as a potential marker for the malignancy of gastric cancer.

  2010cites this paper
• Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer

  2010cites this paper
• Genomic instability and the selection of treatments for cancer

  2009cites this paper