Genome‐wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol‐dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR‐family regulator YraB (AdhR)

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular Microbiology

• Publication date

  2009-02-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1111/j.1365-2958.2008.06568.xPMID 19170879PMCID PMC12149910
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR‐like repressor, YodB in Bacillus subtilis

  2008cited by this paper
• The Bacillus subtilis σM regulon and its contribution to cell envelope stress responses

  2008cited by this paper
• The tandem of free radicals and methylglyoxal.

  2008cited by this paper
• Selective recognition of metal ions by metalloregulatory proteins.

  2008cited by this paper
• Depletion of thiol‐containing proteins in response to quinones in Bacillus subtilis

  2008influential reference
• Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis

  2008cited by this paper
• CsoR regulates the copper efflux operon copZA in Bacillus subtilis.

  2007cited by this paper
• Transcriptome and proteome analyses in response to 2‐methylhydroquinone and 6‐brom‐2‐vinyl‐chroman‐4‐on reveal different degradation systems involved in the catabolism of aromatic compounds in Bacillus subtilis

  2007cited by this paper
• The Archaeon Methanosarcina acetivorans Contains a Protein Disulfide Reductase with an Iron-Sulfur Cluster

  2007cited by this paper
• Saccharomyces cerevisiae Hsp31p, a stress response protein conferring protection against reactive oxygen species.

  2007influential reference
• A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence.

  2007influential reference
• Control of key metabolic intersections in Bacillus subtilis

  2007cited by this paper
• CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.

  2007cited by this paper
• RAGE and RAGE ligands in cancer.

  2007cited by this paper
• Identification of Functional Subclasses in the DJ-1 Superfamily Proteins

  2007cited by this paper
• Physiological responses of Pseudomonas putida to formaldehyde during detoxification

  2007cited by this paper
• RAGE, diabetes, and the nervous system.

  2007cited by this paper
• Characterization and quantification of reversible redox sites in humic substances.

  2007cited by this paper
• Redox regulation of neuronal survival mediated by electrophilic compounds.

  2007cited by this paper
• The MarR‐type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2‐methylhydroquinone and catechol in Bacillus subtilis

  2007cited by this paper
• SigM-Responsive Genes of Bacillus subtilis and Their Promoters

  2007cited by this paper
• Reactive electrophile species.

  2007cited by this paper
• Humic substances

  2007cited by this paper
• Glutathione-Dependent Alcohol Dehydrogenase AdhC Is Required for Defense against Nitrosative Stress in Haemophilus influenzae

  2007cited by this paper
• The Physiological Role of the Ribulose Monophosphate Pathway in Bacteria and Archaea

  2006cited by this paper
• Biochemical Characterization of the Structural Zn2+ Site in the Bacillus subtilis Peroxide Sensor PerR*

  2006cited by this paper
• Predicting metals sensed by ArsR‐SmtB repressors: allosteric interference by a non‐effector metal

  2006cited by this paper
• Differential gene expression in response to phenol and catechol reveals different metabolic activities for the degradation of aromatic compounds in Bacillus subtilis.

  2006influential reference
• Global Control of Cysteine Metabolism by CymR in Bacillus subtilis

  2006cited by this paper
• Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers.

  2006cited by this paper
• Activation of the Keap1 Nrf2 pathway for neuroprotection by electrophillic phase II inducers

  2006cited by this paper
• The solution structure of the methylated form of the N‐terminal 16‐kDa domain of Escherichia coli Ada protein

  2006cited by this paper
• The Rok Protein of Bacillus subtilis Represses Genes for Cell Surface and Extracellular Functions

  2005cited by this paper
• Genetic Composition of the Bacillus subtilis SOS System

  2005cited by this paper
• Global expression profiling of Bacillus subtilis cells during industrial-close fed-batch fermentations with different nitrogen sources.

  2005cited by this paper
• Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.

  2005cited by this paper
• HxlR, a member of the DUF24 protein family, is a DNA‐binding protein that acts as a positive regulator of the formaldehyde‐inducible hxlAB operon in Bacillus subtilis

  2005cited by this paper
• A Design for Life: Prokaryotic Metal-binding MerR Family Regulators

  2005cited by this paper
• The role of Keap1 in cellular protective responses.

  2005cited by this paper
• Genetic and physiological responses of Bacillus subtilis to metal ion stress

  2005cited by this paper
• A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.

  2005influential reference
• Fluorescence spectroscopy reveals ubiquitous presence of oxidized and reduced quinones in dissolved organic matter.

  2005cited by this paper
• NmlR of Neisseria gonorrhoeae: a novel redox responsive transcription factor from the MerR family

  2005influential reference
• Systematic analysis of SigD-regulated genes in Bacillus subtilis by DNA microarray and Northern blotting analyses.

  2004cited by this paper
• Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

  2004cited by this paper
• Open source clustering software.

  2004cited by this paper
• Identification of AbrB‐regulated genes involved in biofilm formation by Bacillus subtilis

  2004cited by this paper
• Diversity in Chemotaxis Mechanisms among the Bacteria and Archaea

  2004cited by this paper
• Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

  2004cited by this paper
• Response of Bacillus subtilis to Nitric Oxide and the Nitrosating Agent Sodium Nitroprusside

  2004cited by this paper
• The role of cysteine residues as redox-sensitive regulatory switches.

  2004cited by this paper
• Spx-RNA Polymerase Interaction and Global Transcriptional Control during Oxidative Stress

  2004cited by this paper
• A comprehensive proteome map of growing Bacillus subtilis cells

  2004cited by this paper
• Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis

  2003cited by this paper
• Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.

  2003influential reference
• The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase.

  2003cited by this paper
• Bacterial production of methylglyoxal: a survival strategy or death by misadventure?

  2003cited by this paper
• SigM, an Extracytoplasmic Function Sigma Factor of Bacillus subtilis, Is Activated in Response to Cell Wall Antibiotics, Ethanol, Heat, Acid, and Superoxide Stress

  2003cited by this paper
• Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon

  2003cited by this paper
• Multiple roles of cysteine in biocatalysis.

  2003cited by this paper
• The MerR family of transcriptional regulators.

  2003cited by this paper
• Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus.

  2003cited by this paper
• Global Characterization of Disulfide Stress in Bacillus subtilis

  2003cited by this paper
• Identification of additional TnrA‐regulated genes of Bacillus subtilis associated with a TnrA box

  2003cited by this paper
• Additional Targets of the Bacillus subtilis Global Regulator CodY Identified by Chromatin Immunoprecipitation and Genome-Wide Transcript Analysis

  2003cited by this paper
• Regulation of inducible peroxide stress responses

  2002influential reference
• Metabolic Enzymes of Mycobacteria Linked to Antioxidant Defense by a Thioredoxin-Like Protein

  2002cited by this paper
• Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles.

  2002cited by this paper
• How oxygen damages microbes: oxygen tolerance and obligate anaerobiosis.

  2002cited by this paper
• Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels.

  2001cited by this paper
• Development and Characterization of a Xylose-Dependent System for Expression of Cloned Genes in Bacillus subtilis: Conditional Complementation of a Teichoic Acid Mutant

  2001cited by this paper
• A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans

  2001cited by this paper
• Development and Characterization of a Xylose-Dependent System for Expression of Cloned Genes inBacillus subtilis: Conditional Complementation of a Teichoic Acid Mutant

  2001cited by this paper
• Electrochemical properties of natural organic matter (NOM), fractions of NOM, and model biogeochemical electron shuttles.

  2000cited by this paper
• Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications.

  1999cited by this paper
• CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in Gram‐positive bacteria

  1999cited by this paper
• Methylglyoxal Modification of Protein

  1999cited by this paper
• The First Gene of the Bacillus subtilis clpC Operon,ctsR, Encodes a Negative Regulator of Its Own Operon and Other Class III Heat Shock Genes

  1998cited by this paper
• S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme.

  1998influential reference
• Characterization of a Protocatechuate Catabolic Gene Cluster from Rhodococcus opacus 1CP: Evidence for a Merged Enzyme with 4-Carboxymuconolactone-Decarboxylating and 3-Oxoadipate Enol-Lactone-Hydrolyzing Activity

  1998cited by this paper
• Methylglyoxal production in bacteria: suicide or survival?

  1998cited by this paper
• Cluster analysis and display of genome-wide expression patterns.

  1998cited by this paper
• Characterization of a Protocatechuate Catabolic Gene Cluster from Rhodococcus opacus 1 CP : Evidence for a Merged Enzyme with 4-Carboxymuconolactone-Decarboxylating and 3-Oxoadipate Enol-Lactone-Hydrolyzing Activity

  1997cited by this paper
• Analysis of chromatin structure by in vivo formaldehyde cross-linking.

  1997cited by this paper
• S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?

  1996influential reference
• Chemotaxis in Bacillus subtilis: how bacteria monitor environmental signals.

  1995cited by this paper
• Temporal activation of beta-glucanase synthesis in Bacillus subtilis is mediated by the GTP pool.

  1993cited by this paper
• SmtB is a metal-dependent repressor of the cyanobacterial metallothionein gene smtA: identification of a Zn inhibited DNA-protein complex.

  1993cited by this paper
• Bacillus Subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics

  1993cited by this paper
• Quinone chemistry and toxicity.

  1992cited by this paper
• Cloning, sequencing, and molecular analysis of the dnaK locus from Bacillus subtilis

  1992cited by this paper
• Widespread adaptive response against environmental methylating agents in microorganisms.

  1991influential reference
• Simultaneous and rapid isolation of bacterial and eukaryotic DNA and RNA: a new approach for isolating DNA.

  1991cited by this paper
• Molecular mechanisms of quinone cytotoxicity.

  1991cited by this paper
• Changes in Menaquinone Concentration During Growth and Early Sporulation in Bacillus subtilis

  1974cited by this paper

• Parageobacillus thermoglucosidasius and the reductive glycine pathway: A journey of Almosts and Maybes

  2025cites this paper
• Methanol metabolism in synthetic methylotrophic microorganisms.

  2025cites this paper
• Deciphering the molecular mechanism and regulation of formaldehyde detoxification in Mycobacterium smegmatis

  2024cites this paper
• The bacillithiol pathway is required for biofilm formation in Staphylococcus aureus.

  2024cites this paper
• Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking

  2024cites this paper
• Mitigating toxic formaldehyde to promote efficient utilization of C1 resources

  2024cites this paper
• The multifarious MerR family of transcriptional regulators

  2023cites this paper
• Differentiating Bacillus subtilis incorporates valine and methionine carbon into the backbone of specific fatty acids

  2023cites this paper
• The MerR‐family regulator NmlR is involved in the defense against oxidative stress in Streptococcus pneumoniae

  2022influential citation
• Transcriptomic Analysis Reveals the Role of tmRNA on Biofilm Formation in Bacillus subtilis

  2022cites this paper
• Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis.

  2022cites this paper
• THOR’s Hammer: the Antibiotic Koreenceine Drives Gene Expression in a Model Microbial Community

  2022cites this paper
• Unravelling Formaldehyde Metabolism in Bacteria: Road towards Synthetic Methylotrophy

  2022influential citation
• Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin’s Effects on Cells

  2021cites this paper
• Illuminating cellular formaldehyde

  2021cites this paper
• Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction

  2021cites this paper
• Molecular dissection of a dedicated formaldehyde dehydrogenase from Mycobacterium smegmatis

  2021cites this paper
• Bacterial MerR family transcription regulators: activationby distortion

  2021cites this paper
• Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction

  2021cites this paper
• Lysinibacillus sphaericus III(3)7 and Plasmid Vector pMK4: New Challenges in Cloning Platforms

  2021cites this paper
• SigB-regulated antioxidant functions in gram‐positive bacteria

  2021cites this paper
• Microsoft Word-fnaa174.docx

  2020cites this paper
• 4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen

  2020cites this paper
• Characterising the mechanism of action of an ancient antimicrobial, honey, using modern transcriptomics

  2020cites this paper
• Characterizing the Mechanism of Action of an Ancient Antimicrobial, Manuka Honey, against Pseudomonas aeruginosa Using Modern Transcriptomics

  2020cites this paper
• Impact of high salinity and the compatible solute glycine betaine on gene expression of Bacillus subtilis.

  2020cites this paper
• Analysis of disulphide bond linkage between CoA and protein cysteine thiols during sporulation and in spores of Bacillus species

  2020cites this paper
• Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.

  2019cites this paper
• Characterization of electrophilicity and oxidative potential of atmospheric carbonyls.

  2019cites this paper
• The Disulfide Stress Response and Protein S-thioallylation Caused by Allicin and Diallyl Polysulfanes in Bacillus subtilis as Revealed by Transcriptomics and Proteomics

  2019cites this paper
• Roles and regulation of Spx family transcription factors in Bacillus subtilis and related species.

  2019cites this paper
• Genome-Scale Metabolic Network Models of Bacillus Species Suggest that Model Improvement is Necessary for Biotechnological Applications

  2018cites this paper
• The bacillithiol pathway is required for biofilm formation in Staphylococcus aureus

  2018cites this paper
• The Role of Bacillithiol in Gram-Positive Firmicutes

  2017cites this paper
• The interactions of bacillithiol with carbonyl containing metabolites

  2017influential citation
• Methylglyoxal synthase regulates cell elongation via alterations of cellular methylglyoxal and spermidine content in Bacillus subtilis.

  2017cites this paper
• Global Transcriptional Response to Organic Hydroperoxide and the Role of OhrR in the Control of Virulence Traits in Chromobacterium violaceum

  2017cites this paper
• Soft Cysteine Signaling Network: The Functional Significance of Cysteine in Protein Function and the Soft Acids/Bases Thiol Chemistry That Facilitates Cysteine Modification.

  2017cites this paper
• Cytochrome c peroxidase regulates intracellular reactive oxygen species and methylglyoxal via enzyme activities of erythroascorbate peroxidase and glutathione-related enzymes in Candida albicans.

  2017cites this paper
• Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro

  2017cites this paper
• Identification of Position-Specific Correlations between DNA-Binding Domains and Their Binding Sites. Application to the MerR Family of Transcription Factors

  2016cites this paper
• Characterization of genes of unknown function in Bacillus subtilis: gene regulation and functional analysis

  2016cites this paper
• A Revolutionary Paradigm of Bacterial Genome Regulation

  2016cites this paper
• Formaldehyde Stress Responses in Bacterial Pathogens

  2016influential citation
• Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region

  2016cites this paper
• Listeria monocytogenes MerR-Like Regulator NmlRlm: Its Transcriptome and Role in Stress Response

  2016cites this paper
• Core pathways operating during methylotrophy of Bacillus methanolicus MGA3 and induction of a bacillithiol‐dependent detoxification pathway upon formaldehyde stress

  2015cites this paper
• Growth of Bacillus methanolicus in 2 M methanol at 50 °C: the effect of high methanol concentration on gene regulation of enzymes involved in formaldehyde detoxification by the ribulose monophosphate pathway

  2015cites this paper
• Cysteine sulfur chemistry in transcriptional regulators at the host-bacterial pathogen interface.

  2015cites this paper
• Two Lactococcus lactis thioredoxin paralogues play different roles in responses to arsenate and oxidative stress.

  2015influential citation
• Oxidative Stress Responses and Redox Signalling Mechanisms in Bacillus subtilis and Staphylococcus aureus

  2015cites this paper
• Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli.

  2015cites this paper
• Bacillithiol is a major buffer of the labile zinc pool in Bacillus subtilis

  2014cites this paper
• Methylglyoxal resistance in Bacillus subtilis: contributions of bacillithiol‐dependent and independent pathways

  2014cites this paper
• Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

  2014cites this paper
• Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection.

  2014cites this paper
• Purification and characterization of four key enzymes from a feather-degrading Bacillus subtilis from the gut of tarantula Chilobrachys guangxiensis

  2014cites this paper
• Insights into Protein Allostery in the CsoR/RcnR Family of Transcriptional Repressors.

  2014cites this paper
• The Lactococcus lactis Thioredoxin System

  2013cites this paper
• Global analysis of transcriptional regulators in Staphylococcus aureus

  2013cites this paper
• Novel regulatory system nemRA–gloA for electrophile reduction in Escherichia coli K‐12

  2013cites this paper
• Integrated stress response of Escherichia coli to methylglyoxal: transcriptional readthrough from the nemRA operon enhances protection through increased expression of glyoxalase I

  2013cites this paper
• Formaldehyde degradation in Corynebacterium glutamicum involves acetaldehyde dehydrogenase and mycothiol-dependent formaldehyde dehydrogenase.

  2013cites this paper
• Metal Homeostasis and Oxidative Stress in Bacillus subtilis

  2013cites this paper
• Transcription initiation control mediated by the global regular, Spx, in Bacillus subtilis

  2013cites this paper
• Comparative genomic and transcriptomic analyses of NaCl-tolerant Staphylococcus sp. OJ82 isolated from fermented seafood

  2013cites this paper
• Molecular basis of bacterial formaldehyde sensing

  2012cites this paper
• Specific non-peroxide antibacterial effect of manuka honey on the Staphylococcus aureus proteome.

  2012cites this paper
• Conservation of thiol‐oxidative stress responses regulated by SigR orthologues in actinomycetes

  2012cites this paper
• Contributions of Individual σB-Dependent General Stress Genes to Oxidative Stress Resistance of Bacillus subtilis

  2012cites this paper
• Evidence that a Single Monomer of Spx Can Productively Interact with RNA Polymerase in Bacillus subtilis

  2012cites this paper
• Defining the structure of the general stress regulon of Bacillus subtilis using targeted microarray analysis and random forest classification.

  2012cites this paper
• Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis.

  2012cites this paper
• Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis

  2012cites this paper
• A glutathione-based system for defense against carbonyl stress in Haemophilus influenzae

  2012cites this paper
• Structural insights into the redox-switch mechanism of the MarR/DUF24-type regulator HypR

  2012cites this paper
• pecific non-peroxide antibacterial effect of manuka honey on the Staphylococcus ureus proteome

  2012cites this paper
• A Putative MerR Family Regulator Involved in Biofilm Formation in Listeria monocytogenes 4b G

  2012cites this paper
• Prokaryotic genome regulation: A revolutionary paradigm

  2012cites this paper
• Primary and secondary oxidative stress in Bacillus.

  2011cites this paper
• S-Bacillithiolation Protects Against Hypochlorite Stress in Bacillus subtilis as Revealed by Transcriptomics and Redox Proteomics*

  2011cites this paper
• YjbH-Enhanced Proteolysis of Spx by ClpXP in Bacillus subtilis Is Inhibited by the Small Protein YirB (YuzO)

  2011cites this paper
• Novel bacterial MerR-like regulators their role in the response to carbonyl and nitrosative stress.

  2011cites this paper
• Thiol-Based Redox Switches and Gene Regulation

  2011influential citation
• Phenotype Enhancement Screen of a Regulatory spx Mutant Unveils a Role for the ytpQ Gene in the Control of Iron Homeostasis

  2011cites this paper
• Crh, the paralogue of the phosphocarrier protein HPr, controls the methylglyoxal bypass of glycolysis in Bacillus subtilis

  2011cites this paper
• Minireview Primary and secondary oxidative stress in Bacillus

  2011cites this paper
• Caractérisation biochimique et fonctionnelle de glutathion-S-transferases (GSTs) chez Phanerochaete chrysosporium

  2011cites this paper
• Bacillithiol, a New Player in Bacterial Redox Homeostasis

  2011cites this paper
• CtsR inactivation during thiol‐specific stress in low GC, Gram+ bacteria

  2011cites this paper
• Stress responses and sugar metabolism in Bacillus subtilis: a transcriptomic portrait

  2011cites this paper
• Prokaryotic genome regulation: multifactor promoters, multitarget regulators and hierarchic networks.

  2010cites this paper
• The Pleiotropic CymR Regulator of Staphylococcus aureus Plays an Important Role in Virulence and Stress Response

  2010cites this paper
• The MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae Responds to Carbonyl Stress and Modulates Hydrogen Peroxide Production

  2010cites this paper
• Regulation of CtsR activity in low GC, Gram+ bacteria.

  2010cites this paper
• The Proteomic Road Map to Explore Novel Mechanisms of Bacterial Physiology

  2010cites this paper
• The redox‐sensing regulator YodB senses quinones and diamide via a thiol‐disulfide switch in Bacillus subtilis

  2010cites this paper
• Identification of the sequences recognized by the Bacillus subtilis response regulator YclJ

  2010cites this paper
• Complex phenotypes of a mutant inactivated for CymR, the global regulator of cysteine metabolism in Bacillus subtilis.

  2010cites this paper
• Coordination chemistry of bacterial metal transport and sensing.

  2009cites this paper