Photoreceptor Signaling: Supporting Vision across a Wide Range of Light Intensities*

For decades, photoreceptors have been an outstanding model system for elucidating basic principles in sensory transduction and biochemistry and for understanding many facets of neuronal cell biology. In recent years, new knowledge of the kinetics of signaling and the large-scale movements of proteins underlying signaling has led to a deeper appreciation of the photoreceptor's unique challenge in mediating the first steps in vision over a wide range of light intensities.

• Publication year

  2011

• Venue

  Journal of Biological Chemistry

• Publication date

  2011-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.R111.305243PMID 22074925PMCID PMC3265842
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diffusion and light-dependent compartmentalization of transducin.

  2011cited by this paper
• The functional cycle of visual arrestins in photoreceptor cells.

  2011cited by this paper
• Robust self-association is a common feature of mammalian visual arrestin-1.

  2011cited by this paper
• Role of Guanylyl Cyclase Modulation in Mouse Cone Phototransduction

  2011cited by this paper
• Conformational dynamics of recoverin's Ca2+‐myristoyl switch probed by 15N NMR relaxation dispersion and chemical shift analysis

  2011cited by this paper
• Roles of Glucose in Photoreceptor Survival*

  2011cited by this paper
• Interaction of Transducin with Uncoordinated 119 Protein (UNC119)

  2011cited by this paper
• Arrestin-1 expression level in rods: balancing functional performance and photoreceptor health.

  2011cited by this paper
• UNC119 is required for G protein trafficking in sensory neurons

  2011cited by this paper
• Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors.

  2011cited by this paper
• Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP.

  2010cited by this paper
• Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors

  2010cited by this paper
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  2010cited by this paper
• Channel Modulation and the Mechanism of Light Adaptation in Mouse Rods

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Control of Rhodopsin's Active Lifetime by Arrestin-1 Expression in Mammalian Rods

  2010cited by this paper
• RGS9 concentration matters in rod phototransduction.

  2009cited by this paper
• Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.

  2009cited by this paper
• Mg2+/Ca2+ cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase

  2009cited by this paper
• Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

  2009cited by this paper
• The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling

  2009cited by this paper
• Mouse cones require an arrestin for normal inactivation of phototransduction.

  2008cited by this paper
• A Role for GCAP2 in Regulating the Photoresponse

  2008cited by this paper
• Electrostatic and Lipid Anchor Contributions to the Interaction of Transducin with Membranes

  2008cited by this paper
• Light-Dependent Compartmentalization of Transducin in Rod Photoreceptors

  2008cited by this paper
• Ca2+‐dependent Regulation of Phototransduction †

  2008cited by this paper
• Rod and cone photoreceptors: molecular basis of the difference in their physiology.

  2008cited by this paper
• ATP consumption by mammalian rod photoreceptors in darkness and in light.

  2008cited by this paper
• Regulation of Arrestin Binding by Rhodopsin Phosphorylation Level*

  2007cited by this paper
• Deletion of PrBP/δ impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments

  2007cited by this paper
• Subunit Dissociation and Diffusion Determine the Subcellular Localization of Rod and Cone Transducins

  2007cited by this paper
• Signaling Properties of a Short-Wave Cone Visual Pigment and Its Role in Phototransduction

  2007cited by this paper
• Phototransduction in mouse rods and cones

  2007cited by this paper
• Mechanism of light‐induced translocation of arrestin and transducin in photoreceptors: Interaction‐restricted diffusion

  2007cited by this paper
• The Function of Guanylate Cyclase 1 and Guanylate Cyclase 2 in Rod and Cone Photoreceptors*

  2007cited by this paper
• Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity.

  2007cited by this paper
• Structure and function of the visual arrestin oligomer

  2007cited by this paper
• Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice.

  2007cited by this paper
• Transducin Translocation in Rods Is Triggered by Saturation of the GTPase-Activating Complex

  2007cited by this paper
• Multiple Phosphorylation Sites Confer Reproducibility of the Rod's Single-Photon Responses

  2006cited by this paper
• Arrestin Translocation Is Induced at a Critical Threshold of Visual Signaling and Is Superstoichiometric to Bleached Rhodopsin

  2006cited by this paper
• Light-driven translocation of signaling proteins in vertebrate photoreceptors.

  2006cited by this paper
• Why photoreceptors die (and why they don't)

  2006cited by this paper
• Photoreceptor vitality in organotypic cultures of mature vertebrate retinas validated by light-dependent molecular movements.

  2006cited by this paper
• Physiological Features of the S- and M-cone Photoreceptors of Wild-type Mice from Single-cell Recordings

  2006cited by this paper
• GC1 deletion prevents light-dependent arrestin translocation in mouse cone photoreceptor cells.

  2005cited by this paper
• A role for cytoskeletal elements in the light-driven translocation of proteins in rod photoreceptors.

  2005cited by this paper
• Farnesylation of retinal transducin underlies its translocation during light adaptation.

  2005cited by this paper
• Evaluation of the 17-kDa Prenyl-binding Protein as a Regulatory Protein for Phototransduction in Retinal Photoreceptors*

  2005cited by this paper
• Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions.

  2005cited by this paper
• Beyond counting photons: trials and trends in vertebrate visual transduction.

  2005cited by this paper
• Highly effective phosphorylation by G protein-coupled receptor kinase 7 of light-activated visual pigment in cones.

  2005cited by this paper
• Phosducin Facilitates Light-driven Transducin Translocation in Rod Photoreceptors

  2004cited by this paper
• Recoverin Regulates Light-dependent Phosphodiesterase Activity in Retinal Rods

  2004cited by this paper
• Absence of the RGS9·Gβ5 GTPase-activating Complex in Photoreceptors of the R9AP Knockout Mouse*

  2004cited by this paper
• Visual pigment phosphorylation but not transducin translocation can contribute to light adaptation in zebrafish cones.

  2004cited by this paper
• Temporal kinetics of the light/dark translocation and compartmentation of arrestin and alpha-transducin in mouse photoreceptor cells.

  2004cited by this paper
• GTPase Regulators and Photoresponses in Cones of the Eastern Chipmunk

  2003cited by this paper
• Rhodopsin phosphorylation: 30 years later.

  2003cited by this paper
• Novel Form of Adaptation in Mouse Retinal Rods Speeds Recovery of Phototransduction

  2003cited by this paper
• Dynamics of cyclic GMP synthesis in retinal rods.

  2002cited by this paper
• GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice

  2002cited by this paper
• Two Temporal Phases of Light Adaptation in Retinal Rods

  2002cited by this paper
• Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation.

  2002cited by this paper
• G proteins and phototransduction.

  2002cited by this paper
• Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors

  2001cited by this paper
• Maximal Rate and Nucleotide Dependence of Rhodopsin-catalyzed Transducin Activation

  2001cited by this paper
• Activation, deactivation, and adaptation in vertebrate photoreceptor cells.

  2001cited by this paper
• Adaptation in vertebrate photoreceptors.

  2001cited by this paper
• Photoreceptor light adaptation. Untangling desensitization and sensitization.

  2000cited by this paper
• The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements.

  2000cited by this paper
• Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites.

  2000cited by this paper
• Mice Lacking G-Protein Receptor Kinase 1 Have Profoundly Slowed Recovery of Cone-Driven Retinal Responses

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• The Effector Enzyme Regulates the Duration of G Protein Signaling in Vertebrate Photoreceptors by Increasing the Affinity between Transducin and RGS Protein*

  2000cited by this paper
• Microtubules in a rod-specific cytoskeleton associated with outer segment incisures

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• The Role of Steady Phosphodiesterase Activity in the Kinetics and Sensitivity of the Light-Adapted Salamander Rod Photoresponse

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• Photoreceptor Light Adaptation

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• Molecular mechanisms of vertebrate photoreceptor light adaptation.

  1999cited by this paper
• Light-dependent Changes in Outer Segment Free-Ca2+ Concentration in Salamander Cone Photoreceptors

  1999cited by this paper
• Disruption of a Retinal Guanylyl Cyclase Gene Leads to Cone-Specific Dystrophy and Paradoxical Rod Behavior

  1999cited by this paper
• Bleached Pigment Produces a Maintained Decrease in Outer Segment Ca2+ in Salamander Rods

  1998cited by this paper
• In Intact Cone Photoreceptors, a Ca2+-dependent, Diffusible Factor Modulates the cGMP-gated Ion Channels Differently than in Rods

  1998cited by this paper
• High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods.

  1998cited by this paper
• Onset of Feedback Reactions Underlying Vertebrate Rod Photoreceptor Light Adaptation

  1998cited by this paper
• Prolonged photoresponses in transgenic mouse rods lacking arrestin

  1997cited by this paper
• Single amino acid residue as a functional determinant of rod and cone visual pigments.

  1997cited by this paper
• Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein 1.

  1997cited by this paper
• Characterization of guanylate cyclase activity in single retinal rod outer segments

  1995cited by this paper
• Ca-dependent Interaction of Recoverin with Rhodopsin Kinase (*)

  1995cited by this paper
• Inhibition of Rhodopsin Kinase by Recoverin

  1995cited by this paper
• The phosphorylation state of phosducin determines its ability to block transducin subunit interactions and inhibit transducin binding to activated rhodopsin.

  1994cited by this paper
• Light adaptation and photopigment bleaching in cone photoreceptors in situ in the retina of the turtle

  1994cited by this paper
• Roles of lipid modifications of transducin subunits in their GDP-dependent association and membrane binding.

  1994cited by this paper
• Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin

  1993cited by this paper
• Nucleotide exchange and cGMP phosphodiesterase activation by pertussis toxin inactivated transducin.

  1991cited by this paper
• Control of light‐sensitive current in salamander rods.

  1988cited by this paper
• Phosphorylation of rhodopsin and quenching of cyclic GMP phosphodiesterase activation by ATP at weak bleaches.

  1983cited by this paper

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