Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Nature

• Publication date

  2012-05-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature11133PMID 22622570
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The fusion of early endosomes induces molecular-motor-driven tubule formation and fission

  2012cited by this paper
• Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin

  2011cited by this paper
• Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores

  2011cited by this paper
• Recycling endosomes in apical plasma membrane domain formation and epithelial cell polarity.

  2010cited by this paper
• Lipid-like materials for low-dose, in vivo gene silencing

  2010cited by this paper
• Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

  2010cited by this paper
• Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms.

  2010cited by this paper
• Systems survey of endocytosis by multiparametric image analysis

  2010cited by this paper
• Identification of the switch in early-to-late endosome transition.

  2010cited by this paper
• Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

  2009cited by this paper
• Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells

  2009cited by this paper
• Apical trafficking in epithelial cells: signals, clusters and motors

  2009cited by this paper
• Rab5 Isoforms Differentially Regulate the Trafficking and Degradation of Epidermal Growth Factor Receptors*

  2009cited by this paper
• Endocytosis as an Essential Process in Liver Function and Pathology

  2009cited by this paper
• Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45.

  2008cited by this paper
• Membrane identity and GTPase cascades regulated by toggle and cut-out switches

  2008cited by this paper
• A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

  2008cited by this paper
• Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells

  2008cited by this paper
• Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins

  2007cited by this paper
• Unsolved mysteries in membrane traffic.

  2007cited by this paper
• SNAREs — engines for membrane fusion

  2006cited by this paper
• Rab7 Associates with Early Endosomes to Mediate Sorting and Transport of Semliki Forest Virus to Late Endosomes

  2005cited by this paper
• Generation of nonidentical compartments in vesicular transport systems

  2005cited by this paper
• Rab conversion as a mechanism of progression from early to late endosomes.

  2005cited by this paper
• Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells.

  2005cited by this paper
• Intracellular trafficking of bile salt export pump (ABCB11) in polarized hepatic cells: constitutive cycling between the canalicular membrane and rab11-positive endosomes.

  2004cited by this paper
• The maintenance and generation of membrane polarity in hepatocytes

  2004cited by this paper
• Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells

  2004cited by this paper
• Review The Mechanisms of Vesicle Budding and Fusion

  2004cited by this paper
• The mechanisms of vesicle budding and fusion.

  2004cited by this paper
• Adaptable adaptors for coated vesicles.

  2004cited by this paper
• Glycogen Storage Diseases

  2003cited by this paper
• Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release

  2003cited by this paper
• A subset of yeast vacuolar protein sorting mutants is blocked in one branch of the exocytic pathway

  2002cited by this paper
• Sequential Roles for Phosphatidylinositol 3-Phosphate and Rab5 in Tethering and Fusion of Early Endosomes via Their Interaction with EEA1* 210

  2002cited by this paper
• Transporters on Demand

  2001cited by this paper
• Rab proteins as membrane organizers

  2001cited by this paper
• The Rab5 effector EEA1 is a core component of endosome docking

  1999cited by this paper
• Apical Plasma Membrane Proteins and Endolyn-78 Travel through a Subapical Compartment in Polarized WIF-B Hepatocytes

  1998cited by this paper
• Endocytosis.

  1997cited by this paper
• Endocytosis and molecular sorting.

  1996cited by this paper
• GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

  1996cited by this paper
• Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin

  1995cited by this paper
• Newly Synthesized Transferrin Receptors Can Be Detected in the Endosome before They Appear on the Cell Surface (*)

  1995cited by this paper
• Co‐operative regulation of endocytosis by three RAB5 isoforms

  1995cited by this paper
• Membrane transport in the endocytic pathway.

  1995cited by this paper
• Mutations in human dynamin block an intermediate stage in coated vesicle formation

  1993cited by this paper
• The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway.

  1992cited by this paper
• rab5 controls early endosome fusion in vitro.

  1991cited by this paper
• Transformational process of the endosomal compartment in nephrocytes of Drosophila melanogaster

  1990cited by this paper
• Hepatic metabolism of colloidal gold‐low‐density lipoprotein complexes in the rat: Evidence for bulk excretion of lysosomal contents into bile

  1989cited by this paper
• Endocytosis

  1985cited by this paper
• The Liver: Biology and Pathobiology

  1983cited by this paper
• Glycogen storage diseases

  1969cited by this paper

• The Rab5 effector Rabankyrin-5 mediates endosomal fusion and trafficking of human papillomavirus during early entry.

  2026cites this paper
• Rab5 Nucleotide Binding Promotes Oxidative Metabolism to Fuel Hepatocellular Carcinoma Cell Proliferation.

  2026cites this paper
• Amelioration of Acetaminophen-Induced Hepatic Oxidative Stress and Inflammation by RNAi Targeting Cyp2e1 In Vivo

  2025cites this paper
• Potential Roles of SNX17, Rab11, and Rab5 in LDLR Recycling.

  2025cites this paper
• Human assembloids recapitulate periportal liver tissue in vitro

  2025cites this paper
• Anti-EGFR therapy can overcome acquired resistance to the third-generation ALK-tyrosine kinase inhibitor lorlatinib mediated by activation of EGFR

  2025cites this paper
• The Rab5 effector Rabankyrin-5 mediates endosomal fusion and trafficking of Human Papillomavirus during early entry

  2025cites this paper
• Rab10 plays a protective role in the development of pathological cardiac hypertrophy

  2025cites this paper
• LncRNA Xist acts as a miR-486-5p sponge to modulate myoblast proliferation by recruiting Stk4

  2025cites this paper
• Integrated technologies for molecular profiling of genetic and modified biomarkers in extracellular vesicles.

  2025cites this paper
• Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly

  2025cites this paper
• The dynamics of ubiquitination and its role within the proteome of extracellular vesicles.

  2025cites this paper
• Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems

  2025cites this paper
• Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy

  2025cites this paper
• A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis

  2025cites this paper
• Spatial organization of phosphoinositide signaling.

  2025cites this paper
• RAB5 NUCLEOTIDE BINDING PROMOTES β-OXIDATION TO FUEL HEPATOCELLULAR CARCINOMA CELL PROLIFERATION

  2025cites this paper
• Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose

  2025cites this paper
• Targeting RPSA to modulate endosomal trafficking and amyloidogenesis in genetic Alzheimer's disease.

  2025cites this paper
• Focal Adhesion Kinase inhibition induces membrane accumulation of aquaporin-2 in renal epithelial cells by actin depolymerization and endocytosis inhibition.

  2025cites this paper
• The multiple facets of Rab proteins modulating the cellular distribution of cholesterol from the late endosomal compartment.

  2025cites this paper
• Cell cycle dependent variation in endocytosis drives phenotypic diversity in M. tuberculosis

  2025cites this paper
• Identification of Rab GTPase‐Activating Proteins Required for Tubular Endosome Formation

  2025cites this paper
• The protein cargo of extracellular vesicles. Recent advances in lung cancer research.

  2025cites this paper
• Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo

  2025cites this paper
• Fluorescent, phosphorescent, magnetic resonance contrast and radioactive tracer labelling of extracellular vesicles.

  2024cites this paper
• Reducing Oxidative Stress-Mediated Alcoholic Liver Injury by Multiplexed RNAi of Cyp2e1, Cyp4a10, and Cyp4a14

  2024cites this paper
• Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex

  2024cites this paper
• Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

  2024cites this paper
• The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation

  2024cites this paper
• Integrin α6‐containing extracellular vesicles promote lymphatic remodelling for pre‐metastatic niche formation in lymph nodes via interplay with CD151

  2024cites this paper
• DRG2 is required for surface localization of PD-L1 and the efficacy of anti-PD-1 therapy

  2024cites this paper
• GNG5 is a novel regulator of Aβ42 production in Alzheimer’s disease

  2024cites this paper
• The beta 2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors.

  2024cites this paper
• A trafficking regulatory subnetwork governs αVβ6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance

  2024cites this paper
• The Role of RIN3 Gene in Alzheimer’s Disease Pathogenesis: a Comprehensive Review

  2023cites this paper
• IST1 regulates select recycling pathways

  2023cites this paper
• Emergent Spatiotemporal Organization in Stochastic Intracellular Transport Dynamics.

  2023cites this paper
• The impact of multiplicative noise on Rab5/Rab7 protein dynamics and escape of pH-sensitive nanoparticles and viruses from endosomes

  2023cites this paper
• Yck3 casein kinase-mediated phosphorylation determines Ivy1 localization and function at endosomes and vacuole.

  2023cites this paper
• A Bispecific METxMET Antibody–Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes

  2023cites this paper
• The Role of Rab Proteins in Mitophagy: Insights into Neurodegenerative Diseases

  2023cites this paper
• Rme-6 integrates EGFR trafficking and signalling to regulate ERK1/2 signalosome dynamics

  2023cites this paper
• Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease

  2023cites this paper
• Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner

  2023cites this paper
• BAR domain is essential for early endosomal trafficking and dynamics in Ascochyta rabiei

  2023cites this paper
• Phosphoinositide 3-kinase (PI3K) classes: From cell signaling to endocytic recycling and autophagy.

  2023cites this paper
• The Roles of Exosomal Proteins: Classification, Function, and Applications

  2023cites this paper
• Insights into the role of the membranes in Rab GTPase regulation.

  2023cites this paper
• NECAB2 is an endosomal protein important for striatal function.

  2023cites this paper
• Research Progress on the Mechanism of Nanoparticles Crossing the Intestinal Epithelial Cell Membrane

  2023influential citation
• Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1

  2023cites this paper
• IST1 regulates select recycling pathways

  2023cites this paper
• Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1.

  2022cites this paper
• Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

  2022cites this paper
• Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation.

  2022cites this paper
• Poly(ADP-ribose) Polymerase 1 Mediates Rab5 Inactivation after DNA Damage

  2022cites this paper
• The Rabep1-Mediated Endocytosis and Activation of Trypsinogen to Promote Pancreatic Stellate Cell Activation

  2022cites this paper
• Rab21 in enterocytes participates in intestinal epithelium maintenance

  2022cites this paper
• Stochastic Model of Virus–Endosome Fusion and Endosomal Escape of pH-Responsive Nanoparticles

  2022cites this paper
• Down Syndrome Fetal Fibroblasts Display Alterations of Endosomal Trafficking Possibly due to SYNJ1 Overexpression

  2022influential citation
• ER Disposal Pathways in Chronic Liver Disease: Protective, Pathogenic, and Potential Therapeutic Targets

  2022cites this paper
• Ribosomal leaky scanning through a translated uORF requires eIF4G2

  2022cites this paper
• Exosomal microRNAs as Potential Biomarkers and Therapeutic Agents for Acute Ischemic Stroke: New Expectations

  2022cites this paper
• Phosphoinositides as membrane organizers

  2022cites this paper
• The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity

  2022influential citation
• Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.

  2022cites this paper
• Endosomal trafficking in metabolic homeostasis and diseases

  2022cites this paper
• Deciphering the interplay between autophagy and polarity in epithelial tubulogenesis.

  2022cites this paper
• Emerging degrader technologies engaging lysosomal pathways

  2022cites this paper
• The Possible Role of Chronic Infection in the Etiopathogenesis of a Case of 5q-Syndrome Associated with Tuberculosis and Abnormality of the X Chromosome

  2022influential citation
• NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition

  2021cites this paper
• Hepatocytes and Their Role in Metabolism

  2021cites this paper
• Rab5ab-Mediated Yolk Cell Membrane Endocytosis Is Essential for Zebrafish Epiboly and Mechanical Equilibrium During Gastrulation

  2021cites this paper
• RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation

  2021cites this paper
• Hepatocytes and Its Role in Metabolism

  2021cites this paper
• Mitochondrial dysfunction and autophagy in neurodegeneration

  2021cites this paper
• Centrosomal P4.1-associated protein (CPAP) positively regulates endocytic vesicular transport and lysosome targeting of EGFR

  2021cites this paper
• Actin and an unconventional myosin motor, TgMyoF, control the organization and dynamics of the endomembrane network in Toxoplasma gondii.

  2021cites this paper
• Alcohol‐Induced Liver Injury: Down‐regulation and Redistribution of Rab3D Results in Atypical Protein Trafficking

  2021cites this paper
• Early Endosomal GTPase Rab5 (Ras-Related Protein in Brain 5) Regulates GPIbβ (Glycoprotein Ib Subunit β) Trafficking and Platelet Production In Vitro

  2021cites this paper
• Identification of a new, Rab14-dependent, endo-lysosomal pathway

  2021cites this paper
• Tumor‐derived exosomes: Key players in non‐small cell lung cancer metastasis and their implication for targeted therapy

  2021cites this paper
• Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function

  2021cites this paper
• AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake

  2021cites this paper
• Exploiting the Potential of Drosophila Models in Lysosomal Storage Disorders: Pathological Mechanisms and Drug Discovery

  2021cites this paper
• The ESCRT-III molecules regulate the apical targeting of bile salt export pump

  2021cites this paper
• NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses

  2021cites this paper
• Identification of Specific Trafficking Defects of Naturally Occurring Variants of the Human ABCG2 Transporter

  2021cites this paper
• Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads

  2021cites this paper
• Bulkhead-like apical membrane structures between hepatocytes are required for anisotropic lumen expansion and liver tissue morphogenesis

  2021cites this paper
• Establishment and analysis of conditional Rab1 and Rab5 knockout cells by using the auxin-inducible degron system.

  2021cites this paper
• Glycans in autophagy, endocytosis and lysosomal functions

  2021cites this paper
• The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7.

  2021cites this paper
• Pathophysiological Potentials of NRF3-Regulated Transcriptional Axes in Protein and Lipid Homeostasis

  2021cites this paper
• Hematopoietically-expressed homeobox protein HHEX regulates adipogenesis in preadipocytes.

  2021cites this paper
• Endocytosis in the adaptation to cellular stress

  2020cites this paper
• Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes

  2020cites this paper
• Modulation of fungal virulence through CRZ1 regulated F-BAR-dependent actin remodeling and endocytosis in chickpea infecting phytopathogen Ascochyta rabiei

  2020cites this paper
• Fusion and fission events regulate endosome maturation and viral escape

  2020influential citation