SUMO: a regulator of gene expression and genome integrity

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Oncogene

• Publication date

  2004-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1207415PMID 15021887
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

  2003cited by this paper
• Polycomb, epigenomes, and control of cell identity.

  2003cited by this paper
• Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.

  2003cited by this paper
• Nuclear and unclear functions of SUMO

  2003cited by this paper
• Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor

  2003cited by this paper
• How the ubiquitin–proteasome system controls transcription

  2003cited by this paper
• Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1*

  2003cited by this paper
• RecQ helicases: caretakers of the genome

  2003cited by this paper
• The Promyelocytic Leukemia Protein Protects p53 from Mdm2-mediated Inhibition and Degradation*

  2003cited by this paper
• Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT

  2003cited by this paper
• Sterol Regulatory Element-binding Proteins Are Negatively Regulated through SUMO-1 Modification Independent of the Ubiquitin/26 S Proteasome Pathway*

  2003cited by this paper
• Role of the promyelocytic leukemia body in the dynamic interaction between the androgen receptor and steroid receptor coactivator-1 in living cells.

  2003cited by this paper
• Activation of Transforming Growth Factor-β Signaling by SUMO-1 Modification of Tumor Suppressor Smad4/DPC4*

  2003cited by this paper
• Modification with SUMO

  2003cited by this paper
• PIAS proteins promote SUMO-1 conjugation to STAT1.

  2003cited by this paper
• Faculty Opinions recommendation of The polycomb protein Pc2 is a SUMO E3.

  2003cited by this paper
• Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity.

  2003cited by this paper
• Molecular views of recombination proteins and their control

  2003cited by this paper
• MDM2-ARF complex regulates p53 sumoylation

  2003cited by this paper
• Physical and Functional Interactions between PML and MDM2*

  2003cited by this paper
• Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.

  2003cited by this paper
• SUMO Modification of STAT1 and Its Role in PIAS-mediated Inhibition of Gene Activation*

  2003cited by this paper
• PIAS/SUMO: new partners in transcriptional regulation

  2003cited by this paper
• Class II histone deacetylases: versatile regulators.

  2003cited by this paper
• Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

  2003cited by this paper
• P300 transcriptional repression is mediated by SUMO modification.

  2003cited by this paper
• Regulation of Transforming Growth Factor-β Signaling by Protein Inhibitor of Activated STAT, PIASy through Smad3*

  2003cited by this paper
• SUMO-1/Ubc9 Promotes Nuclear Accumulation and Metabolic Stability of Tumor Suppressor Smad4*

  2003cited by this paper
• Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins

  2003cited by this paper
• Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization

  2003influential reference
• Modification of CCAAT/Enhancer-binding Protein-β by the Small Ubiquitin-like Modifier (SUMO) Family Members, SUMO-2 and SUMO-3*

  2003cited by this paper
• Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling*

  2003cited by this paper
• A Synergy Control Motif within the Attenuator Domain of CCAAT/Enhancer-binding Protein α Inhibits Transcriptional Synergy through Its PIASy-enhanced Modification by SUMO-1 or SUMO-3*

  2003cited by this paper
• Serum response factor is modulated by the SUMO-1 conjugation system.

  2003cited by this paper
• P14ARF promotes accumulation of SUMO‐1 conjugated (H)Mdm2

  2002cited by this paper
• The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II.

  2002cited by this paper
• Increased K+ Efflux and Apoptosis Induced by the Potassium Channel Modulatory Protein KChAP/PIAS3β in Prostate Cancer Cells*

  2002cited by this paper
• Activation of p53 by Protein Inhibitor of Activated Stat1 (PIAS1)*

  2002cited by this paper
• PIAS3 (protein inhibitor of activated STAT‐3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2

  2002cited by this paper
• The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

  2002cited by this paper
• SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization.

  2002cited by this paper
• SUMO-1 Modification of Histone Deacetylase 1 (HDAC1) Modulates Its Biological Activities*

  2002influential reference
• The Nuclear Receptor Interaction Domain of GRIP1 Is Modulated by Covalent Attachment of SUMO-1*

  2002influential reference
• Signalling: STATs: transcriptional control and biological impact

  2002cited by this paper
• The nucleoporin RanBP2 has SUMO1 E3 ligase activity.

  2002cited by this paper
• Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.

  2002cited by this paper
• Activated MAPK/ERK kinase (MEK-1) induces transdifferentiation of pigmented epithelium into neural retina.

  2002cited by this paper
• Modification of the human thymine‐DNA glycosylase by ubiquitin‐like proteins facilitates enzymatic turnover

  2002cited by this paper
• Sumoylation of Mdm2 by Protein Inhibitor of Activated STAT (PIAS) and RanBP2 Enzymes*

  2002cited by this paper
• Association of the Human SUMO-1 Protease SENP2 with the Nuclear Pore*

  2002cited by this paper
• Potentiation of glucocorticoid receptor transcriptional activity by sumoylation.

  2002cited by this paper
• Nucleolar Delocalization of Human Topoisomerase I in Response to Topotecan Correlates with Sumoylation of the Protein*

  2002cited by this paper
• Perturbation of SUMOlation Enzyme Ubc9 by Distinct Domain within Nucleoporin RanBP2/Nup358*

  2002cited by this paper
• PIAS1 and PIASxα Function as SUMO-E3 Ligases toward Androgen Receptor and Repress Androgen Receptor-dependent Transcription*

  2002cited by this paper
• The Aryl Hydrocarbon Receptor Nuclear Transporter Is Modulated by the SUMO-1 Conjugation System*

  2002cited by this paper
• The amino terminus of the human AR is target for corepressor action and antihormone agonism.

  2002cited by this paper
• Covalent Attachment of the SUMO-1 Protein to the Negative Regulatory Domain of the c-Myb Transcription Factor Modifies Its Stability and Transactivation Capacity*

  2002cited by this paper
• Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma1

  2002cited by this paper
• The Inhibitory Function in Human Progesterone Receptor N Termini Binds SUMO-1 Protein to Regulate Autoinhibition and Transrepression*

  2002cited by this paper
• Ubiquitin‐Related Modifier SUMO1 and Nucleocytoplasmic Transport

  2002cited by this paper
• Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor.

  2002cited by this paper
• AP-1 as a regulator of cell life and death

  2002cited by this paper
• SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin

  2002cited by this paper
• Enzymes of the SUMO Modification Pathway Localize to Filaments of the Nuclear Pore Complex

  2002cited by this paper
• The promise and perils of Wnt signaling through beta-catenin.

  2002cited by this paper
• Sumoylation of Topoisomerase I Is Involved in Its Partitioning between Nucleoli and Nucleoplasm and Its Clearing from Nucleoli in Response to Camptothecin*

  2002cited by this paper
• PIAS3 induces SUMO‐1 modification and transcriptional repression of IRF‐1

  2002cited by this paper
• Emerging Roles of Ubiquitin in Transcription Regulation

  2002cited by this paper
• Transcription factor Sp3 is silenced through SUMO modification by PIAS1

  2002cited by this paper
• Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

  2002cited by this paper
• PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

  2002influential reference
• Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxβ

  2002influential reference
• The Promise and Perils of Wnt Signaling Through β-Catenin

  2002cited by this paper
• RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

  2002cited by this paper
• Cellular roles of DNA topoisomerases: a molecular perspective

  2002cited by this paper
• Ubiquitin and proteasomes: Sumo, ubiquitin's mysterious cousin

  2001cited by this paper
• Functional analysis and intracellular localization of p53 modified by SUMO-1

  2001cited by this paper
• Regulation and Localization of the Bloom Syndrome Protein in Response to DNA Damage

  2001cited by this paper
• A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis

  2001cited by this paper
• Involvement of PIAS1 in the sumoylation of tumor suppressor p53.

  2001cited by this paper
• Ubiquitin and proteasomes: Themes and variations on ubiquitylation

  2001cited by this paper
• P53 and PML: new partners in tumor suppression.

  2001cited by this paper
• SUMO: of branched proteins and nuclear bodies

  2001influential reference
• An E3-like factor that promotes SUMO conjugation to the yeast septins.

  2001cited by this paper
• Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.

  2001cited by this paper
• SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52.

  2001cited by this paper
• Yeast Ull1/Siz1 Is a Novel SUMO1/Smt3 Ligase for Septin Components and Functions as an Adaptor between Conjugating Enzyme and Substrates*

  2001cited by this paper
• Genome maintenance mechanisms for preventing cancer

  2001cited by this paper
• The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome.

  2001cited by this paper
• Post-translational modifications and activation of p53 by genotoxic stresses.

  2001cited by this paper
• PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.

  2001cited by this paper
• PML interaction with p53 and its role in apoptosis and replicative senescence

  2001cited by this paper
• A novel factor required for the SUMO1/Smt3 conjugation of yeast septins.

  2001cited by this paper
• Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

  2001cited by this paper
• Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1).

  2000cited by this paper
• c-Jun and p53 Activity Is Modulated by SUMO-1 Modification*

  2000cited by this paper
• Regulation of p53 activity in nuclear bodies by a specific PML isoform

  2000cited by this paper
• The transcriptional role of PML and the nuclear body

  2000cited by this paper
• SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage.

  2000cited by this paper
• Covalent Modification of the Werner's Syndrome Gene Product with the Ubiquitin-related Protein, SUMO-1*

  2000cited by this paper

• Ovarian SUMO-2/3 targets and their differential response to genotoxic stress induced by 7,12-dimethylbenz(a) anthracene exposure in lean and obese female mice

  2025cites this paper
• Identification of hub genes associated with severe COPD via WGCNA and immune infiltration analysis

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• Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations

  2025cites this paper
• Exploring potential targets for natural product therapy of DN: the role of SUMOylation

  2024cites this paper
• Chemical protein synthesis combined with protein cell delivery reveals new insights on the maturation process of SUMO2

  2024cites this paper
• SUMOylation of the Cardiac Sodium Channel NaV1.5 Modifies Inward Current and Cardiac Excitability.

  2023cites this paper
• The allosteric effect of the upper half of SENP1 contributes to its substrate selectivity for SUMO1 over SUMO2

  2023cites this paper
• The Involvement of Ubiquitination and SUMOylation in Retroviruses Infection and Latency

  2023cites this paper
• Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export

  2023cites this paper
• A Narrative Review of the TP53 and Its Product the p53 Protein

  2023cites this paper
• Sumoylation in astrocytes induces changes in the proteome of the derived small extracellular vesicles which change protein synthesis and dendrite morphology in target neurons.

  2023cites this paper
• The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells

  2022cites this paper
• SUMOylation of the Cardiac Sodium Channel NaV1.5 Modifies Inward Current and Cardiac Excitability

  2022cites this paper
• Studying the ubiquitin code through biotin-based labelling methods.

  2022cites this paper
• SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma

  2022cites this paper
• Exploring the Role of Posttranslational Modifications in Spinal and Bulbar Muscular Atrophy

  2022cites this paper
• Discovery of a Dual SENP1 and SENP2 Inhibitor

  2022cites this paper
• Trophic factor BDNF inhibits GABAergic signaling by facilitating dendritic enrichment of SUMO E3 ligase PIAS3 and altering gephyrin scaffold

  2022influential citation
• Identification of Natural Products as SENP2 Inhibitors for Targeted Therapy in Heart Failure

  2022cites this paper
• Advances in the Study of CircRNAs in Tumor Drug Resistance

  2022cites this paper
• A role for keratin 17 during DNA damage response and tumor initiation

  2021cites this paper
• Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

  2021cites this paper
• Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response

  2021cites this paper
• SUMOylation Is Associated with Aggressive Behavior in Chondrosarcoma of Bone

  2021cites this paper
• miRNAs Copy Number Variations Repertoire as Hallmark Indicator of Cancer Species Predisposition

  2021cites this paper
• Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by Fas ligand via cDNA microarray analysis

  2021cites this paper
• Dissecting multiple roles of SUMOylation in prostate cancer.

  2021cites this paper
• Targeting SUMO Signaling to Wrestle Cancer.

  2020cites this paper
• SUMOylation of MCL1 protein enhances its stability by regulating the ubiquitin-proteasome pathway.

  2020cites this paper
• Not So Slim Anymore—Evidence for the Role of SUMO in the Regulation of Lipid Metabolism

  2020cites this paper
• SUMOylation regulates protein cargo in Astrocyte-derived small extracellular vesicles

  2020cites this paper
• Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation

  2020cites this paper
• Genetic alteration and clinical significance of SUMOylation regulators in multiple cancer types

  2020cites this paper
• The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging.

  2020cites this paper
• Mechanism of SUMO repression of the transcription factor c-Myb – the role of SUMO acetylation

  2019cites this paper
• Molecular mechanisms in SUMO conjugation.

  2019cites this paper
• Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs)

  2019cites this paper
• Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner.

  2019cites this paper
• SUMOlock reveals a more complete Aspergillus nidulans SUMOylome.

  2019cites this paper
• Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis

  2019cites this paper
• Knockdown of Uba2 inhibits colorectal cancer cell invasion and migration through downregulation of the Wnt/β‐catenin signaling pathway

  2018cites this paper
• Walking the wire: Post-transcriptional regulation of T cell effector functions in health and disease

  2018cites this paper
• The post-translational modification, SUMOylation, and cancer (Review)

  2018cites this paper
• A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest

  2018cites this paper
• TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer

  2018cites this paper
• A genome-wide RNAi screen identifies the SMC 5 / 6 complex as a non-redundant regulator of a Topo 2 a-dependent G 2 arrest

  2018cites this paper
• SUMO-1 expression modulates non-small cell lung cancer progression

  2018cites this paper
• Sumoylation Modulates the Susceptibility to Type 1 Diabetes.

  2017cites this paper
• SENP2 suppresses epithelial‐mesenchymal transition of bladder cancer cells through deSUMOylation of TGF‐βRI

  2017cites this paper
• Degradation of nuclear Ubc9 induced by listeriolysin O is dependent on K+ efflux.

  2017cites this paper
• Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1

  2017cites this paper
• Cross-talk between sumoylation and phosphorylation in mouse spermatocytes.

  2017cites this paper
• Computational Prediction of Proteins Sumoylation: A Review on the Methods and Databases

  2016cites this paper
• Inhibition of CDK1 activity by sumoylation.

  2016cites this paper
• Role of Genetics and Epigenetics in Mucosal, Uveal, and Cutaneous Melanomagenesis.

  2016cites this paper
• SUMO and SUMO-Conjugating Enzyme E2 UBC9 Are Involved in White Spot Syndrome Virus Infection in Fenneropenaeus chinensis

  2016cites this paper
• Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis

  2016cites this paper
• HDAC4 stabilizes SIRT1 via sumoylation SIRT1 to delay cellular senescence

  2016cites this paper
• Identification and analysis of a novel nuclear role of Fibroblast Growth Factor 10 (FGF10)

  2016cites this paper
• Structure Determination and Biochemical Characterization of Novel Human Ubiquitin-like Domains

  2015cites this paper
• The Responses of SENP 3 to Different Extents of Oxidative Stress

  2015cites this paper
• Rheumatoid Arthritis Activation of Fibroblast-like Synoviocytes in Regulates Migration, Invasion, and Protein Inhibitor of Activated STAT3

  2015cites this paper
• Can your protein be sumoylated? A quick summary and important tips to study SUMO-modified proteins.

  2015cites this paper
• SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer.

  2015cites this paper
• RETRACTED ARTICLE: SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1

  2015cites this paper
• Knockdown of SUMO-activating enzyme subunit 2 (SAE2) suppresses cancer malignancy and enhances chemotherapy sensitivity in small cell lung cancer

  2015cites this paper
• Molecular mechanisms of oncogénesis mediated by the BTB transcription factor Pipsqueak. Impact of sumoylation and proteolytic processing

  2015cites this paper
• Characterization of the Loss of SUMO Pathway Function on Cancer Cells and Tumor Proliferation

  2015cites this paper
• Study on gene regulation and post-translational modification of Ets transcription factors

  2014cites this paper
• Lentivirus-mediated siRNA targeting SAE1 induces cell cycle arrest and apoptosis in colon cancer cell RKO

  2014cites this paper
• High Mobility Group Nucleosomal Binding Domain 2 (HMGN2) SUMOylation by the SUMO E3 Ligase PIAS1 Decreases the Binding Affinity to Nucleosome Core Particles*

  2014cites this paper
• SUMOylation determines turnover and localization of nephrin at the plasma membrane.

  2014cites this paper
• SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage‐independent growth of cancer cells

  2014cites this paper
• Two-way communications between ubiquitin-like modifiers and DNA

  2014cites this paper
• Nuclear pore complexes in the maintenance of genome integrity.

  2013cites this paper
• Over-Expression of Small Ubiquitin-Related Modifier-1 and Sumoylated p53 in Colon Cancer

  2013cites this paper
• SUMO2/3 modification of cyclin E contributes to the control of replication origin firing

  2013cites this paper
• Sumoylation of the Basic Helix-Loop-Helix Transcription Factor Sharp-1 Regulates Recruitment of the Histone Methyltransferase G9a and Function in Myogenesis*

  2013cites this paper
• Covalent Small Ubiquitin-like Modifier (SUMO) Modification of Maf1 Protein Controls RNA Polymerase III-dependent Transcription Repression*

  2013cites this paper
• SUMO-1 Modification on K166 of PolyQ-Expanded aTaxin-3 Strengthens Its Stability and Increases Its Cytotoxicity

  2013cites this paper
• New insights into the role of the small ubiquitin-like modifier (SUMO) in plants.

  2013cites this paper
• Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity

  2013influential citation
• Diversity within the pRb pathway: is there a code of conduct?

  2012cites this paper
• CHFR is important for the first wave of ubiquitination at DNA damage sites

  2012cites this paper
• SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.

  2012cites this paper
• SUMOylation in Drosophila Development

  2012cites this paper
• Investigation of the FAT10 conjugation pathway

  2012cites this paper
• Lens epithelium‐derived growth factor deSumoylation by Sumo‐specific protease‐1 regulates its transcriptional activation of small heat shock protein and the cellular response

  2012cites this paper
• Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.

  2012cites this paper
• SUMO Modification of Stra13 Is Required for Repression of Cyclin D1 Expression and Cellular Growth Arrest

  2012cites this paper
• An Upregulation of SENP3 After Spinal Cord Injury: Implications for Neuronal Apoptosis

  2012cites this paper
• Identification of Sumoylation Sites in CCDC6, the First Identified RET Partner Gene in Papillary Thyroid Carcinoma, Uncovers a Mode of Regulating CCDC6 Function on CREB1 Transcriptional Activity

  2012cites this paper
• SUMO-1 of mud crab (Scylla paramamosain) in gametogenesis.

  2012cites this paper
• Screening method for isopeptides from small ubiquitin-related modifier-conjugated proteins by ion mobility mass spectrometry.

  2011cites this paper
• SUMO-specific protease 2 in Mdm2-mediated regulation of p53

  2011cites this paper
• Genetic, Epigenetic and Molecular Changes in Melanoma: A New Paradigm for Biological Classification

  2011influential citation
• Caveolin-3 Undergoes SUMOylation by the SUMO E3 Ligase PIASy

  2011cites this paper
• The mouse small ubiquitin-like modifier-2 (SUMO-2) inhibits interleukin-12 (IL-12) production in mature dendritic cells by blocking the translocation of the p65 subunit of NFκB into the nucleus.

  2011cites this paper
• In vivo effects of abolishing the Single canonical sumoylation site in the C-terminal region of Drosophila p53

  2011cites this paper
• SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

  2011cites this paper