Differentiation between Cell Death Modes Using Measurements of Different Soluble Forms of Extracellular Cytokeratin 18

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Cancer Research

• Publication date

  2004-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-03-2455PMID 14996736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Cytokeratin].

  2020cited by this paper
• Measurement of an apoptotic product in the sera of breast cancer patients.

  2003cited by this paper
• Nuclear medicine imaging to predict response to radiotherapy: a review.

  2003cited by this paper
• A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera

  2003cited by this paper
• Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

  2003cited by this paper
• Chemotherapy response and resistance.

  2003cited by this paper
• Monitoring apoptosis in real time.

  2002cited by this paper
• A Novel High-Through-Put Assay for Screening of Pro-Apoptotic Drugs

  2002cited by this paper
• Visualization of cell death in vivo with the annexin A5 imaging protocol.

  2002cited by this paper
• End points in cancer clinical trials and the drug approval process.

  2002cited by this paper
• Increased uptake of the apoptosis-imaging agent (99m)Tc recombinant human Annexin V in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis.

  2002cited by this paper
• Tumor senescence as a determinant of drug response in vivo.

  2002cited by this paper
• Release of cytokeratin‐18 and ‐19 fragments (TPS and CYFRA 21‐1) into the extracellular space during apoptosis

  2002cited by this paper
• A concomitant ATP-depleting strategy markedly enhances anticancer agent activity

  2001cited by this paper
• Does resistance to apoptosis affect clinical response to antitumor drugs?

  2001cited by this paper
• Effect of Mutation and Phosphorylation of Type I Keratins on Their Caspase-mediated Degradation*

  2001cited by this paper
• Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy.

  2001cited by this paper
• The role of caspase 3 in producing cytokeratin 19 fragment (CYFRA21‐1) in human lung cancer cell lines

  2001cited by this paper
• The Versatility of Cytokeratins asTumor Markers

  2000cited by this paper
• Quantitative measurement of soluble cytokeratin fragments in tissue cytosol of 599 node negative breast cancer patients: a prognostic marker possibly associated with apoptosis

  2000cited by this paper
• Induction of apoptosis by cancer chemotherapy.

  2000cited by this paper
• Immunocytochemical detection and mapping of a cytokeratin 18 neo‐epitope exposed during early apoptosis

  1999cited by this paper
• Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group.

  1999cited by this paper
• Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

  1999cited by this paper
• Post-therapy serum prostate-specific antigen level and survival in patients with androgen-independent prostate cancer.

  1999cited by this paper
• Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast

  1999cited by this paper
• Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor.

  1998cited by this paper
• Surface exposure of phosphatidylserine during apoptosis of rat thymocytes precedes nuclear changes.

  1998cited by this paper
• Dysregulation of apoptosis in cancer.

  1998cited by this paper
• Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

  1997cited by this paper
• Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

  1997cited by this paper
• Apoptosis Generates Stable Fragments of Human Type I Keratins*

  1997cited by this paper
• Caspase Cleavage of Keratin 18 and Reorganization of Intermediate Filaments during Epithelial Cell Apoptosis

  1997cited by this paper
• Apoptosis in cancer.

  1996cited by this paper
• Molecular characterization of a tissue-polypeptide-specific-antigen epitope and its relationship to human cytokeratin 18.

  1996cited by this paper
• Significance of cytokeratin markers TPA, TPA (cyk), TPS and CYFRA 21.1 in metastatic disease.

  1996cited by this paper
• Kinetics of cisplatin‐induced apoptosis in murine mammary and ovarian adenocarcinomas

  1995cited by this paper
• Apoptosis in cancer therapy: crossing the threshold.

  1994cited by this paper
• Oncogene activation of human keratin 18 transcription via the Ras signal transduction pathway.

  1994cited by this paper
• Cyfra 21-1, a new marker of lung cancer.

  1994cited by this paper
• Hypoxia and drug resistance

  1994cited by this paper
• CYFRA 21-1, a sensitive and specific new tumour marker for squamous cell lung cancer. Report of the first European multicentre evaluation. CYFRA 21-1 Multicentre Study Group.

  1994cited by this paper
• Serum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer.

  1993cited by this paper
• A significant soluble keratin fraction in 'simple' epithelial cells. Lack of an apparent phosphorylation and glycosylation role in keratin solubility.

  1993cited by this paper
• CYFRA 21‐1: A new marker in lung cancer

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• Tissue polypeptide antigen (TPA) is related to the non‐epidermal keratins 8, 18 and 19 typical of simple and non‐squamous epithelia: re‐evaluation of a human tumor marker.

  1984cited by this paper
• Tissue polypeptide antigen (TPA): Biology, biochemistry, improved assay methodology, clinical significance in cancer and other conditions, and future outlook.

  1978cited by this paper

• Modulation of cytokeratin and cytokine/chemokine expression following influenza virus infection of differentiated human tonsillar epithelial cells

  2025cites this paper
• In vitro liver models for toxicological research.

  2025cites this paper
• Apoptosis markers in children with metabolic-associated fatty liver disease: a preliminary study

  2025cites this paper
• Serum Markers as predictors for treatment benefit in castration-resistant prostate cancer.

  2025cites this paper
• Plasma cytokeratin-18 fragment in adult patients with newly diagnosed acute myeloid leukemia

  2025cites this paper
• Genista cephalantha Spach. protects against acetaminophen-induced liver failure via preserving the glutathione redox system, reducing inflammatory response, and inhibiting hepatocyte death in rats

  2024cites this paper
• Can serum M30 levels be utilized as an activation marker in patients with ulcerative colitis?

  2024cites this paper
• A brief overview of drug-induced liver damage

  2024cites this paper
• Antimicrobial Functions of Galectins from Fish, Mollusks, and Crustaceans: A Review.

  2024cites this paper
• Current trends in luminescence-based assessment of apoptosis

  2023cites this paper
• Serum Cytokeratin 18 as a Potential Early Marker for Chemotherapy Response in Breast Cancer Patients: A Prospective Study

  2023cites this paper
• Can M-30, M-65, and IL-6 serum levels be useful markers in the diagnosis of preeclampsia and gestational diabetes?

  2023cites this paper
• Dialog beyond the Grave: Necrosis in the Tumor Microenvironment and Its Contribution to Tumor Growth

  2023cites this paper
• Early alveolar epithelial cell necrosis is a potential driver of COVID-19-induced acute respiratory distress syndrome

  2022cites this paper
• Early Alveolar Epithelial Cell Necrosis is a Potential Driver of ARDS with COVID-19

  2022cites this paper
• Cell death and ischemia-reperfusion injury in lung transplantation.

  2022cites this paper
• A new detection system for serum fragmented cytokeratin 18 as a biomarker reflecting histologic activities of human nonalcoholic steatohepatitis

  2022cites this paper
• Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses

  2022cites this paper
• Cell-free DNA Release in the Plasma of Patients with Cardiac Disease is Associated with Cell Death Processes

  2022cites this paper
• Major methods and technologies for assessing cell death

  2022cites this paper
• RETRACTED ARTICLE: Hsa-miR-186-3p suppresses colon cancer progression by inhibiting KRT18/MAPK signaling pathway

  2022cites this paper
• Emerging Biomarkers in Alcohol-associated Hepatitis.

  2022cites this paper
• The prognostic potential of fragmented CK18 serum levels in HCC patients reflecting disease progression and overall hepatocyte damage

  2022cites this paper
• Galectin-9 suppresses the tumor growth of colon cancer in vitro and in vivo

  2021cites this paper
• Investigating Novel and Conventional Biomarkers for Post-resuscitation Prognosis: The Role of Cytokeratin-18, Neuron-specific Enolase, and Lactate

  2021cites this paper
• Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective

  2021cites this paper
• Anticancer Activity of Biogenic Selenium Nanoparticles: Apoptotic and Immunogenic Cell Death Markers in Colon Cancer Cells

  2021cites this paper
• Immunohistochemical Evaluation of M30 and M65 in Barrett’s Esophagus and Esophageal Cancer

  2021cites this paper
• The Use of Keratins as Lung Cell Differentiation Markers and as a Diagnostic Tool in Lung Cancer

  2021cites this paper
• KRT18 Modulates Alternative Splicing of Genes Involved in Proliferation and Apoptosis Processes in Both Gastric Cancer Cells and Clinical Samples

  2021cites this paper
• Development of a highly sensitive chemiluminescent enzyme immunoassay for fragmented cytokeratin 18 using new antibodies

  2021cites this paper
• Current and Future Biomarkers in Alcoholic Hepatitis.

  2021cites this paper
• Diagnostic and Prognostic Value of M 30 and M 65 in Laryngeal Squamous Cell Carcinoma

  2021influential citation
• Total Keratin-18 (M65) as a Potential, Early, Non-Invasive Biomarker of Hepatocyte Injury in Alcohol Intoxicated Adolescents—A Preliminary Study

  2021cites this paper
• The application of cytokeratin-18 as a biomarker for drug-induced liver injury

  2021cites this paper
• Matrix and Sampling Effects on Quantification of Protein Biomarkers of Drug-Induced Liver Injury.

  2021cites this paper
• Serum Cytokeratin 18 as a Metastatic and Therapeutic Marker for Extramammary Paget’s Disease

  2021cites this paper
• Immunological Aspects of AXL/GAS‐6 in the Context of Human Liver Regeneration

  2021cites this paper
• Efficacy and Safety of Emricasan in Liver Cirrhosis and/or Fibrosis

  2021cites this paper
• Serum caspase-cleaved cytokeratin-18 fragment as a prognostic biomarker in hematological patients with febrile neutropenia

  2021cites this paper
• Natural products as a means of overcoming cisplatin chemoresistance in bladder cancer

  2020influential citation
• Time-Course Changes of Serum Keratin Concentrations after Liver Transplantation: Contrasting Results of Keratin-18 and Keratin-19 Fragments

  2020cites this paper
• Systemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancer

  2020cites this paper
• Generation of Rat Monoclonal Antibody for Cytokeratin 18 by Immunization of Three-Dimensional-Cultured Cancer Cells

  2020cites this paper
• RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells

  2020cites this paper
• Direct Peritoneal Resuscitation Reduces Lung Injury and Caspase 8 Activity in Brain Death*

  2020cites this paper
• Novel Liquid Biomarker Panels for A Very Early Response Capturing of NSCLC Therapies in Advanced Stages

  2020cites this paper
• Necrosis Rather Than Apoptosis is The Dominant form of Alveolar Epithelial Cell Death In Lipopolysaccharide-Induced Experimental Acute Respiratory Distress Syndrome Model.

  2020cites this paper
• The role of noninvasive biomarkers in diagnosis and risk stratification in nonalcoholic fatty liver disease

  2020cites this paper
• Significance of apoptosis and autophagy of leukemic blasts for the outcomes of acute myeloid leukemia patients.

  2019cites this paper
• First-inHuman Clinical Trial of Oral ONC 201 in Patients with Refractory Solid Tumors

  2019cites this paper
• Emerging Circulating Biomarkers for The Diagnosis and Assessment of Treatment Responses in Patients with Hepatic Fat Accumulation, Nash and Liver Fibrosis

  2019cites this paper
• Introduction to the Virtual Issue "Translational Studies in AUD: Liver Disease".

  2019cites this paper
• Pharmacodynamic Therapeutic Drug Monitoring for Cancer: Challenges, Advances, and Future Opportunities.

  2019cites this paper
• The roles of M30 and M65 in the assessment of treatment response and prognosis in patients with non-small cell lung cancer, who receive neoadjuvant treatment

  2019influential citation
• A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis.

  2019cites this paper
• Molecular pharmacology and antitumor activity of in several human cancer cell lines

  2019cites this paper
• Circulating Biomarkers of Cell Death.

  2019cites this paper
• Prognostic value of non-invasive serum Cytokeratin 18 detection in gastrointestinal cancer: a meta-analysis

  2019cites this paper
• Differential Involvement of Autophagy and Apoptosis in Response to Chemoendocrine and Endocrine Therapy in Breast Cancer: JBCRG-07TR

  2019cites this paper
• Effects of Warm Versus Cold Ischemic Donor Lung Preservation on the Underlying Mechanisms of Injuries During Ischemia and Reperfusion

  2018cites this paper
• Circulating tumor cells, tumor-derived extracellular vesicles and plasma cytokeratins in castration-resistant prostate cancer patients

  2018cites this paper
• An Introduction to DILIsym ® Software, a Mechanistic Mathematical Representation of Drug-Induced Liver Injury

  2018cites this paper
• Serum Caspase-Cleaved Cytokeratin (M30) Indicates Severity of Liver Dysfunction and Predicts Liver Outcome

  2018cites this paper
• Technological Advances in Organ Transplantation

  2018cites this paper
• 6 Cytokeratin 18 ( CK 18 ) and CK 18 Fragments for Detection of Minimal Residual Disease in Colon Cancer Patients

  2018cites this paper
• From TRAIL to ONC201: Case Study on the Safety Benefit of Developing Targeted Agents Against Cancer-selective Pathways

  2018cites this paper
• Serum CK 18-M30 reflect liver pathological severity during NAFLD progression in a rat model.

  2018cites this paper
• Effect of Synbiotic and Probiotic Supplementation on Serum Levels of Endothelial Cell Adhesion Molecules in Hemodialysis Patients: a Randomized Control Study

  2018cites this paper
• Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury.

  2018cites this paper
• Caspase-Cleaved Cytokeratin 18 as a Potential Molecular Biomarker for Monitoring Chemotherapeutic Response in Breast Cancer Patients

  2018cites this paper
• Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury in patients following kidney transplantation – results of an observational pilot study

  2018cites this paper
• Evaluation of liver function by means of serum cytokeratin 18 and hepatocyte growth factor levels in patients with obstructive jaundice

  2018cites this paper
• Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA.

  2018cites this paper
• Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis

  2018cites this paper
• The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance

  2018cites this paper
• Drug-induced liver injury: a safety review

  2018cites this paper
• Multivariate metabotyping of plasma accurately predicts survival in patients with decompensated cirrhosis *

  2017cites this paper
• MicroRNA profiles during galectin-9-induced apoptosis of pancreatic cancer cells.

  2017cites this paper
• Enhancement of glycolysis by inhibition of oxygen‐sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury

  2017cites this paper
• Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells

  2017cites this paper
• Higher M30 and high mobility group box 1 protein levels in ex vivo lung perfusate are associated with primary graft dysfunction after human lung transplantation.

  2017cites this paper
• Explorer Refining Liver Safety Risk Assessment

  2017cites this paper
• A mutation in keratin 18 that causes caspase-digestion resistance protects homozygous transgenic mice from hepatic apoptosis and injury

  2017cites this paper
• Ex Vivo Organ Repair (Drug and Gene Delivery)

  2017cites this paper
• Population Pharmacokinetics of Liposomal Irinotecan in Patients With Cancer

  2017cites this paper
• Cell Death and Prognosis of Mortality in Alcoholic Hepatitis Patients Using Plasma Keratin-18.

  2017cites this paper
• The transformation in biomarker detection and management of drug‐induced liver injury

  2017cites this paper
• Liver Injury and Endotoxemia in Male and Female Alcohol‐Dependent Individuals Admitted to an Alcohol Treatment Program

  2017cites this paper
• M30/M65 ratio predicts the outcome of paclitaxel chemotherapy for NSCLC

  2017cites this paper
• The selective peroxisome proliferator–activated receptor‐delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice

  2017cites this paper
• First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors

  2017cites this paper
• Serological Epithelial Component Proteins Identify Intestinal Complications in Crohn's Disease*

  2017cites this paper
• Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials

  2017cites this paper
• Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells.

  2017cites this paper
• Cell death biomarker M65 is a useful indicator of liver inflammation and fibrosis in chronic hepatitis B

  2017cites this paper
• Cytokeratin-18 and uric acid predicts disease severity in Taiwanese nonalcoholic steatohepatitis patients

  2017cites this paper
• Cell death markers in patients with cirrhosis and acute decompensation

  2017cites this paper
• Complementary Role of Fibroblast Growth Factor 21 and Cytokeratin 18 in Monitoring the Different Stages of Nonalcoholic Fatty Liver Disease

  2017cites this paper
• Galectin-9 suppresses the proliferation of gastric cancer cells in vitro.

  2016cites this paper