The cysteinyl leukotriene 2 receptor mediates retinal edema and pathological neovascularization in a murine model of oxygen‐induced retinopathy

No abstract is available for this paper.

• Publication year

  2012

• Venue

  The FASEB Journal

• Publication date

  2012-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1096/fj.11-195792PMID 22131271
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypoxia differentially regulates VEGFR1 and VEGFR2 levels and alters intracellular signaling and cell migration in endothelial cells.

  2011cited by this paper
• Current update on retinopathy of prematurity: screening and treatment

  2011cited by this paper
• Characterization of the cysteinyl leukotriene 2 receptor in novel expression sites of the gastrointestinal tract.

  2011cited by this paper
• 5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids

  2011cited by this paper
• Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy

  2011cited by this paper
• The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization.

  2011cited by this paper
• A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice

  2011cited by this paper
• The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells.

  2010cited by this paper
• Increased synthesis of leukotrienes in the mouse model of diabetic retinopathy.

  2010cited by this paper
• Pericytes regulate the blood–brain barrier

  2010cited by this paper
• Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy.

  2010cited by this paper
• Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis

  2009influential reference
• Dual 12/15- and 5-Lipoxygenase Deficiency in Macrophages Alters Arachidonic Acid Metabolism and Attenuates Peritonitis and Atherosclerosis in ApoE Knock-out Mice*

  2009cited by this paper
• Leukotriene D4 stimulates the migration but not proliferation of endothelial cells mediated by the cysteinyl leukotriene cyslt(1) receptor via the extracellular signal-regulated kinase pathway.

  2009cited by this paper
• Cysteinyl leukotriene 2 receptor‐mediated vascular permeability via transendothelial vesicle transport

  2008cited by this paper
• Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors

  2008cited by this paper
• Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management.

  2008influential reference
• 5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy

  2008cited by this paper
• Retinopathy of prematurity

  2007cited by this paper
• Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose deprivation-induced PC12 cell death.

  2006cited by this paper
• The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl‐leukotrienes receptor

  2006cited by this paper
• Directed Vascular Expression of Human Cysteinyl Leukotriene 2 Receptor Modulates Endothelial Permeability and Systemic Blood Pressure

  2004cited by this paper
• Desmin ensheathment ratio as an indicator of vessel stability: evidence in normal development and in retinopathy of prematurity.

  2004cited by this paper
• Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression.

  2004cited by this paper
• Mechanisms of fluid accumulation in retinal edema

  2004cited by this paper
• Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity.

  2003cited by this paper
• Role of arteries in oxygen induced vaso-obliteration.

  2003cited by this paper
• Pathogenesis of retinopathy of prematurity

  2002cited by this paper
• Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets

  2001cited by this paper
• Characterization of the Human Cysteinyl Leukotriene 2 Receptor*

  2000cited by this paper
• Characterization of the human cysteinyl leukotriene CysLT1 receptor

  1999cited by this paper
• [Retinopathy of prematurity].

  1998cited by this paper
• Biosynthesis of sulfidopeptide leukotrienes via the transfer of leukotriene A4 from polymorphonuclear cells to bovine retinal pericytes.

  1998influential reference
• Pericytes in the microvasculature.

  1996cited by this paper
• Lipid mediators in the rat retina: light exposure and trauma elicit leukotriene B4 release in vitro.

  1995cited by this paper
• Oxygen-induced retinopathy in the mouse.

  1994cited by this paper
• Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction.

  1994cited by this paper
• Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism.

  1991cited by this paper
• Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes.

  1989cited by this paper
• Native and mutant 5-lipoxygenase expression in a baculovirus/insect cell system.

  1989cited by this paper
• Leukotriene generation and metabolism in isolated human lung macrophages.

  1988cited by this paper
• Synthesis of leukotrienes in frog retina and retinal pigment epithelium

  1987cited by this paper
• Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.

  1983cited by this paper
• Retrolental Fibroplasia: A Modern Parable. By W. A. Silverman. (Grune & Stratton, New York 1980) Price £13.20 (US $23.50).

  1981cited by this paper
• Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

  1981cited by this paper
• Retrolental Fibroplasia: A Modern Parable

  1980cited by this paper
• Immunofluorescent imaging of capillaries and pericytes in human skeletal muscle and retina.

  1980cited by this paper
• Pericytes in diabetic retinopathy.

  1966cited by this paper
• Direct Observation of the Effect of Oxygen on Developing Vessels

  1954cited by this paper

• The effect of CysLTR1 inhibition on cells of the retinal neurovascular unit in 5xFAD Alzheimer mice.

  2025cites this paper
• Leukotriene receptors in GtoPdb v.2025.3

  2025cites this paper
• Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD)

  2025cites this paper
• Cysteine Leukotriene Receptor Antagonist-Montelukast Effects on Diabetic Retinal Microvascular Endothelial Cells Curtail Autophagy

  2024cites this paper
• Leukotriene receptors in GtoPdb v.2023.1 Leukotriene receptors in GtoPdb v.2023.1

  2023cites this paper
• Distribution of the cysteinyl leukotriene system components in the human, rat and mouse eye.

  2023cites this paper
• Clinical and Translational Significance of Basophils in Patients with Cancer

  2022cites this paper
• Montelukast, an Antagonist of Cysteinyl Leukotriene Signaling, Impairs Burn Wound Healing

  2022cites this paper
• Discovery and Development of the Quininib Series of Ocular Drugs

  2022cites this paper
• Retinopatía Diabética: Desarrollo, Implicaciones y Herramientas Diagnosticas Novedosas

  2021cites this paper
• Leukotriene receptors (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database

  2020cites this paper
• The leukotriene receptors as therapeutic targets of inflammatory diseases.

  2019cites this paper
• Steroid Hormones and Other Lipid Molecules Involved in Human Reproduction

  2019cites this paper
• Montelukast Prevents Early Diabetic Retinopathy in Mice

  2019cites this paper
• Leukotriene receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis

  2018cites this paper
• Perspectives in New Advances in Retinal Neovascularization Pathogenesis and Therapeutic Approaches

  2017cites this paper
• Cysteinyl Leukotrienes and Their Receptors: Potential Roles in Endothelial Function and Cancer

  2016cites this paper
• A sustained release formulation of novel quininib-hyaluronan microneedles inhibits angiogenesis and retinal vascular permeability in vivo.

  2016influential citation
• Role of leukotrienes in diabetic retinopathy.

  2016cites this paper
• Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis*

  2016cites this paper
• Diabetic macular edema, retinopathy and age-related macular degeneration as inflammatory conditions

  2016cites this paper
• Endogenously Generated Omega‐3 Fatty Acids Attenuate Vascular Inflammation and Neointimal Hyperplasia by Interaction With Free Fatty Acid Receptor 4 in Mice

  2015cites this paper
• CysLT2 receptor mediates lipopolysaccharide-induced microglial inflammation and consequent neurotoxicity in vitro.

  2015cites this paper
• Multiple-Site Activation of the Cysteinyl Leukotriene Receptor 2 Is Required for Exacerbation of Ischemia/Reperfusion Injury

  2014cites this paper
• Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

  2014cites this paper
• Are GPCRs Still a Source of New Targets?

  2013cites this paper
• Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT2 and CysLT1 receptors

  2013cites this paper
• Intracerebroventricular injection of HAMI 3379, a selective cysteinyl leukotriene receptor 2 antagonist, protects against acute brain injury after focal cerebral ischemia in rats.

  2012cites this paper
• The leukotrienes: immune-modulating lipid mediators of disease.

  2012cites this paper