Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Cell Proliferation

• Publication date

  2011-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1365-2184.2011.00783.xPMID 22011009PMCID PMC6496784
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1990cited by this paper
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  1984cited by this paper

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