WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Nature Structural &Molecular Biology

• Publication date

  2006-05-14

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nsmb1088PMID 16622405
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Accumulation of Werner protein at DNA double-strand breaks in human cells

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  2005cited by this paper
• The Enzymatic Activities of the Werner Syndrome Protein Are Disabled by the Amino Acid Polymorphism R834C*

  2004cited by this paper
• Structure and function of the double-strand break repair machinery.

  2004cited by this paper
• Werner syndrome protein--unwinding function to explain disease.

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• The Werner syndrome protein has separable recombination and survival functions.

  2004cited by this paper
• Linkage between Werner Syndrome Protein and the Mre11 Complex via Nbs1*

  2004cited by this paper
• The Werner syndrome protein at the crossroads of DNA repair and apoptosis.

  2004cited by this paper
• Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

  2004cited by this paper
• Identification and Biochemical Characterization of a Werner's Syndrome Protein Complex with Ku70/80 and Poly(ADP-ribose) Polymerase-1*

  2004cited by this paper
• Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

  2003cited by this paper
• WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair

  2003cited by this paper
• WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*

  2003cited by this paper
• High‐resolution structure of the E.coli RecQ helicase catalytic core

  2003cited by this paper
• Werner Syndrome Protein Contains Three Structure-specific DNA Binding Domains*

  2003cited by this paper
• RecQ helicases: caretakers of the genome

  2003cited by this paper
• Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.

  2002cited by this paper
• Lack of WRN results in extensive deletion at nonhomologous joining ends.

  2002cited by this paper
• Different types of V(D)J recombination and end‐joining defects in DNA double‐strand break repair mutant mammalian cells

  2002cited by this paper
• Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

  2002cited by this paper
• A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities.

  2002cited by this paper
• A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092

  2002cited by this paper
• Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation*

  2002cited by this paper
• Activities

  2001cited by this paper
• Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

  2001cited by this paper
• Requirements for the Nucleolytic Processing of DNA Ends by the Werner Syndrome Protein-Ku70/80 Complex*

  2001cited by this paper
• A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.

  2001cited by this paper
• Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.

  2001cited by this paper
• Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome Protein*

  2001cited by this paper
• Werner helicase relocates into nuclear foci in response to DNA damaging agents and co‐localizes with RPA and Rad51

  2001cited by this paper
• WRN helicase expression in Werner syndrome cell lines.

  2000cited by this paper
• Characterization of the human and mouse WRN 3'-->5' exonuclease.

  2000cited by this paper
• Ku complex interacts with and stimulates the Werner protein.

  2000cited by this paper
• Functional Interaction between Ku and the Werner Syndrome Protein in DNA End Processing*

  2000cited by this paper
• Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

  1998cited by this paper
• Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

  1998cited by this paper
• Impaired nuclear localization of defective DNA helicases in Werner's syndrome

  1997cited by this paper
• Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing.

  1997cited by this paper
• The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.

  1997cited by this paper
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  1997cited by this paper
• Positional Cloning of the Werner's Syndrome Gene

  1996cited by this paper
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  1996cited by this paper
• Structural basis for the 3′‐5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

  1991cited by this paper

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• WRN and WRNIP1 ATPases impose high fidelity on translesion synthesis by Y-family DNA polymerases

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• WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives.

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• Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres

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• Targeting WRN helicase: Discovery and development of its selective inhibitors.

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• Deciphering the mechanisms of PARP inhibitor resistance in prostate cancer: Implications for precision medicine.

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• WRN Nuclease‐Mediated EcDNA Clearance Enhances Antitumor Therapy in Conjunction with Trehalose Dimycolate/Mesoporous Silica Nanoparticles

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• Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome Protein

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• WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases

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• A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection

  2023cites this paper
• Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay

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• The identification of a novel mutation (p.I223fs) in WRN associated with Werner syndrome

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  2022cites this paper
• Size exclusion chromatography coupled small angle X-ray scattering with tandem multiangle light scattering at the SIBYLS beamline.

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• Biochemical and functional characterization of an exonuclease from Chaetomium thermophilum.

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• Enigmatic role of WRN-RECQL helicase in DNA repair and its implications in cancer

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• Mammalian Resilience Revealed by a Comparison of Human Diseases and Mouse Models Associated With DNA Helicase Deficiencies

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• Partial lipodystrophy, severe dyslipidaemia and insulin resistant diabetes as early signs of Werner syndrome.

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