Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice1

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biology of Reproduction

• Publication date

  2008-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1095/biolreprod.108.069104PMID 18650495PMCID PMC2679517
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.

  2008cited by this paper
• Decreased mutant frequency in embryonic brain of DNA polymerase beta null mice.

  2006cited by this paper
• XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage

  2006cited by this paper
• Base excision repair fidelity in normal and cancer cells.

  2006cited by this paper
• Decreased mutant frequency in embryonic brain of DNA polymerase β null mice

  2006cited by this paper
• Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER.

  2006cited by this paper
• DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair.

  2005cited by this paper
• Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death.

  2005cited by this paper
• The overexpression of specialized DNA polymerases in cancer.

  2005cited by this paper
• REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast.

  2005cited by this paper
• The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death.

  2005cited by this paper
• ISfinder: the reference centre for bacterial insertion sequences

  2005cited by this paper
• Apurinic/Apyrimidinic Endonuclease (APE/REF-1) Haploinsufficient Mice Display Tissue-specific Differences in DNA Polymerase β-Dependent Base Excision Repair*

  2004cited by this paper
• p53 Deficiency Rescues Neuronal Apoptosis but Not Differentiation in DNA Polymerase β-Deficient Mice

  2004cited by this paper
• Spontaneous Mutagenesis Is Enhanced in Apex Heterozygous Mice

  2004influential reference
• Age-related base excision repair activity in mouse brain and liver nuclear extracts.

  2003influential reference
• The base excision repair: mechanisms and its relevance for cancer susceptibility.

  2003cited by this paper
• Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens.

  2003cited by this paper
• AP Endonuclease 1 Coordinates Flap Endonuclease 1 and DNA Ligase I Activity in Long Patch Base Excision Repair*

  2002cited by this paper
• Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress

  2002cited by this paper
• Base Excision Repair Is Limited by Different Proteins in Male Germ Cell Nuclear Extracts Prepared from Young and Old Mice

  2002influential reference
• Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice.

  2002cited by this paper
• Cellular responses to DNA damage.

  2001cited by this paper
• Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activity.

  2001influential reference
• Base excision repair in a network of defence and tolerance.

  2001cited by this paper
• Highly efficient base excision repair (BER) in human and rat male germ cells.

  2001cited by this paper
• DNA polymerase beta imbalance increases apoptosis and mutagenesis induced by oxidative stress.

  2001cited by this paper
• DNA polymerase β imbalance increases apoptosis and mutagenesis induced by oxidative stress

  2001cited by this paper
• Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair.

  2000cited by this paper
• Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase β

  2000influential reference
• Mitochondrial DNA ligase III function is independent of Xrcc1.

  2000cited by this paper
• The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity

  2000cited by this paper
• Going APE over ref-1.

  2000cited by this paper
• Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice.

  2000cited by this paper
• FEN1 Stimulation of DNA Polymerase β Mediates an Excision Step in Mammalian Long Patch Base Excision Repair*

  2000cited by this paper
• Passing the baton in base excision repair

  2000cited by this paper
• Quality control by DNA repair.

  1999cited by this paper
• Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.

  1999cited by this paper
• Transgenic Manipulation of the Mouse Genome

  1998cited by this paper
• Mutation frequency declines during spermatogenesis in young mice but increases in old mice.

  1998cited by this paper
• Endogenous lesions, S-phase-independent spontaneous mutations, and evolutionary strategies for base excision repair.

  1998cited by this paper
• Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells.

  1998cited by this paper
• Identification of redox/repair protein Ref-1 as a potent activator of p53.

  1997cited by this paper
• Copyright © 1998, American Society for Microbiology Efficient Repair of Abasic Sites in DNA by

  1997cited by this paper
• Morphological analysis of germ cell apoptosis during postnatal testis development in normal and Hsp70‐2 knockout mice

  1997cited by this paper
• An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination

  1997cited by this paper
• Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.

  1997cited by this paper
• Xrcc-1 expression during male meiosis in the mouse.

  1996cited by this paper
• Two Pathways for Base Excision Repair in Mammalian Cells (*)

  1996cited by this paper
• Reconstitution of DNA base excision‐repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

  1996cited by this paper
• DNA repair in eukaryotes.

  1996cited by this paper
• Specific Interaction of DNA Polymerase β and DNA Ligase I in a Multiprotein Base Excision Repair Complex from Bovine Testis*

  1996cited by this paper
• XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro.

  1996cited by this paper
• Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination

  1995cited by this paper
• Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair.

  1995cited by this paper
• DNA Polymerase Conducts the Gap-filling Step in Uracil-initiated Base Excision Repair in a Bovine Testis Nuclear Extract (*)

  1995cited by this paper
• Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

  1994cited by this paper
• The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

  1994cited by this paper
• Studies of gapped DNA substrate binding by mammalian DNA polymerase beta. Dependence on 5'-phosphate group.

  1994cited by this paper
• Testis and somaticXrcc-1 DNA repair gene expression

  1994cited by this paper
• Transgenic systems for in vivo mutation analysis.

  1993cited by this paper
• Purification, culture, and fractionation of spermatogenic cells.

  1993cited by this paper
• Short gap-filling synthesis by DNA polymerase beta is processive.

  1993cited by this paper
• Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding

  1993cited by this paper
• Identification and characterization of Ref‐1, a nuclear protein that facilitates AP‐1 DNA‐binding activity.

  1992cited by this paper
• DNA polymerase-beta and poly(ADP)ribose polymerase mRNAs are differentially expressed during the development of male germinal cells.

  1992cited by this paper
• Redox activation of Fos‐Jun DNA binding activity is mediated by a DNA repair enzyme.

  1992cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vector

  1991cited by this paper
• Identification of transgenic mice carrying the CAT gene with PCR amplification.

  1989cited by this paper
• Difference in the expression level of DNA polymerase beta among mouse tissues: high expression in the pachytene spermatocyte.

  1989cited by this paper
• Firefly luciferase gene: structure and expression in mammalian cells

  1987cited by this paper
• Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli.

  1985cited by this paper
• Spermatogenic cells of the prepuberal mouse: isolation and morphological characterization

  1977cited by this paper
• Human endonuclease specific for apurinic/apyrimidinic sites in DNA. Partial purification and characterization of multiple forms from placenta.

  1977cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• DNA polymerase β suppresses somatic indels at CpG dinucleotides in developing cortical neurons

  2025cites this paper
• The mutagenic consequences of defective DNA repair.

  2024cites this paper
• Mouse models to explore the biological and organismic role of DNA polymerase beta

  2024cites this paper
• Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice.

  2015cites this paper
• Heterozygosity for a Hypomorphic Polβ Mutation Reduces the Expansion Frequency in a Mouse Model of the Fragile X-Related Disorders

  2015influential citation
• Base excision repair capacity in informing healthspan.

  2014cites this paper
• Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia.

  2014cites this paper
• Decrease in Abundance of Apurinic/Apyrimidinic Endonuclease Causes Failure of Base Excision Repair in Culture‐Adapted Human Embryonic Stem Cells

  2013cites this paper
• Evolving DNA Repair Polymerases: From Double—Strand Break Repair to Base Excision Repair and VDJ Recombination

  2013cites this paper
• The Paternal Age Effect: A Multifaceted Phenomenon

  2013cites this paper
• Human O6‐methylguanine‐DNA methyltransferase containing C145A does not prevent hepatocellular carcinoma in C3HeB/FeJ transgenic mice

  2013cites this paper
• Ionizing radiation-induced mutant frequencies increase transiently in male germ cells of older mice.

  2012cites this paper
• Mouse models of DNA polymerases

  2012cites this paper
• Folate and Colorectal Cancer in Rodents: A Model of DNA Repair Deficiency

  2012cites this paper
• Aging alters tissue resident mesenchymal stem cell properties.

  2012cites this paper
• Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance

  2011cites this paper
• The impact of folate deficiency on the base excision repair pathway: Analysis of enzyme coordination in response to DNA damage and imbalanced repair

  2011cites this paper
• DNA polymerase beta is critical for genomic stability of sperm cells.

  2011cites this paper
• Age‐related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice

  2011cites this paper
• BAX and Tumor Suppressor TRP53 Are Important in Regulating Mutagenesis in Spermatogenic Cells in Mice1

  2010cites this paper
• Effect of dietary folate restriction on colon carcinogenesis in DNA polymerase beta haploinsufficient mice

  2010cites this paper
• BAX and Tumor Suppressor P53 are Important in Regulating Mutant Frequency in Spermatogenic Cells 1

  2010cites this paper
• Gastrointestinal Hyperplasia with Altered Expression of DNA Polymerase β

  2009cites this paper
• Digital Commons @ New Haven Digital Commons @ New Haven

  year unknowninfluential citation