Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2003-03-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.0637114100PMID 12626745PMCID PMC152279
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enzymes of the SUMO Modification Pathway Localize to Filaments of the Nuclear Pore Complex

  2002cited by this paper
• Covalent Attachment of the SUMO-1 Protein to the Negative Regulatory Domain of the c-Myb Transcription Factor Modifies Its Stability and Transactivation Capacity*

  2002cited by this paper
• SUMO-1 Modification of Human Cytomegalovirus IE1/IE72

  2002cited by this paper
• Ubiquitin‐Related Modifier SUMO1 and Nucleocytoplasmic Transport

  2002cited by this paper
• A Lack of SUMO Conjugation Affects cNLS-dependent Nuclear Protein Import in Yeast*

  2002cited by this paper
• Native interface of the SAM domain polymer of TEL

  2002cited by this paper
• PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

  2002cited by this paper
• Versatile protein tag, SUMO: Its enzymology and biological function

  2002cited by this paper
• The nucleoporin RanBP2 has SUMO1 E3 ligase activity.

  2002cited by this paper
• The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

  2002cited by this paper
• Association of the Human SUMO-1 Protease SENP2 with the Nuclear Pore*

  2002cited by this paper
• Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

  2001cited by this paper
• TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3

  2001cited by this paper
• Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila

  2001cited by this paper
• Regulation of Heat Shock Transcription Factor 1 by Stress-induced SUMO-1 Modification*

  2001cited by this paper
• SUMO-1 Modification Regulates the DNA Binding Activity of Heat Shock Transcription Factor 2, a Promyelocytic Leukemia Nuclear Body Associated Transcription Factor*

  2001cited by this paper
• The Mdm-2 Amino Terminus Is Required for Mdm2 Binding and SUMO-1 Conjugation by the E2 SUMO-1 Conjugating Enzyme Ubc9*

  2001cited by this paper
• PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.

  2001cited by this paper
• Involvement of PIAS1 in the sumoylation of tumor suppressor p53.

  2001cited by this paper
• Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6.

  2000cited by this paper
• Tel induces a G1 arrest and suppresses Ras-induced transformation

  2000cited by this paper
• Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein.

  2000cited by this paper
• c-Jun and p53 Activity Is Modulated by SUMO-1 Modification*

  2000cited by this paper
• A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase.

  2000cited by this paper
• Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies.

  2000cited by this paper
• SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

  2000cited by this paper
• Differential Regulation of Sentrinized Proteins by a Novel Sentrin-specific Protease*

  2000cited by this paper
• A New SUMO-1-specific Protease, SUSP1, That Is Highly Expressed in Reproductive Organs*

  2000cited by this paper
• Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL

  2000cited by this paper
• Role of SUMO-1-modified PML in nuclear body formation.

  2000cited by this paper
• TEL, a Putative Tumor Suppressor, Modulates Cell Growth and Cell Morphology of Ras-Transformed Cells While Repressing the Transcription of stromelysin-1

  2000cited by this paper
• Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3*

  2000cited by this paper
• Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components

  1999cited by this paper
• The role of chromosome translocations in leukemogenesis.

  1999cited by this paper
• Cell cycle regulation of PML modification and ND10 composition.

  1999cited by this paper
• The role of TEL fusion genes in pediatric leukemias

  1999cited by this paper
• Both TEL and AML-1 Contribute Repression Domains to the t(12;21) Fusion Protein

  1999cited by this paper
• The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A.

  1999cited by this paper
• TEL Is a Sequence-specific Transcriptional Repressor*

  1999cited by this paper
• A New 30-kDa Ubiquitin-related SUMO-1 Hydrolase from Bovine Brain*

  1999cited by this paper
• Activation of p53 by conjugation to the ubiquitin‐like protein SUMO‐1

  1999cited by this paper
• SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation.

  1999cited by this paper
• Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1.

  1999cited by this paper
• Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region.

  1999cited by this paper
• Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9.

  1999cited by this paper
• The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor.

  1999cited by this paper
• SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.

  1998cited by this paper
• The ets Family Member Tel Binds to the Fli-1 Oncoprotein and Inhibits Its Transcriptional Activity*

  1998cited by this paper
• Conjugation with the ubiquitin‐related modifier SUMO‐1 regulates the partitioning of PML within the nucleus

  1998cited by this paper
• Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1.

  1998cited by this paper
• Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors.

  1997cited by this paper
• A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL–PDGFRβ oncoprotein

  1997cited by this paper
• A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.

  1997cited by this paper
• The TEL gene contributes to the pathogenesis of myeloid and lymphoid leukemias by diverse molecular genetic mechanisms.

  1997cited by this paper
• The TEL gene products: nuclear phosphoproteins with DNA binding properties

  1997cited by this paper
• Evidence for a role of CRM1 in signal-mediated nuclear protein export.

  1997cited by this paper
• RanBP2 associates with Ubc9p and a modified form of RanGAP1.

  1997cited by this paper
• The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

  1996cited by this paper
• A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

  1996cited by this paper
• Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.

  1995cited by this paper

• SUMOylation Protects Endothelial Cell-Expressed Leukocyte-Specific Protein 1 from Ubiquitination-Mediated Proteasomal Degradation and Facilitates Its Nuclear Export

  2026cites this paper
• The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and Other Hematopoietic Cancers.

  2024cites this paper
• hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.

  2023cites this paper
• ETV6-related thrombocytopenia: dominant negative effect of mutations as common pathogenic mechanism

  2022cites this paper
• Identification of UBE2I as a Novel Biomarker in ccRCC Based on a Large-Scale CRISPR-Cas9 Screening Database and Immunohistochemistry

  2022influential citation
• Sumoylation regulates the assembly and activity of the SMN complex

  2021cites this paper
• Functional characterization of a germline ETV6 variant associated with inherited thrombocytopenia, acute lymphoblastic leukemia, and salivary gland carcinoma in childhood

  2020cites this paper
• Molecular Basis of ETV6-Mediated Predisposition to Childhood Acute Lymphoblastic Leukemia.

  2020cites this paper
• SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability

  2019cites this paper
• A role for SUMOylation in the Formation and Cellular Localization of TDP-43 Aggregates in Amyotrophic Lateral Sclerosis

  2019cites this paper
• Expression, purification, and evaluation of in vivo anti-fibrotic activity for soluble truncated TGF-β receptor II as a cleavable His-SUMO fusion protein

  2018cites this paper
• Impact de SRP72 sur le facteur de transcription ETV6 dans la leucémie aiguë lymphoblastique

  2018cites this paper
• Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression

  2018cites this paper
• SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase

  2017cites this paper
• Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation.

  2017cites this paper
• RUNX‐mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins

  2017cites this paper
• ETV6 in hematopoiesis and leukemia predisposition.

  2017influential citation
• Sumoylation and Its Contribution to Cancer.

  2017cites this paper
• Epigenetic regulation of Hoxa1 and Hoxa2

  2017cites this paper
• Transcription Factors - ReadingSample

  2017cites this paper
• ETV6 and ETV7: Siblings in hematopoiesis and its disruption in disease.

  2017cites this paper
• SUMO and Nucleocytoplasmic Transport.

  2017cites this paper
• A conserved antiviral role for a virus-induced cytoplasmic exosome complex

  2016cites this paper
• PHOSPHORYLATION AND SUMOYLATION HELP MAINTAIN THE FUNCTIONS OF ENDOTHELIAL CELL-EXPRESSED LEUKOCYTE-SPECIFIC PROTEIN 1 (LSP1)

  2016cites this paper
• Prognostic impact of RUNX1 and ETV6 gene copy number on pediatric B-cell precursor acute lymphoblastic leukemia with or without hyperdiploidy

  2016cites this paper
• Fibroblastoid and Myofibroblastoid Tumors of the Liver and Bile Ducts

  2016cites this paper
• EZH2 induces methylation of ERG enhancing its transcriptional and transforming activity

  2016cites this paper
• IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation

  2015cites this paper
• SUMOylation Confers Posttranslational Stability on NPM-ALK Oncogenic Protein

  2015cites this paper
• ANTI-MTG16 ANTIBODIES REVEAL MTG16 SUBCELLULAR DISTRIBUTION AND NUCLEOCYTOPLASMIC TRANSPORT IN ERYTHROLEUKEMIA CELLS.

  2015cites this paper
• ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish

  2015cites this paper
• Study on gene regulation and post-translational modification of Ets transcription factors

  2014cites this paper
• Polo-like Kinase 1-mediated Phosphorylation of Forkhead Box Protein M1b Antagonizes Its SUMOylation and Facilitates Its Mitotic Function*

  2014cites this paper
• Non-nuclear function of sumoylated proteins.

  2014cites this paper
• Dissecting the role of the ETV6 transcriptional regulator in development and disease

  2014cites this paper
• ETV6 (TEL1) in blood cell development and malignancy

  2014cites this paper
• PHC3 SAM linker allows open-ended polymerization of PHC3 SAM

  2014cites this paper
• SUMOhunt: Combining Spatial Staging between Lysine and SUMO with Random Forests to Predict SUMOylation

  2013cites this paper
• Molecular mechanisms of ETS transcription factor-mediated tumorigenesis

  2013cites this paper
• SUMO-modification of the RNA-binding protein La enhances its binding to the translational start site of cyclin D1

  2013cites this paper
• SUMOylation is a regulator of the translocation of Jak2 between nucleus and cytosol.

  2013cites this paper
• Untersuchung des Beitrags von ETV6/RUNX1 zur Entstehung akuter lymphatischer Leukämie (ALL) im Kindesalter

  2013cites this paper
• Sumoylation of Nuclear Transport Receptors and the small GTPase Ran

  2013cites this paper
• Mutation of the Salt Bridge-forming Residues in the ETV6-SAM Domain Interface Blocks ETV6-NTRK3-induced Cellular Transformation*

  2013cites this paper
• An electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation.

  2013cites this paper
• Understanding the role of ETS-mediated gene regulation in complex biological processes.

  2013cites this paper
• Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain.

  2012cites this paper
• The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain*

  2012cites this paper
• Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM.

  2012cites this paper
• Investigation of KLF5 Function in Normal Hematopoiesis.

  2012cites this paper
• Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin‐related modifiers

  2011cites this paper
• The Role of MicroRNA-181a in Acute Leukemia: Biological, Clinical, and Therapeutic Implications

  2011cites this paper
• Regulation of REGγ cellular distribution and function by SUMO modification

  2011cites this paper
• Recognition of Host Proteins by Helicobacter Cysteine-Rich Protein C

  2011cites this paper
• Prognostic molecular markers of childhood leukemia

  2010cites this paper
• DNA Binding by the ETS Protein TEL (ETV6) Is Regulated by Autoinhibition and Self-association*

  2010cites this paper
• Expression and purification of an antitumor‐analgesic peptide from the venom of Mesobuthus martensii Karsch by small ubiquitin–related modifier fusion in Escherichia coli

  2010cites this paper
• CHAPTER 3 Downregulation of Vertebrate Tel ( ETV 6 ) and Drosophila Yan is Facilitated by an Evolutionarily Conserved Mechanism of F-box-Mediated Ubiquitination

  2010cites this paper
• Proteasome Activator REGγ Enhances Coxsackieviral Infection by Facilitating p53 Degradation

  2010cites this paper
• SUMO Proteases: Redox Regulation and Biological Consequences

  2009cites this paper
• Characterization of cold shock domain proteins and SUMOylation system from Oryza sativa

  2009cites this paper
• A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import.

  2009cites this paper
• An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing.

  2009cites this paper
• Identification of nuclear localization and nuclear export signals in Ets2, and the transcriptional regulation of Ets2 and CTP:phosphocholine cytidylyltransferase alpha in tetradecanoyl-13-acetate or macrophage-colony stimulating factor stimulated RAW264 cells.

  2009cites this paper
• Downregulation of Vertebrate Tel (ETV6) and Drosophila Yan Is Facilitated by an Evolutionarily Conserved Mechanism of F-Box-Mediated Ubiquitination

  2008cites this paper
• p14ARF interacts with DAXX: Effects on HDM2 and p53

  2008cites this paper
• Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.

  2008cites this paper
• Expression and purification of human urodilatin by small ubiquitin-related modifier fusion in Escherichia coli

  2008cites this paper
• p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53

  2008cites this paper
• Die SUMOylierung des Transkriptionsfaktors Sp3 reprimiert die Genexpression durch Rekrutierung Chromatin-modifizierender Enzyme und Ausbildung lokaler heterochromatischer Strukturen

  2008cites this paper
• Identification of a nuclear export signal sequence for bovine papillomavirus E1 protein.

  2008cites this paper
• Nuclear localization of Myomesin-1: possible functions

  2008cites this paper
• SUMOylation Regulates Nuclear Localization of Krüppel-like Factor 5*

  2008cites this paper
• The Transactivation Function of the Pea3 Subfamily Ets Transcription Factors Is Regulated by Sumoylation

  2008cites this paper
• Cellular stress triggers TEL nuclear export via two genetically separable pathways

  2008cites this paper
• Identification of a New Site of Sumoylation on Tel (ETV6) Uncovers a PIAS-Dependent Mode of Regulating Tel Function

  2008influential citation
• The Ternary Complex Factor Net Is Downregulated by Hypoxia and Regulates Hypoxia-Responsive Genes

  2007cites this paper
• Genetic Studies of Acute Lymphoblastic Leukemia

  2007cites this paper
• Repression of E1AF transcriptional activity by sumoylation and PIASy.

  2007cites this paper
• SUMO and estrogen receptors in breast cancer

  2007cites this paper
• The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60.

  2007cites this paper
• Sumoylation regulates diverse biological processes

  2007cites this paper
• Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of Cysteines 93 and 310

  2007influential citation
• Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation

  2007cites this paper
• The interaction of ETV 6 ( TEL ) and TIP 60 requires a functional histone acetyltransferase domain in TIP 60

  2007cites this paper
• Structure and function of protein modules in chromatin biology.

  2006cites this paper
• A molecular ‘switchboard’ : lysine modifications and their impact on transcription.

  2006cites this paper
• PIASy-mediated repression of the Ets-1 is independent of its sumoylation.

  2006cites this paper
• Overexpression of Ets-1 in human hematopoietic progenitor cells blocks erythroid and promotes megakaryocytic differentiation

  2006cites this paper
• Identification of the nuclear localization motif in the ETV6 (TEL) protein.

  2006cites this paper
• Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells

  2006influential citation
• Beads-on-a-String, Characterization of Ets-1 Sumoylated within Its Flexible N-terminal Sequence*

  2006cites this paper
• A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein.

  2006cites this paper
• SUMO down-regulates the activity of Elf4/myeloid Elf-1-like factor.

  2006cites this paper
• Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia

  2005cites this paper
• SUMO fusion technology for difficult-to-express proteins

  2005cites this paper
• ETS transcription factors and their emerging roles in human cancer.

  2005cites this paper
• Post‐translational modifications influence transcription factor activity: A view from the ETS superfamily

  2005influential citation
• ETV6: a versatile player in leukemogenesis.

  2005cites this paper
• The Many Faces of SAM

  2005cites this paper