Cellular origins of cold‐induced brown adipocytes in adult mice

No abstract is available for this paper.

• Publication year

  2015

• Venue

  The FASEB Journal

• Publication date

  2015-01-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1096/fj.14-263038PMID 25392270PMCID PMC4285542
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

  2014cited by this paper
• Exploring the activated adipogenic niche: Interactions of macrophages and adipocyte progenitors

  2014cited by this paper
• Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans

  2014cited by this paper
• Recruited brown adipose tissue as an antiobesity agent in humans.

  2013cited by this paper
• Cold acclimation recruits human brown fat and increases nonshivering thermogenesis.

  2013cited by this paper
• Bi-directional interconversion of brite and white adipocytes

  2013cited by this paper
• Brown and beige fat: development, function and therapeutic potential

  2013cited by this paper
• Identification of an adipogenic niche for adipose tissue remodeling and restoration.

  2013influential reference
• Tracking adipogenesis during white adipose tissue development, expansion and regeneration

  2013influential reference
• Characterization of the adipocyte cellular lineage in vivo

  2013cited by this paper
• Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.

  2013cited by this paper
• Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues.

  2012cited by this paper
• The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells

  2012cited by this paper
• Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

  2012cited by this paper
• PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.

  2012cited by this paper
• Seeking the source of adipocytes in adult white adipose tissues

  2012cited by this paper
• In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding.

  2012influential reference
• Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans.

  2012cited by this paper
• The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells.

  2012cited by this paper
• Cold but not sympathomimetics activates human brown adipose tissue in vivo

  2012cited by this paper
• Brown adipose tissue activity controls triglyceride clearance

  2011cited by this paper
• Assessment of Oxidative Metabolism in Brown Fat Using PET Imaging

  2011cited by this paper
• Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

  2011cited by this paper
• The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation.

  2010cited by this paper
• Cellular bioenergetics as a target for obesity therapy

  2010cited by this paper
• Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

  2010cited by this paper
• Identification and importance of brown adipose tissue in adult humans.

  2009cited by this paper
• The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

  2009cited by this paper
• Functional brown adipose tissue in healthy adults.

  2009cited by this paper
• Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes*

  2009cited by this paper
• A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

  2009cited by this paper
• Perilipin Controls Lipolysis by Regulating the Interactions of AB-hydrolase Containing 5 (Abhd5) and Adipose Triglyceride Lipase (Atgl)*

  2009cited by this paper
• Cold-activated brown adipose tissue in healthy men.

  2009cited by this paper
• Globally optimal stitching of tiled 3D microscopic image acquisitions

  2009cited by this paper
• PRDM16 controls a brown fat/skeletal muscle switch

  2008cited by this paper
• PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

  2008cited by this paper
• Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis

  2008cited by this paper
• Developmental origin of fat: tracking obesity to its source.

  2007cited by this paper
• Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fats⃞ Published, JLR Papers in Press, October 14, 2006.

  2007cited by this paper
• Perilipin Targets a Novel Pool of Lipid Droplets for Lipolytic Attack by Hormone-sensitive Lipase*

  2005cited by this paper
• Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation.

  2005cited by this paper
• Brown adipose tissue: function and physiological significance.

  2004cited by this paper
• Beta 3-adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat.

  2003cited by this paper
• Rapid generation of inducible mouse mutants.

  2003cited by this paper
• Unexpected deposition of brown fat in mammary gland during postnatal development.

  2002cited by this paper
• Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis.

  2002cited by this paper
• Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes.

  2000cited by this paper
• b 1-Adrenergic Receptors Mediate b 3-Adrenergic-Independent Effects of CGP 12177 in Brown Adipose Tissue

  2000cited by this paper
• beta1-adrenergic receptors mediate beta3-adrenergic-independent effects of CGP 12177 in brown adipose tissue.

  2000cited by this paper
• β1-Adrenergic Receptors Mediate β3-Adrenergic-Independent Effects of CGP 12177 in Brown Adipose Tissue

  2000cited by this paper
• beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation.

  1999cited by this paper
• β1 to β3 Switch in Control of Cyclic Adenosine Monophosphate during Brown Adipocyte Development Explains Distinct β-Adrenoceptor Subtype Mediation of Proliferation and Differentiation1.

  1999cited by this paper
• Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

  1998cited by this paper
• Role of sympathetic innervation in brown adipocyte proliferation.

  1992cited by this paper
• Beta-adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture. Mediation via beta 1 but not via beta 3 adrenoceptors.

  1992cited by this paper
• Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization.

  1992cited by this paper
• Brown adipose tissue thermogenesis: interdisciplinary studies

  1990cited by this paper
• Proliferation and differentiation of brown adipocytes from interstitial cells during cold acclimation.

  1986influential reference
• Effects of sucrose feeding and denervation on lipogenesis in brown adipose tissue.

  1984cited by this paper
• Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia.

  1982influential reference
• Quantitative evaluation of gap junctions during development of the brown adipose tissue.

  1980cited by this paper
• Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis.

  1979cited by this paper
• The role of brown adipose tissue in the calorigenic effect of adrenaline and noradrenaline in cold‐acclimated rats

  1969cited by this paper

• Hilnc-mediated UCP1 translation repression contributes to thermogenesis and energy expenditure

  2026cites this paper
• SOX9 is part of a combinatorial marker that reveals early development and embryological origins of the mouse brown adipose tissue depots.

  2026cites this paper
• Age-dependent progenitor switching shapes adult brown adipose tissue heterogeneity

  2026cites this paper
• Nuciferine suppresses adipogenesis and mitochondrial function in brown adipocytes.

  2025cites this paper
• Interactions among nutrition, metabolism and the immune system in the context of starvation and nutrition-stimulated obesity

  2025cites this paper
• snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation

  2025cites this paper
• Adipose tissue ageing: implications for metabolic health and lifespan

  2025cites this paper
• A DEL-1/αvβ3 integrin axis promotes brown adipocyte progenitor proliferation and cold-induced brown adipose tissue adaptation

  2025cites this paper
• Adrenoceptors in GtoPdb v.2025.3

  2025cites this paper
• Spatial Transcriptomics of Adipose Tissue: Technologies, Applications, and Challenges

  2025cites this paper
• Brd9 antagonism induces beige adipocytes in white adipose tissues and protects against diet‐induced obesity

  2025cites this paper
• Commitment of adipose-resident c-kit+ progenitors to brown adipocytes contributes to adipose tissue homeostasis and remodeling

  2025cites this paper
• Adipose Progenitor Cells in Thermogenesis and Metabolic Regulation.

  2025cites this paper
• FAcTs on fire: Exploring thermogenesis.

  2025cites this paper
• Single-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold exposure

  2025cites this paper
• Brown adipocytes from pluripotent stem cells: a promising therapy for obesity

  2025cites this paper
• G-Protein-Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential

  2025cites this paper
• The innate thermogenic capacity of brown adipose tissue develops independently of sympathetic signaling

  2025cites this paper
• Cold environments and human metabolism: A traditional chinese medicine perspective

  2024cites this paper
• Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a sex-dependent fashion

  2024cites this paper
• Decoding temporal thermogenesis: coregulator selectivity and transcriptional control in brown and beige adipocytes

  2024cites this paper
• Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress

  2024cites this paper
• Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes

  2024cites this paper
• NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis

  2024cites this paper
• Adipose Tissue Dysfunction Determines Lipotoxicity and Triggers the Metabolic Syndrome: Current Challenges and Clinical Perspectives.

  2024cites this paper
• Mitophagy Responds to the Environmental Temperature and Regulates Mitochondrial Mass in Adipose Tissues.

  2024cites this paper
• Effects of Cryolipolysis on the Conversion of White Adipose Tissue: Pilot Study

  2024influential citation
• The Impact of Resident Adipose Tissue Macrophages on Adipocyte Homeostasis and Dedifferentiation

  2024cites this paper
• Differential expression of ADRB1 causes different responses to norepinephrine in adipocytes of Duroc-Landrace-Yorkshire pigs and min pigs.

  2024cites this paper
• Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.

  2024cites this paper
• Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs

  2024cites this paper
• The Notch-PDGFRβ axis suppresses brown adipocyte progenitor differentiation in early post-natal mice.

  2024cites this paper
• Beige or brite adipocytes of the adipose organ: Link with white and brown adipocytes.

  2024cites this paper
• Role of Spexin in White Adipose Tissue Thermogenesis under Basal and Cold-Stimulated Conditions

  2024cites this paper
• Navigating the Adipocyte Precursor Niche: Cell-Cell Interactions, Regulatory Mechanisms and Implications for Adipose Tissue Homeostasis

  2024cites this paper
• Enrichment of novel CD3+F4/80+ cells in brown adipose tissue following adrenergic stimulation

  2024cites this paper
• Adipose tissue at single-cell resolution.

  2023cites this paper
• Beyond energy balance regulation: The underestimated role of adipose tissues in host defense against pathogens

  2023cites this paper
• Abnormal lipid metabolism in cancer-associated cachexia and potential therapy strategy

  2023cites this paper
• Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing

  2023cites this paper
• Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors

  2023cites this paper
• Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm

  2023cites this paper
• Acteoside improves adipocyte browning by CDK6-mediated mTORC1-TFEB pathway.

  2023cites this paper
• CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.

  2023cites this paper
• Role of dysfunctional peri-organ adipose tissue in metabolic disease.

  2023cites this paper
• A Novel LncRNA MSTRG.310246.1 Promotes Differentiation and Thermogenesis in Goat Brown Adipocytes

  2023cites this paper
• Adipose Tissue Remodeling in Obesity: An Overview of the Actions of Thyroid Hormones and Their Derivatives

  2023cites this paper
• H19X-encoded microRNAs induced by IL-4 in adipocyte precursors regulate proliferation to facilitate differentiation

  2023cites this paper
• Involvement of a novel cAMP signaling mediator for beige adipogenesis.

  2023cites this paper
• Emerging roles of histone deacetylases in adaptive thermogenesis

  2023cites this paper
• Thermogenic Adipose Redox Mechanisms: Potential Targets for Metabolic Disease Therapies

  2023cites this paper
• Thermogenic adipose tissue in energy regulation and metabolic health

  2023cites this paper
• Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21

  2023cites this paper
• Elevated Norepinephrine Stimulates Adipocyte Hyperplasia in Ovine Fetuses with Placental Insufficiency and IUGR.

  2023cites this paper
• Pinuseldarone, a Clerodane-Type Diterpene from Pinus eldarica Needles and Phytochemicals as Novel Agents for Regulating Brown Adipogenesis and Thermogenesis.

  2023cites this paper
• Adrenergic Reprogramming of Preexisting Adipogenic Trajectories Steer Naïve Mural Cells Toward Beige Differentiation

  2023cites this paper
• Mesenchymal stromal cells as conductors of adipose tissue remodeling

  2023influential citation
• The Notch-Pdgfrβ axis suppresses brown adipocyte progenitor differentiation in early postnatal mice

  2023cites this paper
• Subacute and Low Dose of Tributyltin Exposure Leads to Brown Adipose Abnormalities in Male Rats.

  2023cites this paper
• Cellular and Transcriptional Dynamics during Brown Adipose Tissue Regeneration under Acute Injury

  2023cites this paper
• Rearing mice at 22°C programs increased capacity to respond to chronic exposure to cold but not high fat diet

  2023cites this paper
• Macrophage-Specific Connexin 43 Knockout Protects Mice from Obesity-Induced Inflammation and Metabolic Dysfunction

  2022cites this paper
• Deconstructing cold-induced brown adipocyte neogenesis in mice

  2022influential citation
• Role of adipocyte browning in prostate and breast tumor microenvironment

  2022cites this paper
• Brown adipose tissue involution associated with progressive restriction in progenitor competence

  2022cites this paper
• A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development

  2022cites this paper
• Skeletal Muscle Uncoupling Proteins in Mice Models of Obesity

  2022cites this paper
• Many Ways to Rome: Exercise, Cold Exposure and Diet—Do They All Affect BAT Activation and WAT Browning in the Same Manner?

  2022cites this paper
• Dysfunction of insulin-AKT-UCP1 signalling inhibits transdifferentiation of human and mouse white preadipocytes into brown-like adipocytes

  2022influential citation
• Global Adipose Tissue Remodeling During the First Month of Postnatal Life in Mice

  2022cites this paper
• Angiogenesis in adipose tissue and obesity

  2022cites this paper
• Insights into the adipose stem cell niche in health and disease

  2022cites this paper
• The Single-Cell Revelation of Thermogenic Adipose Tissue

  2022cites this paper
• The biological actions of prostanoids in adipose tissue in physiological and pathophysiological conditions.

  2022cites this paper
• Adipose Tissue Plasticity in Aging.

  2022cites this paper
• Alternative Complement Pathway Regulates Thermogenic Fat Function via Adipsin and Adipocyte-derived C3aR1 in a Sex-dependent Fashion

  2022cites this paper
• Role of thermogenic adipose tissue in lipid metabolism and atherosclerotic cardiovascular disease: lessons from studies in mice and humans

  2022cites this paper
• Thermogenic adipose tissue aging: Mechanisms and implications

  2022cites this paper
• Dysregulated adipose tissue expansion and impaired adipogenesis in Prader-Willi syndrome children before obesity-onset.

  2022cites this paper
• The cellular and functional complexity of thermogenic fat

  2021cites this paper
• Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue.

  2021cites this paper
• STK3/STK4 signalling in adipocytes regulates mitophagy and energy expenditure

  2021cites this paper
• Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health

  2021cites this paper
• Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential

  2021cites this paper
• Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats

  2021cites this paper
• Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review

  2021cites this paper
• Vascular smooth muscle-derived TRPV1-positive progenitors are a source of cold-induced thermogenic adipocytes

  2021cites this paper
• The genesis of brown fat—a smooth muscle origin story revisited

  2021cites this paper
• FOXP4 differentially controls cold-induced beige adipocyte differentiation and thermogenesis

  2021cites this paper
• Students’ view on supportive co-teaching in medical sciences: a systematic review

  2021cites this paper
• The evolving view of thermogenic adipocytes — ontogeny, niche and function

  2021cites this paper
• ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes

  2021cites this paper
• Obesity Protects Against Sepsis-induced and Norepinephrine-induced White Adipose Tissue Browning.

  2021cites this paper
• Quantification of adipocyte numbers in transgenic mice via the Cre-LoxP recombination sites

  2021cites this paper
• Cold-induced Conversion of Connective Tissue Skeleton in Brown Adipose Tissues

  2021cites this paper
• Insights into current models for developing brown adipocytes from induced pluripotent stem cells

  2021cites this paper
• Formation of thermogenic adipocytes: What we have learned from pigs

  2021cites this paper
• Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential

  2021cites this paper
• ADIPOSE TISSUE: The genesis of brown fat – a smooth muscle origin story, revisited

  2021cites this paper
• Plasticity and heterogeneity of thermogenic adipose tissue

  2021cites this paper