Cardiac Z-disc Signaling Network*

During the last 15 years, the perception of the cardiac z-disc has undergone substantial changes. Initially viewed as a structural component at the lateral boundaries of the sarcomere, the cardiac z-disc has increasingly become recognized as a nodal point in cardiomyocyte signal transduction and disease. This minireview thus focuses on novel components and recent developments in z-disc biology and their role in cardiac signaling and disease.

• Publication year

  2011

• Venue

  Journal of Biological Chemistry

• Publication date

  2011-01-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.R110.174268PMID 21257757PMCID PMC3060542
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• "MLP: A Stress Sensor Goes Nuclear" by Sylvia Gunkel, Jörg Heineke, Denise Hilfiker-Kleiner, Ralph Knöll, J Mol Cell Cardiol. 2009;47(4):423-5.

  2010cited by this paper
• L-type Ca(2+) current in ventricular cardiomyocytes.

  2010cited by this paper
• The Ubiquitin Proteasome System Regulates Cell Signaling and Protein Quality Control in Cardiovascular Development and Disease

  2010cited by this paper
• A distinctive role for focal adhesion proteins in three-dimensional cell motility

  2010cited by this paper
• The sarcomeric Z-disc component myopodin is a multiadapter protein that interacts with filamin and alpha-actinin.

  2010cited by this paper
• Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width.

  2010cited by this paper
• Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo.

  2010cited by this paper
• CIB1 is a Regulator of Pathological Cardiac Hypertrophy

  2010cited by this paper
• MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance.

  2010cited by this paper
• Loss of Enigma Homolog Protein Results in Dilated Cardiomyopathy

  2010cited by this paper
• ALP/Enigma PDZ-LIM domain proteins in the heart.

  2010cited by this paper
• Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy.

  2010cited by this paper
• Tragedy in a heartbeat: malfunctioning desmin causes skeletal and cardiac muscle disease.

  2009cited by this paper
• Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy

  2009cited by this paper
• Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein.

  2009cited by this paper
• The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling

  2009cited by this paper
• Physical and Functional Interaction Between Calcineurin and the Cardiac L-Type Ca2+ Channel

  2009cited by this paper
• Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice

  2009cited by this paper
• The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling

  2009cited by this paper
• HDAC4 and PCAF Bind to Cardiac Sarcomeres and Play a Role in Regulating Myofilament Contractile Activity*

  2008cited by this paper
• Gene Expression Pattern in Biomechanically Stretched Cardiomyocytes: Evidence for a Stretch-Specific Gene Program

  2008cited by this paper
• Back to square one: what do we know about the functions of Muscle LIM Protein in the heart?

  2008cited by this paper
• A Class III PDZ Binding Motif in the Myotilin and FATZ Families Binds Enigma Family Proteins: a Common Link for Z-Disc Myopathies

  2008cited by this paper
• Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy.

  2008cited by this paper
• Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation.

  2008cited by this paper
• Regulation of cardiac excitation and contraction by p21 activated kinase-1.

  2008cited by this paper
• PICOT Attenuates Cardiac Hypertrophy by Disrupting Calcineurin–NFAT Signaling

  2008cited by this paper
• Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.

  2007cited by this paper
• Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.

  2007cited by this paper
• Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease

  2007cited by this paper
• Laminin-&agr;4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells

  2007cited by this paper
• Calsarcin-1 Protects Against Angiotensin-II–Induced Cardiac Hypertrophy

  2007cited by this paper
• Myozenin 2 Is a Novel Gene for Human Hypertrophic Cardiomyopathy

  2007cited by this paper
• Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction

  2007cited by this paper
• Protein Kinase A, Ca2+/Calmodulin-Dependent Kinase II, and Calcineurin Regulate the Intracellular Trafficking of Myopodin between the Z-Disc and the Nucleus of Cardiac Myocytes

  2007cited by this paper
• Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein.

  2007cited by this paper
• Role of the sarcomeric Z-disc in the pathogenesis of cardiomyopathy.

  2007cited by this paper
• Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ.

  2006cited by this paper
• Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure.

  2006cited by this paper
• Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures.

  2006cited by this paper
• Orphaned ryanodine receptors in the failing heart.

  2006cited by this paper
• Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart.

  2006cited by this paper
• Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin.

  2006cited by this paper
• Integrin-Linked Kinase Expression Is Elevated in Human Cardiac Hypertrophy and Induces Hypertrophy in Transgenic Mice

  2006cited by this paper
• The sarcomeric Z-disc: a nodal point in signalling and disease

  2006cited by this paper
• Cardiac Overexpression of Melusin Protects From Dilated Cardiomyopathy Due to Long-Standing Pressure Overload

  2005cited by this paper
• The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins

  2005cited by this paper
• PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists.

  2005cited by this paper
• Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

  2005cited by this paper
• Promotion of importin α–mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3

  2005cited by this paper
• Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt.

  2005cited by this paper
• The genetic basis for cardiac remodeling.

  2005cited by this paper
• LMCD1/Dyxin Is a Novel Transcriptional Cofactor That Restricts GATA6 Function by Inhibiting DNA Binding

  2005cited by this paper
• Protein kinase cascades in the regulation of cardiac hypertrophy.

  2005cited by this paper
• Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc.

  2005cited by this paper
• Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

  2004cited by this paper
• A Cypher/ZASP Mutation Associated with Dilated Cardiomyopathy Alters the Binding Affinity to Protein Kinase C*

  2004cited by this paper
• The LIM domain: from the cytoskeleton to the nucleus

  2004cited by this paper
• At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function.

  2004cited by this paper
• Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex.

  2004cited by this paper
• Mutations in myotilin cause myofibrillar myopathy

  2004cited by this paper
• Focal Adhesion Protein Zyxin Is a Mechanosensitive Modulator of Gene Expression in Vascular Smooth Muscle Cells

  2004cited by this paper
• Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy.

  2004cited by this paper
• Intracellular Localization and Functional Effects of P21-Activated Kinase-1 (Pak1) in Cardiac Myocytes

  2004cited by this paper
• Melusin, a muscle-specific integrin β1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

  2003cited by this paper
• Costameres: the Achilles' Heel of Herculean Muscle* 210

  2003cited by this paper
• Mutations in the Human Muscle LIM Protein Gene in Families With Hypertrophic Cardiomyopathy

  2003cited by this paper
• Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction.

  2003cited by this paper
• Cardiac mechanotransduction and implications for heart disease

  2003cited by this paper
• Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis.

  2003cited by this paper
• The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.

  2002cited by this paper
• Striated muscle cytoarchitecture: an intricate web of form and function.

  2002cited by this paper
• Actin Capping Protein: An Essential Element in Protein Kinase Signaling to the Myofilaments

  2002cited by this paper
• Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy

  2002cited by this paper
• Calsarcin-3, a Novel Skeletal Muscle-specific Member of the Calsarcin Family, Interacts with Multiple Z-disc Proteins*

  2002cited by this paper
• Localization and kinetics of protein kinase C-epsilon anchoring in cardiac myocytes.

  2001cited by this paper
• Cardiac phosphodiesterase 5 (cGMP‐specific) modulates β‐adrenergic signaling in vivo and is down‐regulated in heart failure

  2001cited by this paper
• Isoproterenol Activates Extracellular Signal–Regulated Protein Kinases in Cardiomyocytes Through Calcineurin

  2001cited by this paper
• Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system.

  2001cited by this paper
• Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein

  2001cited by this paper
• Regulation of Microtubule Dynamics and Myogenic Differentiation by Murf, a Striated Muscle Ring-Finger Protein

  2000cited by this paper
• Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

  2000cited by this paper
• Epsilon protein kinase C in pathological myocardial hypertrophy. Analysis by combined transgenic expression of translocation modifiers and Galphaq.

  2000cited by this paper
• Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse.

  2000cited by this paper
• ε Protein Kinase C in Pathological Myocardial Hypertrophy

  2000cited by this paper
• Structural analysis of the titin gene in hypertrophic cardiomyopathy: identification of a novel disease gene.

  1999cited by this paper
• Alpha actinin–CapZ, an anchoring complex for thin filaments in Z-line

  1999cited by this paper
• Melusin Is a New Muscle-specific Interactor for β1Integrin Cytoplasmic Domain*

  1999cited by this paper
• Cypher, a Striated Muscle-restricted PDZ and LIM Domain-containing Protein, Binds to α-Actinin-2 and Protein Kinase C*

  1999cited by this paper
• The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function.

  1999cited by this paper
• Frequency and phenotypes of familial dilated cardiomyopathy.

  1998cited by this paper
• Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

  1998cited by this paper
• MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure.

  1997cited by this paper
• Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.

  1996cited by this paper
• Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

  1996cited by this paper
• The enigma of LIM domains.

  1995cited by this paper
• Inhibition of CapZ during myofibrillogenesis alters assembly of actin filaments

  1995cited by this paper
• Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat.

  1994cited by this paper
• Differential localization and sequence analysis of capping protein beta- subunit isoforms of vertebrates

  1994cited by this paper
• Mechanotransduction across the cell surface and through the cytoskeleton

  1993cited by this paper

• Mechanical factors in cardiac function: Stiffness and dynamic mechanotransduction pathways regulating contractility

  2026cites this paper
• Atlas of lysine acetylation in the mouse

  2026cites this paper
• Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress

  2024cites this paper
• A transcriptional enhancer regulates cardiac maturation

  2024cites this paper
• Compartmentalization in cardiomyocytes modulates creatine kinase and adenylate kinase activities

  2024cites this paper
• RNA-binding proteins in cardiovascular biology and disease: the beat goes on

  2024cites this paper
• Molecular Pathways and Animal Models of Cardiomyopathies.

  2024cites this paper
• Genetics and Pharmacogenetics of Atrial Fibrillation

  2024cites this paper
• In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury

  2024cites this paper
• The cryo-EM 3D image reconstruction of isolated Lethocerus indicus Z-discs

  2023cites this paper
• Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2

  2023cites this paper
• Structural and signaling proteins in the Z-disk and their role in cardiomyopathies

  2023cites this paper
• Stretching the story of titin and muscle function.

  2023cites this paper
• Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells

  2023cites this paper
• Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy

  2023cites this paper
• Fibin regulates cardiomyocyte hypertrophy and causes protein-aggregate-associated cardiomyopathy in vivo

  2023cites this paper
• Silencing MYOT Expression May Inhibit Autophagy in Human Skeletal Muscle Cells

  2023cites this paper
• The Role of Liquid–Liquid Phase Separation in Actin Polymerization

  2023cites this paper
• Considering the impact of age and sex on cardiac cytoskeletal components.

  2023cites this paper
• In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injury

  2023cites this paper
• Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart

  2023cites this paper
• MiRNA-29b and miRNA-497 Modulate the Expression of Carboxypeptidase X Member 2, a Candidate Gene Associated with Left Ventricular Hypertrophy

  2022influential citation
• Zebrafish integrin a3b is required for cardiac contractility and cardiomyocyte proliferation.

  2022cites this paper
• Sarcomere maturation: function acquisition, molecular mechanism, and interplay with other organelles

  2022cites this paper
• Self-construction of actin networks through phase separation–induced abLIM1 condensates

  2022cites this paper
• Nanoenviroments of the β-Subunit of L-Type Voltage-Gated Calcium Channels in Adult Cardiomyocytes

  2022cites this paper
• Enriched Pathways of Calcium Regulation, Cellular/Oxidative Stress, Inflammation, and Cell Proliferation Characterize Gluteal Muscle of Standardbred Horses between Episodes of Recurrent Exertional Rhabdomyolysis

  2022cites this paper
• The role of the M-band myomesin proteins in muscle integrity and cardiac disease

  2022influential citation
• Ultrastructural Adaptation of the Cardiomyocyte to Chronic Mitral Regurgitation

  2021cites this paper
• Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress.

  2021cites this paper
• Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

  2021cites this paper
• Circadian regulation of cardiac muscle function and protein degradation

  2021cites this paper
• Dilated cardiomyopathy: a new insight into the rare but common cause of heart failure

  2021cites this paper
• The Z-Disk Final Common Pathway in Cardiomyopathies

  2021cites this paper
• The Role of Genetics in Cardiomyopaties: A Review

  2021cites this paper
• Cardiac Filaminopathies: Illuminating the Divergent Role of Filamin C Mutations in Human Cardiomyopathy

  2021cites this paper
• How Localized Z-Disc Damage Affects Force Generation and Gene Expression in Cardiomyocytes

  2021cites this paper
• Molecular basis of F-actin regulation and sarcomere assembly via myotilin

  2021cites this paper
• Understanding the Molecular Basis of Cardiomyopathy.

  2021cites this paper
• Mutations in CSRP3/MLP, a Z-disc associated gene are functionally associated with dilated cardiomyopathy in Indian population

  2021cites this paper
• Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy

  2021cites this paper
• In-line holography with hard x-rays at sub-15  nm resolution

  2021cites this paper
• Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C

  2020cites this paper
• Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C

  2020cites this paper
• The M-band: The underestimated part of the sarcomere

  2020cites this paper
• Structural insights into F-actin regulation and sarcomere assembly via myotilin

  2020cites this paper
• Biomechanical Cues Direct Valvulogenesis

  2020cites this paper
• SUMO system – a key regulator in sarcomere organization

  2020cites this paper
• Study of the sarcomeric addition process in a tissue-like cell construct under mechanical overload via TPEF-SHG imaging system

  2020cites this paper
• Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes

  2020cites this paper
• The Drosophila CG1674 gene encodes a synaptopodin 2‐like related protein that localizes to the Z‐disc and is required for normal flight muscle development and function

  2020cites this paper
• Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling

  2020cites this paper
• When Stiffness Matters: Mechanosensing in Heart Development and Disease

  2020cites this paper
• The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics

  2019cites this paper
• Vinculin anchors contractile actin to the cardiomyocyte adherens junction

  2019cites this paper
• The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)

  2019cites this paper
• Mechanical regulation of gene expression in cardiac myocytes and fibroblasts

  2019cites this paper
• The Adherens Junction Interactome and the Role of Vinculin in Cytoskeletal Integration at the Cardiomyocyte ICD

  2019cites this paper
• Sarcomeres regulate cardiomyocyte maturation through MRTF-SRF signaling

  2019cites this paper
• Proteomic Identification of Protein Glutathionylation in Cardiomyocytes.

  2019cites this paper
• Polarization-Resolved Second Harmonic Generation Microscopy Study of Cardiac Hypertrophy

  2019cites this paper
• 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.

  2019cites this paper
• Special Issue: The Actin-Myosin Interaction in Muscle: Background and Overview

  2019cites this paper
• Influence of NO and [Ca2+]o on [Ca2+]i homeostasis in rat ventricular cardiomyocytes

  2018cites this paper
• Modeling Human Cardiac Hypertrophy in Stem Cell-Derived Cardiomyocytes

  2018cites this paper
• Arrangement and structure of α-actinins in striated muscle

  2018cites this paper
• Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling

  2018cites this paper
• Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload

  2018cites this paper
• Increased α-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer

  2018cites this paper
• abLIM1 constructs non-erythroid cortical actin networks to prevent mechanical tension-induced blebbing

  2018cites this paper
• Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells

  2018cites this paper
• University of Groningen Modeling Human Cardiac Hypertrophy in Stem Cell-Derived Cardiomyocytes

  2018cites this paper
• The N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics

  2018cites this paper
• Epicatechin as a Therapeutic Strategy to Mitigate the Development of Cardiac Remodeling and Fibrosis

  2017cites this paper
• Overview of the Muscle Cytoskeleton.

  2017cites this paper
• Progesterone signalling in broiler skeletal muscle is associated with divergent feed efficiency

  2017cites this paper
• Deficiency in Kelch protein Klhl31 causes congenital myopathy in mice.

  2017cites this paper
• Expression and Purification of ZASP Subdomains and Clinically Important Isoforms: High-Affinity Binding to G-Actin.

  2017cites this paper
• Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy

  2017cites this paper
• Muscle Lim Protein and myosin binding protein C form a complex regulating muscle differentiation.

  2017cites this paper
• Transcriptomic analysis of chicken Myozenin 3 regulation reveals its potential role in cell proliferation

  2017cites this paper
• Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z‐Line Proteins

  2017cites this paper
• Structure of isolated Z-disks from honeybee flight muscle

  2017cites this paper
• Molecular Cloning, Expression Profiling, and Marker Validation of the Chicken Myoz3 Gene

  2017influential citation
• Obscure functions: the location–function relationship of obscurins

  2017cites this paper
• MicroRNA miR-301a is a novel cardiac regulator of Cofilin-2

  2017cites this paper
• Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.

  2017cites this paper
• Calcineurin signaling in the heart: The importance of time and place.

  2017cites this paper
• Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms.

  2017cites this paper
• Molecular Changes in Heart Failure

  2017cites this paper
• A map of the phosphoproteomic alterations that occur after a bout of maximal‐intensity contractions

  2017cites this paper
• Real-time Observation of Dynamic Sarcomeric Addition in an In Vivo-like Cardiomyocyte Culture Model

  2017cites this paper
• Increases of desmin and α-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction.

  2016cites this paper
• Myofibrillar Z-discs Are a Protein Phosphorylation Hot Spot with Protein Kinase C (PKCα) Modulating Protein Dynamics*

  2016influential citation
• LRRC10 is required to maintain cardiac function in response to pressure overload.

  2016cites this paper
• The Role of Leucine-Rich Repeat Containing Protein 10 (LRRC10) in Dilated Cardiomyopathy

  2016cites this paper
• Orchestrated regulation of energy supply and energy expenditure: Transcriptional coexpression of metabolism, ion homeostasis, and sarcomeric genes in mammalian myocardium.

  2016cites this paper
• αT-Catenin Is a Constitutive Actin-binding α-Catenin That Directly Couples the Cadherin·Catenin Complex to Actin Filaments*

  2016cites this paper
• Disrupted autophagy undermines skeletal muscle adaptation and integrity

  2016cites this paper
• A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

  2016cites this paper