The Fanconi anaemia/BRCA pathway

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Nature Reviews. Cancer

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrc970PMID 12509764
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fanconi Anemia

  2019cited by this paper
• Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin.

  2005cited by this paper
• Flow cytometric characterization of the response of Fanconi's anemia cells to mitomycin C treatment.

  2005cited by this paper
• DNA damage and repair

  2003cited by this paper
• Cancer incidence in persons with Fanconi anemia.

  2003cited by this paper
• Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions

  2002cited by this paper
• Nijmegen breakage syndrome: clinical characteristics and mutation analysis in eight unrelated Russian families.

  2002cited by this paper
• A novel diagnostic screen for defects in the Fanconi anemia pathway.

  2002cited by this paper
• Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia.

  2002cited by this paper
• Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool.

  2002cited by this paper
• Interaction of FANCD2 and NBS1 in the DNA damage response

  2002cited by this paper
• BRCA1 interacts directly with the Fanconi anemia protein FANCA.

  2002cited by this paper
• BRCA2 Enters the Fray

  2002cited by this paper
• Radiosensitivity in Fanconi's anemia patients.

  2002cited by this paper
• Fanconi anemia group A and C double-mutant mice: functional evidence for a multi-protein Fanconi anemia complex.

  2002cited by this paper
• Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.

  2002cited by this paper
• Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.

  2002cited by this paper
• BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.

  2002cited by this paper
• Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice.

  2002cited by this paper
• Biallelic Inactivation of BRCA2 in Fanconi Anemia

  2002cited by this paper
• In vitro phenotypic correction of hematopoietic progenitors from Fanconi anemia group A knockout mice.

  2002cited by this paper
• Deficiency in BRCA2 leads to increase in non-conservative homologous recombination

  2002cited by this paper
• Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia.

  2002cited by this paper
• Cancer. BRCA2 enters the fray.

  2002cited by this paper
• FANCE: the link between Fanconi anaemia complex assembly and activity

  2002cited by this paper
• S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.

  2002cited by this paper
• Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway.

  2001cited by this paper
• Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

  2001cited by this paper
• Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation

  2001cited by this paper
• The Inherited Basis of Human Radiosensitivity

  2001cited by this paper
• Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.

  2001cited by this paper
• Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.

  2001cited by this paper
• Preimplantation diagnosis for Fanconi anemia combined with HLA matching.

  2001cited by this paper
• Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

  2001cited by this paper
• Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice

  2001cited by this paper
• The emerging genetic and molecular basis of Fanconi anaemia

  2001cited by this paper
• Fanconi anemia and DNA repair.

  2001cited by this paper
• Mutation in Brca2 stimulates error‐prone homology‐directed repair of DNA double‐strand breaks occurring between repeated sequences

  2001cited by this paper
• Positional cloning of a novel Fanconi anemia gene, FANCD2.

  2001cited by this paper
• Fanconi Anemia Proteins Localize to Chromatin and the Nuclear Matrix in a DNA Damage- and Cell Cycle-regulated Manner*

  2001cited by this paper
• Involvement of Nucleotide Excision Repair in a Recombination-Independent and Error-Prone Pathway of DNA Interstrand Cross-Link Repair

  2001cited by this paper
• Functional analysis of patient-derived mutations in the Fanconi anemia gene, FANCG/XRCC9.

  2001cited by this paper
• BRCA2 is required for homology-directed repair of chromosomal breaks.

  2001cited by this paper
• ATM and ATR: networking cellular responses to DNA damage.

  2001cited by this paper
• The 4N cell cycle delay in Fanconi anemia reflects growth arrest in late S phase.

  2001cited by this paper
• Preclinical protocol for in vivo selection of hematopoietic stem cells corrected by gene therapy in Fanconi anemia group C.

  2001cited by this paper
• Prompt and durable hematopoietic reconstitution by unrelated cord blood transplantation in a child with Fanconi anemia

  2001cited by this paper
• Deficient DNA End Joining Activity in Extracts from Fanconi Anemia Fibroblasts*

  2001cited by this paper
• The Mre11 complex and ATM: collaborating to navigate S phase.

  2000cited by this paper
• The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.

  2000cited by this paper
• The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM

  2000cited by this paper
• ATM-dependent phosphorylation of nibrin in response to radiation exposure

  2000cited by this paper
• DNA polymerase stalling, sister chromatid recombination and the BRCA genes

  2000cited by this paper
• Damage-resistant DNA synthesis in Fanconi anemia cells treated with a DNA cross-linking agent.

  2000cited by this paper
• Independence of R/M/N focus formation and the presence of intact BRCA1.

  2000cited by this paper
• Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group.

  2000cited by this paper
• Interferon-gamma-induced apoptotic responses of Fanconi anemia group C hematopoietic progenitor cells involve caspase 8-dependent activation of caspase 3 family members.

  2000cited by this paper
• ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

  2000cited by this paper
• Defining the Roles of Nucleotide Excision Repair and Recombination in the Repair of DNA Interstrand Cross-Links in Mammalian Cells

  2000cited by this paper
• DNA Replication Is Required To Elicit Cellular Responses to Psoralen-Induced DNA Interstrand Cross-Links

  2000cited by this paper
• Arrest of S-phase progression is impaired in Fanconi anemia cells.

  2000cited by this paper
• Isolation of a cDNA representing the Fanconi anemia complementation group E gene.

  2000cited by this paper
• The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex.

  2000cited by this paper
• BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

  2000cited by this paper
• Spontaneous functional correction of homozygous Fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism

  1999cited by this paper
• The Mre11-Rad50-Xrs2 Protein Complex Facilitates Homologous Recombination-Based Double-Strand Break Repair inSaccharomyces cerevisiae

  1999cited by this paper
• RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

  1999cited by this paper
• Engraftment of Hematopoietic Progenitor Cells Transduced with the Fanconi Anemia Group C Gene (FANCC)

  1999cited by this paper
• Chromosomal breakage syndromes.

  1999cited by this paper
• Brca1 controls homology-directed DNA repair.

  1999cited by this paper
• Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

  1999cited by this paper
• Fanconi Anemia Proteins FANCA, FANCC, and FANCG/XRCC9 Interact in a Functional Nuclear Complex

  1999cited by this paper
• In vivo selection of wild-type hematopoietic stem cells in a murine model of Fanconi anemia.

  1999cited by this paper
• Molecular spectra of HPRT deletion mutations in circulating T-lymphocytes in Fanconi anemia patients.

  1999cited by this paper
• Disruption of muREC2/RAD51L1 in Mice Results in Early Embryonic Lethality Which Can Be Partially Rescued in a p53−/− Background

  1999cited by this paper
• Loss of FancC Function Results in Decreased Hematopoietic Stem Cell Repopulating Ability

  1999cited by this paper
• Meiotic chromosomes: integrating structure and function.

  1999cited by this paper
• Enhanced phosphorylation of p53 by ATM in response to DNA damage.

  1998cited by this paper
• The Fanconi anaemia group G gene FANCG is identical with XRCC9

  1998cited by this paper
• Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage.

  1998cited by this paper
• Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice.

  1998cited by this paper
• The fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation.

  1998cited by this paper
• Fanconi's anemia: what have we learned from the genes so far?

  1998cited by this paper
• Involvement of Brca2 in DNA repair.

  1998cited by this paper
• Deubiquitinating enzymes: a new class of biological regulators.

  1998cited by this paper
• Subtyping Analysis of Fanconi Anemia by Immunoblotting and Retroviral Gene Transfer

  1998cited by this paper
• A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

  1998cited by this paper
• Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

  1998cited by this paper
• Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining.

  1998cited by this paper
• The Fanconi anaemia proteins, FAA and FAC interact to form a nuclear complex

  1997cited by this paper
• Retroviral Mediated Gene Transfer of the Fanconi Anemia Complementation Group C Gene to Hematopoietic Progenitors of Group C Patients. National Institutes of Health, Bethesda, Maryland

  1997cited by this paper
• Retroviral mediated gene transfer of the Fanconi anemia complementation group C gene to hematopoietic progenitors of group C patients.

  1997cited by this paper
• Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells.

  1997cited by this paper
• The fidelity of double strand breaks processing is impaired in complementation groups B and D of fanconi anemia, a genetic instability syndrome

  1997cited by this paper
• Phenotypic consequences of mutations in the Fanconi anemia FAC gene: an International Fanconi Anemia Registry study.

  1997cited by this paper
• Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5' to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand

  1997cited by this paper
• Molecular biology of Fanconi anemia: implications for diagnosis and therapy.

  1997cited by this paper
• Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

  1997cited by this paper
• RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2 *

  1997cited by this paper
• Elevated Homologous Recombination Activity in Fanconi Anemia Fibroblasts*

  1997cited by this paper

• FANCA Deficiency Induces Oncogenic R-Loop Dependent Synthetic Lethality with PARP1 Inhibitors

  2025cites this paper
• Fanconi anemia in a 10-year-old girl: Unusual multisystem manifestations with bilateral ectopic kidneys and a novel FANCA mutation

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• A gene program dictionary of human cells

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• The relationship between KSHV and the cellular DNA damage response

  2025cites this paper
• DNA-protein cross-links emerge as major contributors to chemotherapeutic cytotoxicity at physiological equitoxic doses

  2025cites this paper
• The protein-protein interaction landscape of Fanconi anemia protein A (FANCA) reveals its contributions to mRNA processes

  2025cites this paper
• Olaparib maintenance therapy for recurrent adult granulosa cell tumors: A case report

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• Oncogenic properties of wild-type DNA repair gene FANCA in breast cancer

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• Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis, and Treatment

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• Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake

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• Research progress on the fanconi anemia signaling pathway in non-obstructive azoospermia

  2024cites this paper
• Diagnosing Fanconi Anemia: A Rare Case Report From Rural India

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• RFWD3 modulates response to platinum chemotherapy and promotes cancer associated phenotypes in high grade serous ovarian cancer

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• BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality

  2024cites this paper
• Myeloid neoplasms in individuals with breast and ovarian cancer and the association with deleterious germline variants.

  2024cites this paper
• Contribution of p53-dependent and -independent mechanisms to upregulation of p21 in Fanconi anemia

  2024cites this paper
• Modulation of ATM enhances DNA repair in G2/M phase of cell cycle and averts senescence in Fuchs endothelial corneal dystrophy

  2024cites this paper
• Dental management of Fanconi anemia: a rare congenital disorder

  2024cites this paper
• Fanconi Anemia a Rare Disease

  2024cites this paper
• Alu‐Mediated Deletion of FANCA in Turkish Families With Fanconi Anemia: Evidence of a Founder Effect

  2024cites this paper
• Clinical Validation of the Somatic FANCD2 Mutation (c.2022-5C>T) as a Novel Molecular Biomarker for Early Disease Progression in Chronic Myeloid Leukemia: A Case–Control Study

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• UBL5 and Its Role in Viral Infections

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• Different Cytotoxic Effects of Cisplatin on Pancreatic Ductal Adenocarcinoma Cell Lines

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• Identification of small‐molecule binding sites of a ubiquitin‐conjugating enzyme‐UBE2T through fragment‐based screening

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• Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

  2023cites this paper
• Identification of a robust DNA methylation signature for Fanconi anemia.

  2023cites this paper
• SARS-CoV-2 and the DNA damage response

  2023cites this paper
• Contraception as chemoprevention of ovarian cancer in BRCA1 and BRCA2 women

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• Whole-genome bisulfite sequencing reveals the function of DNA methylation in the allotransplantation immunity of pearl oysters

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• Comprehensive analysis of subtypes and risk model based on complement system associated genes in ccRCC.

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• Understanding DNA Damage Response and DNA Repair in Multiple Myeloma

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• ANXA13 promotes cell proliferation and invasion and attenuates apoptosis in renal cell carcinoma

  2023cites this paper
• Exceptional Response to Olaparib: A Case Report of Metastatic Esophageal Squamous Cell Carcinoma in a Patient With Fanconi Anemia, Germline FANCA Mutation, and Somatic BRCA2 Mutations.

  2023cites this paper
• Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism

  2022cites this paper
• A Narrative Review on Fanconi Anemia: Genetic and Diagnostic Considerations

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• Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy.

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• Radiosensitizing Effect of Trabectedin on Human Soft Tissue Sarcoma Cells

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• Pembrolizumab activity in patients with Fanconi anemia repair pathway competent and deficient tumors

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• Germline Cancer Testing in Unselected Patients with Gastric and Esophageal Cancers: A Multi-center Prospective Study

  2022cites this paper
• The RPA inhibitor HAMNO sensitizes Fanconi anemia pathway-deficient cells

  2022cites this paper
• A score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer

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• A synonymous variant contributes to a rare Wiedemann-Rautenstrauch syndrome complicated with mild anemia via affecting pre-mRNA splicing

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• Discovering a qualitative transcriptional signature of homologous recombination defectiveness for prostate cancer

  2021cites this paper
• Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition.

  2021cites this paper
• Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair.

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• BRCA mutations in pancreatic cancer and progress in their targeting

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• DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination

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• Basic and Preclinical Research for Personalized Medicine

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• Novel diagnostic approaches for Fanconi anemia (FA) by single-cell sequencing and capillary nano-immunoassay

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• Beyond visualization of DNA double-strand breaks after radiation exposure

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• Pancreatic cancer.

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• HLA-haploidentical TCRαβ+/CD19+-depleted stem cell transplantation in children and young adults with Fanconi anemia.

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• Should the BCRA1/2-mutations healthy carriers be valid candidates for hematopoietic stem cell donation?

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• Two tSNPs in BRIP1 are associated with breast cancer during TDT analysis

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• GLI1-targeting drugs induce replication stress and homologous recombination deficiency and synergize with PARP-targeted therapies in triple negative breast cancer cells.

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• A new frontier in Fanconi anemia: From DNA repair to ribosome biogenesis.

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• Fanconi Anemia Pathway Genes Advance Cervical Cancer via Immune Regulation and Cell Adhesion

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• Association of BRCA1 and BRCA2 genes in arsenic-induced urinary bladder carcinoma

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• Pediatric Central Nervous System Cancer Predisposition

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• Global miRNA expression of bone marrow mesenchymal stem/stromal cells derived from Fanconi anemia patients

  2021cites this paper
• DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress

  2020cites this paper
• A computational model for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays

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• Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer

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• Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C

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• The role of next‐generation sequencing in the investigation of ultrasound‐identified fetal structural anomalies

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• Defective cell proliferation is an attribute of overexpressed Notch1 receptor and impaired autophagy in Fanconi Anemia.

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• DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives

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• Positive selection and fast turnover rate in tumor suppressor genes reveal how cetaceans resist cancer

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• PARP Inhibitors & Prostate Cancer: To Infinity and Beyond BRCA.

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• Fanconi Anemia Pathway: Mechanisms of Breast Cancer Predisposition Development and Potential Therapeutic Targets

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• Targeting DNA Repair in Ovarian Cancer Treatment Resistance.

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• Inhibitors of the Fanconi anaemia pathway as potential antitumour agents for ovarian cancer

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• TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1

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• Fatal Myelotoxicity Following Palliative Chemotherapy With Cisplatin and Gemcitabine in a Patient With Stage IV Cholangiocarcinoma Linked to Post Mortem Diagnosis of Fanconi Anemia

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• Natural Killer Cell Degranulation Defect: A Cause for Impaired NK-Cell Cytotoxicity and Hyperinflammation in Fanconi Anemia Patients

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• [Hereditary predisposition to breast cancer (1): genetics].

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• The Fanconi Anemia Pathway in Cancer.

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• BRCA1 Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated miR-155 to Disrupt Myeloid Differentiation in Myeloid Malignancies

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• Loss of FANCD2 and related proteins may predict malignant transformation in oral epithelial dysplasia.

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