Matrix Metalloproteinase Responsive, Proximity‐Activated Polymeric Nanoparticles for siRNA Delivery

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Advanced Functional Materials

• Publication date

  2013-06-25

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.1002/adfm.201202215PMID 25214828PMCID PMC4159188
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ex vivo red blood cell hemolysis assay for the evaluation of pH-responsive endosomolytic agents for cytosolic delivery of biomacromolecular drugs.

  2013cited by this paper
• Action and reaction: the biological response to siRNA and its delivery vehicles.

  2012cited by this paper
• Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages

  2012cited by this paper
• pH‐Responsive Peptide Mimic Shell Cross‐Linked Magnetic Nanocarriers for Combination Therapy

  2012cited by this paper
• Multifunctional Mesoporous Silica Nanoparticles for Cancer‐Targeted and Controlled Drug Delivery

  2012cited by this paper
• Sustained local delivery of siRNA from an injectable scaffold.

  2012cited by this paper
• RNA-based therapeutics: current progress and future prospects.

  2012cited by this paper
• Sheddable ternary nanoparticles for tumor acidity-targeted siRNA delivery.

  2012cited by this paper
• Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro.

  2012cited by this paper
• Poly(PS-b-DMA) micelles for reactive oxygen species triggered drug release.

  2012cited by this paper
• Polyplexes based on cationic polymers with strong nucleic acid binding properties.

  2012cited by this paper
• Effect of block compositions of amphiphilic block copolymers on the physicochemical properties of polymeric micelles

  2011cited by this paper
• Thermoresponsive block copolymer-protein conjugates prepared by grafting-from via RAFT polymerization.

  2011cited by this paper
• RAFT-synthesized graft copolymers that enhance pH-dependent membrane destabilization and protein circulation times.

  2011cited by this paper
• Physicochemical and Biological Evaluation of siRNA Polyplexes Based on PEGylated Poly(amido amine)s

  2011cited by this paper
• Opsonization, Biodistribution, Cellular Uptake and Apoptosis Study of PEGylated PBCA Nanoparticle as Potential Drug Delivery Carrier

  2011cited by this paper
• MMP-7 as a prognostic marker in colorectal cancer

  2011cited by this paper
• Delivery of intracellular-acting biologics in pro-apoptotic therapies.

  2011cited by this paper
• Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery.

  2011cited by this paper
• Block copolymer conjugates prepared by sequentially grafting from proteins via RAFT

  2011cited by this paper
• Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid.

  2011cited by this paper
• Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

  2010cited by this paper
• Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA-PCL-PDMAEMA triblock copolymers.

  2010cited by this paper
• MMP-7 overexpression is an independent prognostic marker in gastric cancer

  2010cited by this paper
• Comparative study of the expression of metalloproteases and their inhibitors in different localizations within primary tumours and in metastatic lymph nodes of breast cancer

  2010cited by this paper
• Intracellular delivery of a proapoptotic peptide via conjugation to a RAFT synthesized endosomolytic polymer.

  2010cited by this paper
• pH-Responsive nanoparticles for drug delivery.

  2010cited by this paper
• Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility

  2010cited by this paper
• Matrix metalloproteinase (MMP)-7 in salivary gland cancer

  2010cited by this paper
• Intracellular delivery of a protein antigen with an endosomal-releasing polymer enhances CD8 T-cell production and prophylactic vaccine efficacy.

  2010cited by this paper
• pH-responsive polymeric micelle carriers for siRNA drugs.

  2010cited by this paper
• Folate targeted polymeric ‘green’ nanotherapy for cancer

  2010cited by this paper
• Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery.

  2009cited by this paper
• Matrilysin (MMP‐7) cleaves C‐type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity

  2009cited by this paper
• Surface functionalized nanoparticles for proximity-activated detection and imaging of breast cancer.

  2009cited by this paper
• Development of a novel endosomolytic diblock copolymer for siRNA delivery.

  2009cited by this paper
• Genetic polymorphisms in the MMP‐7 gene and breast cancer survival

  2009cited by this paper
• Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases.

  2008cited by this paper
• Predictive value of MMP‐7 expression for response to chemotherapy and survival in patients with non‐small cell lung cancer

  2008cited by this paper
• Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality.

  2008cited by this paper
• Protease-triggered unveiling of bioactive nanoparticles.

  2008cited by this paper
• Proximity-activated nanoparticles: in vitro performance of specific structural modification by enzymatic cleavage

  2008cited by this paper
• Nanoparticle self-assembly gated by logical proteolytic triggers.

  2007cited by this paper
• Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

  2007cited by this paper
• Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

  2007cited by this paper
• pH-responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study.

  2006cited by this paper
• Proteolytic surface functionalization enhances in vitro magnetic nanoparticle mobility through extracellular matrix.

  2006cited by this paper
• Preoperative serum MMP-9 immunoreactive protein is a prognostic indicator for relapse-free survival in breast carcinoma.

  2005cited by this paper
• Matrilysin (MMP‐7) promotes invasion of ovarian cancer cells by activation of progelatinase

  2005cited by this paper
• Advances in RAFT polymerization: the synthesis of polymers with defined end-groups

  2005cited by this paper
• Steric stabilization of poly(2‐(dimethylamino)ethyl methacrylate)‐based polyplexes mediates prolonged circulation and tumor targeting in mice

  2004cited by this paper
• Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity.

  2004cited by this paper
• Expression of MMPs and TIMPs genes in human breast cancer epithelial cells depends on cell culture conditions and is associated with their invasive potential.

  2004cited by this paper
• Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides.

  2003cited by this paper
• Matrix metalloproteinase-2 (MMP-2) is associated with survival in breast carcinoma

  2003cited by this paper
• Polymeric micelle for tumor pH and folate-mediated targeting.

  2003cited by this paper
• Molecular imaging of proteolytic activity in cancer

  2003cited by this paper
• Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas.

  2002cited by this paper
• Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

  2001cited by this paper
• Metalloproteinases: role in breast carcinogenesis, invasion and metastasis

  2000cited by this paper
• Matrix metalloproteinases: multifunctional contributors to tumor progression.

  2000cited by this paper
• Matrix metalloproteinases as emerging targets in anticancer therapy: status and prospects

  2000cited by this paper
• Matrilysin: an epithelial matrix metalloproteinase with potentially novel functions.

  1996cited by this paper
• The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

  1994cited by this paper
• A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

  1986cited by this paper

• Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

  2025cites this paper
• Recent development in targeted gene silencing and cancer therapy by stimuli responsive multifunctional nanoparticles-based drug delivery system

  2025cites this paper
• Engineering approaches for RNA-based and cell-based osteoarthritis therapies

  2024cites this paper
• Smart Nanoplatforms Responding to the Tumor Microenvironment for Precise Drug Delivery in Cancer Therapy

  2024cites this paper
• Therapeutic delivery of siRNA for the management of breast cancer and triple-negative breast cancer.

  2024cites this paper
• Logic "AND Gate Circuit"-Based Gasdermin Protein Expressing Nanoplatform Induces Tumor-Specific Pyroptosis to Enhance Cancer Immunotherapy.

  2024cites this paper
• Design of Vaterite Nanoparticles for Controlled Delivery of Active Immunotherapeutic Proteins

  2024cites this paper
• Enzymatically Activatable Polymers for Disease Diagnosis and Treatment

  2023cites this paper
• Ongoing Clinical Trials of Nonviral siRNA Therapeutics.

  2023cites this paper
• Responsive nanoplatforms: Versatile design strategies for efficient cancer theranostics

  2023cites this paper
• Recent Advancements on Self‐Immolative System Based on Dynamic Covalent Bonds for Delivering Heterogeneous Payloads

  2023cites this paper
• Polymeric Carriers for Delivery of RNA Cancer Therapeutics

  2022cites this paper
• Non-viral vectors for RNA delivery

  2022cites this paper
• Targeted drug delivery in cervical cancer: Current perspectives.

  2022cites this paper
• Design of Smart Size-, Surface-, and Shape-Switching Nanoparticles to Improve Therapeutic Efficacy.

  2021cites this paper
• Smart transformable nanoparticles for enhanced tumor theranostics

  2021cites this paper
• Pharmacological Activation of cGAS for Cancer Immunotherapy

  2021cites this paper
• Coordination of rigidity modulation and targeting ligand modification on orally-delivered nanoparticles for the treatment of liver fibrosis.

  2021cites this paper
• Stimuli Induced Uptake of Protein-Like Peptide Brush Polymers.

  2021cites this paper
• Current Understandings and Clinical Translation of Nanomedicines for Breast Cancer Therapy.

  2021cites this paper
• D2B antibody and its scFvD2B fragment in nanomedicine: promising tools in the theranostics of prostate cancer

  2021cites this paper
• TME-Responsive Multistage Nanoplatform for siRNA Delivery and Effective Cancer Therapy

  2021cites this paper
• Recent Targeted of siRNA Delivery Vehicles for Cancer Therapy

  2021cites this paper
• Bioresponsive nanomedicines based on dynamic covalent bonds.

  2021cites this paper
• Design of polymers for siRNA delivery: Recent progress and challenges

  2021cites this paper
• Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers

  2021cites this paper
• Recent Advances in the Development of Exogenous dsRNA for the Induction of RNA Interference in Cancer Therapy

  2021cites this paper
• Nanotechnology-assisted medical devices in cancer treatment

  2021cites this paper
• Nanotechnological Strategies for Osteoarthritis Diagnosis, Monitoring, Clinical Management, and Regenerative Medicine: Recent Advances and Future Opportunities

  2020cites this paper
• Gene delivery into cells and tissues

  2020cites this paper
• Importance of Nano Medicine and New Drug Therapies for Cancer

  2020cites this paper
• Biodegradable Cationic Nanogels with Tunable Size, Swelling and pKa for Drug Delivery.

  2020cites this paper
• Micelleplex-based nucleic acid therapeutics: from targeted stimuli-responsiveness to nanotoxicity and regulation.

  2020cites this paper
• Self-assembly of pentapeptides into morphology-adaptable nanomedicines for enhanced combinatorial chemo-photodynamic therapy

  2020cites this paper
• Microfluidic-based Holonomic Constraints of siRNA in Kernel of Lipid/Polymer Hybrid Nano-assembles for Improving in vivo Stable and Safe Delivery.

  2020cites this paper
• Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio–Nano Interface

  2019cites this paper
• Nanomedicine for cancer targeted drug delivery, early detection mechanism and therapeutics

  2019cites this paper
• Nanoparticle-Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions.

  2019cites this paper
• MMP-2-Controlled Transforming Micelles for Heterogeneic Targeting and Programmable Cancer Therapy

  2019cites this paper
• Cartilage-targeting and dual MMP-13/pH responsive theranostic nanoprobes for osteoarthritis imaging and precision therapy.

  2019cites this paper
• Tumor targeting and microenvironment-responsive multifunctional fusion protein for pro-apoptotic peptide delivery.

  2019cites this paper
• Advanced architectures in the design of responsive polymers for cancer nanomedicine.

  2018cites this paper
• Advances in Stimulus‐Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids

  2018cites this paper
• Matrix Metalloproteinase-9-Responsive Nanogels for Proximal Surface Conversion and Activated Cellular Uptake.

  2018cites this paper
• In vivo tumor gene delivery using novel peptideticles: pH‐responsive and ligand targeted core–shell nanoassembly

  2018cites this paper
• Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery.

  2018cites this paper
• Recent advances in siRNA delivery for cancer therapy using smart nanocarriers.

  2018cites this paper
• MMP-Responsive 'Smart' Drug Delivery and Tumor Targeting.

  2018cites this paper
• Targeting the extracellular matrix for delivery of bioactive molecules to sites of arthritis

  2018cites this paper
• Enhanced nanoparticle delivery exploiting tumour-responsive formulations

  2018cites this paper
• Intracellular delivery of peptide drugs using viral nanoparticles of bacteriophage P22: covalent loading and cleavable release.

  2018cites this paper
• DESIGN AND SYNTHESIS OF STIMULI-RESPONSIVE POLYMERIC NANOGELS TOWARDS THERAPEUTIC TRANSLATION

  2018cites this paper
• Matrix metalloprotease triggered bioresponsive drug delivery systems – Design, synthesis and application

  2018cites this paper
• From organelle over cell to tissue: Development of fluorescence-based methods to monitor the fate of model transporting structures

  2018cites this paper
• Development Of Nanoparticles To Leverage Permeability Of Dysfunctional Endothelial Glycocalyx

  2018cites this paper
• Post-nano strategies for drug delivery: Multistage porous silicon microvectors.

  2017cites this paper
• Matrix metalloproteases-responsive nanomaterials for tumor targeting diagnosis and treatment

  2017cites this paper
• Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.

  2017cites this paper
• siRNA Delivery Strategies: A Comprehensive Review of Recent Developments

  2017cites this paper
• Biologically Triggered Delivery of EGF from Polymer Fiber Patches.

  2017cites this paper
• Engineered polymeric nanoparticles to guide the cellular internalization and trafficking of small interfering ribonucleic acids

  2017cites this paper
• The principles and applications of avidin‐based nanoparticles in drug delivery and diagnosis

  2017cites this paper
• Nonviral cancer gene therapy: Delivery cascade and vector nanoproperty integration☆

  2017cites this paper
• Matrix‐metalloproteinases as targets for controlled delivery in cancer: An analysis of upregulation and expression

  2017cites this paper
• Strategies for using nanoprobes to perceive and treat cancer activity: a review

  2017cites this paper
• Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple‐Negative Breast Cancer

  2017cites this paper
• Dual Enzymatic Reaction-Assisted Gemcitabine Delivery Systems for Programmed Pancreatic Cancer Therapy.

  2017cites this paper
• Redox activated polymeric nanoparticles in tumor therapy

  2017cites this paper
• ANTIOXIDANT MICROSPHERES AS DRUG DELIVERY VEHICLES FOR THE PREVENTION OF POST-TRAUMATIC OSTEOARTHRITIS By

  2017cites this paper
• Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer

  2017cites this paper
• The In Vitro and In Vivo Response to MMP-Sensitive Poly(Ethylene Glycol) Hydrogels

  2016cites this paper
• Enzymatically Degradable Poly(ethylene glycol) Hydrogels for Diverse Tissue Engineering Applications and for the Study of the Foreign Body Response

  2016influential citation
• Matrix Metalloproteinase-Sensitive Nanocarriers

  2016cites this paper
• Delivery of nucleic acids for cancer gene therapy : overcoming extra-and intracellular

  2016cites this paper
• Diabetic Retinopathy: Battling the Global Epidemic

  2016cites this paper
• Diabetic retinopathy: Battling the global epidemic

  2016cites this paper
• Ideal and Reality: Barricade in the Delivery of Small Interfering RNA for Cancer Therapy.

  2016cites this paper
• Recent progress in development of siRNA delivery vehicles for cancer therapy.

  2016cites this paper
• A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics.

  2016cites this paper
• Hydrolytic charge-reversal of PEGylated polyplexes enhances intracellular un-packaging and activity of siRNA.

  2016cites this paper
• Endothelial glycocalyx conditions influence nanoparticle uptake for passive targeting

  2016cites this paper
• Particle-based technologies for osteoarthritis detection and therapy

  2016cites this paper
• Delivery of nucleic acids for cancer gene therapy: overcoming extra- and intra-cellular barriers.

  2016cites this paper
• Temperature-Responsive Gene Silencing by a Smart Polymer.

  2016cites this paper
• Enzyme-responsive multistage vector for drug delivery to tumor tissue.

  2016cites this paper
• Polymeric nanoparticles for gene delivery

  2016cites this paper
• Hydrophilicity/Hydrophobicity reversable and redox-sensitive nanogels for anticancer drug delivery.

  2015cites this paper
• Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors.

  2015cites this paper
• Oligoproline-derived nanocarrier for dual stimuli-responsive gene delivery

  2015cites this paper
• Mesoporous silica–chondroitin sulphate hybrid nanoparticles for targeted and bio-responsive drug delivery

  2015cites this paper
• Tumor Intracellular‐Environment Responsive Materials Shielded Nano‐Complexes for Highly Efficient Light‐Triggered Gene Delivery without Cargo Gene Damage

  2015cites this paper
• Multifunctional Delivery Systems for Cancer Gene Therapy

  2015cites this paper
• Biocompatible mannosylated endosomal-escape nanoparticles enhance selective delivery of short nucleotide sequences to tumor associated macrophages.

  2015cites this paper
• Chapter 3 Multifunctional Delivery Systems for Cancer Gene Therapy

  2015influential citation
• Technologies for controlled, local delivery of siRNA.

  2015cites this paper
• Recent Advances in Targeted, Self‐Assembling Nanoparticles to Address Vascular Damage Due to Atherosclerosis

  2015cites this paper
• Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers.

  2015cites this paper
• Tunable Delivery of siRNA from a Biodegradable Scaffold to Promote Angiogenesis In Vivo

  2014cites this paper
• Nanotechnology for cancer treatment

  2014cites this paper
• Smart nanocarrier: self-assembly of bacteria-like vesicles with photoswitchable cilia.

  2014cites this paper