TAp63 prevents premature aging by promoting adult stem cell maintenance.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cell Stem Cell

• Publication date

  2009-07-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.stem.2009.04.003PMID 19570515PMCID PMC3418222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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  1997influential reference
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