Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Biochemical Pharmacology

• Publication date

  2007-07-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.BCP.2007.02.003PMID 17517378
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glutathione synthetase deficiency

  2012cited by this paper
• Hepatocyte‐specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure

  2007cited by this paper
• Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.

  2006cited by this paper
• Transport of glutathione and glutathione conjugates by MRP1.

  2006cited by this paper
• Mechanisms of gamma-glutamylcysteine ligase regulation.

  2006cited by this paper
• Mechanisms of γ-glutamylcysteine ligase regulation

  2006cited by this paper
• Glutathione synthetase deficiency

  2005cited by this paper
• Glutathione transferases.

  2005cited by this paper
• Glutamate Cysteine Ligase Catalysis

  2005cited by this paper
• Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress.

  2004cited by this paper
• Sulfur containing amino acids and human disease.

  2004cited by this paper
• Genetically altered mice to evaluate glutathione homeostasis in health and disease.

  2004cited by this paper
• The changing faces of glutathione, a cellular protagonist.

  2003cited by this paper
• Polymorphism in Glutamate-Cysteine Ligase Modifier Subunit Gene Is Associated With Impairment of Nitric Oxide–Mediated Coronary Vasomotor Function

  2003cited by this paper
• Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction.

  2003cited by this paper
• The Modifier Subunit of Drosophila Glutamate-Cysteine Ligase Regulates Catalytic Activity by Covalent and Noncovalent Interactions and Influences Glutathione Homeostasis in Vivo*

  2003cited by this paper
• Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.

  2002cited by this paper
• Initial Characterization of the Glutamate-Cysteine Ligase Modifier Subunit Gclm(−/−) Knockout Mouse

  2002cited by this paper
• Glutathione in Defense and Signaling

  2002cited by this paper
• Glutathione S‐transferases

  2002cited by this paper
• Glutathione in defense and signaling: lessons from a small thiol.

  2002cited by this paper
• Overexpression of gamma-glutamylcysteine synthetase in human malignant mesothelioma.

  2002cited by this paper
• Expression of heavy subunit of γ‐glutamylcysteine synthetase (γ‐GCSh) in human colorectal carcinoma

  2002cited by this paper
• Drosophila melanogaster Glutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form*

  2002cited by this paper
• Overexpression of γ-glutamylcysteine synthetase in human malignant mesothelioma

  2002cited by this paper
• Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma.

  2002cited by this paper
• Expression of gamma-glutamyl cysteine synthetase in nonsmall cell lung carcinoma.

  2001cited by this paper
• Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes.

  2001cited by this paper
• Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells.

  2001cited by this paper
• Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel.

  2001cited by this paper
• Expression of γ‐glutamyl cysteine synthetase in nonsmall cell lung carcinoma

  2001cited by this paper
• Glutathione, oxidative stress and neurodegeneration.

  2000cited by this paper
• Glutathione synthesis is essential for mouse development but not for cell growth in culture.

  2000cited by this paper
• Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.

  2000cited by this paper
• A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia.

  2000cited by this paper
• The Molecular Basis of a Case of γ-Glutamylcysteine Synthetase Deficiency

  1999cited by this paper
• The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase.

  1999cited by this paper
• Applications of the yeast two-hybrid system.

  1999cited by this paper
• Yeast forward and reverse 'n'-hybrid systems.

  1999cited by this paper
• The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency.

  1999cited by this paper
• The putative gene for the first enzyme of glutathione biosynthesis in Plasmodium berghei and Plasmodium falciparum.

  1999cited by this paper
• Expression and characterization of human glutamate-cysteine ligase.

  1998cited by this paper
• ATP-dependent Transport of Reduced Glutathione on YCF1, the Yeast Orthologue of Mammalian Multidrug Resistance Associated Proteins*

  1998cited by this paper
• Recent trends in glutathione biochemistry--glutathione-protein interactions: a molecular link between oxidative stress and cell proliferation?

  1998cited by this paper
• Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis.

  1998cited by this paper
• Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of gamma-glutamyl-cysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5' untranslated region.

  1996cited by this paper
• PHD: predicting one-dimensional protein structure by profile-based neural networks.

  1996cited by this paper
• Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3.

  1995cited by this paper
• PHD - an automatic mail server for protein secondary structure prediction

  1994cited by this paper
• Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase.

  1993cited by this paper
• Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

  1993cited by this paper
• Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits.

  1984cited by this paper

• Neurodevelopmental Impact of Advanced Glycation End Products in Children with Autism Spectrum Disorder.

  2026cites this paper
• CENPT prevents renal cell carcinoma against ferroptosis by enhancing the synthesis of glutathione

  2025cites this paper
• Involvement of Glutamate Cysteine Ligase Genes in Tolerance to Emamectin Benzoate in Spodoptera frugiperda and Their Putative Regulatory Mechanisms.

  2023cites this paper
• TERT Extra-Telomeric Roles: Antioxidant Activity and Mitochondrial Protection

  2023influential citation
• Inducing ferroptosis has the potential to overcome therapy resistance in breast cancer

  2022cites this paper
• Gegen Qinlian Decoction Relieves Ulcerative Colitis via Adjusting Dysregulated Nrf2/ARE Signaling

  2022influential citation
• Ligaza γ-glutamylocysteiny – od molekularnych mechanizmów regulacji aktywności enzymatycznej do implikacji terapeutycznych

  2021cites this paper
• A Novel Sesquiterpene Lactone Xanthatin-13-(pyrrolidine-2-carboxylic acid) Isolated from Burdock Leaf Up-Regulates Cells’ Oxidative Stress Defense Pathway

  2021cites this paper
• Hepatic metabolic adaptation in a murine model of glutathione deficiency.

  2019cites this paper
• Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease

  2019cites this paper
• Plant glutathione biosynthesis revisited: redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization

  2019cites this paper
• Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase

  2019cites this paper
• Time‐Dependent Measurement of Nrf2‐Regulated Antioxidant Response to Ionizing Radiation Toward Identifying Potential Protein Biomarkers for Acute Radiation Injury

  2019cites this paper
• Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways

  2017cites this paper
• Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms

  2017cites this paper
• Translational and post-translational regulation of mouse cation transport regulator homolog 1

  2016cites this paper
• Glutamate cysteine ligase and the age-related decline in cellular glutathione: The therapeutic potential of γ-glutamylcysteine.

  2016cites this paper
• Translational and post-translational regulation of mouse cation transport regulator homolog 1

  2016cites this paper
• Dysregulation of Glutathione Synthesis in Psychiatric Disorders

  2015cites this paper
• Mitochondria as a Target in the Therapeutic Properties of Curcumin

  2014cites this paper
• Fucoxanthin Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes

  2014cites this paper
• ynthesis and Nuclear factor ( erythroid-derived 2 )-like 2 ( Nrf 2 )-inducing activity f the isothiocyanates iberverin , iberin and cheirolin nsa

  2013cites this paper
• Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin.

  2013cites this paper
• Glycation of Glutamate Cysteine Ligase by 2-Deoxy-d-Ribose and its Potential Impact on Chemoresistance in Glioblastoma

  2013cites this paper
• Astrocyte functions in the copper homeostasis of the brain.

  2013cites this paper
• The Amelioration of N-Acetyl-p-Benzoquinone Imine Toxicity by Ginsenoside Rg3: The Role of Nrf2-Mediated Detoxification and Mrp1/Mrp3 Transports

  2013cites this paper
• Nrf2 in Host Defense: Over the Rainbow

  2013cites this paper
• Neuronal activity-dependent protection against apoptotic and oxidative insults

  2012influential citation
• Curcumin – vom Molekül zur biologischen Wirkung

  2012cites this paper
• Curcumin--from molecule to biological function.

  2012cites this paper
• The Contribution of System Xc-to Prefrontal Cortical Mediated Behaviors Associated with Schizophrenia

  2012cites this paper
• Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts.

  2011cites this paper
• Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal.

  2011influential citation
• S-allylmercapto-N-acetylcysteine up-regulates cellular glutathione and protects vascular endothelial cells from oxidative stress.

  2011cites this paper
• Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits.

  2011cites this paper
• Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity.

  2010influential citation
• Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress*

  2010cites this paper
• Sulforaphane but not ascorbigen, indole‐3‐carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase‐2 and antioxidant enzymes in human keratinocytes in culture

  2010cites this paper
• Allicin up-regulates cellular glutathione level in vascular endothelial cells

  2009cites this paper
• Mechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of Saccharomyces cerevisiae Glutamate Cysteine Ligase*

  2009cites this paper
• Adaptation to G93Asuperoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis

  2009cites this paper
• Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase.

  2009influential citation