DNA polymerase beta is critical for genomic stability of sperm cells.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  DNA Repair

• Publication date

  2011-04-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.dnarep.2011.01.003PMID 21333614PMCID PMC3255305
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.

  2010cited by this paper
• DNA polymerase β is critical for mouse meiotic synapsis

  2010influential reference
• Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice1

  2008cited by this paper
• Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations

  2007cited by this paper
• 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

  2007cited by this paper
• DNA topoisomerases I and II in human mature sperm cells: characterization and unique properties.

  2007cited by this paper
• Decreased mutant frequency in embryonic brain of DNA polymerase β null mice

  2006cited by this paper
• Decreased mutant frequency in embryonic brain of DNA polymerase beta null mice.

  2006cited by this paper
• Base excision repair fidelity in normal and cancer cells.

  2006cited by this paper
• Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

  2005cited by this paper
• The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis1

  2004cited by this paper
• A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair.

  2003cited by this paper
• Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens.

  2003cited by this paper
• Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress

  2002cited by this paper
• Base excision repair capacity in mitochondria and nuclei: tissue‐specific variations

  2002cited by this paper
• Base Excision Repair Is Limited by Different Proteins in Male Germ Cell Nuclear Extracts Prepared from Young and Old Mice

  2002cited by this paper
• Hypermutability to ionizing radiation in mismatch repair-deficient, Pms2 knockout mice.

  2001cited by this paper
• Mammalian DNA beta-polymerase in base excision repair of alkylation damage.

  2001cited by this paper
• 5'-Deoxyribose Phosphate Lyase Activity of Human DNA Polymerase ɩ in Vitro

  2001cited by this paper
• 5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro.

  2001cited by this paper
• Mammalian DNA β-polymerase in base excision repair of alkylation damage

  2001cited by this paper
• Completion of base excision repair by mammalian DNA ligases.

  2001cited by this paper
• Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase β

  2000cited by this paper
• The origins, patterns and implications of human spontaneous mutation

  2000cited by this paper
• AP lyases and dRPases: commonality of mechanism.

  2000cited by this paper
• Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta.

  1999cited by this paper
• Role of DNA Polymerase β in the Excision Step of Long Patch Mammalian Base Excision Repair*

  1999cited by this paper
• Involvement of Flap Endonuclease 1 in Base Excision DNA Repair*

  1998cited by this paper
• Lithocholic Acid, a Putative Tumor Promoter, Inhibits Mammalian DNA Polymerase β

  1998cited by this paper
• Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs.

  1998cited by this paper
• The activity of ENU, iPMS and MMS in male mouse germ cells using the Muta Mouse positive selection transgenic mutation assay.

  1997cited by this paper
• DNA excision repair pathways.

  1997cited by this paper
• The high spontaneous mutation rate: is it a health risk?

  1997cited by this paper
• Two Pathways for Base Excision Repair in Mammalian Cells (*)

  1996cited by this paper
• Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

  1994cited by this paper
• High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E.coli lysogen.

  1993cited by this paper
• DNA polymerase-beta and poly(ADP)ribose polymerase mRNAs are differentially expressed during the development of male germinal cells.

  1992cited by this paper
• Studies of the domain structure of mammalian DNA polymerase beta. Identification of a discrete template binding domain.

  1990cited by this paper
• Difference in the expression level of DNA polymerase beta among mouse tissues: high expression in the pachytene spermatocyte.

  1989cited by this paper
• Detection and analysis of UV-induced mutations in mammalian cell DNA using a lambda phage shuttle vector.

  1986cited by this paper
• Steady-state kinetics of mouse DNA polymerase beta.

  1979cited by this paper

• Harnessing DNA polymerase beta defect enhances synthetic lethality and treatment response in gastric cancer cells: implication for immunotherapy

  2026cites this paper
• Mouse models to explore the biological and organismic role of DNA polymerase beta

  2024cites this paper
• Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without interfering with mouse viability or fertility.

  2023cites this paper
• Mutation in DNA Polymerase Beta Causes Spontaneous Chromosomal Instability and Inflammation-Associated Carcinogenesis in Mice

  2019cites this paper
• Activity of DNA polymerase λ in spikelets of rice and maize

  2016cites this paper
• Involvement of p38MAPK-ATF2 signaling pathway in alternariol induced DNA polymerase β expression.

  2016cites this paper
• Base excision repair capacity in informing healthspan.

  2014cites this paper
• Base excision repair in the mammalian brain: implication for age related neurodegeneration.

  2013cites this paper
• Evolving DNA Repair Polymerases: From Double—Strand Break Repair to Base Excision Repair and VDJ Recombination

  2013cites this paper
• Current world literature.

  2012cites this paper
• Translesion DNA Polymerases and Cancer

  2012cites this paper
• Mouse models of DNA polymerases

  2012cites this paper
• Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates

  2012cites this paper
• DNA polymerase beta promoter mutations affect gene transcription, translation and the sensitivity of esophageal cancer cells to cisplatin treatment

  2012cites this paper
• Alternariol induces DNA polymerase β expression through the PKA-CREB signaling pathway.

  2012cites this paper
• Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance

  2011cites this paper