Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Toxicology and Applied Pharmacology

• Publication date

  2010-02-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.taap.2009.11.010PMID 19914271PMCID PMC2819613
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of glutathione synthesis.

  2009cited by this paper
• Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase.

  2009cited by this paper
• Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes.

  2009influential reference
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase.

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• Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.

  2007influential reference
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  2007cited by this paper
• Knock Down of γ-Glutamylcysteine Synthetase in Rat Causes Acetaminophen-induced Hepatotoxicity*

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• Knock down of gamma-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity.

  2007influential reference
• Modulating Longevity in Drosophila by Over‐ and Underexpression of Glutamate‐Cysteine Ligase

  2007influential reference
• Over expression of glutamate cysteine ligase increases cellular resistance to H2O2‐induced DNA single‐strand breaks

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• Differential regulation of glutamate‐cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation

  2006influential reference
• The kinetics and tissue distribution of protein transduction in mice.

  2006cited by this paper
• Overexpression of Glutamate-Cysteine Ligase Extends Life Span in Drosophila melanogaster*

  2005cited by this paper
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  2005cited by this paper
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  2005influential reference
• Knockdown of Glutamate-Cysteine Ligase by Small Hairpin RNA Reveals That Both Catalytic and Modulatory Subunits Are Essential for the Survival of Primary Neurons*

  2005influential reference
• Glutamate Cysteine Ligase Catalysis

  2005cited by this paper
• Adenoviral Overexpression of the Glutamylcysteine Ligase Catalytic Subunit Protects Pancreatic Islets against Oxidative Stress*

  2004cited by this paper
• Genetically altered mice to evaluate glutathione homeostasis in health and disease.

  2004influential reference
• Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis.

  2004influential reference
• HIV-1 Tat-mediated protein transduction of Cu,Zn-superoxide dismutase into pancreatic β cells in vitro and in vivo

  2004cited by this paper
• Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress.

  2004cited by this paper
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  2004cited by this paper
• Bio-effectiveness of Tat-catalase conjugate: a potential tool for the identification of H2O2-dependent cellular signal transduction pathways.

  2003cited by this paper
• Gene Knockdown of γ-Glutamylcysteine Synthetase by RNAi in the Parasitic Protozoa Trypanosoma brucei Demonstrates That It Is an Essential Enzyme*

  2003cited by this paper
• The importance of glutathione in human disease.

  2003cited by this paper
• Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity.

  2003influential reference
• Modulation of cellular function by TAT mediated transduction of full length proteins.

  2003cited by this paper
• Strategies for reversing drug resistance

  2003cited by this paper
• A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production.

  2003influential reference
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002influential reference
• Caspase-3-Dependent Cleavage of the Glutamate-L-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death.

  2002influential reference
• Drosophila melanogaster Glutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form*

  2002cited by this paper
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  2001cited by this paper
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  2001influential reference
• Hammerhead ribozyme against γ-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins

  2001influential reference
• TAT-mediated protein transduction into mammalian cells.

  2001cited by this paper
• Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression.

  2001cited by this paper
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  2000influential reference
• Glutathione synthesis is essential for mouse development but not for cell growth in culture.

  2000cited by this paper
• Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.

  2000cited by this paper
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  2000cited by this paper
• In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA.

  2000cited by this paper
• Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistance.

  1999cited by this paper
• Overexpression of the regulatory subunit of c -glutamylcysteine synthetase in HeLa cells increases c -glutamylcysteine synthetase activity and confers drug resistance

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• Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

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• Biologic and pharmacologic regulation of mammalian glutathione synthesis.

  1999cited by this paper
• The Molecular Basis of a Case of γ-Glutamylcysteine Synthetase Deficiency

  1999cited by this paper
• In vivo protein transduction: delivery of a biologically active protein into the mouse.

  1999cited by this paper
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  1999influential reference
• Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis.

  1998cited by this paper
• Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

  1998cited by this paper
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