The role of WRN in DNA repair is affected by post-translational modifications.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Mechanisms of Ageing and Development

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.MAD.2006.11.010PMID 17116323
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bmc Molecular Biology Identification of New Reference Genes for the Normalisation of Canine Osteoarthritic Joint Tissue Transcripts from Microarray Data

  2007cited by this paper
• Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV

  2006cited by this paper
• Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links

  2006cited by this paper
• WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

  2006cited by this paper
• The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase β

  2006cited by this paper
• XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.

  2006cited by this paper
• Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome.

  2006cited by this paper
• Accumulation of Werner protein at DNA double-strand breaks in human cells

  2005cited by this paper
• The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA

  2005cited by this paper
• Cellular dynamics and modulation of WRN protein is DNA damage specific.

  2005cited by this paper
• Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?

  2005cited by this paper
• A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

  2005cited by this paper
• RecQ Family Members Combine Strand Pairing and Unwinding Activities to Catalyze Strand Exchange*

  2005cited by this paper
• Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage

  2005cited by this paper
• Repair of Double-Strand DNA Breaks by the Human Nonhomologous DNA End Joining Pathway: The Iterative Processing Model

  2005cited by this paper
• Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1*[boxs]

  2005cited by this paper
• Werner syndrome cells escape hydrogen peroxide‐induced cell proliferation arrest

  2004cited by this paper
• p14 Arf Promotes Small Ubiquitin-like Modifier Conjugation of Werners Helicase*

  2004cited by this paper
• Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.

  2004cited by this paper
• The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.

  2004cited by this paper
• Human RECQ5β, a protein with DNA helicase and strand‐annealing activities in a single polypeptide

  2004cited by this paper
• SUMO: a regulator of gene expression and genome integrity

  2004cited by this paper
• Linkage between Werner Syndrome Protein and the Mre11 Complex via Nbs1*

  2004cited by this paper
• Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

  2004cited by this paper
• Regulation of WRN Helicase Activity in Human Base Excision Repair*

  2004cited by this paper
• WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair

  2003cited by this paper
• Gene expression profiling in Werner syndrome closely resembles that of normal aging

  2003cited by this paper
• WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*

  2003cited by this paper
• Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.

  2003cited by this paper
• RecQ helicases: caretakers of the genome

  2003cited by this paper
• Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

  2003cited by this paper
• Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

  2003cited by this paper
• Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage

  2003cited by this paper
• Werner protein stimulates topoisomerase I DNA relaxation activity.

  2003cited by this paper
• Werner Syndrome Protein Phosphorylation by Abl Tyrosine Kinase Regulates Its Activity and Distribution

  2003cited by this paper
• The Werner Syndrome Protein Stimulates DNA Polymerase β Strand Displacement Synthesis via Its Helicase Activity*

  2003cited by this paper
• Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

  2003cited by this paper
• The 3′–5′ exonucleases

  2002cited by this paper
• Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.

  2002cited by this paper
• Roles of the Werner syndrome protein in pathways required for maintenance of genome stability.

  2002cited by this paper
• Werner syndrome diploid fibroblasts are sensitive to 4‐nitroquinoline‐N‐oxide and 8‐methoxypsoralen: implications for the disease phenotype

  2002cited by this paper
• Recombinational DNA repair and human disease.

  2002cited by this paper
• Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation*

  2002cited by this paper
• Homologous Recombination Resolution Defect in Werner Syndrome

  2002cited by this paper
• DNA Damage-induced Translocation of the Werner Helicase Is Regulated by Acetylation*

  2002cited by this paper
• Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases*

  2002cited by this paper
• Werner and Bloom helicases are involved in DNA repair in a complementary fashion

  2002cited by this paper
• Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.

  2002cited by this paper
• Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.

  2002cited by this paper
• A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.

  2001cited by this paper
• Base excision repair in a network of defence and tolerance.

  2001cited by this paper
• Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.

  2001cited by this paper
• Werner helicase relocates into nuclear foci in response to DNA damaging agents and co‐localizes with RPA and Rad51

  2001cited by this paper
• Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

  2001cited by this paper
• The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

  2001cited by this paper
• Requirements for the Nucleolytic Processing of DNA Ends by the Werner Syndrome Protein-Ku70/80 Complex*

  2001cited by this paper
• p53 Modulates the Exonuclease Activity of Werner Syndrome Protein*

  2001cited by this paper
• Covalent Modification of the Werner's Syndrome Gene Product with the Ubiquitin-related Protein, SUMO-1*

  2000cited by this paper
• Werner protein recruits DNA polymerase δ to the nucleolus

  2000cited by this paper
• [Werner syndrome].

  2000cited by this paper
• Nuclear structure in normal and Bloom syndrome cells.

  2000cited by this paper
• Characterization of the human and mouse WRN 3'-->5' exonuclease.

  2000cited by this paper
• Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

  2000cited by this paper
• Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest

  2000cited by this paper
• Functional interaction between the Werner Syndrome protein and DNA polymerase delta.

  2000cited by this paper
• Werner protein recruits DNA polymerase delta to the nucleolus.

  2000cited by this paper
• Ku complex interacts with and stimulates the Werner protein.

  2000cited by this paper
• Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

  1999cited by this paper
• Functional and Physical Interaction between WRN Helicase and Human Replication Protein A*

  1999cited by this paper
• The Werner Syndrome Gene Product Co-purifies with the DNA Replication Complex and Interacts with PCNA and Topoisomerase I*

  1999cited by this paper
• Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members*

  1999cited by this paper
• Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding.

  1999cited by this paper
• Werner Syndrome Protein

  1998cited by this paper
• The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

  1998cited by this paper
• Werner helicase is localized to transcriptionally active nucleoli of cycling cells.

  1998cited by this paper
• Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

  1997cited by this paper
• The Werner syndrome protein is a DNA helicase

  1997cited by this paper
• Positional Cloning of the Werner's Syndrome Gene

  1996cited by this paper
• Genetic syndromes in man with potential relevance to the pathobiology of aging.

  1978cited by this paper

• History of DNA Helicases

  2020cites this paper
• WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells

  2020cites this paper
• WRN modulates mRNA translation by influencing mRNA export from the 1 nucleus through its interaction with the export receptor NXF1 in HeLa 2 cancer cell 3

  2020cites this paper
• MIB1‐mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment

  2020cites this paper
• WRN modulates translation by influencing mRNA export from the nucleus through its interaction with the export receptor NXF1 in HeLa cancer cell

  2020cites this paper
• Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase

  2020cites this paper
• Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases

  2019cites this paper
• MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner

  2018cites this paper
• Estudio de la funcionalidad de la proteína del síndrome de Werner (WRN) en la maquinaria traduccional y alteraciones moleculares derivadas de su silenciamiento en células HeLa

  2018cites this paper
• Werner Syndrome Protein and DNA Replication

  2018cites this paper
• Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins.

  2018cites this paper
• Localization of the Werner Protein Together with H2AX in γ-Irradiation-Induced Neoplastic Transformed Human Mesenchymal Stem Cells.

  2017cites this paper
• Studies on the regulation of genome maintenance factors by non-covalent interaction with poly(ADP-ribose) with a focus on RECQL helicases

  2016cites this paper
• Lesson 321 : Preanesthetic Assessment of The Patient With a Progeroid Syndrome

  2016cites this paper
• Mathematical Modeling for DNA Repair, Carcinogenesis and Cancer Detection

  2015cites this paper
• Genomic Instability and Cancer Metastasis

  2015cites this paper
• Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway

  2015cites this paper
• Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities

  2014cites this paper
• Functional deficit associated with a missense Werner syndrome mutation.

  2013cites this paper
• DNA repair deficiency in neurodegeneration.

  2011cites this paper
• GENOTOXIN-INDUCED ACETYLATION OF THE WERNER SYNDROME PROTEIN (WRN) AND EFFECT ON ITS DNA METABOLIC FUNCTION

  2011cites this paper
• Roles of Werner syndrome protein in protection of genome integrity.

  2010cites this paper
• Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver.

  2010cites this paper
• Regulation of WRN Function by Acetylation and SIRT1-Mediated Deacetylation in Response to DNA Damage: A Dissertation

  2010cites this paper
• Role of SIRT1 in homologous recombination.

  2010cites this paper
• Acetylation of WRN Protein Regulates Its Stability by Inhibiting Ubiquitination

  2010cites this paper
• From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging.

  2009cites this paper
• Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.

  2009cites this paper
• Étude de la régulation des gènes CYP2B par les inducteurs de type phénobarbital, comprenant la mise à l'épreuve du modèle actuel

  2009influential citation
• DNA Damage and Repair: From Molecular Mechanisms to Health Implications

  2008cites this paper
• Krebs und Telomere

  2008cites this paper
• Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability.

  2008cites this paper
• Emerging links between premature ageing and defective DNA repair.

  2008cites this paper
• Processing of DNA replication and repair intermediates by the concerted action of RecQ helicases and Rad2 structure-specific nucleases.

  2008cites this paper
• Delayed kinetics of DNA double‐strand break processing in normal and pathological aging

  2008cites this paper
• Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging.

  2008cites this paper
• Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes

  2007cites this paper
• The molecular basis of aging

  2007cites this paper
• Human premature aging, DNA repair and RecQ helicases

  2007cites this paper
• 95th International Titisee Conference

  2007cites this paper
• Telomere Biology and Cardiovascular Disease Vascular Cell Senescence: Contribution to Atherosclerosis Stem Cells and the Regeneration of the Aging Cardiovascular System Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes Mechanisms Underlying Caloric Restriction, Lipid Metabolism, an

  year unknowncites this paper