C. Funk

Target Product Profile Analysis of COVID-19 Vaccines in Phase III Clinical Trials and Beyond: An Early 2021 Perspective
202155 citationsauthor #1
Arginase-1 deficiency in neural cells does not contribute to neurodevelopment or functional outcomes after sciatic nerve injury.
20213 citationsauthor #5
A Novel Strategy to Mitigate the Hyperinflammatory Response to COVID-19 by Targeting Leukotrienes
202040 citationsauthor #1
A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic
2020179 citationsauthor #1
Perivascular adipose tissue–derived extracellular vesicle miR‐221‐3p mediates vascular remodeling
2019103 citationsauthor #4
Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy
201817 citationsauthor #5
Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin‐synthetic capacity under basal conditions
20186 citationsauthor #6
Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice
201854 citationsauthor #15
Erratum: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions
20181 citationsauthor #8
Resolvin E1 attenuates inj ury‐induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration
201846 citationsauthor #12
Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice1,2[S]
201720 citationsauthor #6
Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions1,2[S]
201713 citationsauthor #8
Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice
201716 citationsauthor #4
Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
20170 citationsauthor #4
Effects of p53-knockout in vascular smooth muscle cells on atherosclerosis in mice
201718 citationsauthor #4
Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
201716 citationsauthor #4
Thromboxane Governs the Differentiation of Adipose-Derived Stromal Cells Toward Endothelial Cells In Vitro and In Vivo.
201615 citationsauthor #18
Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency
201624 citationsauthor #6
EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling.
201579 citationsauthor #24
Strategies to Rescue the Consequences of Inducible Arginase-1 Deficiency in Mice
201513 citationsauthor #10
Arginase-1 deficiency
201577 citationsauthor #4
Aspirin enhances protective effect of fish oil against thrombosis and injury‐induced vascular remodelling
201534 citationsauthor #12
Endogenously Generated Omega‐3 Fatty Acids Attenuate Vascular Inflammation and Neointimal Hyperplasia by Interaction With Free Fatty Acid Receptor 4 in Mice
201538 citationsauthor #9
Multiple-Site Activation of the Cysteinyl Leukotriene Receptor 2 Is Required for Exacerbation of Ischemia/Reperfusion Injury
201420 citationsauthor #4
Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice.
201448 citationsauthor #12
Whole Blood Transcriptomics and Urinary Metabolomics to Define Adaptive Biochemical Pathways of High-Intensity Exercise in 50-60 Year Old Masters Athletes
201464 citationsauthor #8
Ectopic mineralization in late stage atherosclerosis of heme oxygenase‐1 deficient mice (832.11)
20140 citationsauthor #3
A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity.
201420 citationsauthor #6
Generation of an inducible arginase‐1 deficient mouse model
20130 citationsauthor #5
Cyclooxygenase-2–Derived Prostaglandin E2 Promotes Injury-Induced Vascular Neointimal Hyperplasia Through the E-prostanoid 3 Receptor
201379 citationsauthor #11
Cysteinyl leukotriene receptor 2 (CysLT2R)‐mediated vascular permeability and ischemia/reperfusion injury
20130 citationsauthor #4
Inducible Arginase 1 Deficiency in Mice Leads to Hyperargininemia and Altered Amino Acid Metabolism
201341 citationsauthor #7
Cyclooxygenase‐2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4)
201393 citationsauthor #3
Comparative expression profiling of 50–60 year old male competitive athletes and lean healthy individuals
20130 citationsauthor #4
Ex Vivo Akt/HO-1 Gene Therapy to Human Endothelial Progenitor Cells Enhances Myocardial Infarction Recovery
201235 citationsauthor #7
Development of myeloproliferative disease in 12/15-lipoxygenase deficiency.
201211 citationsauthor #5
Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice
2012229 citationsauthor #11
Prostaglandin receptor EP4 in abdominal aortic aneurysms.
201241 citationsauthor #10
The cysteinyl leukotriene 2 receptor mediates retinal edema and pathological neovascularization in a murine model of oxygen‐induced retinopathy
201229 citationsauthor #6
Atherosclerosis Lipoxygenase Pathways as Mediators of Early Inflammatory Events in
20120 citationsauthor #1
Targeted exchange of an expression cassette encoding cyclooxygenase-2 at the Ptgs1 locus.
20124 citationsauthor #4
Leukotriene Inflammatory Mediators Meet Their Match
201118 citationsauthor #1
A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice
201160 citationsauthor #7
064 Cysteinyl leukotriene 2 receptor-specific antagonist attenuates inflammation response-mediated myocardial ischemia/reperfusion injury
20110 citationsauthor #5
EX VIVO AKT/HO-1 GENE THERAPY TO HUMAN ENDOTHELIAL PROGENITOR CELLS SYNERGISTICALLY ENHANCES FUNCTIONAL RECOVERY AFTER MYOCARDIAL INFARCTION
20110 citationsauthor #7
Characterization of the cysteinyl leukotriene 2 receptor in novel expression sites of the gastrointestinal tract.
201132 citationsauthor #6
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.
2011795 citationsauthor #2
Differential Signaling of Cysteinyl Leukotrienes and a Novel Cysteinyl Leukotriene Receptor 2 (CysLT2) Agonist, N-Methyl-Leukotriene C4, in Calcium Reporter and β Arrestin Assays
201132 citationsauthor #6
Hemodynamics of the mouse abdominal aortic aneurysm.
201117 citationsauthor #4
Pulmonary Oxidative Stress Is Increased in Cyclooxygenase-2 Knockdown Mice with Mild Pulmonary Hypertension Induced by Monocrotaline
201149 citationsauthor #4
The Murine Angiotensin II-Induced Abdominal Aortic Aneurysm Model: Rupture Risk and Inflammatory Progression Patterns
201086 citationsauthor #5
Regulation Of Cysteinyl Leukotriene (CysL) Type 1 Receptor (CysLT1R) By Protein Kinase C (PKC)
20100 citationsauthor #4
5‐lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor α–induced hepatocyte damage in hyperlipidemia‐prone ApoE‐null mice
2010103 citationsauthor #10
The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease.
2010198 citationsauthor #2
Cyclooxygenase-2–Dependent Prostacyclin Formation and Blood Pressure Homeostasis: Targeted Exchange of Cyclooxygenase Isoforms in Mice
201049 citationsauthor #6
Numerical Simulations of the Intra-Aneurysmal Vortex Shedding in Induced Mouse Abdominal Aortic Aneurysms
20102 citationsauthor #4
A cell-based assay for screening lipoxygenase inhibitors.
200918 citationsauthor #2
134 DECREASED HEPATIC MACROPHAGE INFILTRATION, INSULIN RESISTANCE AND TNFa-INDUCED HEPATOCYTE DAMAGE IN APOE/5-LIPOXYGENASE DOUBLE KNOCKOUT MICE
20090 citationsauthor #10
Dual 12/15- and 5-Lipoxygenase Deficiency in Macrophages Alters Arachidonic Acid Metabolism and Attenuates Peritonitis and Atherosclerosis in ApoE Knock-out Mice*
200979 citationsauthor #4
Renal and cardiovascular characterization of COX-2 knockdown mice.
200949 citationsauthor #6
Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice.
200950 citationsauthor #5
Chapter 6 – Prostaglandins and Other Lipid Mediators in Reproductive Medicine
20098 citationsauthor #1
Endothelial cysteinyl leukotriene 2 receptor expression and myocardial ischemia/reperfusion injury.
200818 citationsauthor #2
EXAMINATION OF THE 5-LIPOXYGENASE/LEUKOTRIENE PATHWAY IN ADVANCED ATHEROSCLEROTIC LESION AND ABDOMINAL AORTIC ANEURYSM DEVELOPMENT IN 5-LIPOXYGENASE/APOE DEFICIENT MICE
20080 citationsauthor #2
Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury.
200863 citationsauthor #8
Cysteinyl leukotriene 2 receptor‐mediated vascular permeability via transendothelial vesicle transport
200852 citationsauthor #9
5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells.
20079 citationsauthor #6
COX-2 inhibitors and cardiovascular risk.
2007175 citationsauthor #1
Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice.
200735 citationsauthor #4
Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin.
200716 citationsauthor #2
PKC‐dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation
200731 citationsauthor #6
Targeted Cyclooxygenase Gene (Ptgs) Exchange Reveals Discriminant Isoform Functionality*
200760 citationsauthor #8
Eicosanoid Biology Prostaglandins and Leukotrienes: Advances in
20070 citationsauthor #1
A novel genetic model of selective COX-2 inhibition: comparison with COX-2 null mice.
200721 citationsauthor #2
Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.
2006108 citationsauthor #11
Lipoxygenase pathways as mediators of early inflammatory events in atherosclerosis.
200668 citationsauthor #1
Novel aspects of eicosanoid signaling through the use of gene-targeted mice
20062 citationsauthor #2
Is There a Role for the Macrophage 5‐Lipoxygenase Pathway in Aortic Aneurysm Development in Apolipoprotein E–Deficient Mice?
200610 citationsauthor #1
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function.
2006350 citationsauthor #5
Genetic model of selective COX2 inhibition reveals novel heterodimer signaling
200681 citationsauthor #8
Lipoxygenases: Potential Therapeutic Target in Atherosclerosis
20054 citationsauthor #2
12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway.
200538 citationsauthor #4
Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress Published, JLR Papers in Press, May 16, 2005. DOI 10.1194/jlr.M400469-JLR200
200581 citationsauthor #4
The Lamina Adventitia Is the Major Site of Immune Cell Accumulation in Standard Chow-Fed Apolipoprotein E–Deficient Mice
2005243 citationsauthor #7
Leukotriene modifiers as potential therapeutics for cardiovascular disease
2005302 citationsauthor #1
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
200551 citationsauthor #7
The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis.
2005116 citationsauthor #2
Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition.
200570 citationsauthor #7
Absence of 12/15 lipoxygenase reduces brain oxidative stress in apolipoprotein E-deficient mice.
200540 citationsauthor #4
Erratum: Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4 (American Journal of Physiology - Lung Cellular and Molecular Physiology (May 2004) 30 (L992-L1000)
20044 citationsauthor #10
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.
2004231 citationsauthor #5
Lipoxygenase pathways in atherogenesis.
2004200 citationsauthor #2
Directed Vascular Expression of Human Cysteinyl Leukotriene 2 Receptor Modulates Endothelial Permeability and Systemic Blood Pressure
200499 citationsauthor #7
P1-389 Increase of 12/15 lipooxygenase AD: potential role in oxidative stress
20040 citationsauthor #5
Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4.
200432 citationsauthor #10
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm
2004369 citationsauthor #16
" Isolation and structural characterization of a cDNA clone encoding rat gastric intrinsic factor , " by
20030 citationsauthor #2
Anion exchanger 2 is essential for spermiogenesis in mice
200381 citationsauthor #6
Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase.
200358 citationsauthor #3
12-Lipoxygenase Metabolites of Arachidonic Acid Mediate Metabotropic Glutamate Receptor-Dependent Long-Term Depression at Hippocampal CA3-CA1 Synapses
2003109 citationsauthor #5

PROFILE

PAPERS

TIMELINE

COAUTHOR MAP

CONCEPT FOOTPRINT